Top Senior Data Science Jobs in St. Louis, MO

Reposted 4 Days AgoSaved
Hybrid
St. Louis, MO
99K-232K Annually
Senior level
99K-232K Annually
Senior level
Artificial Intelligence • Professional Services • Business Intelligence • Consulting • Cybersecurity • Generative AI
Lead teams applying advanced data science and machine learning to large-scale claims, clinical, and member data to generate actionable insights that reduce cost of care and improve population health. Manage client relationships, mentor staff, ensure project delivery and quality, develop payer-focused analytics products, present findings to senior stakeholders, and promote continuous improvement and knowledge sharing.
Top Skills: Claims DataClinical DataCms Star RatingsMachine LearningNcqa HedisNlpSocial Determinants Of Health (Sdoh) Data
Reposted 12 Days AgoSaved
In-Office
St. Louis, MO
128K-174K Annually
Senior level
128K-174K Annually
Senior level
Aerospace • Information Technology • Software • Cybersecurity • Design • Defense • Manufacturing
Design, build, and deploy machine learning solutions in distributed systems; collaborate with engineers and subject-matter experts; evaluate and improve models; ensure data security and compliance; communicate insights to stakeholders; mentor junior data scientists.
Top Skills: AWSAzureCC#C++ClearmlGenerative AiJavaJuliaLlmsMlflowMlopsNoSQLPythonPyTorchRSQLTensorFlow
12 Days AgoSaved
Hybrid
St. Louis, MO
91K-322K Annually
Senior level
91K-322K Annually
Senior level
Artificial Intelligence • Professional Services • Business Intelligence • Consulting • Cybersecurity • Generative AI
Lead analytics initiatives to deliver strategic insights for consumer markets. Develop advanced analytics and BI solutions, manage teams, engage stakeholders, implement cloud analytics, and coach diverse teams to improve performance and decision-making.
Top Skills: QlikviewSpotfire
Reposted 5 Days AgoSaved
Remote
St. Louis, MO
170K-272K Annually
Senior level
170K-272K Annually
Senior level
Cloud • Fintech • Food • Information Technology • Software • Hospitality
Lead design and delivery of scalable ML systems across the full lifecycle for recommendations, demand forecasting, targeting, and personalization. Collaborate with engineers, product, and stakeholders to set architecture, metrics, and production best practices; mentor data scientists; lead experimentation and deploy/monitor models using cloud and MLOps tooling.
Top Skills: AthenaAWSBedrockDistributed Data ProcessingDynamoDBGlueLlm Fine-TuningMlopsPythonPyTorchReal-Time InferenceRlhfSagemakerScikit-LearnSQLTensorFlow
Reposted 6 Days AgoSaved
Easy Apply
Remote or Hybrid
St. Louis, MO
Easy Apply
160K-194K Annually
Senior level
160K-194K Annually
Senior level
Artificial Intelligence • Insurance • Machine Learning • Software • Analytics
Lead complex modeling projects combining deep learning, LLMs, and traditional techniques. Prototype, deploy, and monitor production models, mentor data scientists, collaborate with engineering/product, and translate results into business impact for insurance customers.
Top Skills: APIsBig DataCi/CdDockerExperiment TrackingFederated LearningGlmJupyterLlmsMlopsModel ServingNeural NetworksPipeline OrchestrationPythonTime Series ModelingTransformersXgboost
Reposted 6 Days AgoSaved
Easy Apply
Remote
St. Louis, MO
Easy Apply
207K-244K Annually
Senior level
207K-244K Annually
Senior level
Artificial Intelligence • Blockchain • Fintech • Financial Services • Cryptocurrency • NFT • Web3
Lead end-to-end pricing experimentation and strategy for consumer and business products. Design and analyze A/B tests, build pricing models and production-grade data pipelines, partner cross-functionally, and present actionable recommendations to senior leadership.
Top Skills: Generative AiPythonRSQL
7 Days AgoSaved
Remote
St. Louis, MO
166K-193K Annually
Senior level
166K-193K Annually
Senior level
Healthtech • Social Impact • Software • Telehealth
Analyze billing patterns, healthcare claims, and complex datasets to identify anomalies, audit data integrity, and support Trust and Safety initiatives. Build risk-monitoring pipelines and compliance dashboards using SQL, Python/R, and visualization tools. Translate technical findings into risk assessments for legal, compliance, and executive partners while developing safeguards to protect patients, regulatory standing, and platform operations.
Top Skills: HexLookerModePythonRSQLTableau
11 Days AgoSaved
Remote or Hybrid
St. Louis, MO
120K-180K Annually
Senior level
120K-180K Annually
Senior level
Cloud • Computer Vision • Information Technology • Sales • Security • Cybersecurity
Lead research and engineering of production-grade LLM/GenAI systems for cybersecurity: design models and architectures, drive data labeling and evaluation, collaborate with product and engineering to deploy scalable solutions, mentor data scientists, set technical strategy, and advance AI safety, red-teaming, and applied ML innovations for detection and operational use.
Top Skills: Cloud TechnologiesDeep Learning FrameworksGenaiGpu TechnologiesLlmsPython
Reposted 12 Days AgoSaved
Remote
St. Louis, MO
200K-240K Annually
Senior level
200K-240K Annually
Senior level
Fintech • Information Technology • Software
As a Staff Data Scientist at SentiLink, you will develop fraud detection models, conduct analyses, collaborate across teams, and drive the development of financial risk products.
Top Skills: AWSPostgresPython 3
14 Days AgoSaved
Easy Apply
Remote
St. Louis, MO
Easy Apply
153K-180K Annually
Senior level
153K-180K Annually
Senior level
Artificial Intelligence • Fintech • Healthtech • Software
Lead product analytics efforts by designing and evaluating experiments, building dashboards, and producing statistical insights. Partner with product, design, and engineering to measure product success, identify optimization opportunities, and embed ML-driven personalization into the product.
Top Skills: DbtHexLookerPythonSQL
Reposted 20 Days AgoSaved
Easy Apply
Remote
St. Louis, MO
Easy Apply
236K-295K Annually
Senior level
236K-295K Annually
Senior level
Artificial Intelligence • Enterprise Web • Information Technology • Productivity • Sales • Software • Database
Lead product analytics to inform strategy and optimize user experience: translate business questions into analysis, build reliable analytics infrastructure, run A/B tests and ML/statistical analyses, track funnels and cohorts, support 0-to-1 product launches, and communicate actionable insights to cross-functional teams.
Top Skills: A/B TestingAmplitudeHeapLookerMachine LearningMixpanelPythonRSASSQLStatistical Analysis
Reposted 5 Days AgoSaved
In-Office
St. Louis, MO
112K-131K Annually
Senior level
112K-131K Annually
Senior level
Fintech
Design and maintain data models and pipelines for mortgage and lending platforms. Develop ML/AI, predictive and prescriptive analytics, and LLM/Generative AI solutions. Collaborate with engineering and business stakeholders to build scalable cloud and data warehouse solutions, ensure data quality and governance, and deliver dashboards and executive reporting.
Top Skills: AIAws Ai ServicesAzure AiAzure OpenaiCloudData WarehouseETLGenerative AiLlm OptimizationLlmsMachine LearningMlopsPrompt EngineeringRetrieval-Augmented Generation (Rag)
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Reposted 2 Days AgoSaved
Easy Apply
Remote
St. Louis, MO
Easy Apply
160K-200K Annually
Senior level
160K-200K Annually
Senior level
Artificial Intelligence • Enterprise Web • Information Technology • Productivity • Sales • Software • Database
The Senior Data Scientist will analyze data to drive product strategy, optimize performance, and support product launches, collaborating with cross-functional teams.
Top Skills: A/B TestingAmplitudeHeapLookerMachine LearningMixpanelPythonRSASSQL
Reposted 2 Days AgoSaved
Remote
St. Louis, MO
180K-230K Annually
Senior level
180K-230K Annually
Senior level
Fintech • Information Technology • Software
As a Senior Data Scientist, you'll develop fraud detection models, perform detailed analyses, and work closely with teams to drive product innovation and business outcomes.
Top Skills: Aws Ec2Aws RdsAws RedshiftAws S3PostgresPython 3
Reposted 12 Days AgoSaved
In-Office
St. Louis, MO
162K-220K Annually
Senior level
162K-220K Annually
Senior level
Aerospace • Information Technology • Software • Cybersecurity • Design • Defense • Manufacturing
Lead data science efforts for a defense program onsite in Hazelwood, MO. Define data requirements, build analysis systems, design/deploy ML models, collaborate with engineers and SMEs, mentor junior scientists, ensure security/compliance, and communicate results to stakeholders while improving models and establishing best practices.
Top Skills: AWSAzureCC#C++ClearmlJavaJuliaLlmsMlflowNoSQLPythonPyTorchRSQLTensorFlow
Reposted 5 Days AgoSaved
Remote
St. Louis, MO
160K-220K Annually
Senior level
160K-220K Annually
Senior level
Fintech • Financial Services
Lead and deliver end-to-end data science projects: design, build, deploy, and monitor ML/statistical models for credit risk, pricing, collections, and fraud. Partner with cross-functional teams to integrate models into production, set model development standards, mentor engineers, and maintain reliable ML pipelines and monitoring systems.
Top Skills: AWSGitPythonSagemakerSQL
Reposted 9 Days AgoSaved
In-Office
St. Louis, MO
Senior level
Senior level
Information Technology • Software • Cybersecurity • Defense
Support GEOINT dissemination systems by developing automation, data management, API integrations, and AI/ML methods for geospatial analysis. Maintain Python codebases, integrate security requirements, perform database and cloud administration, and collaborate with content teams to ensure data integrity and efficient distribution.
Top Skills: Ai/MlApi IntegrationCloud ServicesCustom Media ServicesEnterprise File Delivery (Efd)GatewayGeopandasNsg Consolidated LibraryPandasPythonRedhat LinuxRelational DatabasesWeb Development Tools
6 Days AgoSaved
Remote
St. Louis, MO
165K-220K Annually
Senior level
165K-220K Annually
Senior level
Artificial Intelligence • Machine Learning • Natural Language Processing • Software • Conversational AI
Analyze and characterize conversational audio data, identify underrepresented areas, and build active-learning and human-in-the-loop workflows. Develop representative benchmarks, automate model adaptation, and create reusable data analysis and scoring systems. Partner with research, engineering, and data teams to run experiments, improve models, organize data, and translate complex findings into measurable product improvements.
Top Skills: Active LearningAsrData PipelinesEnsemble LabelingGdprLlmsMachine LearningNlpPseudo-LabelingPythonTts
YesterdaySaved
Remote
St. Louis, MO
Senior level
Senior level
Information Technology
Leads complex machine learning and advanced analytics initiatives for customer intelligence, segmentation, propensity scoring, behavioral prediction, and personalized engagement. Owns models through the full lifecycle, from problem framing and feature engineering to deployment, monitoring, retraining, and interpretation. Partners with product, engineering, MLOps, and data teams; defines evaluation metrics; mentors technical contributors; promotes responsible AI practices; and communicates results to technical leaders, clients, and business stakeholders.
Top Skills: AWSLightgbmMlopsPandasPythonScikit-LearnSnowflakeSQLXgboost
Reposted 6 Days AgoSaved
Easy Apply
Remote or Hybrid
St. Louis, MO
Easy Apply
190K-235K Annually
Senior level
190K-235K Annually
Senior level
Artificial Intelligence • Insurance • Machine Learning • Software • Analytics
Lead high-impact modeling initiatives using deep learning, LLMs, and traditional methods. Prototype, deploy, and monitor hybrid models on large insurance datasets, drive MLOps standards, and communicate results to nontechnical stakeholders to realize business impact.
Top Skills: Deep LearningFederated LearningGlmJupyterLarge Language ModelsMlopsPythonSequence ModelingTime Series ModelingTransformersXgboost
Reposted 6 Days AgoSaved
Easy Apply
Remote or Hybrid
St. Louis, MO
Easy Apply
135K-165K Annually
Senior level
135K-165K Annually
Senior level
Artificial Intelligence • Insurance • Machine Learning • Software • Analytics
Lead end-to-end development and deployment of predictive and hybrid deep learning/LLM models for insurance use cases. Prototype, validate, and productionize models using modern ML frameworks and MLOps, collaborate with product and engineering, and communicate technical results to stakeholders to drive measurable business impact.
Top Skills: APIsAWSAzureCi/CdDatabricksDockerExperiment TrackingFederated LearningGCPJupyterLightgbmLlmsModel ServingNeural NetworksNumpyPandasPipeline OrchestrationPythonPyTorchRelational DatabasesScikit-LearnSQLTensorFlowTime Series ModelingTransformersXgboost
Reposted 6 Days AgoSaved
Remote or Hybrid
St. Louis, MO
151K-323K Annually
Senior level
151K-323K Annually
Senior level
Consumer Web • Coupons • Healthtech • Social Impact • Pharmaceutical
Lead and deliver productionized ML solutions across audience, marketing, pharma direct, and employer analytics. Design segmentation, propensity, attribution, and identity models; apply causal inference and experimentation; operationalize models with MLOps; evaluate generative AI/LLM use cases; set technical roadmap and mentor data scientists to drive measurable business impact.
Top Skills: AWSAzureDatabricksEmrExperimentation PlatformsFeature StoreGCPGenerative AiLlmsMlopsModel MonitoringNumpyPandasPostgresPysparkPythonPyTorchRedshiftScikit-LearnSparkTensorFlow
Reposted 10 Days AgoSaved
In-Office
St. Louis, MO
Senior level
Senior level
Hardware
Design, refine, and operationalize geospatial analytic models to bring structure and defensibility to GEOINT. Extract, transform, and structure complex datasets using Python and SQL, integrate models with ArcGIS, automate workflows, build dashboards, and ensure GEOINT tradecraft integrity and transparency in scoring frameworks.
Top Skills: ArcgisPythonSQL
YesterdaySaved
Remote
St. Louis, MO
120K-155K Annually
Senior level
120K-155K Annually
Senior level
AdTech • Big Data • Analytics
Leads graph analytics, identity resolution, forecasting, and predictive modeling initiatives for operational, commercial, and product decisions. Designs scalable graph data models, production-ready machine learning solutions, and time-series forecasts. Establishes validation, monitoring, governance, and experimentation practices while partnering with product, engineering, and platform teams. Translates complex analytical findings into business recommendations and provides technical leadership across graph science, forecasting, optimization, and decision-support capabilities.
Top Skills: AWSNeo4JNeptunePythonTigergraph
Reposted 11 Days AgoSaved
In-Office
St. Louis, MO
Senior level
Senior level
Hardware • Security • Manufacturing
Design, refine, and operationalize geospatial analytic models to bring consistency and transparency to GEOINT analysis. Extract, transform, and structure complex datasets, automate workflows, build dashboards, integrate models with analytic platforms, and ensure tradecraft integrity and defensible scoring frameworks that withstand scrutiny.
Top Skills: ArcgisPythonSQL
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