Top Senior IT Jobs in Philadelphia, PA

Leads and supports internal IT operations for a globally distributed workforce. Manages a small IT team, oversees infrastructure and systems, improves identity, device, and SaaS tooling, partners across departments on onboarding and security, supports SOC 2 and ISO 27001 compliance, and establishes scalable processes, SLAs, ticketing workflows, and documentation. This is a hands-on player-coach role focused on reliability, security, efficiency, and employee experience.

Provides senior technical leadership for IT support and operations in a remote healthcare technology environment. Owns complex escalations, incident resolution, root cause analysis, endpoint and identity administration, onboarding and offboarding, vendor escalations, documentation, automation, and reliability improvements. Coaches support staff, develops scalable processes, partners with Security, Compliance, Engineering, Product, and clinical teams, and communicates clearly during high-impact incidents affecting clinical workflows.

Deploys, hardens, troubleshoots, and modernizes Windows and .NET applications across on-premises environments and AWS. Responsibilities include Terraform infrastructure, CI/CD pipelines, SQL Server and Amazon RDS administration, load balancing, WAF configuration, observability, certificate management, automation, migrations, incident response, documentation, and collaboration with application owners. The role is remote but requires weekly onsite availability in Rockville, Maryland, and may involve occasional after-hours maintenance or outage troubleshooting.

Administer Epic’s corporate identity, access, endpoints, applications, devices, and employee IT support. Manage onboarding and offboarding, access reviews, authentication and device standards, MDM provisioning, asset inventories, procedures, and audit evidence. Support SOC 2 or similar compliance activities, security reviews, and incident response while partnering with infrastructure and people operations. This is a fully remote, US-based role supporting a global engineering team.

Oversee and finalize legal documents governing data sharing between Healthcare Fraud Prevention Partnership members and a trusted third party. Collaborate with CMS, HFPP leadership, partner engagement teams, and private payer partners on agreements, compliance, and negotiations. Present to management, support partner relationships, and ensure legal requirements are met for data governance and sharing.

Lead administration of Microsoft 365, Google Workspace, SaaS applications, Azure identity, and cloud infrastructure in a fully cloud-based organization. Provide Level 2/3 service desk escalation, execute migrations and cybersecurity projects, establish IT service processes, manage assets and vendors, and support onboarding, offboarding, incident response, change management, and M&A initiatives. The role partners with IT leadership and may help build and manage a growing internal technical team.

Lead governance for the firm's enterprise application portfolio: manage software intake/vetting, maintain the Olympus catalog, own lifecycles and roadmaps, coordinate security/privacy/AI reviews, drive adoption and metrics, and supervise a team to rationalize and optimize technology usage.

Design and execute IT compliance and security audits, perform risk assessments and SOX testing, document systems and controls, analyze data, identify control deficiencies and recommend remediations, prepare audit reports and present findings, manage multiple engagements, supervise IT risk staff, and liaise with business and technical teams.

Lead AppOps Engineer responsible for end-to-end application runtime health and reliability. Own production reliability, incident response, release/change operations, observability, automation, capacity and DR planning, security-by-default, runbook and SOP development, and mentor AppOps engineers while partnering with Engineering, CloudOps, Security, and Compliance.

The Senior Clinical Trials IT Business Analyst bridges Clinical Development and IT, optimizing clinical trial technologies and managing system implementations, validations, and stakeholder engagement.

Leads enterprise architecture for Biogen’s Veeva ecosystem across Development, Quality, Regulatory, Safety, and Commercial functions. Translates business needs into scalable Veeva configurations and integrations, governs target-state architecture and platform standards, reviews solution designs, and oversees implementation and release planning. Mentors configuration teams, drives cross-vault consistency, manages architecture governance, aligns with Veeva product roadmaps, and advises IT leadership on platform strategy, investments, regulatory compliance, and business objectives.

Leads the design, development, integration, deployment, and operation of large-scale Zero Trust security solutions for DoD environments. Creates system architecture blueprints, selects technologies, integrates distributed systems across on-premise and cloud environments, optimizes performance, ensures compliance with DoD requirements, and leads engineering teams. Diagnoses system issues, implements solutions, and produces architecture documentation while supporting installation, migration, and configuration activities across multiple client locations.

Leads the architecture, design, integration, deployment, and operation of large-scale Zero Trust security solutions for DoD environments. Creates system blueprints, selects technologies, integrates distributed systems across on-premises, cloud, and hybrid environments, optimizes performance, resolves system issues, and ensures compliance with DoD requirements. Leads engineering teams, supports installation and migration at multiple locations, and documents architecture and implementation decisions.

Act as the technical lead for field sales, manage evaluations, deliver on-site and remote demos, prepare SOWs/RFIs/RFPs, respond to security questionnaires, train sales teams, and support sales across U.S. and Canada while maintaining client relationships and achieving technical sales targets.

Sell radiology IT solutions by building strategic account plans, managing long technical sales cycles, maintaining a 3-5× quota pipeline, forecasting in Salesforce, partnering with marketing/inside sales, and representing the company at industry conferences.

Support risk assessment, audit planning, and oversight of audit management and staff. Provide advisory services and ensure compliance with standards.

Leads business analysis for enterprise applications and reporting initiatives. Translates stakeholder needs into requirements and functional or technical specifications, partners with IT on scalable solutions, manages project scope and risks, maintains process documentation, supports UAT and change readiness, and drives process standardization. Establishes business analysis standards and best practices across a growing, multi-location organization.

Lead a team to design, build, and operate scalable, secure platform and MLOps capabilities on GCP and hybrid cloud. Drive DevSecOps, CI/CD, telemetry, and platform modernization to accelerate AI/ML and software delivery while managing delivery, budgets, vendors, and stakeholder alignment.

The IT Project Manager will oversee project planning, implementation, and client interactions while ensuring compliance with federal and state regulations in the public sector.

The IT Project Manager will lead public sector ERP migration projects, ensuring high-quality deliverables and strategic alignment while collaborating with various stakeholders.

Lead global IT sourcing strategy and a multi-year technology modernization agenda. Manage $450M spend, strategic supplier relationships, governance, risk, and value delivery. Oversee category management (cloud, software, infrastructure, cyber), negotiations with hyperscalers and SaaS vendors, stakeholder engagement, and build a high-performing sourcing organization.

Leads the architecture, implementation, and governance of enterprise IAM and IGA solutions using SailPoint and ServiceNow. Designs integrations, provisioning workflows, access certifications, role management, and segregation-of-duties controls across enterprise systems. Provides technical leadership, conducts design reviews, mentors IAM teams, leads workshops, manages risks, and ensures GxP, SOX, security, compliance, and audit requirements are met.

Provide high-level administrative and operational support to the CPMO and CEO, including calendar management, communication screening, meeting coordination, minutes and action‑item tracking, project support, travel coordination, document and records management, and office logistics while maintaining confidentiality and recommending process improvements.

Designs and operates IT services for laboratory environments, including networks, compute, security, private cloud, and SDN platforms. Translates business and IT requirements into secure, standardized architectures and operational processes. Leads deployments, design reviews, documentation, incident gap analysis, automation, and infrastructure optimization. Requires extensive enterprise networking, datacenter, virtualization, Linux, security, and ITIL experience.

Designs and operates laboratory IT services covering compute, networks, security, private and public cloud, and software-defined networking. Translates business requirements into secure, high-performance service offerings; defines architectures, configurations, processes, and operational procedures. Leads implementations, design reviews, documentation, incident analysis, gap remediation, automation, and infrastructure optimization across global laboratory environments.