Top Senior IT Jobs in San Diego, CA

The Senior Clinical Trials IT Business Analyst bridges Clinical Development and IT, optimizing clinical trial technologies and managing system implementations, validations, and stakeholder engagement.

Lead design, implementation, and optimization of ServiceNow ITOM (Discovery, Service Mapping, Event Management) and CMDB governance. Configure MID Servers, patterns, probes, and integrations; manage cloud discovery across AWS/Azure/GCP; build automations with Flow Designer and APIs; perform performance and root-cause analysis; liaise with vendors; produce technical strategy, capacity planning, and translate technical solutions for business stakeholders.

The IT Operations Director leads Service Desk and Infrastructure teams, overseeing IT operations lifecycle, managing metrics, enforcing security, and enhancing service quality through automation and ITIL processes.

Manage full project lifecycle for IT Operations and Services, including enterprise applications, security, network/systems infrastructure, and process improvements. Create plans, governance, change management, vendor onboarding, KPIs, roadmaps, and transition projects to operations while communicating status and driving cross-team collaboration.

Lead and manage Level 1-3 Service Desk analysts supporting external clients, oversee daily operations, escalations, SLAs, and reporting. Improve service management, automation, and first-call resolution; partner with Engineering and Incident/Problem/Change Management to resolve production issues. Provide hands-on technical leadership across Splunk, Datadog, MuleSoft, SQL, and ServiceNow while managing client communications and operational metrics.

Lead strength and conditioning expert who develops, delivers, and evaluates evidence-based training programs for SOF and high-performance personnel. Supervises staff, coordinates return-to-duty and injury-mitigation processes, liaises with sports medicine, nutrition, and cognitive performance teams, and ensures safe operation and maintenance of training facilities and equipment.

Provide human performance technical expertise: plan, develop, and oversee training, conditioning, nutrition, and reconditioning programs for operators; manage supplies/equipment, document and report program data, train and supervise HP staff, attend interdisciplinary meetings, and support program leadership with policy and training materials. Work in austere environments and with military chains of command.

The Senior IT Project Manager will lead client-facing IT infrastructure projects, manage timelines and expectations, and coordinate engineering teams while ensuring high-quality delivery of services.

The role involves leading and improving IT operations, focusing on proactive service organization, process design, and team development while managing IT projects and vendor relationships.

Lead Manhattan Active WM solution design and multi-site rollout, migrate legacy WMS/TMS/WES/WCS, define processes and standards, validate warehouse hardware and automation, manage integrations, testing, cutover, go-live stabilization, documentation, and mentor internal teams.

The Director of IT Infrastructure leads the strategy and operations of the company's IT infrastructure, managing cloud platforms, team development, budget, compliance, and system reliability.

The Senior IT Manager will lead the IT team, manage infrastructure, oversee compliance, and drive operational improvements in a defense technology environment.

As an IT Systems Administrator III, you'll manage system infrastructure, enforce security, troubleshoot technical issues, lead IT projects, and mentor junior staff, ensuring compliance and efficient operations.

Owner of company internal IT: provide employee IT support, manage devices/accounts and MDM, administer Google Workspace/M365 and identity, maintain office networks and AV, enforce security controls, build onboarding/offboarding and IT processes, document systems, and develop the IT roadmap and budget while supporting engineering and manufacturing environments.

Responsible for IT support and administration for Commercial systems. Partners with business owners to ensure system performance, compliance, and operational excellence across various business functions.

Contract IT System Administrator to manage and harden multi-cloud (AWS/Azure) infrastructure and Microsoft 365 identity/collaboration stack, support endpoints and managed IT/security SaaS platforms, automate routine tasks with scripting, maintain documentation and compliance posture for Department of War mission spaces, and serve as hands-on technical escalation for operational issues.

Contract IT System Administrator to manage and harden multi-cloud (AWS/Azure) infrastructure and Microsoft 365/Entra ID, support endpoints and managed IT/security SaaS, automate admin tasks with scripting, maintain documentation, and help meet DoW security and compliance expectations.

Lead design, implementation, and integration of large-scale Zero Trust solutions for DoD environments. Create system blueprints, select technologies, integrate components, optimize performance, lead engineering teams, ensure DoD compliance, diagnose issues, and produce architecture and implementation documentation.

Lead and advance the enterprise IT risk management program by identifying, quantifying, and managing technology risks. Conduct complex risk assessments using NIST CSF and CIS Controls, maintain the IT risk register, drive mitigation and exception processes, build KRIs and executive reporting, enable GRC platforms and automation, and mentor junior analysts while translating technical risk into business context for leadership.

Lead a nine-person delivery team for DOT WCF IT Financial Management: oversee cost model development, systems integration, monthly billing, revenue management, reporting, analytics, IMS and RAID management, enforce AQL quality gates, manage CLIN-level hours accounting, and serve as primary Government-facing program lead.

Lead Internal IT through an AI-first transformation, owning AI platforms, playbook, governance, uptime and metrics. Serve on the AI Innovation Board, prioritize and deploy AI tools, build AI-focused IT org structure, ensure CJIS-compliant AI governance, partner with CISO on security and integrations, and manage IT budget and project portfolio to meet AI enablement goals.

Lead and scale internal IT operations including endpoint and identity management, network and vendor management, security and compliance (SOC 2/ISO27001), help desk support, IT policy and budgeting, and build a small IT team. Partner cross-functionally to align tooling, improve efficiency, and execute a 6–12 month IT roadmap.

Lead integration of technology into information systems, design data warehouse and BI capabilities, define data architecture and dictionaries, centralize disparate data, design dashboards, document system architecture, perform data quality and management, and provide solution engineering, pilots, and enablement for analytics and resource management.

The Managing Partner will sustain and grow client relationships, advising on strategic IT solutions, and leading teams to drive public sector priorities, particularly in state and local government.

Lead and deliver cross-functional technology projects, manage project plans, risks, budgets, and change control, coordinate technical integrations, drive adoption through change management, communicate with technical and non-technical stakeholders, and ensure alignment with enterprise governance using Smartsheet and common tooling.