Top Senior IT Jobs in Philadelphia, PA

Lead and manage IT infrastructure projects across the city: define scope, schedule, budgets, assemble teams, ensure architecture consistency, follow PMO SDLC practices, prepare status reports and dashboards, and mentor project staff to deliver on-time, in-budget outcomes.

Lead product vision, roadmap, and delivery for portfolio and project management platforms supporting R&D and Supply Chain. Translate stakeholder requirements into user stories, prioritize work, drive agile delivery, monitor KPIs, improve governance and processes, and apply AI/analytics to modernize R&D platforms while ensuring regulatory compliance.

Lead and execute remote technical implementations for dental practices from signing through go-live. Configure PMS integrations, set up remote access and network configurations, manage AWS-hosted Windows VMs/ETL, handle support volume, liaise with MSPs, and improve onboarding processes and automation while partnering with cross-functional teams.

Lead and supervise IT audit activities, design and execute audit programs, evaluate IT controls and cybersecurity frameworks, manage audit staff and deliver audit reports, provide advisory support for IT initiatives, perform risk assessments and follow-up audits, and liaise with senior management and regulators to ensure compliance and control effectiveness.

Design, build, and operate AWS-native AI/ML systems: RAG pipelines, fine-tuned LLMs, and microservices. Implement IaC (Terraform), CI/CD, policy guardrails, and production deployments integrating Bedrock/SageMaker, LangChain, and telemetry for secure, scalable enterprise use.

The IT Systems Administrator manages Centri's technology ecosystem, ensuring security and performance across Microsoft 365 and Azure environments, and integrates automation tools. Responsibilities include security management, enterprise application support, and optimizing system performance.

Lead selection, deployment, validation, administration, and continuous improvement of GxP-compliant Quality and Laboratory systems (LIMS/QMS) for manufacturing and labs. Provide operational support, integrations, instrument connectivity, CSV (IQ/OQ/PQ), regulatory compliance (21 CFR Part 11, Annex 11, ALCOA+), root cause/CAPA support, and technical leadership.

Remote IT Manager responsible for analyzing, upgrading, and administering IT systems (networks, servers, email, backups), evaluating vendors and technologies, managing projects, tracking inventory, training staff, and providing technical support to improve operational efficiency.

The Senior IT Systems Administrator oversees the administration, security, and optimization of financial systems, ensuring reliability and compliance while leading system enhancements and integrations.

The Senior Clinical Trials IT Business Analyst bridges Clinical Development and IT, optimizing clinical trial technologies and managing system implementations, validations, and stakeholder engagement.

Lead design, implementation, and optimization of ServiceNow ITOM (Discovery, Service Mapping, Event Management) and CMDB governance. Configure MID Servers, patterns, probes, and integrations; manage cloud discovery across AWS/Azure/GCP; build automations with Flow Designer and APIs; perform performance and root-cause analysis; liaise with vendors; produce technical strategy, capacity planning, and translate technical solutions for business stakeholders.

The IT Manager, Product Owner - Finance drives financial process transformations, prioritizes product backlogs, and manages stakeholder relationships to ensure high-quality delivery of financial systems solutions.

Lead IT technical learning strategy and design, create scalable onboarding and continuous development programs aligned to engineering and AI practices, partner with senior stakeholders, measure learning impact, and manage a team of learning designers and trainers to drive capability growth across global IT.

Administer and maintain IBM i (AS/400) platform to ensure stability, security, performance, and high availability for RPG-based ERP/WMS. Own DR/replication (Maxava), backup (BRMS), system upgrades, performance tuning, security/audit, automation (CL/QShell/PASE/Python/Rexx), integrations (SFTP/APIs/EDI), and documentation/runbooks across hybrid on-prem Power Systems and PowerVS cloud environments.

The IT Operations Director leads Service Desk and Infrastructure teams, overseeing IT operations lifecycle, managing metrics, enforcing security, and enhancing service quality through automation and ITIL processes.

Manage full project lifecycle for IT Operations and Services, including enterprise applications, security, network/systems infrastructure, and process improvements. Create plans, governance, change management, vendor onboarding, KPIs, roadmaps, and transition projects to operations while communicating status and driving cross-team collaboration.

Lead and manage Level 1-3 Service Desk analysts supporting external clients, oversee daily operations, escalations, SLAs, and reporting. Improve service management, automation, and first-call resolution; partner with Engineering and Incident/Problem/Change Management to resolve production issues. Provide hands-on technical leadership across Splunk, Datadog, MuleSoft, SQL, and ServiceNow while managing client communications and operational metrics.

The Senior IT Project Manager will lead client-facing IT infrastructure projects, manage timelines and expectations, and coordinate engineering teams while ensuring high-quality delivery of services.

The role involves leading and improving IT operations, focusing on proactive service organization, process design, and team development while managing IT projects and vendor relationships.

Lead and independently manage multiple large, complex IT projects with cross-functional teams. Define and implement PM standards, resolve technical and business escalations, coordinate shared resources, and ensure projects deliver on time and within budget while meeting public sector compliance.

Lead Manhattan Active WM solution design and multi-site rollout, migrate legacy WMS/TMS/WES/WCS, define processes and standards, validate warehouse hardware and automation, manage integrations, testing, cutover, go-live stabilization, documentation, and mentor internal teams.

The Senior Director of IT Platform Services drives global strategy for IT platforms, overseeing ServiceNow and Jira governance while leading a global team for technology delivery.

Manage end-to-end delivery of mid-to-large IT initiatives (applications, integrations, AI-enabled solutions) for P&C insurance and M&A projects. Lead planning, resourcing, risk management, governance, stakeholder communications, and compliance while using PM methodologies (Waterfall/Agile/Hybrid) and PPM tools to ensure on-time, on-budget delivery.

Responsible for IT support and administration for Commercial systems. Partners with business owners to ensure system performance, compliance, and operational excellence across various business functions.

Contract IT System Administrator to manage and harden multi-cloud (AWS/Azure) infrastructure and Microsoft 365 identity/collaboration stack, support endpoints and managed IT/security SaaS platforms, automate routine tasks with scripting, maintain documentation and compliance posture for Department of War mission spaces, and serve as hands-on technical escalation for operational issues.