Top Senior IT Jobs in St. Louis, MO

The Senior Network Engineer will design, implement, and secure global networking infrastructure, ensuring resilience and security across various environments. They will collaborate with IT, Security, and Engineering to support mission-critical operations and compliance with relevant frameworks.

Lead IT support operations, ensuring high-quality technical support, vendor management, and IT processes for a remote workforce while improving contributor experience.

The Senior Manager of Corporate Operations will lead technical strategy for internal systems, focusing on IAM, MDM, and corporate infrastructure, ensuring security and operational excellence across environments.

The IT Cloud Engineer will design and implement VMware environments, migrate on-prem workloads to cloud platforms, optimize cloud architectures, and ensure compliance and security within hybrid environments while collaborating with teams across the organization.

The Lead IT Telecom Architect designs and optimizes Telecom and Contact Center architecture to meet business goals, ensuring security and performance. Responsibilities include strategy development, technology evaluation, system implementation oversight, and stakeholder collaboration.

Lead design, implementation, and administration of enterprise IT infrastructure with a strong focus on identity and access management across GCP, AWS, and GitHub. Build Okta-driven provisioning workflows, automate processes, manage IAM governance and compliance, support IT support escalations, and evolve security policies including PAM and EDR controls.

Lead and operate Vynca's IT function for a fully remote, HIPAA-regulated healthcare organization. Manage a distributed IT team, own day-to-day operations (hardware lifecycle, provisioning, identity and access), enforce security and compliance (HIPAA, SOC 2), administer MDM/SSO/endpoint tools, support audits, and drive operational improvements while mentoring staff.

The Senior Technology Specialist oversees the design and support of technology solutions, ensuring they meet business needs and compliance standards, while mentoring junior staff and optimizing operations.

Lead technical program manager responsible for planning and delivering corporate IT projects including IAM, M&A integrations, infrastructure and networking upgrades. Own project lifecycle, stakeholder communication, risk and vendor management, IT project intake/process definition, documentation, and budget oversight.

Lead architecture, deployment, and operations of CloudClinic IT infrastructure across sites. Design MDM/imaging, automate processes, manage networking and endpoint security, perform root-cause analysis, support go-lives, monitor observability, and collaborate with cross-functional teams to ensure scalable, secure systems.

The Business Development Manager will focus on acquiring new clients and expanding accounts within the IT staffing sector, managing the full sales cycle and meeting revenue targets.

Lead design, implementation, and optimization of ServiceNow ITOM (Discovery, Service Mapping, Event Management) and CMDB governance. Configure MID Servers, patterns, probes, and integrations; manage cloud discovery across AWS/Azure/GCP; build automations with Flow Designer and APIs; perform performance and root-cause analysis; liaise with vendors; produce technical strategy, capacity planning, and translate technical solutions for business stakeholders.

Remote IT Manager responsible for analyzing, upgrading, and administering IT systems (networks, servers, email, backups), evaluating vendors and technologies, managing projects, tracking inventory, training staff, and providing technical support to improve operational efficiency.

Act as liaison between various teams to gather and document business needs, create test plans, and assist in project execution.

Lead strategy and execution of IT Computer System Validation and QA for GxP-regulated IT systems. Develop CSV strategy, SOPs, risk management, change control, and training. Oversee validation, vendor qualification, audits/inspections, and compliance of ERP and lab systems throughout the system lifecycle.

The Enterprise Architect leads architectural strategy and integration for technology and processes while aligning IT investments with business goals. Responsibilities include overseeing cloud modernization, governance, and communication with stakeholders.

The Senior IT Systems Administrator oversees the administration, security, and optimization of financial systems, ensuring reliability and compliance while leading system enhancements and integrations.

The Senior Clinical Trials IT Business Analyst bridges Clinical Development and IT, optimizing clinical trial technologies and managing system implementations, validations, and stakeholder engagement.

Provide remote technical support, troubleshoot issues, design security solutions, manage cloud and virtualization environments, and communicate with clients. Requires strong IT skills and customer service.

Manage full project lifecycle for IT Operations and Services, including enterprise applications, security, network/systems infrastructure, and process improvements. Create plans, governance, change management, vendor onboarding, KPIs, roadmaps, and transition projects to operations while communicating status and driving cross-team collaboration.

Lead and manage Level 1-3 Service Desk analysts supporting external clients, oversee daily operations, escalations, SLAs, and reporting. Improve service management, automation, and first-call resolution; partner with Engineering and Incident/Problem/Change Management to resolve production issues. Provide hands-on technical leadership across Splunk, Datadog, MuleSoft, SQL, and ServiceNow while managing client communications and operational metrics.

The IT Operations Director leads Service Desk and Infrastructure teams, overseeing IT operations lifecycle, managing metrics, enforcing security, and enhancing service quality through automation and ITIL processes.

The Enterprise Architect defines technology strategies, aligns investments with company goals, and leads cloud modernization and data analytics initiatives while ensuring compliance and governance.

Manage SAP ERP solutions for finance, design and implement configurations, provide user support, and ensure integration across relevant business areas.

The Senior Director Analyst at Gartner leads research initiatives, providing thought leadership, actionable insights, and market analysis to clients and organizations, while mentoring junior team members.