Top Senior Python Jobs in Washington, DC

Lead the technical strategy and architecture for Redfin’s CDN, edge, and AWS cloud networking. Drive ambiguous, cross-team infrastructure initiatives, establish scalable multi-account environments, and serve as the organization’s networking expert. Mentor engineers, improve infrastructure-as-code quality, evaluate AWS services and vendors, support incidents, and define availability, latency, cost, and security metrics.

Owns technical strategy, architecture, and engineering delivery across a portfolio of national security customer accounts. The role involves hands-on software development, customer discovery, prototype-to-production delivery, platform contribution, security authorization, technical governance, and mentoring engineers. Responsibilities include integrating with government systems, shaping opportunities, managing engineering capacity, producing architecture artifacts, and guiding systems through DoD compliance and ATO requirements. Requires regular customer engagement and up to 20% travel.

Owns build and deployment automation, platform health, scaling, monitoring, and high-availability DevOps pipelines. The role involves developing self-service tools, expanding a multi-account AWS environment, improving SRE practices, and securing systems for commercial and high-side environments. Requires strong AWS, CI/CD, infrastructure-as-code, containerization, scripting, and monitoring expertise, plus U.S. citizenship and TS/SCI with full-scope polygraph clearance. Travel to a Washington, DC customer site may reach 50%.

Designs and executes automated and manual tests for web applications, develops automation scripts, validates front-end functionality, identifies and tracks defects, analyzes test results, and collaborates with development teams throughout the software lifecycle. Maintains test documentation and participates in planning and status activities. The role requires onsite work at a Washington, D.C. government facility and an active Top Secret clearance with SCI and CI Poly eligibility.

Lead cloud engineering strategy, architecture, implementation, and maintenance for DOT’s Google Workspace and Microsoft infrastructure. Direct technical and managerial team efforts, gather requirements, develop enterprise cloud solutions, oversee strategic initiatives, mentor engineers, communicate with senior leadership, and collaborate with infrastructure teams and vendors. The role requires expertise across AWS, Google Cloud, Azure, cloud security, DevSecOps, automation, orchestration, containers, and enterprise architecture.

Administer and optimize Linux, Windows, and cloud environments across development and production systems. Design secure infrastructure, support enterprise services and applications, automate deployment and monitoring with Python and scripting, maintain Jenkins CI/CD pipelines, perform patching and vulnerability remediation, monitor system health, resolve incidents, and collaborate with Agile development and engineering teams.

Lead the MinuteClinic Product Engineering team in building reliable, cloud-native software for patient and provider experiences. Own engineering roadmaps, technical direction, distributed systems architecture, AI capabilities, production reliability, and modernization across applications, APIs, and kiosks. Hire, coach, and develop engineers while partnering with product, clinical, security, and infrastructure stakeholders. Remain hands-on through architecture, coding, prototyping, code reviews, and complex production investigations.

Designs, develops, modernizes, and maintains secure, scalable full-stack applications on AWS. Responsibilities include architecture, RESTful and GraphQL APIs, frontend and backend development, infrastructure as code, DevOps automation, CI/CD, performance optimization, security, code review, troubleshooting, and technical mentoring. The role guides architecture decisions involving monoliths, microservices, distributed systems, databases, containers, and cloud infrastructure while collaborating with government and contractor stakeholders in an Agile environment.

Develop and optimize GPU-accelerated quantum computing simulators for NVIDIA CUDA-Q. Build simulation components, quantum circuit and operator representations, execution interfaces, Python bindings, and resource management. Improve performance, memory use, CPU-GPU movement, and multi-GPU scaling. Collaborate with SDK, research, product, and open-source teams while implementing simulation methods such as state-vector, tensor-network, stabilizer, and open-system dynamics approaches.

Own and ship major user-facing platform features across search, dashboards, maps, networks, tables, documents, automations, and mobile. Collaborate with product, design, deployment teams, and users to build fast, intuitive, trustworthy experiences. Develop full-stack software using React and TypeScript frontend technologies alongside Python-based backend systems, distributed data infrastructure, AI capabilities, and cloud platforms. Solve complex problems involving semantic discovery, real-time collaboration, scalability, latency, resilience, and transparent AI-powered workflows.

Lead development of enterprise-grade full-stack applications using React, modern backend frameworks, cloud architectures, and secure public-facing systems. Use AI coding tools and agentic workflows to accelerate prototyping and production delivery. Partner with stakeholders, establish AI-first engineering practices, and ensure application security, performance, reliability, and compliance for sensitive financial and customer data.

Develops and maintains on-premises DevOps infrastructure, CI/CD pipelines, automation, infrastructure-as-code, monitoring, virtualization, and deployment workflows. Supports secure application builds, releases, testing, disaster recovery, and Tier II/III troubleshooting while ensuring compliance with DISA STIGs and DoD cybersecurity requirements. Collaborates with systems, network, security, application, and government teams at the Washington Navy Yard.

Build scalable full-stack interview-platform features, including AI-enhanced capabilities, APIs, user interfaces, infrastructure, and production services. Collaborate with product, design, and data science teams; contribute to architecture decisions; improve reliability, performance, and security; and provide technical leadership through mentoring and engineering best practices.

Designs and delivers cloud-based software solutions for government customers using modern engineering practices. Partners with customers, Microsoft product teams, and open-source communities to develop scalable solutions. Leads architecture and design, mentors engineers, drives cross-product project and release plans, and serves as a designated responsible individual for system reliability, monitoring, and on-call support.

Operate, modernize, and automate secure Oracle Cloud Infrastructure for a mission-critical federal program. Design and manage OCI resources, networking, databases, IAM, storage, monitoring, and security controls. Develop Terraform infrastructure as code, GitLab CI/CD pipelines, and PowerShell, Bash, or Python automation. Troubleshoot infrastructure and performance issues, maintain platform reliability, and support NIST, RMF, and FedRAMP compliance while collaborating with federal stakeholders onsite in Washington, DC.

Lead the architecture and development of scalable, secure healthcare technology, including real-time data pipelines, distributed systems, microservices, and clinical data integrations. Own products from concept through deployment, optimize performance and infrastructure costs, lead modernization efforts, and build cloud-native solutions using AWS and Kubernetes. Collaborate with product and engineering teams, mentor engineers, communicate technical concepts, and explore AI/ML and real-time analytics applications.

Owns secure deployment and authorization of software across AWS GovCloud and classified environments. Designs infrastructure as code, Kubernetes platforms, CI/CD and DevSecOps pipelines for restricted and air-gapped networks. Onboards and hardens commercial software, manages RMF-to-ATO activities, remediates vulnerabilities, develops compliance artifacts, and works with government security personnel. Builds reusable deployment tooling and mentors engineers.

Own the reliability, security, observability, infrastructure, and delivery pipelines for CFR’s web and mobile properties. Manage AWS infrastructure with Terraform, CI/CD pipelines, WordPress VIP and Pantheon deployments, monitoring, backups, disaster recovery, access controls, secrets, and WAF configuration. Lead incident response, root cause analysis, postmortems, and resilience improvements while supporting AI services, contractors, vendors, and cross-functional engineering partners.

Leads the design, deployment, administration, and optimization of enterprise virtualized data center infrastructure. Manages VMware, Cisco UCS, SAN/NAS storage, cloud integration, disaster recovery, backups, incident escalation, documentation, and infrastructure automation. Supports high availability, security, performance, and modernization initiatives while participating in on-call coverage and periodic onsite rotations.

Develop highly available, scalable cloud-based integration services for Axon’s real-time operations platform. Drive cross-team technical architecture, integration frameworks, partner onboarding, technical roadmaps, and reusable platform components. Collaborate with engineering, product, design, professional services, and external partners; lead architecture reviews, mentor engineers, improve engineering processes, and leverage AI to enhance customer experiences.

Designs and delivers cloud-based software solutions with strategic customers and Microsoft product teams. Leads requirements definition, architecture, dependency identification, design documentation, and development of maintainable code. Mentors engineers, contributes to open-source assets, coordinates project and release plans, and serves as a designated responsible individual for system reliability, monitoring, on-call support, performance, and operational improvements.

Owns and operates cloud infrastructure, Kubernetes clusters, identity, secrets, networking, observability, and infrastructure as code. Builds GitOps workflows and CI controls, manages production incidents and on-call responsibilities, implements security and compliance controls, automates toil, and maintains technical documentation. Partners with platform, security, network, and ground-station teams to deliver reliable cloud infrastructure.

Designs, implements, and maintains VMware-based hyperconverged infrastructure in a large enterprise data center. Responsibilities include administering VxRail and vSAN environments, resolving storage and performance issues, managing the data lifecycle, planning capacity, monitoring compliance, supporting upgrades and migrations, documenting systems, and participating in incident response and root cause analysis. The role requires onsite work and the ability to obtain and maintain a Secret clearance or suitability determination.

Manage Linux and Windows cloud environments supporting development and production applications. Administer Red Hat and Windows servers, configure enterprise services including email, SSO, DNS, and Active Directory, apply patches, monitor performance, improve security, and troubleshoot service desk and monitoring issues. The role also supports automation, CI/CD, application deployment, and enterprise architecture initiatives.

Leads software and Salesforce engineering teams delivering scalable CRM, microservices, integrations, outreach workflows, contact center technologies, and partner portals. Owns technical vision, architecture, Agile delivery, hiring, mentoring, DevOps, CI/CD, quality, security, compliance, and AI adoption. Collaborates with Product, Design, Security, Marketing, Sales Operations, and executives to deliver solutions supporting brand, marketing, partnerships, contact center sales, and outreach programs.