Top Senior Python Jobs in Washington, DC

Designs and implements automation, infrastructure improvements, monitoring, observability, and infrastructure-as-code solutions for mission-critical applications and systems. Manages SLOs and SLIs, supports incident response and root cause analysis, optimizes performance and reliability, and collaborates across software, operations, and security teams in cloud and hybrid-cloud environments.

Develop and maintain PHP, Python, C, and C++ applications supporting real-time data enrichment and sharing. Integrate external capabilities and workflows into internal operations, working across web front ends and back-end processing pipelines. Support OpenStack, private cloud, virtualization, Linux, and Windows environments. Collaborate with developers and research AI engine implementation within the cloud ecosystem.

Lead the architecture and development of backend platforms, REST and GraphQL APIs, service integrations, security patterns, and AI/LLM integration capabilities. Build observability and reliability infrastructure, contribute to full-stack features using TypeScript and Next.js, and establish engineering standards across the team. Ensure HIPAA-compliant handling of PHI while owning complex systems from architecture through production operations.

Build and deploy full-stack healthcare features using TypeScript, React, and Next.js. Develop accessible, trustworthy interfaces for AI-generated clinical content, integrate APIs, manage client state, contribute to component libraries and design systems, and implement HIPAA-compliant data handling. Collaborate with engineers, product managers, and designers through code, architecture, and design reviews. Own features from design handoff through production deployment.

Develop and maintain full-stack web applications for the Congressional Budget Office using Python/FastAPI, ReactJS, PostgreSQL, Docker, and AWS. Responsibilities include building REST APIs, responsive accessible interfaces, database models and migrations, automated testing, CI/CD and trunk-based development, containerized deployments, code reviews, documentation, troubleshooting, and security remediation. The role requires collaboration with engineers, product owners, and analysts in an agile environment.

Design, implement, and support scalable cloud networking and identity solutions in AWS. Lead cloud strategy, solve complex technical problems, write and maintain Infrastructure as Code, mentor peers, drive cross-team consensus, and track engineering metrics to improve performance, scaling, and cost-efficiency.

Design, build, and maintain scalable CI/CD workflows and GitOps deployments using GitHub Actions, Argo CD, and Kubernetes. Improve developer experience, embed AI tooling into DevOps, enforce GitHub governance, lead incident response, and mentor engineers to enhance reliability and deployment safety.

Technical lead for production database and storage systems: define and execute cloud DB/storage architecture and strategy focused on reliability, scalability, observability, and security. Support and operate large-scale self-managed and AWS-managed databases, lead incident response and RCA, run HA/DR drills, mentor engineers, participate in on-call rotation, and use AI code-generation tools to improve infrastructure delivery.

The Azure DevSecOps Engineer designs and implements secure multi-cloud infrastructure, supports cloud migration, develops automation tools, and ensures compliance for Air Force projects.

Leads software quality engineering for healthcare data applications. Develops and executes manual and automated tests, analyzes large datasets and test results, reports defects, creates automation frameworks and scripts, reviews clinical definition manuals, mentors quality engineers, and contributes to Scrum planning, estimation, test strategy, and standardized quality metrics.

Participate in all SDLC phases on a scrum team to design, develop, test, and deploy large-scale healthcare applications. Collaborate with architects, QA, product and clinical analysts, contribute to security and risk assessments, interact with customers to resolve issues, and support on-call/operational needs.

Lead complex deployments of Deepgram's Voice AI platform to federal customers, guiding technical discovery, solution design, and integration builds while ensuring successful implementations.

Leads technical initiatives and designs, builds, operates, and improves scalable distributed systems. Collaborates across organizations, drives maintainability and performance, evaluates emerging technologies, delivers iterative releases, and mentors engineers. Requires polyglot full-stack development, strong SQL and distributed systems expertise, cloud experience, communication skills, and quarterly or as-needed travel. Preferred experience includes event-driven architectures, AI-assisted development, Kafka, APIs, containers, infrastructure as code, monitoring, CI/CD, and agile methodologies.

Design, deploy, maintain, and optimize secure, scalable, highly available cloud infrastructure across AWS and other cloud platforms. Develop infrastructure-as-code, automation, and CI/CD solutions; manage cloud security, compliance, migrations, and modernization; troubleshoot complex infrastructure issues; and collaborate with engineering, cybersecurity, and operations teams. The role requires extensive AWS experience, an active Secret clearance, U.S. citizenship, and AWS Solutions Architect Professional certification.

Design, build, and sustain secure mobile and web applications and backend services for a classified federal customer. Develop UIs, REST APIs, SQL-backed services, automation scripts, telemetry/monitoring tools, and diagnostics in Linux environments. Apply secure coding, troubleshoot integrations, document architecture and SOPs, and coordinate with security, network, and government stakeholders in an Agile delivery model.

Design, deploy, and optimize Azure cloud infrastructure using IaC (Terraform/ARM), automation (Ansible, Python, PowerShell), CI/CD (GitLab, Jenkins, Azure DevOps), and Azure monitoring. Ensure security, compliance (FedRAMP/NIST/DoD), networking, hybrid migrations, and disaster recovery while collaborating with government and cross-functional teams.

Maintain and improve multi-cloud Kubernetes infrastructure, CI/CD (Argo Workflows/ArgoCD), observability, and networking. Build reliable continuous deployment tooling and onboarding flows, provide internal support, collaborate across Platform Engineering, contribute upstream (open-source/operators), and participate in a 24/7 on-call rotation to resolve deployment infrastructure issues.

Own and develop production systems across backend services, data infrastructure, AI/LLM workflows, and React/TypeScript applications. Build LLM-powered agents and RAG systems on AWS Bedrock, develop scalable ML and data pipelines, and design PostgreSQL, OpenSearch, Kafka, Redis/Celery, and Kubernetes-based architectures. Partner with technical leadership on system design and roadmap decisions while translating customer and analyst needs into reliable software.

Manage and optimize hybrid Azure, AWS, and on-premises infrastructure across its full lifecycle. Responsibilities include cloud administration, automation with PowerShell, Python, and Terraform, AIOps monitoring, Docker and Kubernetes management, identity and security enforcement, disaster recovery, VMware and Windows Server administration, and CI/CD enablement. The role also collaborates with data science teams on machine learning and intelligent-agent infrastructure optimization while mentoring junior staff.

Designs, deploys, maintains, and troubleshoots VMware and Nutanix virtualization clusters supporting Air Force infrastructure. Provides senior technical support, performs migrations, manages patches and upgrades, monitors capacity and performance, maintains documentation, and supports compliance with DISA STIGs and NIST SP 800-171. Collaborates with cybersecurity, network, and application teams, participates in change-control activities, trains engineers, and supports an on-call rotation.

Serve as the technical lead modernizing mission-critical defense software: deploy and extend agentic modernization platforms, analyze large codebases, design scalable architectures, ensure RMF/NIST-compliant deployments, and deliver production-ready solutions in classified environments.

Design, implement, and deploy autonomy capabilities for space platforms including distributed optimization, tasking/scheduling, track fusion, RPO, and motion/behavior planning. Build high-performance, well-tested software modules, collaborate across perception, planning, simulation, hardware, and flight test teams, support deployments and mission log analysis, and contribute R&D and roadmaps to advance autonomy for satellites and missile defense.

Lead development of autonomy capabilities for space platforms including distributed optimization, tasking/scheduling, track fusion, RPO and motion planning. Build high-performance, well-tested software, integrate on real vehicles, support deployments and testing, and research/roadmap advanced autonomy techniques for defense applications.

Lead development of space autonomy capabilities including distributed optimization, tasking/scheduling, track fusion, rendezvous/RPO, and motion/behavior planning. Build high-performance, testable software, integrate and validate on real platforms, support deployments, and mentor engineers while contributing R&D and roadmaps.

Develop highly available, scalable cloud-based integration services for Axon’s real-time operations platform. Drive cross-team technical architecture, integration frameworks, partner onboarding, technical roadmaps, and reusable platform components. Collaborate with engineering, product, design, professional services, and external partners; lead architecture reviews, mentor engineers, improve engineering processes, and leverage AI to enhance customer experiences.