Top Des Moines, IA Startups (10,000+)

Engrain’s mission is to fundamentally transform the way people find, lease and manage property. A recognized leader in next-generation touring technology and map-based data visualization software, Engrain’s advanced integrations and technical flexibility offer solutions for any real-estate technology stack.

Dandy is transforming the massive ($400B) but antiquated dental industry. Backed by some of the world's leading venture capital investors, we’re building custom, end-to-end, precision software and manufacturing from the ground up to provide high-quality, consistent, and affordable restorations to our doctors and their patients. 2 million people already have a Dandy product in their mouth and that number is...

Atlassian creates teamwork solutions for high-performing teams. Our portfolio of collaboration and work management software products includes Jira, Confluence, Trello, Loom and Rovo. More than 300,000 businesses worldwide rely on Atlassian’s technology, including 80 percent of Fortune 500 companies. Our solutions support various business teams and they help organizations plan, track, and deliver their biggest ideas together.

Join. Grow. Lead the Future of Supply Chain. At Cleo, we don’t just integrate supply chains—we orchestrate them. As the pioneer and global leader of the Supply Chain Orchestration software category, Cleo is helping thousands of companies around the globe drive transformation, deliver excellence, and shape the future of their global operations. Whether you're joining us from outside or growing within, Cleo...

We started as a company that turned phones into walkie-talkies. Today, we modernize instant voice communication with our industry-leading push-to-talk technology to help mobile workers meet quickly changing, urgent, real-world challenges. We have the highest-rated walkie-talkie app, with over 8 billion messages sent per month and 170 million users in industries such as transportation, retail, construction, hospitality, healthcare, and more....

Riskified (NYSE:RSKD) empowers businesses to unleash ecommerce growth by outsmarting risk. Many of the world’s biggest brands and publicly traded companies selling online rely on Riskified for guaranteed protection against chargebacks, to fight fraud and policy abuse at scale, and to improve customer retention. Developed and managed by the largest team of ecommerce risk analysts, data scientists and researchers, Riskified’s...

MarketAxess is on a journey to digitally transform one of the world's largest financial markets, enabling the shift from analog, phone-based trading to a fully electronic marketplace. Why does this matter? Because our platform makes trading fixed-income more accessible, ultimately improving transparency, efficiency and competition in the marketplace. Changing the way an established industry transacts is no easy feat. There...

Founded in 2010, Doximity is the leading digital platform for U.S. medical professionals. Our network members include over 80% of U.S. physicians across all states and every medical specialty. Our mission is to help every physician be more productive and provide better care for their patients. We are physicians-first, putting technology to work for doctors instead of the other way around....

Akeneo is the product experience (PX) company and global leader in Product Information Management (PIM). Akeneo empowers business leaders with software, education, and an engaged community all focused on the practice of product experience management. Leading brands, manufacturers, distributors, and retailers, including Chico’s, CarParts.com, TaylorMade Golf, Rail Europe, Kering, and more trust Akeneo to scale their commerce initiatives. Using Akeneo’s...

As a full-service agency, program operator, and SaaS technology platform, Share Local Media helps tech and e-commerce companies leverage direct mail to achieve efficient direct response outcomes with high quality branding.

We are a purpose driven healthcare technology company passionate about innovation and using technology to help people by solving real world problems. The ALIS team designs, builds, delivers, and supports our flagship product ALIS (pronounced “Alice” and stands for Assisted Living Integrated Solution).

Agero is a leading provider of driver assistance, accident management, consumer affairs support and connected vehicle services for stakeholders across the automotive industry, including the world’s largest automakers, auto retailers, insurers, rideshare providers and other brands. As the driving force behind mobility support throughout all points in the vehicle ownership journey - from purchase to maintenance and breakdown to resell or...

Hiya is trusted by global businesses, carriers, and consumers to enable secure, engaging connections and stop unwanted calls. Hiya is pioneering the next generation of AI-powered voice intelligence with real-time analysis and an AI assistant to enhance voice protection, productivity, and call performance. Hiya connects businesses with their customers, helps carriers secure their networks, and protects people from spam and...

Aceable is a mobile education platform, focused on creating affordable, engaging, and convenient educational content. Our Austin-based team is obsessed with helping people pursue their dreams with continued education. After launching our first mobile app to provide accredited driver's ed courses, Aceable expanded into real estate, mortgage, insurance, and healthcare education. We actively work to foster a creative, collaborative, and...

BuildOps is the only all-in-one management software built specifically for the modern commercial contractor, combining service and project management and everything in between. Focused on serving the commercial Mechanical, Electrical, Plumbing (MEP) market, the BuildOps platform enables contractors to prove out current market trends, optimize their business for higher profits, and stay ahead of the competition.

Named among the World’s Most Admired Companies™ by Fortune and recognized in the Fortune 100 Best Companies to Work For® list in 2025, MetLife is leading the global transformation of an industry we’ve defined for more than 155 years. At MetLife, every innovation and line of code is a lifeline for our customers and their families—from victims of natural disasters...

Grainger is a leading broad line distributor with operations primarily in North America, Japan and the United Kingdom. We Keep The World Working® by serving more than 4.5 million customers worldwide with products delivered through innovative technology and deep customer relationships. We’re dedicated to providing value for customers, fostering an engaging culture for team members and driving strong financial results....

Genius Sports is the layer between what happens on the field and how the world engages with it. Our solutions across the global sports ecosystem are underpinned by our next generation big data and artificial intelligence platform, GeniusIQ. By ingesting and computing multiple real-time data feeds, GeniusIQ powers a wide range of functions and applications across sports performance and officiation, fan engagement,...

Founded in Chicago in 1987 by Stan Day, SRAM, LLC has grown to be one of the world's largest bicycle component manufacturers. Today, we are led by CEO, Ken Lousberg, and Stan Day serves as Chairman of our Board. SRAM’s global footprint helps us bring cycling to every corner of the globe, including your local roads and trails. We design and...

Jellyfish is the leading Software Engineering Intelligence Platform, helping more than 500 companies including DraftKings, Keller Williams and Blue Yonder, leverage Al to transform how they build software. By turning fragmented data into context-rich guidance, Jellyfish enables better decision-making across Al use adoption, planning, developer experience and delivery so R&D teams can deliver stronger business outcomes.