Top Portland, ME Startups (10,000+)

A tapestry is made of many threads woven into one story. So are we. Our global house of brands unites the magic of Coach and Kate Spade New York. By intertwining different people and ideas, we push ourselves in our work, pull out the unexpected in what we create, and expand the bounds of possibility. Our brands were created by...

Sysco LABS is a technology-focused division within Sysco, dedicated to reimagining foodservice through innovation. Sysco LABS uses customer and market intelligence, data-driven insights and agile technology development to rethink the entire foodservice ecosystem.

ClickMint pairs proprietary generative-AI diagnostics with senior CRO operators to uncover friction, launch precision tests, and unlock compounding gains—helping high-growth e-commerce brands scale faster without buying more traffic. Founded by the creator of one of the nation’s top-performing digital marketing firms—honored by Inc. as a Fastest-Growing Company for seven consecutive years and ranked among the Top 50 U.S. marketing agencies...

Initially built to take the pain out of peer-to-peer payments, Cash App has gone from a simple product with a single purpose to a dynamic app, bringing a better way to send, spend, invest, borrow and save to our millions of monthly active users. With a mission to redefine the world's relationship with money by making it more relatable, instantly...

Improving the future and protecting lives is an ambitious mission, but it’s what we do. As a leading aerospace, defense, and security company, we work together to deliver a full range of products and services for air, land, space, and naval forces, as well as advanced electronics, security, information technology solutions and customer support services. How we work is rooted...

The Wolverine companies comprise a number of diversified financial institutions specializing in proprietary trading, asset management, order execution services, and technology solutions. We are recognized as a market leader in derivatives valuation, trading, and value-added order execution across global equity, options, and futures markets.

Our purpose ensures that patients remain at the center of all we do. We live our purpose by sourcing the best science in the world; partnering with others in the healthcare system to improve access to our medicines; using digital technologies to enhance our drug discovery and development, as well as patient outcomes; and leading the conversation to advocate for...

Scrunch AI is the leading platform for helping brands gain visibility in AI search results. As discovery shifts from traditional SEO to large language models and AI agents, Scrunch provides marketers with the platform to understand how their brand is being interpreted — and the necessary technology infrastructure to shape it.

Leading a successful professional service firm is an art. Running a profitable firm is a business. We understand this because our founder ran an IT Consulting firm for over 15 years. He grappled with the same challenges that professional service firm owners face today. How do I know what my employees are working on? How can I connect time and...

MoneyLion is a leader in financial technology powering the next generation of personalized products and content, with a top consumer finance super app, a premier embedded finance platform for enterprise businesses and a world-class media arm. MoneyLion’s mission is to give everyone the power to make their best financial decisions. We pride ourselves on serving the many, not the few;...

Performance-driven learning & development teams achieve business impact with 360Learning. L&D teams leverage AI and collaborative learning to pinpoint skills gaps, capture knowledge from experts, and deliver it to learners when needed most. 360Learning’s learning platform is equipped with powerful LMS automation, collaborative learning Academies, tools to create a top-notch learner experience, and an AI-powered Skills ontology to activate skills-based...

Headway’s mission is a big one – to build a new mental health care system everyone can access. We’ve built technology that helps people find great therapists with the first software-enabled national network of providers accepting insurance. 1 in 4 people in the US have a treatable mental health condition, but the majority of providers don’t accept insurance, making therapy...

Named among the World’s Most Admired Companies™ by Fortune and recognized in the Fortune 100 Best Companies to Work For® list in 2025, MetLife is leading the global transformation of an industry we’ve defined for more than 155 years. At MetLife, every innovation and line of code is a lifeline for our customers and their families—from victims of natural disasters...

Hudson River Trading brings a scientific approach to trading financial products. We have built one of the world's most sophisticated computing environments for research and development. Our researchers are at the forefront of innovation in the world of algorithmic trading.

Rundoo gives independent paint and hardware stores the best technology to rise above the competition, so you can win customers, streamline operations, and grow your business.

With over 1,400 team members across multiple companies, dedicated to improving the lives of people and their pets, we create best-in-class products that bring health and happiness. Our creative content educates the world on making smarter health choices, while the brands we own generate over $1 billion of revenue annually. From brand ideation to ad creation to product fulfillment, the...

CAIS is the leading alternative investment platform for independent financial advisors. The CAIS platform powers the pre-trade, trade, and post-trade lifecycle of alternative investments providing financial advisors and alternative asset managers a single operating system for scale and efficiency. CAIS serves over 2,000 wealth management firms that support more than 50,000 financial advisors who oversee approximately $6 trillion in end-client assets....

We’re powering a better social safety net. Building healthier and happier communities starts with supporting the whole person. That’s why Findhelp was founded in 2010: to connect all people in need to the programs that serve them with dignity and ease. Our software platform enables community organizations, governments, and businesses across industries to easily manage and coordinate care. From screening and...

Founded in 2002, Leader Bank is a Massachusetts-based entrepreneurial financial institution that approaches banking differently. The core tenets of Leader Bank include client services, exemplary products, and innovation to meet the needs of its clients. Leader Bank’s best-in-class staff has been at the forefront of supporting the bank’s rapid growth and client-oriented solutions, as the bank has continued to expand...

Introducing FRONTSTEPS — We are a resident engagement platform powering communities to be safe, informed, and efficient. Anyone can offer HOAs a website and document storage, FRONTSTEPS provides the opportunity to make a difference in a community. We are building the #1 software platform for HOAs, PMCs, builders, and security companies.