Top Senior Project Manager Jobs in St. Louis, MO

Manage life sciences construction projects from concept through closeout ($20M–$200M+). Oversee budgeting, cost reporting, scheduling, subcontractors, submittals, change orders, safety, quality, site logistics, staffing/training, equipment, bidding, and project closeout. Requires travel to service St. Louis clients and nationwide projects.

Manages the full lifecycle of engineering and controls installation projects, including scope, budgets, schedules, resources, vendors, subcontractors, client communications, reporting, and closeout. Supervises project managers and technical staff, supports proposals and business development, coordinates material delivery, and ensures projects meet schedule, budget, quality, and client expectations. The role requires substantial travel to job sites and offices.

Manages security and access control installation and maintenance projects from concept through completion. Leads technicians, project engineers, contractors, and customer relationships while overseeing scheduling, job coordination, inventory, labor efficiency, financial performance, safety, compliance, and customer satisfaction. Provides technical guidance, supports operational excellence, and collaborates with sales, marketing, and accounting. The role requires local and occasional overnight travel, blueprint interpretation, job estimating, and project cost management.

Leads complex enterprise portfolios and Agile programs, establishing portfolio governance, investment roadmaps, dependency management, risk frameworks, KPIs, and value realization. Champions AI-first project management, evaluates AI platforms, develops predictive analytics and executive dashboards, and drives enterprise Agile transformation. Oversees vendors, resources, financial management, and multi-stream delivery while advising executives and boards. Mentors project managers and leads Agile Centers of Excellence, training, maturity assessments, and organizational change initiatives.

Own end-to-end delivery of technical IT projects from intake and procurement through deployment and closeout. Manage SaaS rollouts, system integrations, requirements, vendor milestones, security reviews, testing, go-live, risks, dependencies, and stakeholder communications. Maintain project plans and reporting in Jira and Confluence, enforce lifecycle handoffs, manage change control, and report portfolio health. Improve delivery processes through templates, automation, intake criteria, and standardized reporting while coordinating Procurement, Engineering, IT Security, vendors, and business stakeholders.

Leads digital projects from scope through delivery, managing budgets, timelines, risks, dependencies, resources, and client expectations. Serves as Scrum Master, facilitates Agile ceremonies, coordinates distributed teams, reports project status, and drives on-time, on-budget outcomes. Partners with clients, product owners, business development, and program leadership to define solutions and improve delivery processes. Coaches team members, supports new opportunities, and promotes information security and data privacy practices.

Leads customer projects from proposal development through completion. Responsibilities include defining scopes, reviewing technical documentation, coordinating contractors and engineering resources, managing schedules and risks, maintaining project records, supporting contracts and invoicing, and serving as the primary client contact. The role manages multiple concurrent projects, prepares status reports, supports process improvements, and coordinates field activities across engineering, construction, and industrial-service environments.

Manage customer-facing software and AI/GenAI delivery projects from initiation through closure. Responsibilities include project planning, scheduling, RAID tracking, stakeholder communication, risk and dependency management, escalation handling, cross-functional coordination, and PMO process improvement. The role also supports AI project evaluation, data readiness, model performance monitoring, AI-specific risk tracking, prompt engineering awareness, cost considerations, and governance practices.

Lead complex, multi-track consulting programs for strategic oil, gas, and energy customers. Responsibilities include customer engagement, digital transformation planning, executive governance, resource coordination, partner contracting, delivery oversight, risk and financial management, metrics tracking, and cloud-consumption growth. The role also develops program plans, manages customer feedback, supports P&L accountability, and serves as a trusted industry advisor. Remote work is available, with 25–50% travel to customer sites.

Manage franchise rollout coordination across data readiness, planning, training, go-live, and hypercare. Maintain readiness checklists, dependencies, risks, issues, action items, documentation, and integrated plans. Coordinate franchise owners, program leadership, Data, Product, and technical teams; facilitate meetings, validate data, support training and communications, track post-launch issues, and escalate blockers. This remote role works EST hours, supports overlapping rollout waves, and may require limited periodic travel.

Manage end-to-end CMMC audit delivery for an enterprise customer, including planning, timelines, resources, risks, dependencies, evidence collection, stakeholder communication, and project closeout. Coordinate cybersecurity consultants and engineers, ensure SSPs, POA&Ms, artifacts, and control mappings meet audit requirements, and serve as the primary customer-facing project-management contact throughout the assessment lifecycle.

Leads curriculum development for a federal contract, overseeing training materials, e-learning content, project schedules, metrics, reporting, quality, staffing, and client relationships. Provides curriculum expertise, project management support, analytical evaluation, process improvement, and guidance on delivery standards. The role requires adult learning and instructional design experience, federal project experience, stakeholder management, and eligibility for a Public Trust clearance. It is remote with occasional travel for in-person meetings.

Leads day-to-day operations for large-scale federal transition assistance programs supporting military Service members and Veterans. Oversees dispersed teams, staffing, scheduling, service continuity, performance reporting, operational risks, stakeholder coordination, training, quality assurance, and process improvements across worldwide installations. Ensures contractual compliance, resolves issues, supports program execution, and maintains operational readiness. The role is remote with occasional travel for in-person meetings.

Leads federal contract operations supporting the VA’s veteran-support organization recognition program. Manages work plans, schedules, staffing, workloads, request reviews, quality assurance, reporting, risks, governance, stakeholder communications, and continuous improvement. Coordinates a multidisciplinary team, monitors performance and deadlines, prepares executive-ready status materials, and ensures accurate, traceable deliverables in a documentation-intensive environment.

Leads cross-functional federal healthcare projects from planning through implementation, managing scope, budget, resources, milestones, stakeholders, partner relationships, and government customers. Supports revenue cycle, clinician solutions, procurement initiatives, and proposal development for future federal awards. The role is remote, requires a T3 Public Trust background check, and may involve up to 25% domestic travel.

Manage multiple customer-facing technology implementation projects from kickoff through closure. Own delivery outcomes while coordinating customers, implementation engineers, executives, and cross-functional teams. Oversee scope, schedules, budgets, risks, quality, forecasting, and resource management. Lead planning sessions and delivery meetings, communicate project status, and help improve PMO best practices. The role focuses on cloud-based, integration-oriented solutions, with EDI, MFT, data movement, or file transfer experience preferred.

Leads production ramp-up projects across multiple manufacturing sites, managing project plans, capital expenditures, equipment delivery and integration, timelines, risks, records, and cross-functional coordination. Facilitates status meetings, reports performance to senior leadership, and supports continuous improvement and best-practice adoption. The role partners with engineering, procurement, operations, and site leadership to expand manufacturing capacity for optical communication systems.

Lead electrical and controls projects from planning through closeout, managing scope, schedules, budgets, resources, safety, client relationships, subcontractors, change orders, profitability, forecasting, and technical deliverables. Serve as the primary liaison between clients, field teams, and internal departments while resolving issues and ensuring high-quality project execution.

Manage high-volume, multi-site projects by developing and maintaining detailed schedules, tracking milestones, coordinating resources, communicating with stakeholders, and escalating risks. The role requires identifying scheduling constraints, developing mitigation strategies, maintaining project data, improving processes, and supporting on-time delivery across complex enterprise initiatives.

Leads project management office activities supporting Special Operations efforts in PACOM. Coordinates priorities, resources, stakeholders, vendors, subcontractors, deliverables, financial reporting, operational planning, documentation, metrics, and process improvement. Serves as a liaison with government program managers, briefs senior government officials, supports complex contracts in austere environments, and manages subcontractor statements of work. Requires travel of up to 25% and an active Top Secret clearance with SCI eligibility.

Leads complex pediatric public health research projects for the CHAMPS National program. Responsibilities include developing protocols and assessment tools, coordinating hospitals and research teams, managing timelines and budgets, overseeing data collection and analysis, ensuring protocol and HIPAA compliance, training staff, supervising research personnel, supporting IRB and safety board activities, and contributing to manuscripts, presentations, proposals, and CDC reporting. Some travel to hospitals and community project locations is required.

Manage the Legacy AMPS task order supporting DLA identity and access management operations. Responsibilities include project planning, integrated master schedule management, resource leadership, risk management, quality assurance, stakeholder coordination, deliverable production, compliance tracking, and transition planning across IAM, SSO, PAM, GRC, and application security programs.

Leads multiple complex, cross-functional projects from requirements gathering through completion. Develops schedules, resource plans, budgets, and project documentation; manages risks, issues, changes, costs, and deliverables; communicates status to stakeholders; ensures projects meet scope, schedule, and budget objectives; and mentors project team members while improving project management processes.

Lead and deliver Oracle Cloud HCM implementation projects from initiation through closure. Define scope, plans, budgets, and staffing; manage risks, issues, QA, and stakeholder communication; present status to leadership and ensure on-time, on-budget delivery.

Lead and deliver ServiceNow technical projects using Agile and Waterfall. Coach teams on Scrum, remove impediments, manage scope/schedule/budget, coordinate vendors, interface with clients, analyze resource utilization, drive services revenue, and close projects with post-implementation reviews.