Top Senior Python Jobs in St. Louis, MO

The Senior Full Stack Developer will design, develop, test, and debug software solutions, collaborating with teams and optimizing applications. Responsibilities include user interaction design, back-end functionality, and ensuring software scalability and security.

The Principal Python Engineer will design, build, and maintain backend services and APIs, focusing on system reliability and engineering quality. The role involves working with databases, applying DevOps practices, and leveraging AI for development efficiency.

The Python Engineer will write maintainable Python software, lead technical initiatives, collaborate globally, and contribute to community engagement at Canonical.

Lead a team to integrate data engineering practices within actuarial processes, developing scalable solutions for insurance pricing and analytics.

The role involves software development lifecycle participation, application development in Java and Python, and production support, with a focus on large-scale distributed systems.

The Senior Python Engineer will develop and support MongoDB Python drivers, enhance library quality, and collaborate on product features.

Design and implement durable, fault-tolerant AI orchestration and backend systems using Temporal and agentic ReAct patterns. Deliver features end-to-end with testing, CI/CD, monitoring, and observability; mentor engineers and collaborate with cross-functional teams to translate legal workflows into reliable AI-powered features.

Design, implement, and maintain SaaS features using Python and React on AWS. Lead system design, code reviews, CI/CD pipelines, AI-integrated development (LLMs and AI coding agents), prompt engineering, testing (Cypress), and on-call production support. Mentor teammates and ensure secure, scalable, well-documented software.

Design and build end-to-end AI-driven automation to replace manual operational workflows. Partner with ops, sales, and support to discover problems, architect agentic orchestration, deploy production systems, measure impact, and iterate with robust guardrails and error handling.

The Backend Software Engineer will develop and maintain backend systems for data processing related to coffee farming, utilizing Python and PostgreSQL. Responsibilities include feature development, problem-solving, and adapting systems to regulatory changes while ensuring system resilience.

Lead backend development on the scheduling platform modernization. Contribute across Python and .NET ecosystems, write APIs, review code, and support AI-accelerated development workflows while collaborating in a remote team environment.

Lead backend development on the scheduling platform modernization, contribute across products, write APIs, and drive AI-accelerated software development workflows.

Lead development of Python-based web applications using Django and FastAPI, architect scalable solutions, and establish technical standards while mentoring developers and optimizing infrastructure.

The Senior Full Stack Engineer will develop scalable web applications using Python and React.js, mentor team members, and enhance system performance while leveraging AI technologies. The role emphasizes collaboration, end-to-end feature ownership, and architectural improvements in a remote setting.

Lead the development of data science dashboards to mitigate fire hazards, collaborating with various teams to enhance the web application and optimize backend services.

Design and build backend systems and APIs for AI-driven products, ensuring scalability, reliability, and integration of ML models while collaborating with engineering and product teams.

Develop and enhance features for EnrollWise, contribute to a scalable software architecture, review code, collaborate on design and technical feasibility, and maintain software quality.

The Senior Python Developer will enhance commerce and communication infrastructure by developing features, collaborating with stakeholders, ensuring system reliability, and integrating with third-party tools, while maintaining high-performance standards.

As a Senior Software Engineer, you'll enhance ClickHouse's Python integrations, drive AI integration strategies, and collaborate with open-source communities, requiring deep expertise in data engineering and AI applications.

As a Founding Staff Software Engineer, you will lead the design and development of robust backend systems and APIs, optimize large-scale data workflows, and mentor a growing engineering team.

The Forward Deployed Engineer will serve as a technical bridge between clients and engineering teams, writing custom code and integrations, while ensuring customer success with Socket's security platform through strong relationships and expert technical guidance.

Design and implement high-performance system software for medical devices, collaborating with hardware engineers and ensuring adherence to clinical standards.

The Senior Software Engineer will build a large-scale data ingestion and classification system using web scraping, data processing, and search technologies, overseeing data extraction from various sources and developing search capabilities.

The Senior Python Developer will design and implement secure backend systems using Python and Pyodide, ensuring compliance with DoD cybersecurity requirements and cloud deployment practices. Responsibilities include leading Python code optimization, supporting CI/CD pipelines, and participating in Agile sprint cycles, all while collaborating with cross-functional teams and ensuring secure coding standards.

As a Staff Software Engineer, you’ll lead the design and reliability of Duetto's data lakehouse, evolving data systems using Python and AWS, ensuring data quality, and implementing AI-driven solutions.