Top Charleston, SC Startups (10,000+)

Founded in 2010, Doximity is the leading digital platform for U.S. medical professionals. Our network members include over 80% of U.S. physicians across all states and every medical specialty. Our mission is to help every physician be more productive and provide better care for their patients. We are physicians-first, putting technology to work for doctors instead of the other way around....

Our digital marketplace connects thousands of businesses and more than six million workers, actively working to help bridge the labor demand/supply gap. Instawork helps businesses in food & beverage, hospitality, and warehouse/logistics industries fill temporary and permanent roles in more than 40 U.S. markets. We have been fortunate to be funded by world-class investors in Silicon Valley including: Benchmark (Bill Gurley),...

For more than two decades, Imprivata has been redefining how life- and mission-critical industries secure and manage digital identities. We empower healthcare and enterprise organizations to enable fast, compliant, and secure access to technology—allowing clinicians and staff to stay focused on what matters most: patient care and operational excellence. Our digital identity platform is purpose-built for complex environments where every second...

Attain is the most trusted and comprehensive source for permissioned, real-time purchase data in the United States. By connecting directly with over 10 million consumers, Attain delivers unmatched accuracy and scale across audience activation, insights, and in-flight optimization, and measurement, helping marketers tie every dollar of media to real-world sales outcomes. Attain’s portfolio of owned and operated apps, spanning financial...

Stepful unlocks the full potential of the global workforce, improving access to quality healthcare for everyone, everywhere. Our platform is designed for working adults, particularly from historically underserved communities, providing virtual instructor-led courses that include live, cohort-based learning sessions and one-on-one coaching for those looking for entry-level positions in hospitals and healthcare settings. Stepful graduates, primarily from underrepresented communities, go...

Genius Sports is the layer between what happens on the field and how the world engages with it. Our solutions across the global sports ecosystem are underpinned by our next generation big data and artificial intelligence platform, GeniusIQ. By ingesting and computing multiple real-time data feeds, GeniusIQ powers a wide range of functions and applications across sports performance and officiation, fan engagement,...

Workhuman® is helping companies meet today’s biggest human capital challenges - including unprecedented turnover, employee engagement, hybrid work environments, and DE&I - through the Workhuman Cloud®, a secure SaaS platform that provides the industry’s best-in-class Social Recognition® solution. Co-Headquartered in Dublin, Ireland, and Framingham, Massachusetts, USA, Workhuman has been pioneering the human workplace to improve the employee experience at work,...

Philo is a streaming television service that's reimagining the TV experience for the modern viewer. Founded by a group of technology and product enthusiasts, we set out to build the future of television by combining the best of modern technology with the most compelling medium ever invented—delivering the TV experience we've always wanted for ourselves. At our core, Philo provides an...

Circle (NYSE: CRCL) is a global financial technology firm that enables businesses of all sizes to harness the power of digital currencies and public blockchains for payments, commerce, and financial applications worldwide. Circle is building the world’s largest, most-widely used, stablecoin network, and issues, through its regulated affiliates, USDC and EURC stablecoins. Circle provides a comprehensive suite of financial and technology...

We are a purpose driven healthcare technology company passionate about innovation and using technology to help people by solving real world problems. The ALIS team designs, builds, delivers, and supports our flagship product ALIS (pronounced “Alice” and stands for Assisted Living Integrated Solution).

Resident is a house of direct-to-consumer brands in the home goods space. We started with the award-winning including Nectar mattress in 2016 and have continued our meteoric growth with an expanding portfolio, DreamCloud and Awara to name a few. At Resident, we are relentless in our passion to provide customers with better choices when it comes to everyday home design....

HiBob helps modern, mid-size businesses transform the way they manage people, giving HR and managers all they need to connect, engage, develop, and retain top talent. Since 2015, we’ve achieved consecutive triple-digit year-over-year growth, all backed by our amazing team of Bobbers from across the globe, making us the choice HRIS of over 4000 midsize and multinational companies. Our HR platform...

It’s curious to think of innovation and stability co-existing. But we pair a 100-year track record of success with a hunger to do things differently. Everyone is in the work — tackling complex problems where your impact can build back or build up the communities we serve. We fill our halls with curious minds from all walks of life. Our...

Engrain’s mission is to fundamentally transform the way people find, lease and manage property. A recognized leader in next-generation touring technology and map-based data visualization software, Engrain’s advanced integrations and technical flexibility offer solutions for any real-estate technology stack.

Alchemy powers the top blockchain companies globally and has been featured in TechCrunch, Forbes, Bloomberg, and elsewhere. Our mission is to bring web3 to a billion people, by providing builders with the tools they need to build exceptional onchain products. Alchemy is the only complete developer platform that offers the powerful APIs, SDKs, and tools necessary to build and scale onchain...

Named among the World’s Most Admired Companies™ by Fortune and recognized in the Fortune 100 Best Companies to Work For® list in 2025, MetLife is leading the global transformation of an industry we’ve defined for more than 155 years. At MetLife, every innovation and line of code is a lifeline for our customers and their families—from victims of natural disasters...

Founded in 2013 in Hawaii and acquired by Booking Holdings in 2018, FareHarbor creates powerful tools that enable our clients (think boat rentals, museums, food tours, events and more!) to operate and grow. With over 20,000 clients across 90+ countries—we’re the largest in our industry and shaping the future of travel, together. Our team is an ‘Ohana of 900+...

Authorization controls who has access to what in an app. It’s a problem as old as computers, and it turns out, it’s a hard problem. At Oso, we help our customers build features to meet enterprise requirements, like fine-grained access controls or custom roles and permissions. We also provide the tools needed to build the next generation of secure, permissions...

Hi, we’re PI. We want to help create a better work better world by promoting self-awareness at the individual, team, and organizational levels. We are champions - and practitioners - of talent optimization: the strategic use of behavioral data to fuel business success. When companies understand their people’s natural behaviors, they can put them in positions to succeed. They also keep them...

Vivian Health's mission is to empower every healthcare professional to find their perfect job opportunity, faster and easier than ever before.