Top Senior Data Science Jobs in St. Louis, MO

Reposted 5 Days AgoSaved
Hybrid
St. Louis, MO
99K-232K Annually
Senior level
99K-232K Annually
Senior level
Artificial Intelligence • Professional Services • Business Intelligence • Consulting • Cybersecurity • Generative AI
This role involves applying advanced data science and machine learning methods to healthcare data, leading teams, managing client relations, and developing analytics products for payers, while mentoring junior staff.
Top Skills: Clinical Data AnalysisData ScienceMachine LearningNlp
Reposted 5 Days AgoSaved
Easy Apply
Remote
St. Louis, MO
Easy Apply
236K-295K Annually
Senior level
236K-295K Annually
Senior level
Artificial Intelligence • Enterprise Web • Information Technology • Productivity • Sales • Software • Database
Lead product analytics to inform strategy and optimize user experience: translate business questions into analysis, build reliable analytics infrastructure, run A/B tests and ML/statistical analyses, track funnels and cohorts, support 0-to-1 product launches, and communicate actionable insights to cross-functional teams.
Top Skills: A/B TestingAmplitudeHeapLookerMachine LearningMixpanelPythonRSASSQLStatistical Analysis
8 Days AgoSaved
Remote
St. Louis, MO
170K-272K Annually
Senior level
170K-272K Annually
Senior level
Cloud • Fintech • Food • Information Technology • Software • Hospitality
Lead design and delivery of scalable ML systems across the full lifecycle for recommendations, demand forecasting, targeting, and personalization. Collaborate with engineers, product, and stakeholders to set architecture, metrics, and production best practices; mentor data scientists; lead experimentation and deploy/monitor models using cloud and MLOps tooling.
Top Skills: AthenaAWSBedrockDistributed Data ProcessingDynamoDBGlueLlm Fine-TuningMlopsPythonPyTorchReal-Time InferenceRlhfSagemakerScikit-LearnSQLTensorFlow
Reposted 9 Days AgoSaved
Remote or Hybrid
St. Louis, MO
120K-180K Annually
Senior level
120K-180K Annually
Senior level
Cloud • Computer Vision • Information Technology • Sales • Security • Cybersecurity
Design and train LLMs and agentic systems for cybersecurity using RLHF/RLAIF and supervised fine-tuning. Build agent architectures, tooling, retrieval/memory, and evaluation pipelines with rigorous statistical benchmarking. Optimize prompts and inference, collaborate with engineers to productionize prototypes, and drive research on agent planning, safety, and reliability.
Top Skills: DeepspeedDpoFsdpGpusGrpoHugging Face TransformersLlmsPeftPpoPythonPyTorchReward ModelingRlaifRlhfSglangTgiTrlVllm
3 Days AgoSaved
In-Office
St. Louis, MO
112K-131K Annually
Senior level
112K-131K Annually
Senior level
Fintech
Design and maintain data models and pipelines for mortgage and lending platforms. Develop ML/AI, predictive and prescriptive analytics, and LLM/Generative AI solutions. Collaborate with engineering and business stakeholders to build scalable cloud and data warehouse solutions, ensure data quality and governance, and deliver dashboards and executive reporting.
Top Skills: AIAws Ai ServicesAzure AiAzure OpenaiCloudData WarehouseETLGenerative AiLlm OptimizationLlmsMachine LearningMlopsPrompt EngineeringRetrieval-Augmented Generation (Rag)
Reposted 22 Days AgoSaved
Remote
St. Louis, MO
200K-240K Annually
Senior level
200K-240K Annually
Senior level
Fintech • Information Technology • Software
As a Staff Data Scientist at SentiLink, you will develop fraud detection models, conduct analyses, collaborate across teams, and drive the development of financial risk products.
Top Skills: AWSPostgresPython 3
Reposted YesterdaySaved
Easy Apply
In-Office or Remote
St. Louis, MO
Easy Apply
170K-200K Annually
Senior level
170K-200K Annually
Senior level
Artificial Intelligence • Hardware • Healthtech • Software
The Senior Data Scientist will build models and analyses, design experiments, integrate datasets, and leverage AI for improved workflows and insights in data science.
Top Skills: DatabricksMlflowPandasPythonPyTorch
Reposted 5 Days AgoSaved
In-Office
St. Louis, MO
160K-190K Annually
Senior level
160K-190K Annually
Senior level
Information Technology • Software • Cybersecurity • Defense
The Data Scientist will create and deliver analytic processes and data solutions while coordinating with clients to address data-related issues. Responsibilities include designing data architecture, building ETL pipelines, integrating APIs, conducting impact analysis, and preprocessing geospatial data.
Top Skills: Cloud ArchitecturesJavaJavaScriptNoSQLPythonSQL
2 Days AgoSaved
Easy Apply
Remote or Hybrid
St. Louis, MO
Easy Apply
128K-240K Annually
Senior level
128K-240K Annually
Senior level
Fintech • Mobile • Software • Financial Services
Lead AML model development, optimization, validation, and governance for transaction and customer screening across banking, brokerage, and lending. Build ML/statistical models, maintain vendor solutions, ensure regulatory compliance, document methodologies, produce AML dashboards, and support audits, risk assessments, and stakeholder communications.
Top Skills: DatadogDockerKubernetesLexisnexisMachine LearningMonte CarloPythonSnowflakeSQLTableauTerraformVerafin
Reposted 4 Days AgoSaved
Easy Apply
Remote
St. Louis, MO
Easy Apply
180K-212K Annually
Senior level
180K-212K Annually
Senior level
Artificial Intelligence • Blockchain • Fintech • Financial Services • Cryptocurrency • NFT • Web3
Own and evolve revenue calibration models tying CX interactions to revenue, design causal inference and experimentation frameworks, build LLM-powered classification/NLP pipelines, productionize models with Analytics Engineers, define segmentation and behavioral signals, and ensure statistical rigor for executive reporting and regulatory defensibility.
Top Skills: A/B TestingCausal InferenceGeminiGenerative AiGleanLibrechatLlmMlNlp
Reposted 9 Days AgoSaved
In-Office
St. Louis, MO
Senior level
Senior level
Artificial Intelligence • Cloud • Information Technology • Professional Services
The role involves leading ML project implementations, designing production-grade ML solutions, and optimizing AI applications for clients while ensuring effective communication and project management.
Top Skills: SparkDatabricks Mlops StackDockerGenerative AiMachine LearningMlopsNatural Language Processing
6 Hours AgoSaved
Remote or Hybrid
St. Louis, MO
140K-170K Annually
Senior level
140K-170K Annually
Senior level
Artificial Intelligence • Machine Learning • Software • Analytics
Develop ML features, models, and analytical methods from device, network, browser, mobile, session, and behavioral telemetry to detect fraud and improve identity confidence. Handle large-scale, noisy, high-cardinality data, design validations, assess drift and leakage, collaborate with engineering/product/risk for production rollout, document models and features, and mentor junior team members.
Top Skills: DatabricksNumpyPandasPysparkPythonPyTorchScikit-LearnSparkSQLTensorFlowXgboost
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Reposted 10 Hours AgoSaved
Remote
St. Louis, MO
163K-218K Annually
Senior level
163K-218K Annually
Senior level
Internet of Things
The Staff Data Scientist will lead analytical strategies for Firefox, focusing on product growth, measurement frameworks, and mentoring data scientists while guiding data-driven decisions.
Top Skills: PythonSQL
Reposted YesterdaySaved
Remote
St. Louis, MO
Senior level
Senior level
Machine Learning • Software
The Staff Data Scientist will lead the development and deployment of ML and GenAI systems to detect billing errors and fraud in healthcare payments, collaborating with cross-functional teams.
Top Skills: AIData ScienceMachine Learning
Reposted YesterdaySaved
Remote
St. Louis, MO
Senior level
Senior level
Information Technology • Consulting
The Data Scientist will develop tools for enhancing signature management capabilities, integrate diverse data holdings, and leverage AI/ML solutions for operational support.
Top Skills: Amazon Web ServicesDockerFlaskGradioPythonSQLStreamlit
Reposted YesterdaySaved
Remote
St. Louis, MO
Senior level
Senior level
Information Technology • Consulting
Develop a tool to enhance signature management capabilities and integrate diverse data holdings, leveraging AI/ML solutions to meet operational needs.
Top Skills: DockerFlaskGradioPythonSQLStreamlit
Reposted YesterdaySaved
Remote
St. Louis, MO
Senior level
Senior level
Software
Customer-facing data scientist advising customers on experiment design, statistical methodology, and experimentation architecture; running and analyzing A/B tests; building scalable experimentation programs; creating repeatable frameworks and technical enablement; partnering with Sales, Solutions Engineering, Product, and Engineering to drive customer success.
Top Skills: AmplitudeBigQueryEppoLaunchdarklyOptimizelyPythonRRedshiftSnowflakeSQLStatsig
2 Days AgoSaved
Remote
St. Louis, MO
220K-290K Annually
Senior level
220K-290K Annually
Senior level
Information Technology • Software
Build and productionize ML models and data infrastructure to analyze millions of chaos engineering experiments, detect and explain failures, recommend automated remediation, and integrate AI-driven failure analysis into Gremlin's product using techniques like causal inference, graph ML, time-series modeling, and reinforcement learning.
Top Skills: Agentic AiCausal InferenceChaos EngineeringData PipelinesFeature StoresGraph MlMlopsModel MonitoringModel ServingReinforcement LearningSite Reliability EngineeringTime-Series Modeling
Reposted 7 Days AgoSaved
Remote
St. Louis, MO
160K-220K Annually
Senior level
160K-220K Annually
Senior level
Fintech • Financial Services
Lead and deliver end-to-end data science projects: design, build, deploy, and monitor ML/statistical models for credit risk, pricing, collections, and fraud. Partner with cross-functional teams to integrate models into production, set model development standards, mentor engineers, and maintain reliable ML pipelines and monitoring systems.
Top Skills: AWSGitPythonSagemakerSQL
2 Days AgoSaved
Remote
St. Louis, MO
138K-198K Annually
Senior level
138K-198K Annually
Senior level
Aerospace • Defense
Lead development of orthomosaic tile imagery products for FireSat and SBEM: design and implement scalable mosaicking, orthorectification, and radiometric normalization algorithms; write production-ready code; author technical and customer-facing documentation; validate scientific quality; engage stakeholders and act as product owner for SBEM granule product; collaborate with engineers and scientists.
Top Skills: AWSCloud Optimized GeotiffGdalPythonXarray
2 Days AgoSaved
Remote
St. Louis, MO
138K-198K Annually
Senior level
138K-198K Annually
Senior level
Aerospace • Defense
Lead radiometric calibration and image processing for multispectral infrared instruments, commission FireSat satellites, and develop/execute SBEM calibration plans. Implement production-ready pipelines, perform R&D to improve calibration, write production-quality code, and collaborate cross-functionally to maintain operational remote sensing data products and services.
Top Skills: AWSCogNetcdfPythonXarray
3 Days AgoSaved
Remote
St. Louis, MO
Senior level
Senior level
Healthtech • Telehealth
Lead and grow a 4–6 person data science team, set the roadmap, deliver marketplace forecasting and production ML (matching, scoring), embed data science cross-functionally, and establish modeling, experimentation, and monitoring best practices.
Top Skills: ArimaCi/CdDbtDockerMlflowProphetPythonSagemakerSnowflakeSQL
3 Days AgoSaved
Remote
St. Louis, MO
170K-210K Annually
Senior level
170K-210K Annually
Senior level
Artificial Intelligence • Automotive • Machine Learning • Financial Services
Embedded on the central Data Science team, you will define the right problems, build metrics, run analyses and experiments, create reports, and drive data-informed recommendations end-to-end across growth, product, AI/automation, or partnerships.
Top Skills: GitJupyter HubMetabasePythonSql (Clickhouse)
3 Days AgoSaved
Remote
St. Louis, MO
170K-210K Annually
Senior level
170K-210K Annually
Senior level
Artificial Intelligence • Automotive • Insurance • Software
Embed on a central Data Science team to define problems, build analyses, metrics and experiments, surface insights, and drive cross-functional decisions that move product, growth, AI/automation, or partnerships metrics end-to-end.
Top Skills: ClickhouseGitJupyter HubMetabasePythonSQL
Reposted 3 Days AgoSaved
Remote
St. Louis, MO
194K-253K Annually
Senior level
194K-253K Annually
Senior level
Healthtech
Lead the technical development and automation of enrollment forecasting models, collaborating with various departments to enhance decision-making and forecast accuracy.
Top Skills: NumpyPandasProphetPythonScikit-LearnSQLStatsmodels
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