Top Project Manager Jobs in St. Louis, MO

Leads complex, high-risk enterprise initiatives from planning through closeout, managing scope, schedules, budgets, risks, quality, vendors, and stakeholder expectations. Presents decision-ready recommendations to executives and steering committees, maintains financial forecasts, ensures governance compliance, and mentors project managers. Coordinates technical and business teams across data platforms, integrations, and enterprise applications while improving PMO standards and delivery maturity.

Lead high-impact M&A, integration, partnership, and other complex cross-functional projects from planning through execution. Develop project plans, manage risks and dependencies, coordinate finance, legal, HR, product, engineering, operations, security, leadership, and external partners, and facilitate executive communications. Support due diligence, integration readiness, governance, and post-close execution while improving M&A processes and playbooks. The role requires independent leadership, stakeholder alignment, proactive problem-solving, and travel up to 35%.

Leads the ClaimsCore modernization workstream across systems integration, data migration, Medicare claims processing, interface planning, testing, cutover, and production readiness. Coordinates Peraton, CMS, MACs, vendors, and multidisciplinary technical teams; manages dependencies, risks, technical issues, implementation schedules, migration validation, phased onboarding, and stabilization. Translates Medicare operational and technical requirements into executable plans and provides executive-level reporting and implementation recommendations.

Leads end-to-end technology delivery for fraud-related client projects and initiatives. Coordinates internal teams, service providers, vendors, stakeholders, and engineering groups; manages risks, issues, metrics, integrations, and system enhancements. Guides technical trade-off decisions while balancing business objectives, platform strategy, customer experience, and maintainability. Analyzes complex application-support problems, recommends solutions, and provides technical oversight across the fraud book of work.

Leads the full lifecycle of complex gas power, simple-cycle, and combined-cycle projects from contract signing through completion. Manages customer relationships, contracts, stakeholders, resources, schedules, budgets, risks, safety, quality, delivery, cost, and project profit and loss. Provides matrix leadership across engineering, manufacturing, contractors, vendors, and internal functions while resolving execution challenges and driving continuous improvement.

Owns end-to-end delivery of complex customer infrastructure builds lasting 90–120 days. Coordinates customers, OEMs, infrastructure partners, integrators, and internal teams; manages schedules, scope, risks, dependencies, budgets, change control, phased acceptance, and operational handoffs. Leads executive communications, resolves blockers, improves professional services methodologies, mentors engagement managers, and supports customer growth opportunities.

Manages Enterprise Health software deployments from pre-sale through go-live. Responsibilities include stakeholder alignment, project governance, scheduling, scope and change control, documentation, progress tracking, budget and timeline management, issue resolution, project closure, and process improvement. The role requires coordinating internal and external stakeholders, translating customer requirements into project specifications, supporting pre-sales activities, and traveling up to 20%.

Lead and manage construction and qualification projects from setup through completion. Develop project charters, schedules, budgets, and risk mitigation. Oversee contractors, procurement (RFQs/RFPs), contract negotiations, cost validation, and stakeholder/client meetings. Mentor team members and support business development while ensuring operational readiness and adherence to standards and best practices.

Lead complex customer-facing projects for Fortune 500 clients, managing planning, execution, scope, resources, milestones, dependencies, and stakeholder expectations. Establish and optimize internal project and operational processes while coordinating cross-functional teams. Ensure customer value, satisfaction, and the reliability and security of mission-critical systems throughout project lifecycles. The role supports EMEA and North America time zones and requires travel of up to 25%.

Manage marketing agency projects from statements of work and estimates through timelines, budgets, media authorizations, invoicing, file organization, meetings, communications, and campaign reconciliation. Coordinate account teams, track project scope and deadlines, facilitate internal processes, manage client setup in Advantage, and ensure deliverables and client requests are handled accurately and on time.

Leads end-to-end procurement initiatives, translating business goals into project plans and technology roadmaps. Responsibilities include cross-functional collaboration, requirements gathering, procurement process redesign, master data governance, compliance oversight, KPI tracking, tool implementation, change management, and analytics-driven sourcing improvements. The role partners with Engineering, Quality, Manufacturing, Regulatory, Finance, and IT in a regulated medical device and pharmaceutical manufacturing environment.

Manage IT and OT projects across infrastructure, EMS, software, storage, networking, and IAM/PAM initiatives. Develop project charters, schedules, budgets, risk plans, reports, and statements of work. Coordinate technical and non-technical stakeholders, resources, vendors, milestones, and deliverables across a project portfolio. Monitor costs, project health, scope, and dependencies while providing hands-on oversight during equipment installation and configuration. Travel to remote sites as needed in a regulated utility environment.

Provides portfolio-level oversight of project controls services, establishing delivery strategies, governance frameworks, and controls standards. Advises clients, leads and mentors project controls managers and senior staff, influences staffing and delivery models, and advances internal tools and processes. The role requires advanced project controls expertise, strong client consulting and communication skills, and substantial experience in construction, life sciences, data centers, industrial, or related technical industries.

Lead Yahoo’s HR project portfolio across M&A, Total Rewards, and enterprise transformations. Manage people-side M&A from due diligence through post-close integration, maintain portfolio governance, prepare executive communications, facilitate leadership decisions, and drive change management and adoption. Use AI tools to improve project workflows, reporting, synthesis, and artifact creation while maintaining confidentiality and compliance.

Leads commercial nuclear energy projects from scope through delivery, managing schedules, budgets, risks, quality, resources, contracts, vendors, and customer relationships. Provides strategic oversight to project teams, ensures regulatory and safety compliance, tracks performance, negotiates changes, and mentors junior project managers. The role requires nuclear industry expertise, strong stakeholder communication, technical decision-making, and willingness to travel domestically and internationally.

Lead client implementation projects from inception through deployment, managing scope, resources, deliverables, budgets, timelines, stakeholders, vendors, and project reporting. Maintain project artifacts and implementation data in Salesforce, coordinate internal and external meetings, identify expansion opportunities, and support change-order pricing and Statements of Work. Projects may support RMIS, GRC, EHS, and healthcare SaaS products.

Leads complex, cross-regional IT programs from business case through deployment and stabilization, with emphasis on SAP implementations and transformations. Establishes governance, plans, budgets, risk controls, dependencies, and executive reporting. Coordinates business, technical, data, testing, integration, and deployment teams while managing consulting partners, systems integrators, and vendors. Also supports recovery planning, portfolio prioritization, PMO standards, and coaching of project managers.

Leads technical, operational, construction, and warehouse/eCommerce projects across distribution and fulfillment centers. Develops facility layouts, workflows, capacity plans, implementation strategies, financial models, ROI analyses, and operational improvements. Coordinates cross-functional teams, supports site implementations, optimizes storage and material handling, identifies automation opportunities, and ensures safety and GMP compliance across a nationwide network.

Manages complex, cross-functional IT projects from planning through completion. Responsibilities include decomposing work, estimating effort, coordinating stakeholders and team members, maintaining schedules, tracking tasks and decisions, reporting status, managing risks, facilitating meetings, and ensuring success criteria are met. The role also provides project leadership without direct managerial authority, resolves escalated issues, and identifies process improvements.

Lead the IT workstream for complex business separations, divestitures, and Transition Services Agreements. Manage integrated plans, milestones, dependencies, risks, issues, vendors, and technology impacts across applications, infrastructure, data, cybersecurity, networks, and end-user technology. Coordinate internal teams and service providers, align technology requirements with business needs, and deliver executive reporting and recommendations throughout transition, stabilization, and exit activities.

Manage enterprise implementation projects from planning through launch, coordinating cross-functional teams, resources, timelines, risks, and deliverables. Maintain high on-time execution, lead project kickoffs, operate PMO systems and dashboards, facilitate Agile practices, and conduct retrospectives for continuous improvement. The role partners with internal teams to improve implementation efficiency, resolve bottlenecks, and support repeatable B2B cohort delivery.

The Project Manager will lead digital marketing and event projects, oversee client relationships, ensure quality delivery, and analyze project outcomes for engagement marketing.

Leads complex, cross-functional projects from initiation through completion, managing scope, schedules, budgets, resources, risks, governance, quality, and stakeholder communication. Oversees financial forecasting, burn tracking, variance reporting, and client commitments. Mentors project managers, improves PMO processes, facilitates governance meetings, and ensures successful delivery across media and pharmaceutical client engagements.

Coordinates Electrical Preventative Maintenance projects by supporting planning, performance analysis, documentation, billing milestones, customer and contractor deliverables, purchase orders, change orders, invoicing, materials, scheduling, and service-platform tracking. Maintains customer relationships and satisfaction while supporting account scorecards, cost-effective quotes, and issue resolution. The role is remote but requires schedule flexibility, including nights and weekends, and limited customer-site travel.

Leads PEMCO’s enterprise Project Management Office within Digital, AI & Technology. Responsibilities include managing the project portfolio, intake and prioritization, governance, reporting, capacity planning, delivery standards, risk escalation, and executive communications. The role leads and coaches Project and Program Managers, coordinates cross-functional stakeholders, supports quarterly planning, oversees vendor and budget coordination, develops portfolio metrics, and drives continuous PMO process improvement.