Top IT Jobs in St. Louis, MO

Lead global IT sourcing strategy and a multi-year technology modernization agenda. Manage $450M spend, strategic supplier relationships, governance, risk, and value delivery. Oversee category management (cloud, software, infrastructure, cyber), negotiations with hyperscalers and SaaS vendors, stakeholder engagement, and build a high-performing sourcing organization.

Lead technical onboarding and ongoing support for remote connectivity at dental practices. Configure and troubleshoot VPNs, Splashtop, remote desktop, printers/scanners, and network authentication. Manage implementations, validate connectivity and integrations, coordinate with clients and third-party IT, escalate complex issues, document processes, and contribute to improvements in remote access infrastructure and automation.

Lead planning, execution, and delivery of enterprise technology projects. Manage scope, timelines, budgets, resources, risks, vendors, stakeholders, and communications across Agile, Scrum, and Waterfall environments. Oversee software development, technology implementations, cloud transformation, application modernization, and concurrent project priorities while ensuring business and technology objectives are achieved.

Build and operate internal IT systems across identity, endpoints, Google Workspace, Slack, SaaS governance, and automation. Own Okta access engineering, Workspace ONE macOS fleet management, lifecycle workflows, compliance controls, audit evidence, and technical escalations. Partner with Security, Engineering, People, and Finance to improve security, reliability, and scalability while reducing manual IT support through automation.

Own identity and access engineering in Okta, macOS endpoint management in Workspace ONE, Google Workspace and Slack administration, SaaS governance, and IT automation. Build onboarding, deprovisioning, access reporting, device compliance, and audit-evidence workflows. Serve as a technical escalation point for identity, endpoint, access, and internal infrastructure issues while translating security and compliance requirements into durable IT controls.

Leads the global IT quality assurance and compliance program for regulated environments. Responsibilities include managing audits and inspections, validating computerized systems, maintaining QMS procedures, addressing compliance risks, overseeing test and lifecycle management tools, supporting supplier quality, driving automation and continuous improvement, and leading team development. The role partners with IT and business stakeholders, provides regulatory guidance and training, and ensures compliance with FDA, ISO 13485, GxP, SOX, and related requirements.

Leads IT operations across change management, service desk, end-user support, incident and problem management, infrastructure monitoring, operational security, compliance, vendors, assets, and team development. Chairs the Change Advisory Board, oversees 24/7 operations, manages audit readiness for SOC and PCI controls, drives SLA and uptime performance, and provides executive-level operational reporting. This remote leadership role requires building scalable processes and developing a multifunctional IT operations team.

Designs and operates IT services for laboratory environments, including networks, compute, security, private cloud, and SDN platforms. Translates business and IT requirements into secure, standardized architectures and operational processes. Leads deployments, design reviews, documentation, incident gap analysis, automation, and infrastructure optimization. Requires extensive enterprise networking, datacenter, virtualization, Linux, security, and ITIL experience.

Designs and operates laboratory IT services covering compute, networks, security, private and public cloud, and software-defined networking. Translates business requirements into secure, high-performance service offerings; defines architectures, configurations, processes, and operational procedures. Leads implementations, design reviews, documentation, incident analysis, gap remediation, automation, and infrastructure optimization across global laboratory environments.

Lead an Automation Center of Excellence to build and maintain IaC, automation pipelines, and configuration management across colo and multi-cloud (Azure, GCP, OCI). Drive standardization, governance, security controls, CI/CD integration, incident management, GitOps and policy-as-code adoption. Mentor team members, manage vendor relationships, measure automation KPIs, and provide executive reporting. Participate in on-call rotation and work outside normal hours as needed.

Define and execute enterprise strategy for data, analytics, AI, automation, and innovation. Build data governance, architecture, engineering, BI, and AI adoption (including Generative and Agentic AI). Identify high-value use cases, scale emerging technologies, partner with IT functions, lead high-performing teams, advise executives and board-level stakeholders, and ensure security, privacy, governance, and responsible AI compliance.

Drive net-new enterprise IT services revenue by owning full sales lifecycle: prospecting, executive engagement, solution positioning, collaboration with presales/delivery, pipeline management, and closing multi-year managed services, application modernization, and digital transformation deals to meet $5M–$10M annual targets.

The Senior IT Project Manager oversees the delivery of technology and business transformation projects, supports PMO standards, manages project risks, and mentors junior managers.

The role involves managing user accounts, administering ITSM platforms, improving system performance, and providing technical support, focusing on IT service management best practices.

Manage and direct a team responsible for CRM applications, applying technical expertise to solve business issues. Lead hiring, training, work assignment, and performance management; support large cross-functional projects and require knowledge of Appeals & Grievances processes.

Lead planning, execution, and delivery of enterprise technology projects. Manage scope, timelines, budgets, resources, risks, vendors, and stakeholder communications across Agile, Scrum, and Waterfall environments. Oversee software development, technology implementations, cloud transformation, application modernization, and other enterprise initiatives while coordinating cross-functional teams and multiple concurrent priorities.

Lead global IT operations for a HIPAA-regulated healthtech company, managing a small support team and hands-on ticketing. Build and maintain systems for compliance and visibility, optimize vendor costs, implement security/onboarding processes, drive process improvements with KPIs and automation, and serve as primary IT liaison to leadership and partners.

Serve as IT Infrastructure Project Manager for public sector clients, delivering networking, wireless, UC, and data center/security projects on time and within budget. Manage schedules, budgets, vendors, stakeholders, risks, QA, and multiple concurrent projects. Provide client-facing communication, financial reporting, and leadership of internal and external teams while ensuring project profitability and adherence to methodology.

Lead AI/ML strategy, architecture, development, deployment, and operationalization for CMS mission environments. Design predictive analytics, automation, and decision-support systems; oversee data pipelines, MLOps, model validation, explainability, and bias mitigation. Integrate secure AI solutions with cybersecurity, governance, compliance, and risk management requirements. Develop RAG and agentic AI capabilities, transition prototypes to production, advise stakeholders, support audits and governance reviews, and mentor engineering teams.

Drive national sales and account growth for IT cooling equipment, services, and software. Develop strategic customer relationships, pursue new business, manage channel partners, lead proposals and negotiations, forecast revenue, analyze market trends, and represent the company at industry events. The role requires technical knowledge of HVAC, mission-critical infrastructure, power quality, and data center solutions, along with strong commercial, communication, and relationship-management skills.

Provide frontline and advanced application support for radiology imaging workflows: incident triage, user provisioning, configuration changes, DICOM troubleshooting, monitoring interfaces, coordinating with networks/storage/vendors, maintaining SOPs and knowledge base, delivering end‑user training and on‑call doctor support to meet SLAs.

Manage and deliver data center IT infrastructure projects (GPU servers, networking, storage). Coordinate stakeholders, lead technical discussions, resolve operational issues, document plans and risks, and support automation and process improvements.

Lead and manage the global IT business applications portfolio (ERP, Salesforce, custom apps). Oversee architecture, integrations, compliance (SOX, segregation of duties), change control, disaster recovery, SLAs, and vendor relationships. Mentor and hire an applications team, coordinate implementations and migrations, and ensure solution delivery aligns with business priorities and security best practices.

The role involves leading the data governance team, managing IT projects, collaborating with stakeholders, and ensuring continuous improvement of processes. Responsibilities include strategic planning, client management, and optimizing resource utilization, while overseeing governance activities and departmental management.

Leads IT engineering strategy, teams, and delivery across infrastructure, cloud, networking, compliance, and client implementations. Oversees enterprise and hybrid-cloud solutions, automation, monitoring, DevOps, security compliance, and continuous improvement. Partners with executives, service delivery, sales, account management, and clients on roadmaps, technical solutions, proposals, and business outcomes. Ensures projects meet scope, budget, quality, security, and client requirements while driving scalable MSP services.