Top California Biotech Startups (603)
Character Biosciences is a precision medicine company transforming drug development for progressive, polygenic diseases, beginning with ophthalmology. Our mission is to identify the genetic and molecular drivers of disease progression so we can develop targeted therapies for patients who urgently need them. We've built one of the most comprehensive resources in age-related eye diseases by partnering with over 150 ophthalmology...
Vividion Therapeutics, Inc. is a biotechnology company focused on transforming the future of human health through the creation of highly selective small molecule medicines that drug traditionally inaccessible targets. The company is advancing a broad, diversified pipeline of multiple, selective small molecule therapeutics for highly sought-after disease-causing target proteins in oncology and immunology. The company’s cutting-edge platform was spun out...
Tr1X Inc. (pr. "Trix") is a biotechnology company dedicated to the development of novel cellular immunotherapies for patients with autoimmune and inflammatory diseases. The Company uses its proprietary platform for the generation of first-in-class cell therapy products aimed at rebalancing the immune system and restoring homeostasis, leading to long term tolerance. Tr1X is headquartered in La Jolla, CA.
The Cancer Research Institute (CRI) is a New York City–based nonprofit organization dedicated to advancing cancer immunotherapy. Founded in 1953, it funds scientists and researchers, supports clinical-trial networks, and promotes global collaboration and shared data to accelerate discoveries from fundamental immunology through clinical translation. Its mission is to help turn breakthrough science into life-saving treatments and create a world immune...
ClearNote Health – Cancer detection company enabling people at risk for high-mortality cancers to live longer, healthier lives. We focus on developing non-invasive tests to detect cancer through a standard blood draw earlier than existing methods by harnessing the power of epigenomics. We apply our proprietary epigenomic platform, combining biology and artificial intelligence, to identify DNA-based changes in biology as cancer...
We are a biopharmaceutical company focused on the discovery and development of oral covalent small molecules to treat patients with metabolic diseases and genetically defined cancers. A covalent small molecule is a synthetic compound that forms a permanent bond to its target protein and offers a number of potential advantages over conventional non-covalent drugs, including greater target selectivity, lower drug...
Fluxergy was founded 10 years ago with a vision to democratize the world of laboratory testing, by making testing more accessible and affordable. Fluxergy’s platform technology enables us to understand our world and our health in ways that were never possible before. Fluxergy is developing a platform with multi-modal detection technologies which bring the variety of tests found in the central...
Atomic AI is a well-funded, early-stage biotech company transforming the rational design of molecules and medicines through the cutting-edge fusion of artificial intelligence and structural biology. Atomic’s unique R&D platform, based on research featured on the cover of Science (doi.org/10.1126/science.abe5650), provides new strategies to treat or cure previously-undruggable diseases by targeting RNA structure. We are an interdisciplinary team working across...
ArsenalBio is a privately held, programmable cell therapy company focused on the realization of solid tumor cell therapy to defeat cancer. Our discovery engine comprises precise CRISPR-enabled genome editing, integrated circuits incorporating logic gates for improved tumor targeting, and therapeutic enhancements enabling multiple pharmaceutical functions. With our programmable and computationally driven approach, we aim for enhanced and broader efficacy, increased...
Pliant Therapeutics is a late-stage biopharmaceutical company and leader in the discovery and development of novel therapeutics for the treatment of fibrotic diseases. At Pliant, we share a commitment and a clear passion to drive innovative science towards addressing areas of unmet medical need. Together we believe we have the power to make a difference in the lives of patients...
Building frontier artificial intelligence to predict and reprogram the interactions between biochemical molecules.
Excel Scientific Inc. designs and manufactures microplate sealing films, foils, and custom laminate constructions for life-science and diagnostic applications. Its medical-grade products support PCR, qPCR, ELISA, cell culture, sample storage, point-of-care disposables, and microfluidic components. The company serves pharmaceutical and biotechnology firms, diagnostic OEMs, clinical laboratories, research organizations, and academic institutions, producing its solutions in the United States under an...
This page is intended for US audiences only. Tenpoint Therapeutics Limited is a commercial-ready biotech company developing groundbreaking treatments to rejuvenate vision in the aging eye. Its pipeline includes paradigm-shifting treatments for ophthalmic indications with the greatest need and global market potential, including presbyopia, cataracts, and geographic atrophy. Its lead asset, BRIMOCHOL PF, is a novel, pupil-modulating investigational therapeutic designed to correct...
BillionToOne is a precision diagnostics company with the mission to make molecular diagnostics more accurate, efficient, and accessible for all. Our patent-pending molecular counter platform is the only technology platform that can accurately count the DNA molecules at the single-count level.
At Seer, we develop innovative solutions that act as a gateway to the proteome. Our goal is to empower the scientific community with tools to achieve exceptional scientific outcomes. We do this by removing the technological barriers that stand between breakthrough ideas and the information that can make them a reality. Over the last 15 years, the fields of genomics and...
Tamarind Bio provides an AI-powered computational biology platform and API that gives scientists a simple, scalable interface to drug-discovery tools. Its no-code web platform and API support protein structure prediction, protein and enzyme design, molecular docking, and molecule optimization using models such as AlphaFold. The company serves researchers at pharmaceutical companies, biotech firms, and academic institutions without requiring specialized computing...
Septerna is on a mission to make the promise of future GPCR medicines a reality for patients. Combining the latest advances in biochemical, structural and computational drug discovery approaches, we have built an industrialized platform to precisely control and modulate GPCR biology and pharmacology to discover and develop new high-impact medicines. With our Native Complex™ platform, we are opening a...
NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.
Biocytogen provides integrated solutions for next-generation antibody drug development to the global biomedical communities. Powered by cutting-edge gene editing technologies and a state-of-the-art animal facility, Biocytogen developed a seamlessly integrated platform for efficient antibody drug discovery and validation, including animal model generation, therapeutic antibody discovery (via RenMab™ mice), and in vivo/in vitro preclinical validation studies. Biocytogen collaborates with more than...
