Top Senior Python Jobs in Washington, DC

Lead secure DevOps for federal spectrum management systems across Azure Commercial, Government, and Secret environments. Design infrastructure as code, Kubernetes platforms, Azure DevOps pipelines, security controls, monitoring, and recovery processes. Support classified deployments, RMF and ATO activities, incident response, production troubleshooting, documentation, and stakeholder briefings while mentoring junior engineers.

Build and operate backend microservices and AWS cloud infrastructure using Go, Python, Terraform, Kubernetes, and CI/CD. Design APIs, improve reliability and observability, respond to incidents, and implement security controls supporting FedRAMP and CMMC compliance. The role owns infrastructure and backend workstreams end to end, collaborates with US and UK teams, and participates in architecture, technical design, and on-call support.

Develop and optimize cloud architectures across AWS and Google Cloud, supporting PaaS, IaaS, SaaS, and DaaS initiatives. Responsibilities include cloud migration, infrastructure development, cost optimization, governance, disaster recovery, security, zero-trust implementation, CI/CD, debugging, and cloud resource management. The role also leads large-scale modernization efforts, develops cloud applications, and translates business requirements into secure technical solutions.

Designs, evaluates, tests, deploys, and operates complex technical architectures and software systems. Leads system integration, technical planning, design implementation, troubleshooting, vulnerability assessment, mitigation planning, cloud operations, API and frontend/backend design, and data migration. Collaborates with technical leaders, program managers, customers, and external organizations while supporting Authorization to Operate and accreditation activities.

Administer and engineer mission-critical Oracle databases, applications, middleware, and operating systems in secure, high-availability environments. Responsibilities include installation, upgrades, performance tuning, backup and recovery, disaster recovery, storage troubleshooting, automation, security compliance, Tier III support, system modernization, documentation, and technical mentorship. The role supports DoD and intelligence mission systems across Oracle, Linux, Solaris, WebLogic, VMware, containerized applications, and enterprise storage infrastructure.

The Azure DevSecOps Engineer designs and implements secure multi-cloud infrastructure, supports cloud migration, develops automation tools, and ensures compliance for Air Force projects.

Design and implement advanced modeling and simulation tools to evaluate system performance and support strategic decision-making for national defense. Perform quantitative analysis, develop physics-based and agent-based models, optimize AI and machine-learning algorithms, and collaborate with government clients. The role involves EO-IR and 3D simulation, computational modeling, and potentially high-performance computing, computer vision, and autonomous-system behavior development.

Lead the design, development, and delivery of scalable backend and patient-facing software for MinuteClinic. Set technical direction, mentor engineers, drive architecture and engineering excellence, and collaborate with product, design, and architecture teams. Build cloud-based services, APIs, distributed systems, CI/CD pipelines, automated testing, and observability solutions while adopting AI-assisted development practices. Healthcare technology, interoperability standards, microservices, and front-end experience are preferred.

Architect and guide the FSDS cloud platform across Azure Commercial, Azure Government, and classified environments. Own the platform roadmap, target-state architecture, integration patterns, shared services, security standards, and technical planning. Collaborate with DevOps, security, operations, application, and data teams; review Infrastructure as Code and Kubernetes designs; support RMF and ATO activities; guide upgrades, resilience, observability, and production transitions; and communicate architectural tradeoffs to government stakeholders.

Leads the design, deployment, and operation of secure Azure infrastructure and CI/CD pipelines across commercial, government, and classified environments. Develops Infrastructure as Code, manages Kubernetes and container platforms, implements security and compliance controls, and supports monitoring, incident response, backup, and recovery. Partners with engineering, security, and government stakeholders to resolve issues, document operations, improve reliability, and guide junior DevOps engineers.

Owns the architecture, roadmap, integration, and evolution of the FSDS cloud platform across Azure Commercial and classified Azure Government environments. Defines shared platform services, standards, target-state designs, and integration patterns while guiding DevOps, security, operations, application, and data teams. The role supports infrastructure planning, platform upgrades, resilience, observability, RMF/ATO activities, and technical stakeholder decisions. It requires active Secret clearance, strong Azure architecture experience, and the ability to lead platform strategy without performing day-to-day implementation.

Build, automate, operate, and secure Google Cloud platforms for federal customers. Configure GCP networking, IAM, and GKE; maintain Terraform infrastructure as code; build secure CI/CD pipelines; monitor and troubleshoot systems; apply NIST and FedRAMP controls; onboard customers; automate tasks; document solutions; and support audits and technical issue resolution.

Own end-to-end engineering projects, build scalable backend services and React experiences, and expand a core API handling millions of daily requests. Investigate production issues, participate in code reviews and interviews, and collaborate on product roadmaps. The role requires strong software engineering expertise, scalable application development experience, and the ability to balance speed with reliability. Fintech, data pipeline, payment rail, and DevOps experience are advantageous.

Lead the migration of enterprise Jira and Confluence Data Center environments to Atlassian Government Cloud. Administer and maintain DevSecOps tooling, CI/CD pipelines, security scanning, and AWS infrastructure. Develop Infrastructure as Code using CloudFormation and Terraform, automate monitoring and patching, support FedRAMP and ATO requirements, execute testing and cutover runbooks, and provide post-migration operational support.

Lead and grow a software engineering team responsible for CUDA Math Libraries platform expansion and readiness. Own integration, qualification, compliance, validation, performance testing, defect triage, and technical roadmaps across specialized platforms. Collaborate with library, DevOps, QA, compiler, CUDA, release, and platform teams. The role requires hands-on high-performance numerical software development using C++ and Python, parallel computing, performance optimization, and software engineering leadership.

Deploy, manage, validate, and optimize large-scale AI compute and HPC infrastructure in Linux environments. Serve as a technical liaison among NVIDIA, partners, and enterprise customers; lead planning through implementation, document handoffs, transfer knowledge, troubleshoot hardware and software, and provide feedback for product and architecture improvements. The role involves networking, system design, automation, benchmarking, cluster provisioning, and customer-site travel up to 30%.

Develop and optimize GPU-accelerated algorithms for quantum circuit simulations, collaborating with various teams, and leading technical efforts.

Develop and maintain Android applications and ATAK plugins across the TAK ecosystem, integrating CoT messaging, geospatial overlays, situational-awareness feeds, local storage, and TAK Server APIs. Translate government and tactical requirements into production mobile software, support application architecture and performance, and mentor junior developers through code and design reviews. The role is remote and requires collaboration with government customers and operational users.

Leads systems integration and technical development for government web, cloud, content management, and mobile application environments. Manages lifecycle changes, risks, issues, configuration, security support, QA, accessibility, and stakeholder expectations. Develops and maintains public-facing websites and iOS, Android, and Apple Watch applications, including testing, releases, bug fixes, and app store updates. Supports AI-driven sentiment analysis, data presentation, web forms, user training, and junior engineer development.

Design, administer, secure, automate, and maintain enterprise Linux infrastructure across physical, virtual, and cloud environments. Lead configuration management, patching, monitoring, storage, networking, identity integration, backup and disaster recovery, compliance, and vulnerability remediation. Serve as the escalation point for complex incidents, lead infrastructure migrations and site deployments, establish technical standards, mentor administrators, document systems, and contribute to infrastructure planning. Participate in on-call support and occasional maintenance windows.

Designs and deploys AWS and Azure cloud infrastructure across hybrid and multi-cloud environments. Develops infrastructure-as-code, cloud governance, monitoring, security controls, and automation. Supports 24/7 cloud operations, migrations, incident escalation, performance tuning, cost optimization, and compliance with FedRAMP, NIST, FISMA, and Zero Trust frameworks. Leads stakeholder collaboration, documentation, knowledge transfer, and technical mentorship for a Department of State cloud program.

Designs, deploys, and supports hybrid cloud, VMware, IaaS, PaaS, and data center infrastructure for a federal enterprise environment. Develops infrastructure-as-code automation, governance, monitoring, disaster recovery, and security controls aligned with federal frameworks. Supports cloud operations, migrations, performance optimization, incident escalation, compliance, and continuous monitoring. Collaborates with engineering teams and government stakeholders while providing technical leadership, documentation, and mentorship. Requires an active Top Secret clearance and hybrid work in the National Capital Region.

Designs, refactors, tests, and deploys secure PowerShell automation frameworks for Navy Records Management modernization. Processes large datasets, optimizes analytics pipelines, develops dashboards and workflow tools, and improves script performance, scalability, and resilience. The role applies Pester testing, secure coding, role-based access controls, Agile delivery, and data science practices while collaborating with program managers, developers, and Navy stakeholders.

Design and implement cloud and air-gapped infrastructure for defense and maritime systems. Develop infrastructure as code, CI/CD and DevSecOps pipelines, containerized platforms, observability solutions, and compliance controls. Deploy and troubleshoot systems in customer environments, including RHEL/Linux, Kubernetes, Docker, Podman, and Helm platforms. Partner with customer engineering teams on integration, testing, upgrades, and mission execution, with travel to customer sites as needed.

Provide Tier III database administration and O&M support for enterprise applications: monitor and tune SQL Server/MySQL, resolve critical incidents, maintain environments, manage backups/recovery, update documentation, support SDLC/Agile processes, and coordinate security and operational tasks.