Top Senior IT Jobs in San Diego, CA

Develops, tests, deploys, and maintains enterprise applications using Microsoft .NET technologies, SQL Server, REST/SOAP services, and modern web tools. Participates in SAFe Agile Scrum ceremonies, CI/CD automation, DevSecOps, secure coding, testing, code reviews, vulnerability remediation, troubleshooting, and application modernization. Collaborates with product owners, developers, testers, stakeholders, and technical teams while supporting documentation, production operations, and software lifecycle delivery for Department of Veterans Affairs systems.

Manages and optimizes procurement operations, Coupa workflows, supplier onboarding, purchase orders, invoices, and procurement integrations. Maps and improves business processes, implements ITGC-compliant changes, leads testing and sign-off, develops spend and supplier performance reporting, and resolves invoice and purchase order discrepancies. Drives Coupa Supplier Portal, CXML onboarding, and e-invoicing adoption while partnering with finance, accounts payable, stakeholders, suppliers, and Coupa support.

Support enterprise IT systems, infrastructure, laboratory applications, business platforms, and end users in a regulated biopharmaceutical environment. Responsibilities include SOX and GxP compliance support, ERP and business application administration, helpdesk and onboarding services, Microsoft 365 and identity administration, infrastructure maintenance, backup and disaster recovery, asset procurement, vulnerability remediation, automation, and inspection readiness activities.

Leads agile transformation across multiple project teams, establishes program-wide Scrum practices, coaches Scrum Masters, facilitates ceremonies and PI planning, and drives continuous improvement. The role aligns agile delivery with government mission objectives across cloud modernization and legacy system maintenance. It requires scaling agile practices across numerous teams, supporting product roadmapping and retrospectives, and applying AWS and DevOps knowledge to CI/CD and automated testing strategies.

Develop and maintain full-stack web interfaces, backend scoring services, databases, and automated agents for cyber range environments. Responsibilities include architecture, coding, unit and integration testing, system validation, documentation, requirements analysis, and integration with versioned cyber ranges. The role requires collaboration across complex hybrid and multi-vendor environments, with a focus on cyber training systems, infrastructure automation, networking, virtualization, and Agile software development.

Develops and audits government contract pricing models, cost proposals, BOEs, and supporting narratives. Ensures compliance with solicitation requirements, corporate policies, FAR, CAS, and TINA. Reviews complex Excel models for accuracy and traceability, supports pricing policy and training initiatives, provides corrective feedback, and assists with DCAA and DCMA audit preparation. Requires strong government contract pricing or defense auditing experience, advanced Excel and Word skills, regulatory expertise, and exceptional attention to detail.

Develop and maintain full-stack web interfaces, backend scoring services, databases, and automated scoring agents for cyber range environments. Responsibilities include architecture, coding, unit and integration testing, documentation, system integration, and collaboration with RangeOS developers. The role requires work across Linux, Windows, virtualization, networking, cloud, hybrid, and multi-vendor environments, with participation in requirements analysis, solution design, Agile development, and cyber training platform integration.

Provides enterprise technical leadership and architectural governance for application maintenance and modernization. Leads migration from legacy on-premise systems to AWS, establishes architecture standards, reviews major technical decisions, manages risks, and ensures federal security and GSA compliance. Guides cloud, service-oriented, microservice, API-based, event-driven, SecDevOps, legacy modernization, and AI-enabled development strategies while collaborating with government stakeholders and engineering teams.

The Senior IT Security Engineer strengthens cybersecurity across architecture reviews, AI and emerging technology assessments, IAM governance, vulnerability management, third-party risk, security assurance, incident response, phishing simulations, automation, and regulatory compliance. The role validates security controls, supports remediation, develops risk metrics and reporting, oversees identity platforms, and partners with technology, business, audit, compliance, procurement, and vendors in a regulated banking environment.

Leads secure, reliable IT infrastructure supporting distributed clinical research sites and remote employees. Manages enterprise networking, Azure and Microsoft 365 services, endpoint platforms, automation, AI-enabled operations, vendors, budgets, and technology projects. Oversees site deployments, security and compliance initiatives, service delivery, and operational improvements while recruiting, coaching, and developing technical teams.

Evaluates IT infrastructure, applications, cybersecurity, compliance, costs, scalability, and compatibility during mergers and acquisitions. Leads technology integration and separation planning, identifies modernization and consolidation opportunities, conducts IT capability and maturity assessments, recommends governance frameworks, and aligns technology strategy with business objectives. The role also prepares diligence reports and executive presentations while collaborating with internal and external stakeholders in fast-paced transaction environments.

Provides application and system support, troubleshoots issues, manages testing and deployments, develops ETL tools and reports, and conducts business analysis. The role defines requirements, identifies IT solutions, supports system integrations, documents procedures, guides team members, and communicates with stakeholders. It also applies agile practices and supports process improvements within a financial services environment.

Leads IT governance, risk, and compliance activities, including SOC 2 readiness, audit planning and execution, policy development, control assessments, evidence gathering, remediation tracking, and regulatory research. Partners with auditors, control owners, IT leadership, and GRC team members to maintain compliance with NIST CSF and financial services regulations. Provides guidance on audit and policy matters while improving GRC processes and tooling.

Monitors and triages security alerts, investigates and documents incidents, supports identity and access management, vulnerability remediation, security awareness, phishing simulations, incident response, and security control checks. Collaborates with IT teams and an MSSP to resolve security issues, tune security tools, maintain documentation, and escalate threats. Requires availability for identity and access management, incident response, and escalation outside standard business hours.

Provides functional leadership and hands-on production support for Oracle Fusion Cloud Payroll clients. Manages payroll processing, validation, reconciliation, corrections, issue resolution, year-end activities, regulatory updates, quarterly releases, regression testing, integrations, and process improvements. Serves as an escalation point while maintaining client relationships and coordinating with consulting teams.

Lead life sciences IT compliance and quality consulting projects, including CSV, CSA, risk-based validation, regulatory assessments, audits, data integrity reviews, and compliance modernization. Develop validation plans, requirements, risk assessments, test plans, trace matrices, policies, and client presentations. Evaluate regulated systems and infrastructure, support technology implementations, communicate with technical and executive stakeholders, and contribute to proposals, business development, and client relationship growth.

Implement Adobe Experience Platform and Real-Time CDP solutions end to end, including data ingestion through connectors, SDKs, and APIs; XDM schema mapping; unified profile and identity stitching; audience segmentation; destination activation; and Customer Journey Analytics analysis. The specialist will refine segments, optimize activation and measurement, share implementation best practices, and guide cross-functional teams.

Support ServiceNow security architecture, RMF compliance, continuous monitoring, vulnerability remediation, and ATO activities for DoD environments. Develop SSPs, SARs, POA&Ms, and other RMF artifacts; implement RBAC, ACLs, data policies, encryption, and IL4/IL5 segregation; coordinate with government program managers and authorizing officials; and ensure compliance with NIST, FedRAMP, DoD, and DoDM 8140.03 requirements.

Leads strategy, implementation, integration, and continuous improvement of GxP and non-GxP laboratory informatics systems supporting research, preclinical development, and technical operations. Oversees LIMS, ELN, analytics, AI/ML, data governance, application configuration, releases, technical issue resolution, and system enhancements. Serves as a scientific data steward, develops standards and procedures, manages complex cross-functional programs, advises stakeholders, and mentors colleagues while ensuring effective, compliant, and efficient data and software solutions.

Supports the configuration, implementation, maintenance, and upgrades of Microsoft Dynamics 365 ERP, primarily across manufacturing and supply chain functions. Acts as the liaison between business departments, technical teams, vendors, and stakeholders; analyzes requirements, supports data migration, testing, validation, change requests, documentation, integrations, and user adoption. Provides guidance and backup support to application team members while ensuring solutions meet business, quality, and project objectives.

Oversee the Blue List platform’s software development lifecycle, ServiceNow implementation and sustainment, technical integration, IV&V, schedules, dependencies, dashboards, risks, and cross-vendor performance. Provide PMO support, validate technical submissions, maintain integrated schedules and risk logs, and deliver executive status briefings. The role requires ServiceNow expertise, federal or DoD IT project management experience, Agile or PMP certification, technical cloud and DevSecOps knowledge, U.S. citizenship, and a Tier 3 investigation for CUI access.

Oversee the software development lifecycle, modernization, integration, and sustainment of a federal digital platform. Manage ServiceNow-based program tracking, sprint metrics, dashboards, dependencies, risks, and milestones across vendors. Evaluate technical submissions, coordinate development teams, provide PMO support, deliver executive status briefings, and ensure DoD qualification and certification compliance.

Architects and implements ServiceNow security controls for DoD IL4/IL5 environments, including RBAC, ACLs, data policies, encryption, and identity integration. Owns ATO and RMF activities by maintaining SSPs, POA&Ms, SARs, and compliance artifacts mapped to NIST and DoD requirements. Conducts continuous monitoring, vulnerability remediation, and penetration-test reviews while coordinating with government program managers and authorizing officials. Ensures personnel qualifications and cybersecurity certifications meet DoD requirements.

Lead and execute remote technical implementations for dental practices from signing through go-live. Configure PMS integrations, set up remote access and network configurations, manage AWS-hosted Windows VMs/ETL, handle support volume, liaise with MSPs, and improve onboarding processes and automation while partnering with cross-functional teams.

Provides advanced internal IT support across identity, devices, software, SaaS, and workplace applications. The role resolves complex employee technology issues, manages support workflows, builds AI-assisted automations and self-service resources, analyzes support metrics, and improves onboarding, access, device, and software processes. It also coordinates with security, infrastructure, endpoint, identity, and enterprise systems teams while supporting distributed employees across time zones.