Top Senior Python Jobs in St. Louis, MO

The Principal Python Engineer will design, build, and maintain backend services and APIs, focusing on system reliability and engineering quality. The role involves working with databases, applying DevOps practices, and leveraging AI for development efficiency.

The Python Engineer will write maintainable Python software, lead technical initiatives, collaborate globally, and contribute to community engagement at Canonical.

Lead a team to integrate data engineering practices within actuarial processes, developing scalable solutions for insurance pricing and analytics.

The role involves software development lifecycle participation, application development in Java and Python, and production support, with a focus on large-scale distributed systems.

The Senior Python Engineer will develop and support MongoDB Python drivers, enhance library quality, and collaborate on product features.

Design, develop, and maintain scalable Python applications and cloud-native solutions. Architect microservices, containerized deployments (Docker/Kubernetes), optimize cloud infrastructure, build CI/CD pipelines, integrate messaging systems, ensure security and high code quality, and mentor junior developers. Generative AI/ML experience is a plus.

Develop, test, and maintain a complex distributed processing application using Python and Java. Collaborate with product owners, data coaches, analysts, DBAs, and Agile teams to meet backend/frontend requirements. Work with distributed workloads (Spark/Hadoop), SQL/Snowflake, AWS, shell scripting, and job scheduling/process automation. Support delivery under Agile/SAFe practices and ensure alignment with program standards.

Lead Software Engineer responsible for designing, developing, testing, and maintaining a distributed processing application using Python and Java. Collaborate with product owners, data coaches, analysts, DBAs, and Agile teams to meet backend/frontend requirements, implement cloud and big-data solutions (Spark/Hadoop), and ensure program standards and reliable delivery.

Lead backend development on the scheduling platform modernization, contribute across products, write APIs, and drive AI-accelerated software development workflows.

Lead backend development on the scheduling platform modernization. Contribute across Python and .NET ecosystems, write APIs, review code, and support AI-accelerated development workflows while collaborating in a remote team environment.

The Senior Full Stack Engineer will develop scalable web applications using Python and React.js, mentor team members, and enhance system performance while leveraging AI technologies. The role emphasizes collaboration, end-to-end feature ownership, and architectural improvements in a remote setting.

Lead development of Python-based web applications using Django and FastAPI, architect scalable solutions, and establish technical standards while mentoring developers and optimizing infrastructure.

Develop and enhance features for EnrollWise, contribute to a scalable software architecture, review code, collaborate on design and technical feasibility, and maintain software quality.

The Senior Full Stack Developer will design, develop, test, and debug software solutions, collaborating with teams and optimizing applications. Responsibilities include user interaction design, back-end functionality, and ensuring software scalability and security.

Support the cloud engineering team with hands-on AWS work, develop and maintain Python/Django applications on Linux, provide development and support tasks, work onsite with the customer, and apply sysadmin and security framework knowledge as needed. Strong communication required.

Design, develop, and maintain scalable Python applications; collaborate with cross-functional teams to deliver features; ensure performance and quality; identify and fix bugs; maintain code quality and automation; lead and mentor team members using agile practices.

Design, build, test, and maintain backend applications using FastAPI and SQLAlchemy. Implement database schemas, integrate front-end components, optimize for performance and scalability, debug issues, participate in code reviews, and collaborate on feature design. Maintain clean, testable code and stay current with best practices.

Design and implement durable, fault-tolerant AI orchestration and backend systems using Temporal and agentic ReAct patterns. Deliver features end-to-end with testing, CI/CD, monitoring, and observability; mentor engineers and collaborate with cross-functional teams to translate legal workflows into reliable AI-powered features.

Design and build backend systems and APIs for AI-driven products, ensuring scalability, reliability, and integration of ML models while collaborating with engineering and product teams.

As a Senior Software Engineer, you'll enhance ClickHouse's Python integrations, drive AI integration strategies, and collaborate with open-source communities, requiring deep expertise in data engineering and AI applications.

The Senior Python Developer will enhance commerce and communication infrastructure by developing features, collaborating with stakeholders, ensuring system reliability, and integrating with third-party tools, while maintaining high-performance standards.

As a Founding Staff Software Engineer, you will lead the design and development of robust backend systems and APIs, optimize large-scale data workflows, and mentor a growing engineering team.

The Forward Deployed Engineer will serve as a technical bridge between clients and engineering teams, writing custom code and integrations, while ensuring customer success with Socket's security platform through strong relationships and expert technical guidance.

Design, develop, deploy, monitor, and support APIs and system integrations (Salesforce, REST, third-party). Work directly with clients to gather requirements, troubleshoot and optimize integrations, operate solutions in AWS, collaborate with teams, and mentor junior developers.

Build and ship full‑stack features for transportation management and other client products. Design and implement APIs and UIs, collaborate with product and design, own delivery, write modular testable code, troubleshoot and iterate quickly, and mentor peers.