Top Senior Python Jobs in Washington, DC

The Principal Software Engineer leads a team to develop full-stack real-time applications, integrates machine learning models, and influences software architecture in cloud environments while supporting healthcare analytics.

Lead engineer responsible for designing, developing, and optimizing petabyte-scale distributed data processing systems (Hadoop/Spark/Hive/Trino) on AWS. Leads performance tuning, system architecture, DevOps/CI-CD, security, AI tool adoption, and mentors engineers to improve product quality and delivery.

The Senior IT Systems Engineer will design, implement, and maintain IT systems, ensuring reliability and performance, while providing technical leadership and guidance.

Lead end-to-end testing across sprints, design and maintain automated regression suites, create test plans/cases, perform functional/integration/regression/performance testing, log and track bugs, collaborate with developers and product teams, and validate releases. Requires flexibility for occasional evenings/weekends and independent problem-solving.

Lead design and delivery of scalable, cloud-native healthcare systems and real-time data pipelines. Architect event-driven, batch/stream hybrid solutions, integrate clinical data standards, optimize performance and costs, mentor engineers, and collaborate with product and stakeholders to deploy resilient, compliant services.

Develop and maintain cloud-based enterprise web applications using React, C#/.NET and/or Python. Build RESTful APIs, work with SQL Server/PostgreSQL, participate in CI/CD and Azure deployments, troubleshoot production issues, follow secure coding and accessibility standards, and collaborate on Agile teams.

Manage and automate infrastructure for on-prem and cloud deployments using infrastructure-as-code. Build, deploy, and operate services (containers, orchestration, fleet management), improve observability and availability, support security practices, and collaborate with cross-functional teams to scale and operationalize ML and web applications.

Develop and optimize GPU-accelerated algorithms for quantum circuit simulations, collaborating with various teams, and leading technical efforts.

As a Forward Deployed Engineer, you will lead government AI model deployments, design full-stack systems, and ensure successful integrations and relationships with public sector stakeholders.

Lead solutions architecture for government clients, embedding with stakeholders to deploy GenAI solutions, and ensuring project success through prototype development and technical guidance.

Lead technical design, development, modernization, and deployment of enterprise web applications on Azure Government and Microsoft 365. Mentor teams, enforce standards, implement CI/CD and DevSecOps, migrate legacy systems, develop Python/ASP.NET backends and React frontends, manage databases (SQL Server/PostgreSQL), and ensure security/compliance (FISMA, NIST, ATO).

Lead a DevOps team to design, implement, and improve CI/CD, IaC, and cloud-native deployments (Kubernetes/AWS). Build automation, ensure scalability/high availability, enforce best practices, collaborate across teams, and support secure deployment to US Government classified environments.

Design and implement core identity infrastructure for authentication and authorization. Build SSO, MFA, federated identity, and authorization systems (ReBAC/ABAC/RBAC). Create identity governance policies for compliance, integrate IAM with cloud services, and present technical guidance to stakeholders.

The Kong API Gateway Specialist will design, implement, and maintain Kong solutions to modernize and secure enterprise APIs, ensuring compliance with federal standards and optimizing API performance.

The Cloud Services Engineer leads the design and implementation of secure cloud architectures, driving cloud transformation projects while mentoring teams and ensuring high availability, security, and performance.

Lead design, automation, and operation of large-scale cloud services for federal customers. Improve reliability via SRE practices (SLIs/SLOs, incident response), build automation and self-service platforms using Go/Python, Terraform, and Kubernetes, and ensure compliance with FedRAMP/IL6. Mentor teams, drive reliability initiatives, and modernize deployments with CI/CD and GitOps.

Embed with U.S. government customers to design, build, deploy, and maintain mission software from prototype to production. Own end-to-end delivery, build backend systems and data integrations, collaborate with product and engineering to scale reusable capabilities, and serve as the technical point of contact to drive adoption and mission impact.

Design, build, and operate petabyte-scale data infrastructure: real-time ingestion, storage (open table formats), and serving. Lead performance, reliability, and cost optimization across Spark and streaming pipelines (Kafka/Flink), define data contracts, and establish best practices and tooling. Collaborate with platform, product, and deployment teams to deliver production-grade data systems on AWS GovCloud, Kubernetes, and Airflow.

Build and maintain scalable, user-centered backend and frontend systems. Design permission and secure collaboration frameworks for cross-organizational data sharing. Own major features end-to-end, work with product and design, iterate with deployment and users, and solve high-scale distributed system challenges.

Design and build control plane and automation systems to provision and manage network connectivity at scale. Extend APIs and self-service networking, automate infrastructure workflows across AWS and customer environments using Python, Terraform and Pulumi, and lead debugging of complex connectivity and distributed system issues.

Lead and mentor engineering teams to design, build, and ship scalable, production-grade software. Own major features, drive technical decisions, collaborate with product and design, and ensure reliable distributed systems supporting real-time collaboration, high-scale data ingestion, and ML-powered features.

Responsible for deploying, configuring, maintaining Linux servers, assisting with system administration, and managing OS patches using various tools.

Lead QA efforts for a modern AWS GovCloud-based workflow application: design and execute test strategy, implement and maintain automation (Playwright/Selenium), validate front-end (Angular), APIs, and databases (Postgres/SQL Server), run CI/CD integrated test suites, support performance testing, and drive quality in Agile teams.

The Principal Engineer will lead technical initiatives in AI-driven tax software, mentor engineers, enforce technical standards, and contribute to architectural design and product innovation.

Lead the design and implementation of secure, scalable data processing platforms, focusing on ETL frameworks, event-driven systems, and high-performance microservices.