50 Best Startups to Work in San Francisco in 2025

We are building AI to simulate the world through merging art and science.

We believe that world models are at the frontier of progress in artificial intelligence. Language models alone won't solve the world’s hardest problems – robotics, disease, scientific discovery. Real progress requires models that experience the world and ...

Doppler is the uncomplicated way to sync, manage, orchestrate, and rotate secrets across any environment or app config with easy-to-use tools.

Truffle Security is a cybersecurity company that offers open-source and enterprise solutions for finding and remediating leaked software credentials. Our secret-scanning engine, Truffle Hog, identifies and addresses credentials and passwords before hackers are able to find and exploit them. Detecting these credentials early allows companies to ...

Globality was founded with a simple but lofty goal: to use AI to transform enterprise spending into a smarter, fairer process, and create more efficient, inclusive markets around the globe. Globality is the future of enterprise spending: an AI solution that is guaranteed to empower employees, bolster the bottom line, and improve business outcomes ...

Galileo is the AI observability and evaluation platform that helps engineers ship reliable agents.

With one line of code, Galileo provides instant insight into multi-agent behavior so teams can find & fix errors quickly. Galileo provides automated testing in the development lifecycle to prevent regressions. And Galileo is ...

Airbyte specializes in open-source data integration, designed to centralize data from diverse sources into storage solutions like data warehouses and lakes. Supporting over 400 connectors and a self-serve, extensible framework, Airbyte enables organizations to move both structured and unstructured data seamlessly for uses like AI, analytics, and ...

Robust Intelligence's mission is to eliminate risks introduced by AI technologies. We consider the effect of AI risk not only on organizations but also on our society. Our product RIME has the ability to monitor and detect AI failures. We’ve built AI Stress Testing to detect a specific model’s weaknesses in the pre-deployment stage. In the ...

Matik automates the creation and sending of Google/PowerPoint decks with personalized text, images, charts, tables, and AI-powered insights. Just tell Matik who it's for and Matik will query the data to create data-driven content, like QBRs, EBRs, renewal decks, pitch decks, and ROI one-pagers.

At OpenSea, we’re building the destination for the onchain economy — a place where anyone, anywhere, can trade everything seamlessly. In 2021, we helped bring the first wave of everyday internet users onchain, introducing millions to digital ownership through NFTs. Collectors, artists, gamers, and creators all found a new way to own and exchange ...

At Render we are building a powerful, easy-to-use cloud platform to host anything online: from simple static sites to complex applications with dozens of microservices. Render offers the flexibility of traditional cloud providers without their complexity and maintenance headaches so developers and businesses can focus on building products instead ...

Machinify is an AI start-up in the Healthcare space. Our software platform leverages the latest advances in machine learning, large language models, data analytics, and cloud processing to solve previously intractable problems in the healthcare industry impacting millions of lives.

Open Source has become the critical supplier for modern software companies, changing everything about how people think about their code. FOSSA builds the infrastructure for modern teams to be successful with open source.

FOSSA's flagship product helps teams track the open source used in their code and automate license scanning ...

Distributional’s active AI testing platform enables AI product teams to identify, understand and address AI risk before production so they can ship high quality AI products with confidence. We've raised $30M in the past year to accomplish our mission.

Nova Credit is a credit infrastructure and analytics company that enables businesses to grow responsibly through alternative credit data. As a Consumer Reporting Agency (CRA), Nova Credit leverages its unique data infrastructure, compliance framework, and credit expertise to help lenders fill critical gaps in traditional credit analytics. The ...

Noyo is building the digital infrastructure to bring health insurance enrollment into the modern era. Noyo replaces today’s manual data entry and cumbersome legacy systems with a powerful API platform that enables faster, more accurate data exchange between health insurance platforms and their carrier partners.

Sprig is the leading product experience insights platform for teams building innovative, user-driven digital products. Our mission is to empower teams to make experiences that matter.

Making awesome products requires working with awesome people. At Sprig, our values are at the core of everything we do, say, and create as a team. ...

Check is a payroll-as-a-service API that lets you embed payroll directly in your vertical SaaS, HR, or time-tracking platform. Our API abstracts away the complexities of running payroll: tax calculation, remittance, and filing, plus the movement of money between companies and employees. This enables companies to easily build fully integrated ...

Subscription companies are losing 10%+ of revenue to failed payments—billions of dollars a year—a problem known as “Involuntary churn.”

Butter is on a mission to end involuntary churn. Using machine learning we help the greatest subscription companies in the world—Fabletics, The Athletic, Savage x Fenty, Found, Tonal, Hairstory— ...

Since its launch in 2016, Jackpot.com has become a world leader in the online lottery sector, with the goal of fundamentally changing the lottery experience through innovation and variety. Besides offering players the opportunity to bet on the outcomes of the world’s biggest lotteries, Jackpot.com offers an enriched gaming experience through ...

Privacy is messy. And complicated.

Organizations today rely on dozens of inter-connected data platforms-- SaaS apps, data lakes, and hosted databases -- making it difficult to know where all of a single person's data could be. But with the right solution, it is possible to make sense of privacy, and turn it into an advantage to ...

Craft illuminates the path to global supply chain resilience. We empower businesses to strengthen their supplier networks and supply chains with the industry's most trusted and comprehensive data fabric and advanced risk mitigation engine. Our easy-to-use platform provides 360-degree visibility to quickly explore and evaluate supplier ...

Cavnue is building smart roads for smart vehicles, and future-proofing the nation’s roadways.

The interstate highway system defined mobility in the second half of the 20th century. Now, transportation is changing again. Mobility in the 21st century will be defined by intelligent, connected, and autonomous vehicles and while billions ...

At January, we bring humanity to consumer finance. Using data intelligence, we create trust and deliver better outcomes for consumers and creditors alike. Our mission is simple: expand access to credit while empowering consumers to achieve lasting stability and control of their financial lives.

We began by building the foundation ...

Unlearn is advancing AI to eliminate trial and error in medicine, starting with reinventing clinical trials for the 21st century. We create AI-generated digital twins of individual trial participants that are forecasts of their future health outcomes. Digital twins of participants are used to run smaller, more efficient clinical trials that help ...

Parade is the leading capacity management platform for freight brokerages. By integrating with our customers' technology stack, we're able to create a single pane of glass that enables freight brokers to automate and scale their business. Parade's platform is built using cutting edge AI, Machine Learning, and advance automation ...

We automate and streamline repetitive, manual work so finance organizations can focus on driving the business forward. We're proudly backed by industry-leading investors, executives, and finance teams.

Fractal provides aspiring entrepreneurs with a business idea, a highly capable and complementary co-founder, capital, and ongoing support. Together, we’ll create fast-growing vertical SaaS companies that help modernize overlooked American industries.

Xage is a global leader in zero trust access and protection on a mission to pioneer a secure tomorrow. Control access and prevent attacks in the cloud, in the data center, at the remote operational edge anywhere on Earth, and even in orbit with the Xage Fabric Platform. Xage is easy to manage and can be deployed in a day, giving users easy and ...

On Aalto, buyers and sellers directly connect in a new, tech-enabled way that helps everyone save time, stress, and money.

Our mission is to build a place where buyers and sellers come together to accomplish their homeownership goals through a trusted, flexible, and transparent experience.

Aalto has raised over $17M ...

We work with global corporate partners to identify the most pressing challenges that they, and broader society, face. Inspired by these complex problems, we launch startups built by proven entrepreneurs, product leaders and technologists that use their agility and talent to develop transformative solutions. After these companies have matured and ...

Stytch is the most powerful identity platform built for developers. By powerful, we mean:

**Comprehensive:** Stytch has everything you need to identify, authenticate, and manage your users, including fraud prevention tools like device fingerprinting.
**Adaptable:** Stytch is the only auth provider that enables you to build ...

The world is moving towards more standardized, open, and interconnected data systems. However, employment infrastructure remains complex, closed, and fragmented.

Our mission is to democratize access to the infrastructure that underpins the employment sector and unlock much-needed innovations and create tremendous economic ...

Onfleet helps businesses around the globe power their deliveries.

Our mission is to make it easy for every retailer to offer fast, affordable, and delightful delivery to their customers.

Our software platform includes intuitive smartphone apps for drivers, a powerful modern web dashboard for dispatchers, and automatic ...

Opto Investments (“Opto”) are engineering the future of private markets, offering the solution for wealth managers to efficiently build and manage differentiated private investment programs.

Opto’s end-to-end technology solution dramatically streamlines building, fundraising for, and managing a bespoke private markets fund or ...

Tonic.ai frees developers to build with safe, high-fidelity synthetic data to accelerate software and AI innovation while protecting data privacy. Through industry-leading solutions for data synthesis, de-identification, and subsetting, our products enable on-demand access to realistic structured, semi-structured, and unstructured data for ...

Every day, thousands of brain images and signals are captured during clinical trials and in the course of routine patient care. Our software platform helps partners in med-tech and pharma ingest, organize, and analyze large amounts of brain data, all on state-of-the-art secure cloud infrastructure. Enabled by brain data, StrivePD, our patient and ...

Tired of taking manual screenshots or recording (and re-recording…) videos for documentation? We hear you. Tango takes the pain out of documenting processes by automatically generating how-to guides while you work.

Easily share and scale your team's knowledge—all while conducting business as usual. No more disruptions, ...

Deepgram is the leading voice AI platform for developers building speech-to-text (STT), text-to-speech (TTS) and full speech-to-speech (STS) offerings. 200,000+ developers build with Deepgram’s voice-native foundational models – accessed through APIs or as self-managed software – due to our unmatched accuracy, latency and pricing. Customers ...

Arc is the future of startup finance. Founded in 2021, Arc converts startups’ future revenue into upfront capital, provides a cash management account to store, manage and spend funds, and delivers financial analytics to drive growth. The company is based in San Francisco and is funded by Left Lane Capital, NFX, Bain Capital Ventures, Clocktower ...

Culture’s mission is to make bioprocess development and scale-up as fast and easy as scaling software. Towards this aim, Culture’s first offering enables biopharma, biotechnology, and synthetic biology companies to run their bioprocessing R&D in the cloud. Clients design, manage, and analyze bioprocess experiments in Culture’s Console web ...

Our mission is to drive rapid decarbonization in global transport and power sectors by intelligently connecting electric vehicles to the grid.

We are building the trust and governance infrastructure for the internet.

Data protection and trust go beyond borders, beyond organizations, and beyond individual teams.

Believing that the global data protection and privacy environments have been far more complex than they should be, Relyance is reimagining what data ...

Hex is changing the way people work with data. Our platform makes analytics workflows more powerful, collaborative, and shareable. Hex solves key pain points with today's data and analytics tooling, and is loved by thousands of users all over the world for the beautiful UI, new superpowers, and boundless flexibility.

We are a ...

We’re a passionate bunch dedicated to transforming collectible cards – and eventually other assets such as watches, sneakers, and art – into investable assets. Join our thriving team that is redefining the alternative investing space!

Nirvana is on a mission to modernize commercial insurance and enable a safer world. Our technology platform delivers modern insurance & risk management to not only help our customers protect their businesses, but actually improve safety for everyone.

To start, we’re transforming the legacy, $750B+ commercial insurance industry ...

Dealpath is the industry’s most trusted cloud-based real estate investment management platform, providing real-time access to vetted, secure, up-to-date investment data to empower collaboration, strategic, and predictive decisions. Investment and development firms leverage Dealpath as their command center for smart pipeline tracking, powerful deal ...

Memfault is the first IoT reliability platform that empowers teams to build more robust devices with software at scale. We believe that device reliability engineering will transform how developers build and operate IoT and edge devices with more productivity and more collaboration. As IoT applications continue to grow in complexity, it is more ...

SamaCare helps to eliminate the administrative barriers that limit patient access to life-changing therapies. Insurance-related administrative hassles for prescription drugs worsen outcomes for patients, delay therapy, and result in over $100B of administrative waste for the US healthcare system. Medical providers are forced to manage these ...

Founded by the original creators of Apache Pulsar, StreamNative offers the most cost-effective data streaming platform. It is Kafka API-compatible, easy to operate and scale. StreamNative rearchitected data streaming from ground up making sure it scales without high cost and without sacrificing performance. It’s available across all three major ...