Top Senior IT Jobs in St. Louis, MO

Lead and optimize delivery for a defined IT portfolio, aligning initiatives to strategy and business outcomes. Orchestrate cross-team planning, manage dependencies, risks, and capacity, and drive portfolio governance. Coach teams on Agile/Scrum practices and Azure DevOps hygiene, define delivery metrics and dashboards, and communicate status to senior leadership while producing program plans, go-live readiness, and continuous improvement artifacts.

Lead Manhattan Active WM solution design and multi-site rollout, migrate legacy WMS/TMS/WES/WCS, define processes and standards, validate warehouse hardware and automation, manage integrations, testing, cutover, go-live stabilization, documentation, and mentor internal teams.

Support and enforce NIST/CMMC-aligned security controls; monitor SIEM/EDR and perform incident triage and response; manage Windows/AD environments; conduct vulnerability scanning and remediation; protect and classify FCI/CUI; support audits and control validation; maintain compliance documentation; collaborate with IT and business teams and communicate security risks to technical and non-technical stakeholders.

The Director of IT Operations leads the IT infrastructure, ensuring reliability, security, scalability, and efficiency while supporting business growth and managing the IT Operations team.

The IT Applications Lead manages the production support and implementation of Manufacturing and Quality applications in Oracle E-Business Suite, overseeing incident management, supporting users, and leading enhancements and projects.

The Manager of IT Engineering leads IT operations including identity management, SaaS, endpoint management, and internal tooling. This role ensures service quality and scalability for a remote workforce.

Lead IT procurement and contracting for Digital Services: run RFx/RFPs, draft and negotiate contracts, manage renewals, oversee software licensing and vendor relationships, maintain procurement records, resolve disputes, and mentor junior staff.

Lead global strategic sourcing for IT & automation categories ($450M+ spend). Develop category strategies, drive multi-million dollar savings, lead supplier relationship and risk management, conduct tenders and contract negotiations (> $500K), mentor sourcing managers, align senior stakeholders, implement supplier performance KPIs and innovation, and support cross-functional procurement initiatives. Expect ~20% travel.

The IT Communications Officer manages all IT networks and systems on board luxury cruise ships, providing technical support, user management, and ensuring communication infrastructure is operational.

The IT Project Manager will oversee project planning, implementation, and client interactions while ensuring compliance with federal and state regulations in the public sector.

The IT Project Manager will lead public sector ERP migration projects, ensuring high-quality deliverables and strategic alignment while collaborating with various stakeholders.

Build end-to-end automation and AI agents across identity, endpoint, SaaS, and ITSM systems. Automate onboarding/offboarding, ticket triage, self-service flows, and integrations. Operate and govern Vertex AI agents, establish KPIs, mentor sysadmins, and maintain reliable, auditable automations with security and compliance controls.

The Senior IT Project Manager oversees the delivery of technology and business transformation projects, supports PMO standards, manages project risks, and mentors junior managers.

The IT Systems Engineer will manage IT operations, support M&A integrations, and optimize Microsoft cloud systems, ensuring reliability and security.

The Manager of Internal Audit (IT) leads audit engagements, supervises staff, and develops risk-based audit schedules while ensuring compliance with regulatory standards.

The Senior IT Risk and Compliance Analyst manages vendor risk, ensures compliance with regulations, documents controls, and supports risk mitigation efforts across IT teams.

The IT Manager, Product Owner - Finance drives financial process transformations, prioritizes product backlogs, and manages stakeholder relationships to ensure high-quality delivery of financial systems solutions.

Serve as the primary IT–business liaison, owning executive relationships, technology strategy, vendor management, and prioritization of IT/AI initiatives. Drive modernization, cost/benefit analyses, budgeting, continuous improvement, and successful deployment of technology solutions across business units.

The IT Category Manager will lead sourcing negotiations for IT services, manage supplier relationships, and implement procurement best practices while achieving cost savings and improving processes.

Lead requirements analysis, design, and delivery of Cass TIS solutions. Document requirements, conduct gap analysis, define acceptance criteria, coordinate teams, create project plans, and mentor junior analysts to ensure successful deployments.

The Senior IT Program Manager leads program development and implementation, ensuring projects align with business needs and are delivered on time and budget. They manage stakeholder relationships and facilitate communication with senior leadership, oversee financial management, and develop risk management strategies.

The IT Operations Manager will oversee the internal technology ecosystem, ensuring reliability, security, and optimization of IT operations, while leading a team and collaborating with business leaders.

The Senior Procurement Manager will oversee IT sourcing and software procurement, manage renewals, drive savings, and mentor team members in procurement practices.

The Sr. Manager of Indirect Procurement will oversee procurement strategies to enhance cost efficiencies, ensuring the best products and services for veterinary practices.

Design and automate compliance systems to enhance efficiency in audit readiness. Collaborate with teams to integrate tools and optimize processes.