Top Senior IT Jobs in San Diego, CA

Lead and grow a product support team for a live digital court reporting product (Maggie). Supervise analysts, triage and lead incident response for P0/P1 events, coordinate escalations to IT and engineering, run on-call rotations, develop runbooks/KB/training, track support metrics, provision hardware kits, and hire and train support staff.

Design, implement, and evolve enterprise IT architecture solutions across cloud/hybrid, SaaS, and on‑prem platforms. Lead cross-functional architecture initiatives, define integration approaches, support AI/automation enablement, ensure security and governance alignment, optimize performance and cost, mentor teams, and contribute to standards, vendor evaluations, and modernization efforts.

Own and operate core corporate IT systems including identity, endpoints, cloud infrastructure, and automations. Administer AWS, ServiceNow, MDM, and SaaS integrations; build workflows, govern AI tools, handle Tier 3 incidents and on-call duties, and partner with Security, People, and Enterprise apps to ensure reliability, security, and compliance.

Manage configuration and release management for NAWCWD programs: serve as government liaison, support program/project execution, define and roll out releases, build and integrate application modules, maintain technical documentation, and measure progress to ensure timely, compliant deliveries.

Lead enterprise IT procurement strategy, governance, and operations across hardware, software, cloud, and services. Own vendor relationships, commercial negotiations, licensing and asset lifecycle, M&A procurement integration, and procurement process/tooling. Mentor and scale the procurement team, partner with Finance, Legal, and Security, and deliver executive reporting and cost-optimization initiatives.

The role involves strategic sourcing for indirect goods and services, overseeing supplier relationships, driving cost savings, and developing procurement strategies while collaborating with cross-functional teams.

Serve as the primary on-site IT contact for the NYC office, resolving AV, network, hardware, and access issues via Jira Service Management. Manage device logistics and inventory, ensure timely laptop delivery, handle asset returns and e-waste, participate in sprint planning, escalate SEV1s, keep documentation current, and drive process improvements to elevate the employee IT experience.

Lead IT operations and strategy for enterprise systems, cloud infrastructure, networks, servers, and business applications. Ensure 24/7 production support, implement monitoring and security, manage maintenance/patching/backups, document inventories and processes, coordinate cross-site support, recommend technology improvements, and recruit/lead IT staff while prioritizing and delivering multiple projects.

The Director, IT Applications will lead SAP S/4HANA implementation and optimization, manage projects and teams, aligning strategies with business goals in a regulated environment.

Lead the design and development of scalable business intelligence and analytics solutions for decision making in research and development at Neurocrine. Collaborate with various stakeholders to translate complex questions into actionable insights and dashboards.

Design, build, and operate AWS-native AI/ML systems: RAG pipelines, fine-tuned LLMs, and microservices. Implement IaC (Terraform), CI/CD, policy guardrails, and production deployments integrating Bedrock/SageMaker, LangChain, and telemetry for secure, scalable enterprise use.

Act as the technical lead for field sales, manage evaluations, deliver on-site and remote demos, prepare SOWs/RFIs/RFPs, respond to security questionnaires, train sales teams, and support sales across U.S. and Canada while maintaining client relationships and achieving technical sales targets.

Sell radiology IT solutions by building strategic account plans, managing long technical sales cycles, maintaining a 3-5× quota pipeline, forecasting in Salesforce, partnering with marketing/inside sales, and representing the company at industry conferences.

Lead IT SOX controls testing for ITGCs (access, change, operations) across blockchain-native and enterprise systems. Build testing programs, validate remediation, perform root-cause analysis, report to Audit Committee, and collaborate with Engineering, Security, and external auditors to ensure SOX compliance and scalable audit processes.

Develops, maintains, and delivers classroom and lab training for Aegis Baseline 9C+. Teaches course content, assesses sailor performance, updates curriculum, and advises fleet best practices and tactical doctrine for BMD and integrated fire control. Maintains training records and evaluates program effectiveness; supports standards-based certification and occasional travel.

Lead a team to design, deploy, and maintain physical and virtual servers and network devices, enforce DISA STIG/RMF security compliance, automate tasks with scripting/configuration tools, troubleshoot complex networks, manage patching in air-gapped environments, and produce technical documentation while acting as liaison with stakeholders.

Lead information security governance, risk, and compliance programs. Manage cross-functional teams, SOC 2 Type II audits, regulatory engagements, enterprise data security and governance, incident communications, information security questionnaires, KPI/KRI reporting, and mentor junior staff to ensure regulatory and standards alignment.

The Manager of IT Engineering leads IT operations including identity management, SaaS, endpoint management, and internal tooling. This role ensures service quality and scalability for a remote workforce.

Support and enforce NIST/CMMC-aligned security controls; monitor SIEM/EDR and perform incident triage and response; manage Windows/AD environments; conduct vulnerability scanning and remediation; protect and classify FCI/CUI; support audits and control validation; maintain compliance documentation; collaborate with IT and business teams and communicate security risks to technical and non-technical stakeholders.

Lead strategy and execution for enterprise infrastructure, cloud platforms, and systems reliability. Build and scale a high-performing IT operations team, drive automation and observability, manage incident and change processes, partner cross-functionally on security and architecture, and lead large-scale infrastructure transformation to ensure resilient, scalable services.

Lead research and advisory work on enterprise IT and AI strategy; produce thought leadership and actionable insights for CIOs and C-suite; advise clients, present at events, support sales, mentor analysts, and drive research agenda and process improvements.

The IT Manager, Product Owner - Finance drives financial process transformations, prioritizes product backlogs, and manages stakeholder relationships to ensure high-quality delivery of financial systems solutions.

Build end-to-end automation and AI agents across identity, endpoint, SaaS, and ITSM systems. Automate onboarding/offboarding, ticket triage, self-service flows, and integrations. Operate and govern Vertex AI agents, establish KPIs, mentor sysadmins, and maintain reliable, auditable automations with security and compliance controls.

The IT Project Manager will oversee project planning, implementation, and client interactions while ensuring compliance with federal and state regulations in the public sector.

The IT Project Manager will lead public sector ERP migration projects, ensuring high-quality deliverables and strategic alignment while collaborating with various stakeholders.