Top IT Jobs in St. Louis, MO

Lead strategy and operations for high-availability enterprise platforms (HP NonStop, Stratus, mainframe, Linux/x86). Drive modernization, resiliency, capacity planning, incident/problem management, security and compliance, vendor and budget management, and engineering leadership for 24x7 mission-critical infrastructure. Present metrics to executives and coordinate cross-functional initiatives.

Provides technical support to local and remote users by troubleshooting hardware, software, operating systems, peripherals, and computer systems. Installs and configures equipment, resolves help desk tickets, performs diagnostics and minor repairs, trains users, develops support materials, recommends upgrades, and follows IT security policies. Participates in after-hours on-call support and handles complex technical issues under general supervision.

Develop and enhance cross-platform applications using Java, Python, or Node.js; build APIs; work with cloud and container orchestration platforms; query databases; conduct testing and debugging; review code; define technical specifications; support SDLC transitions; evaluate vendor products; and maintain IT controls and audit compliance.

Leads an Operations and DevOps team supporting secure, resilient OpenShift environments for an intelligence customer. Responsibilities include team leadership, system administration, troubleshooting, testing, hardening, configuration, deployment automation, CI/CD support, security operations, PKI management, Helm chart development, Infrastructure as Code, documentation, compliance, and performance monitoring. The role requires collaboration with government customers and users, Agile/SAFe experience, cybersecurity implementation, cloud expertise, Kubernetes/OpenShift skills, and an active TS/SCI clearance with CI polygraph eligibility.

Administer and support the ServiceNow platform and related enterprise systems. Responsibilities include configuration, performance and capacity monitoring, user and access management, patching, troubleshooting, integrations, operational readiness, documentation, incident analysis, and backup and disaster recovery testing. The role provides Tier 2 user support and collaborates with developers, architects, and business analysts in a remote federal environment.

Build and operate AWS infrastructure for Windows and IIS applications using Terraform, CI/CD pipelines, and automation. Migrate on-premises workloads to AWS, troubleshoot application and infrastructure issues, implement monitoring and security hardening, automate patching and credential or certificate rotation, and support ECS containerization. Collaborate with application, development, and security teams while reviewing infrastructure code and maintaining production services. Occasional after-hours maintenance or outage support is required.

Leads teams and strategy for manufacturing processing applications and platforms, including scheduling, inventory, reporting, capacity planning, and operational modeling. Partners with manufacturing and technology stakeholders to deliver reliable, scalable solutions, automation, modernization, and continuous improvement. Oversees application portfolios, production support, incident management, performance metrics, prioritization, and operational planning while developing high-performing teams and improving manufacturing efficiency, throughput, accuracy, and service delivery.

Leads complex enterprise IT projects and software implementations, managing scope, schedules, budgets, resources, vendors, risks, quality, and stakeholder communications. Provides project team leadership, executive reporting, process improvement, and mentorship to junior project managers. Partners across functions to deliver business value and applies Agile, hybrid project management, and AI-enabled practices.

Designs, develops, and maintains instructional curricula for Seabee Steelworkers. Responsibilities include analyzing training and media requirements, creating objectives, tests, storyboards, flow diagrams, lessons, and technology-based learning solutions. The role collaborates with subject matter experts to ensure technical accuracy and maintains the integrity of training materials and evaluation plans. Candidates need extensive Seabee Steelworker and Naval Construction Force experience, strong written communication skills, U.S. citizenship, and eligibility for an IT Level II CAC.

Leads the design, implementation, and optimization of enterprise infrastructure, cloud services, identity, endpoint management, and monitoring systems. Drives automation, security hardening, incident response, root-cause analysis, migrations, disaster recovery, and operational improvements. Mentors junior administrators, maintains technical documentation, manages vendor escalations, and supports cross-functional technology initiatives. Requires strong infrastructure, cloud, security, troubleshooting, scripting, observability, and IT service management expertise.

Provides frontline technical support for MacBooks, PCs, software, networks, Salesforce, and Jira. Troubleshoots hardware, software, connectivity, audio, and application issues; supports remote employees; trains users; documents resolutions; maintains knowledge resources; and escalates complex problems to higher-level IT staff.

Manage smaller IT projects and support larger technology initiatives for pharmaceutical and biotechnology clients. Responsibilities include developing project plans, schedules, budgets, and deliverables; coordinating stakeholders, vendors, offshore teams, and technical resources; leading client meetings; tracking risks, financials, and resources; preparing status reports and dashboards; and supporting projects through requirements, testing, deployment, and completion.

Leads Microsoft 365 strategy, operations, security, governance, and adoption while overseeing Azure, infrastructure, business-critical applications, vendors, and a distributed IT team. Partners with business and technology leaders to deliver cost-effective solutions, improve service consistency, maintain asset and licensing compliance, and manage disaster recovery and business continuity.

Develop and maintain PHP web applications for a federal client, including application migration, requirements analysis, API and database integration, testing, deployment, monitoring, maintenance, outage contingency planning, and performance improvements. The role is client-facing, collaborates with technical and design teams, manages multiple priorities, and provides guidance to junior developers. Remote work is available, with no travel required.

Leads Padagis’s global IT organization, strategy, roadmap, operations, infrastructure, security, applications, and enterprise systems. Oversees budgets, vendors, contracts, compliance, risk management, incident response, SAP implementations, system upgrades, and integrations following acquisitions. Aligns technology initiatives with business objectives and leads IT professionals across a regulated pharmaceutical environment.

Provide hands-on Tier 2/3 IT and OT systems support in a manufacturing environment, troubleshoot production-impacting issues across servers, workstations, networks, applications and industrial systems, support software lifecycle tasks, ensure high availability, follow safety and compliance, and coordinate with operations, engineering, maintenance, cybersecurity and vendors.

Own day-to-day IT operations for a global remote workforce, including end-user support, device and access management, onboarding and offboarding, internal systems administration, security controls, compliance audits, process automation, vendor management, and asset tracking. The role partners with Compliance, Engineering, DevOps, and HR to maintain reliable, secure, and efficient IT infrastructure while supporting growth and regulated-industry requirements.

Leads global strategic sourcing and category management for IT and indirect spend. Develops sourcing strategies, negotiates contracts, manages supplier performance and risk, drives cost savings and procurement transformation, ensures compliance, and leads a global sourcing team. Partners with IT, Finance, Legal, Operations, and business stakeholders across regions while monitoring KPIs and improving sourcing processes.

Leads IT audit engagements assessing digital environments, processes, controls, cybersecurity, data integrity, and AI systems. Manages client relationships, audit teams, project delivery, compliance challenges, data quality validation, governance improvements, and risk management. The role also involves mentoring staff, applying IT governance frameworks, promoting innovative audit technologies, and ensuring assurance standards are met.

Manages the full lifecycle of patient safety and compliance cases for OPTN member organizations. Responsibilities include intake, triage, clinical review, investigations, stakeholder coordination, corrective action tracking, trend analysis, reporting, documentation, and process improvement. The role supports HRSA and OPTN committees, handles sensitive healthcare information, manages multiple concurrent cases, and assesses compliance risks and patient safety concerns.

Supports IT solution design and implementation, analyzes cybersecurity protocols and recommends improvements, and collaborates with data science teams to analyze data and generate actionable insights. The internship provides hands-on experience, mentorship, professional development, and exposure to aerospace technology. Candidates must be enrolled in a relevant bachelor's or higher degree program, maintain a 3.0 GPA, and graduate in December 2027 or later.

Summer intern assisting with IT solution design and implementation, supporting cybersecurity initiatives through security protocol analysis, and collaborating with data science teams to analyze data and generate actionable insights. The role offers hands-on experience, mentorship, and professional development within Honeywell Aerospace. Candidates must remain enrolled in a relevant degree program, maintain at least a 3.0 GPA, and meet U.S. person requirements.

Summer 2027 interns will support IT solution design, cybersecurity initiatives, and data science projects at Honeywell Aerospace. Responsibilities include implementing business-focused IT solutions, analyzing security protocols and recommending improvements, and collaborating with data science teams to generate actionable insights. Interns receive hands-on experience, mentorship, professional development, relocation benefits, and short-term housing when eligible. The role is available at multiple U.S. locations.

Leads provider contracting and network development for the World Trade Center Health Program. Responsibilities include assessing network gaps, recruiting providers, negotiating agreements and reimbursement structures, managing contract lifecycles, overseeing network adequacy and access reporting, improving workflows, mitigating network risks, and coordinating with credentialing, finance, compliance, and provider data teams.

Provide hands-on IT administration for approximately 230 employees across macOS and Windows. Responsibilities include Tier 1 and Tier 2 support, SaaS and identity administration, endpoint management, onboarding and offboarding, asset inventory, compliance reporting, workflow monitoring, scripting, documentation, lab and VDI support, and vendor coordination.