50 Best Startups to Work in San Francisco in 2025

Runway was founded in 2018 with the vision that AI systems applied to audiovisual content would forever change media, art, and creativity. To achieve that vision, our research focuses on building AI systems that can understand and simulate the world and its dynamics, which we believe will form the next paradigm of computing.

Over ...

Doppler is the uncomplicated way to sync, manage, orchestrate, and rotate secrets across any environment or app config with easy to use tools.

Truffle Security is a cybersecurity company that offers open-source and enterprise solutions for finding and remediating leaked software credentials. Our secret-scanning engine, Truffle Hog, identifies and addresses credentials and passwords before hackers are able to find and exploit them. Detecting these credentials early allows companies to ...

Globality was founded with a simple but lofty goal: to use AI to transform enterprise spending into a smarter, fairer process, and create more efficient, inclusive markets around the globe. Globality is the future of enterprise spending: an AI solution that is guaranteed to empower employees, bolster the bottom line, and improve business outcomes ...

Galileo is the world’s first Machine Learning Data Intelligence platform- enabling data scientists to build better-performing ML models, faster, by finding and fixing data errors in minutes.

Our founding team Vikram Chatterji, Yash Sheth, and Atindriyo Sanyal have built Machine Learning models for over a decade at Google and Uber. ...

Airbyte specializes in open-source data integration, designed to centralize data from diverse sources into storage solutions like data warehouses and lakes. Supporting over 400 connectors and a self-serve, extensible framework, Airbyte enables organizations to move both structured and unstructured data seamlessly for uses like AI, analytics, and ...

Robust Intelligence's mission is to eliminate risks introduced by AI technologies. We consider the effect of AI risk not only on organizations but also on our society. Our product RIME has the ability to monitor and detect AI failures. We’ve built AI Stress Testing to detect a specific model’s weaknesses in the pre-deployment stage. In the ...

Matik automates the creation and sending of Google/PowerPoint decks with personalized text, images, charts, tables, and AI-powered insights. Just tell Matik who it's for and Matik will query the data to create data-driven content, like QBRs, EBRs, renewal decks, pitch decks, and ROI one-pagers.

At OpenSea, we're excited about a brand new type of digital good called a non-fungible token or NFT. NFTs have exciting new properties: they’re unique, provably scarce, tradeable, and usable across multiple applications. Just like physical goods, you can do whatever you want with them! You could throw them in the trash, gift them to a friend ...

At Render we are building a powerful, easy-to-use cloud platform to host anything online: from simple static sites to complex applications with dozens of microservices. Render offers the flexibility of traditional cloud providers without their complexity and maintenance headaches so developers and businesses can focus on building products instead ...

Machinify is an AI start-up in the Healthcare space. Our software platform leverages the latest advances in machine learning, large language models, data analytics, and cloud processing to solve previously intractable problems in the healthcare industry impacting millions of lives.

Open Source has become the critical supplier for modern software companies, changing everything about how people think about their code. FOSSA builds the infrastructure for modern teams to be successful with open source.

FOSSA's flagship product helps teams track the open source used in their code and automate license scanning ...

Distributional’s active AI testing platform enables AI product teams to identify, understand and address AI risk before production so they can ship high quality AI products with confidence. We've raised $30M in the past year to accomplish our mission.

At Nova Credit, our mission is to power a more fair and inclusive financial system for the world. We are on our way to accomplishing this mission by rewiring the financial industry with better credit infrastructure, analytics, and workflows, enabling more people to access credit opportunities. Our cross-border credit product, Credit Passport®, ...

Noyo is building the digital infrastructure to bring health insurance enrollment into the modern era. Noyo replaces today’s manual data entry and cumbersome legacy systems with a powerful API platform that enables faster, more accurate data exchange between health insurance platforms and their carrier partners.

Sprig is the leading product experience insights platform for teams building innovative, user-driven digital products. Our mission is to empower teams to make experiences that matter.

Making awesome products requires working with awesome people. At Sprig, our values are at the core of everything we do, say, and create as a team. ...

Check is a payroll-as-a-service API that lets you embed payroll directly in your vertical SaaS, HR, or time-tracking platform. Our API abstracts away the complexities of running payroll: tax calculation, remittance, and filing, plus the movement of money between companies and employees. This enables companies to easily build fully integrated ...

Subscription companies are losing 10%+ of revenue to failed payments—billions of dollars a year—a problem known as “Involuntary churn.”

Butter is on a mission to end involuntary churn. Using machine learning we help the greatest subscription companies in the world—Fabletics, The Athletic, Savage x Fenty, Found, Tonal, Hairstory— ...

Since its launch in 2016, Jackpot.com has become a world leader in the online lottery sector, with the goal of fundamentally changing the lottery experience through innovation and variety. Besides offering players the opportunity to bet on the outcomes of the world’s biggest lotteries, Jackpot.com offers an enriched gaming experience through ...

Privacy is messy. And complicated.

Organizations today rely on dozens of inter-connected data platforms-- SaaS apps, data lakes, and hosted databases -- making it difficult to know where all of a single person's data could be. But with the right solution, it is possible to make sense of privacy, and turn it into an advantage to ...

Craft illuminates the path to global supply chain resilience. We empower businesses to strengthen their supplier networks and supply chains with the industry's most trusted and comprehensive data fabric and advanced risk mitigation engine. Our easy-to-use platform provides 360-degree visibility to quickly explore and evaluate supplier ...

Cavnue is building smart roads for smart vehicles, and future-proofing the nation’s roadways.

The interstate highway system defined mobility in the second half of the 20th century. Now, transportation is changing again. Mobility in the 21st century will be defined by intelligent, connected, and autonomous vehicles and while billions ...

January is a Series B fintech company that works with borrowers who fall behind their loans to achieve financial stability while helping creditors modernize their collections process.

Traditional debt collection is rife with harassment and fraud. January is driving systemic change in this predatory industry by providing borrowers ...

Unlearn is advancing AI to eliminate trial and error in medicine, starting with reinventing clinical trials for the 21st century. We create AI-generated digital twins of individual trial participants that are forecasts of their future health outcomes. Digital twins of participants are used to run smaller, more efficient clinical trials that help ...

Parade is the leading capacity management platform for freight brokerages. By integrating with our customers' technology stack, we're able to create a single pane of glass that enables freight brokers to automate and scale their business. Parade's platform is built using cutting edge AI, Machine Learning, and advance automation ...

We automate and streamline repetitive, manual work so finance organizations can focus on driving the business forward. We're proudly backed by industry-leading investors, executives, and finance teams.

Fractal provides aspiring entrepreneurs with a business idea, a highly capable and complementary co-founder, capital, and ongoing support. Together, we’ll create fast-growing vertical SaaS companies that help modernize overlooked American industries.

Xage is a global leader in zero trust access and protection on a mission to pioneer a secure tomorrow. Control access and prevent attacks in the cloud, in the data center, at the remote operational edge anywhere on Earth, and even in orbit with the Xage Fabric Platform. Xage is easy to manage and can be deployed in a day, giving users easy and ...

On Aalto, buyers and sellers directly connect in a new, tech-enabled way that helps everyone save time, stress, and money.

Our mission is to build a place where buyers and sellers come together to accomplish their homeownership goals through a trusted, flexible, and transparent experience.

Aalto has raised over $17M ...

We work with global corporate partners to identify the most pressing challenges that they, and broader society, face. Inspired by these complex problems, we launch startups built by proven entrepreneurs, product leaders and technologists that use their agility and talent to develop transformative solutions. After these companies have matured and ...

Stytch is the most powerful identity platform built for developers. By powerful, we mean:

**Comprehensive:** Stytch has everything you need to identify, authenticate, and manage your users, including fraud prevention tools like device fingerprinting.
**Adaptable:** Stytch is the only auth provider that enables you to build ...

The world is moving towards more standardized, open, and interconnected data systems. However, employment infrastructure remains complex, closed, and fragmented.

Our mission is to democratize access to the infrastructure that underpins the employment sector and unlock much-needed innovations and create tremendous economic ...

Onfleet helps businesses around the globe power their deliveries.

Our mission is to make it easy for every retailer to offer fast, affordable, and delightful delivery to their customers.

Our software platform includes intuitive smartphone apps for drivers, a powerful modern web dashboard for dispatchers, and automatic ...

Opto Investments is a technology firm changing the way fiduciaries experience private markets.

Opto partners with advisors, CIOs, and other fiduciaries to solve the challenges of building and distributing customized private markets solutions at scale.

We bring all of Opto to our partnerships and provide hands-on ...

Tonic.ai was born out of a very tangible, practical need: equipping developers with high-quality, realistic data for dev and testing. Admittedly, it makes us sound like just another developer tool, but at the core of that need is our belief for why it truly matters. We wholeheartedly believe that data privacy is a human right. It isn’t just about ...

Every day, thousands of brain images and signals are captured during clinical trials and in the course of routine patient care. Our software platform helps partners in med-tech and pharma ingest, organize, and analyze large amounts of brain data, all on state-of-the-art secure cloud infrastructure. Enabled by brain data, StrivePD, our patient and ...

Tired of taking manual screenshots or recording (and re-recording…) videos for documentation? We hear you. Tango takes the pain out of documenting processes by automatically generating how-to guides while you work.

Easily share and scale your team's knowledge—all while conducting business as usual. No more disruptions, ...

Our end-to-end deep neural network is revolutionizing the speech-to-text market and taking on the big guys. We’re redefining what companies can do with voice by offering a platform with AI architectural advantage, not legacy tech retrofitted with AI. We’ve raised over $56M and have been recognized as an Inc. Best Workplace (2021 and 2022), a ...

Arc is the future of startup finance. Founded in 2021, Arc converts startups’ future revenue into upfront capital, provides a cash management account to store, manage and spend funds, and delivers financial analytics to drive growth. The company is based in San Francisco and is funded by Left Lane Capital, NFX, Bain Capital Ventures, Clocktower ...

Culture’s mission is to make bioprocess development and scale-up as fast and easy as scaling software. Towards this aim, Culture’s first offering enables biopharma, biotechnology, and synthetic biology companies to run their bioprocessing R&D in the cloud. Clients design, manage, and analyze bioprocess experiments in Culture’s Console web ...

Our mission is to drive rapid decarbonization in global transport and power sectors by intelligently connecting electric vehicles to the grid.

We are building the trust and governance infrastructure for the internet.

Data protection and trust go beyond borders, beyond organizations, and beyond individual teams.

Believing that the global data protection and privacy environments have been far more complex than they should be, Relyance is reimagining what data ...

We're building a collaborative platform for data science and analytics. Our product empowers users to explore, analyze, and share data more effectively and has become essential to how data teams at 800+ companies like Notion, Brex, and Fivetran operate.

Every day, Hex empowers thousands of people to ask and answer new ...

We’re a passionate bunch dedicated to transforming collectible cards – and eventually other assets such as watches, sneakers, and art – into investable assets. Join our thriving team that is redefining the alternative investing space!

Nirvana is on a mission to modernize commercial insurance and enable a safer world. Our technology platform delivers modern insurance & risk management to not only help our customers protect their businesses, but actually improve safety for everyone.

To start, we’re transforming the legacy, $750B+ commercial insurance industry ...

Dealpath is the industry’s most trusted cloud-based real estate investment management platform, providing real-time access to vetted, secure, up-to-date investment data to empower collaboration, strategic, and predictive decisions. Investment and development firms leverage Dealpath as their command center for smart pipeline tracking, powerful deal ...

Memfault is the first IoT reliability platform that empowers teams to build more robust devices with software at scale. We believe that device reliability engineering will transform how developers build and operate IoT and edge devices with more productivity and more collaboration. As IoT applications continue to grow in complexity, it is more ...

SamaCare helps to eliminate the administrative barriers that limit patient access to life-changing therapies. Insurance-related administrative hassles for prescription drugs worsen outcomes for patients, delay therapy, and result in over $100B of administrative waste for the US healthcare system. Medical providers are forced to manage these ...

Founded by the original creators of Apache Pulsar, StreamNative offers the most cost-effective data streaming platform. It is Kafka API-compatible, easy to operate and scale. StreamNative rearchitected data streaming from ground up making sure it scales without high cost and without sacrificing performance. It’s available across all three major ...