Top Python Jobs in St. Louis, MO

Hands-on engineer responsible for troubleshooting AWS infrastructure and DevOps issues, developing Python automation, improving CI/CD pipelines, and building reusable self-service cloud solutions. The role partners with application, security, and technology teams, performs root-cause analysis, manages source-control and artifact workflows, and applies secure engineering practices across cloud and delivery environments.

Develop and support secure full-stack web applications using Python and JavaScript/TypeScript. Responsibilities include building responsive interfaces, backend services, RESTful APIs, database integrations, automated tests, CI/CD pipelines, and production deployments. The role involves Agile collaboration, code reviews, troubleshooting, monitoring, and secure-development practices. Candidates must hold Top Secret/SCI clearance with CI Poly eligibility, have at least five years of full-stack experience, and be local to Springfield, Virginia or St. Louis, Missouri for periodic onsite access.

Own the technical foundation of a manufacturing software product, including auditing and hardening the existing codebase, designing architecture, shipping full-stack features, integrating ERP systems, evolving data models, building real-time capabilities, and managing infrastructure, deployment, and monitoring. The founding engineer will engage users, guide product decisions, establish engineering standards, help hire future engineers, and contribute to AI-powered features.

Build and evolve low-latency, high-throughput news delivery services using Java and Python. Own architecture, feature delivery, performance, observability, production support, and technical direction. Collaborate within a scrum team, automate deployment and maintenance using DevOps practices, and participate in a sustainable on-call rotation. Apply real-time systems, cloud infrastructure, container orchestration, search technology, testing, and news data standards to deliver reliable services globally.

Build and scale Neuroscale’s backend platform for AI-powered recruiting workflows. Responsibilities include developing Python/FastAPI REST APIs, designing high-throughput systems, managing PostgreSQL, Redis, OpenSearch, Celery, and Temporal infrastructure, deploying services on AWS, maintaining containerized CI/CD pipelines, and supporting integrations, data pipelines, and asynchronous workflows. The role owns architecture and reliability decisions, mentors engineers, and collaborates with AI, product, and frontend teams in a high-ownership startup environment.

Design and build applications using Python, manage component design, optimize performance, and collaborate with clients on innovative products.

Own Telnyx’s global phone-number ordering pipeline, carrier integrations, regulatory automation, AI-powered order review, and Postgres data layer. Build reliable async Python services with retries, rollbacks, queues, SLA monitoring, document verification, auditability, and human escalation. Improve automation across dozens of vendors and 45+ countries while maintaining dashboards, analytics, and operational alerts across a large microservice estate.

Build and maintain AI-assisted full-stack platforms for manufacturing, spanning AWS infrastructure, Python Lambda services, Java microservices, agentic LLM workflows, and Angular interfaces. Develop event-driven architectures, APIs, retrieval and scoring systems, infrastructure as code, observability, CI/CD, and secure deployment strategies. Apply rigorous testing, specification-driven development, concurrency practices, and production reliability techniques across multi-repository systems. The role requires hands-on software development experience with enterprise server, storage, or networking products.

Design, develop, and maintain scalable Python applications; collaborate with cross-functional teams to deliver features; ensure performance and quality; identify and fix bugs; maintain code quality and automation; lead and mentor team members using agile practices.

Work as a Python development intern building applications and APIs, processing and analyzing data, working with databases and data pipelines, contributing to system architecture, writing clean documented code, and collaborating with the team. Strong emphasis on backend development, SQL, ORMs, and REST API design with potential conversion to full-time.

Build and maintain Django-based web applications, design RESTful APIs, implement frontend features (HTML/CSS/JS), optimize performance and security, collaborate with cross-functional teams throughout the development lifecycle.

Lead the design, development, and implementation of resilient pricing tools using Python and cloud technologies. Improve automation, deployment reliability, testing, documentation, and technical standards. Coordinate complex projects, research new development practices, identify technical blockers, and mentor junior developers. Collaborate with stakeholders while developing expertise in insurance pricing and supporting applications built with technologies such as Streamlit, Flask, Docker, Kubernetes, and cloud compute.

Designs and builds scalable applications using React and Python, contributing to component development, data storage, deployment practices, performance optimization, testing, and client requirements analysis. The role collaborates with technical leaders, clients, and distributed teams in agile environments, using Git, code reviews, cloud platforms, databases, and AI-native development practices. U.S.-based travel to client sites is required.

Own end-to-end product features for a SaaS platform serving HR, therapists, and employees. Build, scale, and evolve frontend and backend components, lead architecture and standards, collaborate with design and product, and incorporate customer feedback and QA. Work in an early-stage startup environment with product-focused ownership.

Design, develop, and maintain scalable Python applications and cloud-native solutions. Architect microservices, containerized deployments (Docker/Kubernetes), optimize cloud infrastructure, build CI/CD pipelines, integrate messaging systems, ensure security and high code quality, and mentor junior developers. Generative AI/ML experience is a plus.

Build and maintain Supabase’s public Python SDK across database, authentication, storage, realtime, and edge functions. Develop natural sync and async APIs, manage typing, packaging, testing, release automation, documentation, and issue triage. Collaborate with cross-functional teams and open-source contributors, support multiple Python environments, maintain WebSocket functionality, and design migration paths for API changes. Work autonomously in a remote, asynchronous environment while making the SDK accessible to developers and AI coding agents.

Evaluate AI coding agents such as Codex, Claude Code, and Cursor for engineering judgment, response quality, reasoning, explanations, and usefulness. Provide clear written and recorded feedback, distinguish quality levels, and help define standards for excellent AI-assisted development interactions. This contract role requires senior-level software engineering experience, strong Python or TypeScript/JavaScript skills, familiarity with modern AI development workflows, and excellent English communication.

Build, maintain, and scale e-commerce backend services using Python and Django. Develop REST APIs and features for catalogs, inventory, carts, checkout, orders, payments, and accounts. Integrate third-party services, optimize databases and performance, implement security controls, write tested code, resolve production issues, and collaborate on architecture, planning, reviews, deployment, and CI/CD.

Build and maintain full-stack applications that deliver AI/ML insights through backend services, REST APIs, containerized microservices, and high-performance front-end interfaces. Responsibilities include cloud-native development on Google Cloud or Azure, database management, testing, CI/CD automation, security, troubleshooting, and Agile collaboration.

Build and maintain Python backend services and serverless architectures for a restaurant operations platform. Ship end-to-end features, design robust systems, and help define product roadmap. Implement CI/CD and productionization, collaborate with product and GTM teams, and contribute to team culture and technical execution.

Designs and develops APIs, system integrations, and AI-agent workflows for enterprise applications. Builds integrations with platforms such as Salesforce and REST APIs, deploys and supports solutions on AWS, and develops AI-powered automation using LLMs, tool calling, and multi-step workflows. The role includes client requirements gathering, troubleshooting, reliability optimization, cross-functional collaboration, and mentoring junior developers.

Designs, develops, deploys, and operates scalable Go and Python microservices in distributed production environments. Responsibilities include API design, Kubernetes deployment, monitoring, scaling, troubleshooting incidents, system architecture, security, testing, code reviews, and continuous improvements to development processes and infrastructure. The role requires end-to-end service ownership, strong Linux and Docker expertise, observability knowledge, and experience with reliability, performance, and CI/CD practices.

Build and maintain reliable data pipelines, APIs, integrations, and event-driven or batch processing systems. Transform data from advertising, ecommerce, order management, and event sources while improving monitoring, freshness, performance, and scalability. Collaborate with data engineering, infrastructure, product, and business teams to extend the integration platform in a cloud-native, multi-tenant environment.

Build backend services, APIs, data-processing systems, and frontend features for Northbeam’s marketing intelligence platform. Work on experimentation, near-real-time data infrastructure, AI-powered workflows, data integrations, RBAC, and end-to-end product delivery. Collaborate with data scientists, product managers, designers, and senior engineers while contributing across backend, frontend, pipelines, and infrastructure in a fast-moving environment.

Lead backend-focused software architecture and development across distributed systems, data ingestion, experimentation platforms, AI workflows, and product capabilities. Build primarily in Python while contributing to React and TypeScript frontend work. Translate ambiguous product needs into scalable production systems, guide technical direction, partner with product and data teams, mentor engineers, and improve engineering practices.