Top Senior IT Jobs in St. Louis, MO

Provide hands-on Tier 2/3 IT and OT systems support in a manufacturing environment, troubleshoot production-impacting issues across servers, workstations, networks, applications and industrial systems, support software lifecycle tasks, ensure high availability, follow safety and compliance, and coordinate with operations, engineering, maintenance, cybersecurity and vendors.

Own day-to-day IT operations for a global remote workforce, including end-user support, device and access management, onboarding and offboarding, internal systems administration, security controls, compliance audits, process automation, vendor management, and asset tracking. The role partners with Compliance, Engineering, DevOps, and HR to maintain reliable, secure, and efficient IT infrastructure while supporting growth and regulated-industry requirements.

Leads global strategic sourcing and category management for IT and indirect spend. Develops sourcing strategies, negotiates contracts, manages supplier performance and risk, drives cost savings and procurement transformation, ensures compliance, and leads a global sourcing team. Partners with IT, Finance, Legal, Operations, and business stakeholders across regions while monitoring KPIs and improving sourcing processes.

Manages the full lifecycle of patient safety and compliance cases for OPTN member organizations. Responsibilities include intake, triage, clinical review, investigations, stakeholder coordination, corrective action tracking, trend analysis, reporting, documentation, and process improvement. The role supports HRSA and OPTN committees, handles sensitive healthcare information, manages multiple concurrent cases, and assesses compliance risks and patient safety concerns.

Leads provider contracting and network development for the World Trade Center Health Program. Responsibilities include assessing network gaps, recruiting providers, negotiating agreements and reimbursement structures, managing contract lifecycles, overseeing network adequacy and access reporting, improving workflows, mitigating network risks, and coordinating with credentialing, finance, compliance, and provider data teams.

Leads the IT Order to Cash function and roadmap across SAP platforms, including configuration, integration, customization, master data, reporting, and analytics. Manages SAP OTC process improvements, KPIs, OKRs, stakeholder communications, solution design, and SAP BTP innovation. Supervises and develops business analysts, software engineers, and subject matter experts while aligning technology delivery with business transformation goals.

Leads Order-to-Cash business process analysis and technology initiatives across customer data, pricing, orders, contracts, billing, rebates, receivables, and reporting. Translates business needs into process models, requirements, user stories, and solution designs; coordinates testing, deployment, issue resolution, and continuous improvement. Partners with business, technology, finance, operations, and vendors while supporting roadmap planning, change adoption, standards, and analyst mentoring.

Own Baseten’s internal identity and authentication infrastructure, including Okta architecture, SSO, MFA, lifecycle management, and application integrations. Build automated joiner, mover, and leaver workflows across HRIS, Google Workspace, MDM, and SaaS systems using scripting and APIs. Implement access controls, device trust, compliance processes, documentation, and audit evidence. Serve as a technical escalation point for IT Support and partner with Security on least-privilege access and SOC 2 requirements.

Leads SAP Source-to-Procure capabilities across sourcing, procurement, supplier management, and supply chain processes. Translates business requirements into scalable SAP solutions, facilitates fit-to-standard workshops, guides solution design, and supports testing, deployment, integrations, adoption, and production readiness. Partners with business stakeholders, architects, developers, implementation partners, and support teams to drive ERP transformation, process standardization, continuous improvement, data quality, and reliable enterprise operations.

Leads the SAP S/4HANA Financials Record to Report workstream, specializing in COPA, product costing, fixed assets, and related SAP FI/CO processes. Oversees solution design, configuration, implementation, testing, integrations, cutover, and support readiness. Coordinates stakeholders, vendors, contractors, and delivery plans while managing risks and dependencies. Provides functional leadership, mentors team members, translates business requirements into SAP solutions, and drives process improvements throughout a multi-year SAP transformation.

Leads distributed software development teams across legacy, modern, and cloud-native applications. Oversees planning, Agile delivery, engineering standards, DevSecOps, CI/CD, AWS and Kubernetes deployments, AI-assisted development, governance, compliance, modernization, and stakeholder communication. Manages team performance, mentoring, workload allocation, hiring, retention, and culture while ensuring secure, scalable, high-quality application delivery.

Plans, initiates, and manages enterprise IT projects involving payments and core platform architecture. Leads technical staff, coordinates business and technical teams, develops project plans, manages execution, assesses risks, and oversees Agile delivery, roadmaps, backlogs, and the software development lifecycle.

Leads enterprise business analysis strategy across programs and portfolios, partnering with executives to define requirements, evaluate investments, measure business value, manage risks, and guide transformation initiatives. Establishes standards and governance, analyzes operational and financial data, supports regulatory compliance, and mentors analysts. The role also advances AI-enabled tools, automation, and analytics to improve decision-making and business outcomes within a healthcare payer environment.

Provide Tier 2/3 technical support for distributed employees across macOS and Windows endpoints, identity and access platforms, collaboration tools, and office technology. Own complex incidents through root-cause resolution, manage endpoint configurations and compliance, improve ITSM workflows and documentation, support onboarding and device lifecycles, and collaborate with Security and IT Engineering. The role also includes mentoring junior analysts and occasional travel to company offices for deployments and events.

The Senior Scrum Master coaches Agile teams and Product Owners, facilitates Scrum ceremonies, manages backlogs and release planning, coordinates dependencies and risks, and promotes team self-management and continuous improvement. The role supports SAFe practices, cross-team collaboration, stakeholder communication, conflict resolution, and delivery transparency. It requires experience in software development environments, SAFe implementation, strong facilitation and coaching skills, a bachelor’s degree, five or more years of experience, CSM or PMI-ACP certification, and PMP certification.

Own IT operations and employee experience for a remote workforce. Support users, administer Google Workspace, Okta, and Apple device management, and optimize AI-powered ticketing, automation, self-service, and documentation. Analyze ticket trends to resolve root causes, manage onboarding and offboarding, maintain asset inventory, support security and compliance audits, deliver training and communications, and partner with teams to improve workflows and scale IT operations.

Designs, implements, configures, and supports enterprise cybersecurity solutions across IAM, endpoint, network, email, application, cloud, and security awareness domains. Conducts vulnerability assessments, threat hunting, incident investigation, security tool tuning, policy development, and security architecture reviews. Serves as a security subject matter expert on technology projects, collaborates with an MSSP, provides incident escalation support, and maintains availability for critical security operations.

Manage IT SOX assurance engagements for multiple clients, including planning, risk assessment, staffing, control testing, workpaper review, reporting, billing, and client communication. Evaluate SDLC, security, change management, cloud, ERP, operating system, and database controls. Lead teams, mentor staff, support business development, deliver training, and serve as a trusted client advisor while ensuring professional and regulatory standards.

Performs application and system risk assessments, security audits, policy and procedure development, compliance support, security documentation, and risk communication. Advises business and security stakeholders, helps project teams implement controls addressing regulations such as Sarbanes-Oxley and HIPAA, supports organizational security awareness, and contributes to strategic information risk management initiatives and roadmaps.

Provides cybersecurity, vulnerability management, and Splunk administration support for DOE business applications. Responsibilities include developing security policies and logging standards, creating Splunk dashboards and queries, analyzing security events, conducting vulnerability scans, securing applications and databases, investigating issues, and documenting systems and procedures. The role requires collaboration with system owners and application teams to identify and mitigate vulnerabilities while supporting compliance with government security mandates.

Leads the strategy, architecture, and implementation of enterprise AI-assisted and cloud-native software development capabilities. Evaluates AI tools, establishes engineering standards, develops proof-of-concept solutions, guides technical architecture, and coaches engineering teams. The role requires full-stack development, cloud platforms, CI/CD, DevSecOps, secure coding, distributed systems, and experience delivering mission software across complex programs.

Performs application analysis and functional testing for enterprise systems supporting AmeriCorps. Responsibilities include analyzing workflows, defects, and change requests; creating and executing functional, regression, automated, and user acceptance tests; validating data integrations; coordinating test cycles; documenting defects and results; supporting release readiness; and maintaining system documentation.

Analyze enterprise application behavior, defects, workflows, and change requests; develop and execute functional, regression, automated, and user acceptance tests; coordinate testing with development, database, and operations teams; validate data flows and integrations; document defects, results, process gaps, and system workflows; track remediation and support release readiness across development, test, and production environments.

Provides Tier 2/3 support for IT and OT systems in a manufacturing environment. Troubleshoots production-impacting issues across applications, servers, workstations, networks, enterprise software, SCADA, historians, and other industrial platforms. Supports installations, upgrades, patching, lifecycle management, cybersecurity, compliance, and IT-OT integrations. Collaborates with operations, engineering, maintenance, IT, cybersecurity, and vendors while responding to outages and maintaining reliable, high-availability plant operations.

Develop and maintain AmeriCorps grants management applications using Java, Oracle, PL/SQL, and SQL. Modernize systems, implement enhancements and interfaces, support security and privacy requirements, collaborate with stakeholders to capture and deliver requirements, and perform application testing and maintenance.