Top Senior IT Jobs in San Diego, CA

Serve as the primary IT–business liaison, owning executive relationships, technology strategy, vendor management, and prioritization of IT/AI initiatives. Drive modernization, cost/benefit analyses, budgeting, continuous improvement, and successful deployment of technology solutions across business units.

Lead delivery and oversight of internal and client projects, ensuring on-time, on-budget completion. Manage resources, risks, scope, finances, stakeholders, vendor relationships, project documentation, performance tracking, and reporting. Apply project management methodologies (Agile/Waterfall) and leverage AI platforms to increase efficiency.

Build and maintain internal platforms, automations, and integrations to scale IT operations. Own identity, access, lifecycle automation, endpoint trust, SaaS provisioning, and operational reporting. Develop scripts and services (Python, Bash), partner with Security and Engineering for secure AI, Zero Trust, HIPAA and SOC 2 compliance, and apply DevOps/SRE/ITIL practices for monitoring and incident response.

Lead and deliver complex cross-functional IT projects using Agile, predictive, and hybrid methods. Create schedules, manage budgets, risks, changes, and stakeholders; mentor PM staff and ensure projects meet scope, schedule, and cost baselines.

The IT Applications Business Analyst supports Oracle EBS, translating business needs into solution designs, improving processes, and resolving application issues across various operational sectors.

The Senior Systems Engineer is responsible for the design, implementation, and maintenance of core infrastructure systems, including virtualization, storage, networking, and security, while driving automation and operational reliability.

The Project & IT Budget Analyst manages project coordination and IT budget oversight, supporting strategic initiatives and ensuring financial accuracy.

The Senior IT Project Manager oversees the delivery of technology and business transformation projects, supports PMO standards, manages project risks, and mentors junior managers.

The Senior IT Risk and Compliance Analyst manages vendor risk, ensures compliance with regulations, documents controls, and supports risk mitigation efforts across IT teams.

The IT Systems Engineer will manage IT operations, support M&A integrations, and optimize Microsoft cloud systems, ensuring reliability and security.

Lead and grow the IT Engineering team while hands-on securing endpoints, offices, networks, and SaaS tools. Implement automation-first workflows (scripting, IaC), manage MDM and identity systems, support office buildouts, ensure SOC 2/ISO 27001 compliance, mentor engineers, and collaborate with Security and Operations.

The M&A Lead Integration Architect will strategize and implement integration plans for acquired entities, collaborating with various teams to ensure seamless transitions and alignment with business goals.

The LN Support Analyst III provides support for LN Finance, ensuring effective implementation, end-user training, and process mapping while resolving user issues and documenting solutions.

Lead the Global IT department, managing endpoint operations, software procurement, identity management, and IT team development. Drive proactive IT automation and ensure operational excellence across remote teams.

The Senior Procurement Manager will oversee IT sourcing and software procurement, manage renewals, drive savings, and mentor team members in procurement practices.

We are looking for a Lead IT Engineer to oversee our IT infrastructure and manage technology-related projects in a dynamic global environment.

Lead design and development of customer profile operational data stores and integration pathways. Drive architecture, security, compliance, DevOps and CI/CD practices, mentor engineers, govern vendor delivery, troubleshoot production, and align technical solutions to business outcomes across cross-functional teams.

Lead end-to-end IT sourcing for hardware, software, SaaS, and security services. Develop sourcing strategies, run RFx and negotiations, draft and manage contracts, perform market and TCO analysis, mitigate risks, manage supplier performance, and align cross-functional stakeholders to optimize cost, performance, and vendor portfolios.

Lead IT sourcing for applications, software, cloud services and consulting. Develop sourcing strategies, run RFP/RFI, manage vendor relationships and performance, negotiate contracts, analyze spend for cost savings, ensure regulatory compliance (medical device, data privacy), and collaborate with IT, Finance, Legal and business stakeholders to deliver required IT resources.

Manage multi-site IT support operations for a manufacturing organization: lead L1/L2 teams, resolve hardware/software issues, oversee infrastructure, enforce cybersecurity, coordinate vendors, manage imaging and deployments, document systems, and align IT with production goals.

Lead and own global hosting and infrastructure operations across cloud (Azure), co-location, and hybrid environments. Manage major incident response, reliability, capacity planning, M&A infrastructure integrations, core infrastructure projects, security/compliance (SOC2, GDPR), and a distributed hosting operations team. Drive observability, automation, and DR readiness while partnering with enterprise architecture, security, and senior leadership to deliver scalable, secure hosting services.

Design and implement Epic hospital billing and revenue cycle solutions. Gather business requirements, lead technical direction for projects, support claims/denials and cash posting/reconciliation, create process mappings, measure project outcomes, mentor IT staff, and coordinate with business stakeholders to achieve operational excellence.

Lead IT and cybersecurity governance, risk, and compliance programs including IT SOX/ITGC execution, ERM for IT risks, audit liaison, policy authoring, KRI/KPI tracking, GRC tool integration, third-party risk review, and people leadership to improve control maturity and regulatory alignment.

Provide frontline and advanced application support for radiology imaging workflows: incident triage, user provisioning, configuration changes, DICOM troubleshooting, monitoring interfaces, coordinating with networks/storage/vendors, maintaining SOPs and knowledge base, delivering end‑user training and on‑call doctor support to meet SLAs.

The Senior Internal IT Auditor conducts IT audits, ensures internal controls, manages risk, and improves processes across the company.