Top Senior IT Jobs in St. Louis, MO

The role involves leading and improving IT operations, focusing on proactive service organization, process design, and team development while managing IT projects and vendor relationships.

Hands-on senior IT systems administrator responsible for administering Google Workspace and Microsoft 365 environments, endpoint and MDM support across ChromeOS/Windows/macOS, SaaS administration, help desk support, and executing compliance controls (CMMC/NIST800-171/ISO27001/SOC2). Uses AI tools to automate IT workflows, supports engineering teams' toolchains, and assists in audit readiness and evidence collection.

The IT Operations Manager will oversee day-to-day IT operations, including managing MSP, network and cloud infrastructure, identity management, systems administration, and user support, while ensuring security and optimal performance across all platforms.

Lead IT project management and application support for a national cooperative, focusing on Azure cloud modernization, data storage optimization, database analysis, 2nd-level troubleshooting, enterprise chatbot implementation, vendor management, requirements gathering, and coordinating internal and external IT resources to deliver complex software solutions.

The Senior IT Project Manager will lead client-facing IT infrastructure projects, manage timelines and expectations, and coordinate engineering teams while ensuring high-quality delivery of services.

Responsible for IT support and administration for Commercial systems. Partners with business owners to ensure system performance, compliance, and operational excellence across various business functions.

The Senior IT Engineer will provide advanced technical support, manage IT infrastructures, ensure security, and lead incident response efforts in a remote environment.

The IT Systems Engineer III will improve Ophelia's IT systems through integration, automation, and security while managing IT projects, overseeing service providers, and ensuring compliance.

The IT Support Lead oversees L1/L2 IT support operations, leading a team, ensuring effective issue resolution, and managing IT support functions.

Supervise and perform SOC examinations, HITRUST certifications, and ISO assessments. Lead a team, review workpapers, analyze controls, and assess internal deficiencies while ensuring compliance with quality control policy.

Lead and manage a remote US IT support team to deliver high-quality technical support. Oversee daily operations, SLAs, ticket triage, knowledge base, training, metrics reporting, and escalation for complex issues while coordinating cross-functional initiatives and adopting industry best practices to improve customer satisfaction.

Lead and grow a product support team for a live digital court reporting product (Maggie). Supervise analysts, triage and lead incident response for P0/P1 events, coordinate escalations to IT and engineering, run on-call rotations, develop runbooks/KB/training, track support metrics, provision hardware kits, and hire and train support staff.

Design, implement, and evolve enterprise IT architecture solutions across cloud/hybrid, SaaS, and on‑prem platforms. Lead cross-functional architecture initiatives, define integration approaches, support AI/automation enablement, ensure security and governance alignment, optimize performance and cost, mentor teams, and contribute to standards, vendor evaluations, and modernization efforts.

Own and operate core corporate IT systems including identity, endpoints, cloud infrastructure, and automations. Administer AWS, ServiceNow, MDM, and SaaS integrations; build workflows, govern AI tools, handle Tier 3 incidents and on-call duties, and partner with Security, People, and Enterprise apps to ensure reliability, security, and compliance.

The role involves strategic sourcing for indirect goods and services, overseeing supplier relationships, driving cost savings, and developing procurement strategies while collaborating with cross-functional teams.

Lead research and produce high-impact insights on outsourced managed security services and public cloud. Advise clients and vendors, develop thought leadership, deliver presentations, support sales, mentor analysts, improve research processes, and represent Gartner externally. Focus areas include MDR/SOC, cloud security operations, sourcing/contracts, and hyperscaler/cloud workload optimization. Up to 25% travel.

Lead enterprise IT procurement strategy, governance, and operations across hardware, software, cloud, and services. Own vendor relationships, commercial negotiations, licensing and asset lifecycle, M&A procurement integration, and procurement process/tooling. Mentor and scale the procurement team, partner with Finance, Legal, and Security, and deliver executive reporting and cost-optimization initiatives.

Serve as first-line IT support for hardware, software, networking, and enterprise applications. Triage and resolve support tickets, manage onboarding/offboarding, administer Okta and endpoint management (Intune, Jamf), maintain device health and access controls, collaborate with Security and Engineering, document processes, and improve support workflows to ensure a secure, compliant, and user-friendly hybrid work environment.

The Senior IT Engineer will lead IT architecture and security processes, manage identity and access, and mentor team members while ensuring compliance and operational efficiency.

Act as the technical lead for field sales, manage evaluations, deliver on-site and remote demos, prepare SOWs/RFIs/RFPs, respond to security questionnaires, train sales teams, and support sales across U.S. and Canada while maintaining client relationships and achieving technical sales targets.

Sell radiology IT solutions by building strategic account plans, managing long technical sales cycles, maintaining a 3-5× quota pipeline, forecasting in Salesforce, partnering with marketing/inside sales, and representing the company at industry conferences.

Lead IT SOX controls testing for ITGCs (access, change, operations) across blockchain-native and enterprise systems. Build testing programs, validate remediation, perform root-cause analysis, report to Audit Committee, and collaborate with Engineering, Security, and external auditors to ensure SOX compliance and scalable audit processes.

Lead strategy and execution for enterprise infrastructure, cloud platforms, and systems reliability. Build and scale a high-performing IT operations team, drive automation and observability, manage incident and change processes, partner cross-functionally on security and architecture, and lead large-scale infrastructure transformation to ensure resilient, scalable services.

First IT hire responsible for end-to-end IT: systems administration (Rippling, Google Workspace, SSO), device lifecycle, help desk, vendor and license management, security operations (endpoint protection, phishing simulations, awareness training), and establishing HIPAA compliance and documentation.

Lead information security governance, risk, and compliance programs. Manage cross-functional teams, SOC 2 Type II audits, regulatory engagements, enterprise data security and governance, incident communications, information security questionnaires, KPI/KRI reporting, and mentor junior staff to ensure regulatory and standards alignment.