Top Senior IT Jobs in St. Louis, MO

Conduct IT audits of digital environments, internal controls, cybersecurity measures, data and AI systems, governance, and regulatory compliance. Analyze risks, assess data quality, collaborate with clients, develop recommendations, and apply IT governance and auditing methodologies. The role also requires client relationship management, mentoring junior staff, and maintaining professional and technical standards.

Lead end-to-end delivery of critical IT systems initiatives and integrations across identity, service management, infrastructure, collaboration, and compliance domains. Manage a project manager, coordinate cross-functional technical teams, unblock dependencies, define program metrics, build executive dashboards, drive user adoption, and communicate technical outcomes to business stakeholders. The role also oversees tooling consolidation, documentation, training, release communications, post-mortems, and enterprise IT roadmap execution.

Lead development and implementation of consultative and technical IT solutions for clients. Communicate deliverables, assess risks, collect and analyze data, document findings, and serve as subject-matter expert. Mentor junior consultants, train clients, and contribute to R&D to deliver innovative solutions. Requires client-facing delivery and occasional travel.

Leads enterprise network security architecture, engineering, and modernization across cloud and on-premises environments. Designs firewalls, WAF, DDoS protection, Azure connectivity, microsegmentation, Zero Trust, SASE, and SD-WAN solutions. Serves as a Level 3 incident escalation point, drives root-cause analysis and resilience improvements, establishes automation and DevSecOps standards, and mentors engineers. Partners with stakeholders and vendors to deliver secure, scalable network security platforms.

Manage full-lifecycle recruiting for technical and IT roles, including sourcing passive candidates, building talent pipelines, partnering with hiring managers, screening applicants, conducting initial interviews, and guiding candidates through the hiring process. The role also provides market intelligence on IT talent and compensation while recruiting for positions such as program managers, AI architects, AI engineers, technical product managers, and product owners.

Lead enterprise automation and agentic AI initiatives, owning the automation and integration stack and Center of Excellence. Build secure, reusable workflows and integration frameworks using platforms such as Zapier, Claude, and Glean. Establish governance, standards, documentation, and prioritization practices while partnering with IT, innovation teams, engineers, business stakeholders, and executives. Identify operational inefficiencies, develop automation roadmaps, and deliver scalable systems with secure data handling, access controls, human oversight, and measurable business impact.

Designs, configures, maintains, and troubleshoots large enterprise virtual desktop environments. Provides Tier 3/4 support, optimizes desktop interoperability, manages identity lifecycles, automates processes, evaluates solutions, and serves as a subject matter expert across complex production environments. Requires extensive Citrix VDI expertise, systems integration experience, and an active TS/SCI clearance with polygraph eligibility.

Serves as the primary liaison between business customers and IT, translating business objectives and processes into technology requirements. Facilitates requirements gathering, prioritization, vendor and solution selection, project initiation, business case development, ROI analysis, project portfolio management, and capital budgeting. Coordinates with functional managers on technology design, equipment procurement, logistics, and installation for organizational moves, construction, and acquisitions.

Supports strategic procurement and category management by analyzing spend, markets, suppliers, and demand; executing sourcing activities; preparing solicitations and contract materials; supporting negotiations; managing supplier and business relationships; developing supply chain strategies; and implementing continuous improvements. The role requires cross-functional collaboration, strong analytical and communication skills, and experience in sourcing or procurement.

Leads advanced IT service management analysis, process improvement, request fulfillment, reporting, and automation initiatives using ServiceNow and AI technologies. Translates customer feedback into requirements, identifies process gaps and automation opportunities, designs business processes, evaluates solutions, documents best practices, and collaborates with cross-functional IT teams and senior management. The role requires strong ITSM, analytical, communication, risk management, and stakeholder collaboration skills, with expertise ranging from experienced to advanced analyst levels.

Designs and operates CI/CD pipelines, infrastructure as code, and secure application deployments across Kubernetes and OpenShift environments. Builds and tests software, authors Helm charts, manages configuration, monitoring, networking, databases, and system security, and supports cloud solutions. The role also develops automation with Python and Bash, contributes to architecture and documentation, and improves observability, incident response, scalability, and operational resilience for classified intelligence systems.

Manages security and access control installation and maintenance projects from concept through completion. Leads technicians, project engineers, contractors, and customer relationships while overseeing scheduling, job coordination, inventory, labor efficiency, financial performance, safety, compliance, and customer satisfaction. Provides technical guidance, supports operational excellence, and collaborates with sales, marketing, and accounting. The role requires local and occasional overnight travel, blueprint interpretation, job estimating, and project cost management.

Leads corporate and commercial IT business systems for a biopharmaceutical company, including ERP, P2P, HCM, CRM, data, BI, and AI capabilities. Owns technology roadmaps, implementations, budgets, vendor partnerships, and stakeholder relationships across Finance, HR, Legal, Compliance, and Commercial. Partners with the IT PMO to establish portfolio governance and reporting, supports R&D and GxP systems, and ensures CSV/CSA, security, privacy, and audit readiness.

Designs, implements, and maintains automated security detection, orchestration, and integration capabilities for USPS. Analyzes security telemetry, identifies anomalies and detection gaps, enhances detection content, validates workflows, and supports SOC, threat intelligence, and incident response teams. The role also translates operational needs into technical solutions, researches emerging security and machine-learning capabilities, and maintains documentation, runbooks, and procedures.

Manages Safety and Compliance Committee operations, including member rosters, appointments, onboarding, training records, conflict-of-interest logs, SME coordination, SOP implementation, reporting, and meeting support. The role maintains accurate governance documentation, coordinates with HRSA, OPTN contractors, internal teams, and committee members, and ensures compliance with oversight requirements and established operational plans.

The Senior IT QA Engineer owns quality strategy and outcomes across complex technology initiatives. Responsibilities include designing automated testing solutions, integrating quality verification into CI/CD pipelines, analyzing quality and production data, developing dashboards, managing risk, leading root-cause analysis, and influencing product, engineering, architecture, security, operations, and business stakeholders. The role requires technical contributions across web, mobile, API, data, cloud, and distributed systems, plus mentoring engineers and advancing quality engineering practices.

Administer enterprise SharePoint Server and SharePoint Online environments, including configuration, permissions, governance, monitoring, migrations, backup and recovery, security, compliance, and troubleshooting. Automate administrative tasks with PowerShell and support integrations with Microsoft 365, Power Apps, and Power Automate. Maintain infrastructure involving Active Directory, IIS, SQL Server, and network load balancing. Document procedures, enforce change management, communicate technical concepts, and mentor junior staff.

Develop and maintain secure, scalable SharePoint Online solutions using SPFx, TypeScript, React, JavaScript, and Microsoft 365 integrations. Build reusable web parts and extensions, modernize legacy solutions, support migrations, troubleshoot performance and integration issues, manage testing and deployments, and document technical solutions. Collaborate with architects, administrators, developers, security teams, analysts, and stakeholders to translate business requirements into maintainable applications. Provide technical support and knowledge transfer while following accessibility, security, ALM, and development best practices.

Administers and governs enterprise Microsoft Power Platform environments across development, test, and production. Manages security, DLP policies, Dataverse, capacity, licensing, connectors, gateways, ALM, deployment pipelines, monitoring, and CoE operations. Develops governance standards, documentation, and reporting while troubleshooting platform issues and supporting compliance and change management. Collaborates with developers, architects, security teams, and business stakeholders, communicates technical concepts, and mentors junior staff.

Leads a Unix and Linux infrastructure team responsible for service delivery, operations, maintenance, incident resolution, and strategic project execution. Oversees technical strategy, modernization, automation, Agile delivery, ITIL practices, stakeholder communications, and continuous improvement. Manages recruitment, performance, training, mentoring, and professional development while guiding teams through complex technical and operational challenges. The role requires obtaining and maintaining a Public Trust and completing onsite fingerprinting.

Leads IT GxP and SOX compliance, FDA inspection readiness, audit response, remediation, and evidence management. Owns the IT technology portfolio, including prioritization, roadmap governance, dependencies, reporting, and launch-readiness programs. Coordinates IT governance, procurement, budgeting, policies, SOPs, steering cadences, and cross-functional delivery. Partners with quality, finance, legal, vendors, and managed-service teams to maintain compliant, inspection-ready IT operations across biotech systems.

Drive business growth across North American IT and SAP accounts. Manage client relationships, identify new and expansion opportunities, lead sales pitches, proposals, contract negotiations, and SOW execution. Coordinate offshore delivery alignment, engage executive stakeholders, and manage sales pipelines, account roadmaps, and revenue metrics. The role operates remotely from India during North American night-shift hours and requires strong IT services, SAP, and enterprise client experience.

Manage the company’s IT department and ensure reliable operation of networks, servers, systems, security, and end-user technology. Responsibilities include AWS and Oracle administration, Microsoft 365 access management, technical support, cybersecurity monitoring, compliance, vendor coordination, budgeting, and leading IT infrastructure projects. The role also supports Windows and Apple devices, manages IT tickets, and coordinates cross-functional technology initiatives.

Lead cybersecurity consulting and engineering engagements securing OT and IT environments for water, wastewater, and environmental infrastructure clients. Conduct ICS, SCADA, network, architecture, risk, and compliance assessments; design secure IT/OT architectures; develop governance, incident response, security plans, and improvement roadmaps; evaluate security technologies; and support proposals and client presentations. Mentor junior staff and advise on cloud, IoT, AI, and critical infrastructure security.

Develop and improve core software services supporting customer intake, application screening, and information dissemination. Design distributed, cloud-based, microservice architectures; identify bottlenecks; improve reliability and scalability; and deliver production-ready features. Work across the technology stack, contribute to system design and modernization, mentor junior developers, communicate technical decisions, and use data, AI, and automation to improve engineering outcomes.