Top Senior Data Science Jobs in St. Louis, MO

YesterdaySaved
In-Office or Remote
St. Louis, MO
62K-217K Annually
Senior level
62K-217K Annually
Senior level
Agency • Information Technology
Design, build, and deploy production Generative AI applications: orchestrate multi-agent workflows, implement advanced RAG with vector DBs, integrate and fine-tune LLMs, develop scalable FastAPI/async backends, containerize with Docker, and optimize GenAI systems for latency, cost, and reliability.
Top Skills: Async PythonCi/CdClaudeDockerEmbedding ModelsFastapiGeminiHugging FaceLangchainLanggraphLlamaLlamaindexLlm MonitoringLocal LlmsMulti-Agent SystemsOpenaiPostgresPrompt EngineeringPythonPyTorchRagTensorFlowVector DatabasesVector Search
YesterdaySaved
In-Office or Remote
St. Louis, MO
62K-217K Annually
Senior level
62K-217K Annually
Senior level
Agency • Information Technology
Design, build, and deploy production-grade generative AI applications: orchestrate multi-agent systems, implement advanced RAG with vector DBs, fine-tune and host LLMs, optimize GenAI workflows, and deliver scalable FastAPI-based backend services with Docker and monitoring.
Top Skills: Api SecurityAsynchronous ProgrammingCi/CdClaudeDockerEmbedding ModelsFastapiGeminiHugging FaceLangchainLanggraphLlamaLlamaindexLlm MonitoringLlm QuantizationLocal LlmsModel Fine-TuningMulti-Agent SystemsOpenaiPostgresPrompt EngineeringPythonPyTorchTensorFlowVector DatabasesVector Search
YesterdaySaved
In-Office or Remote
St. Louis, MO
62K-217K Annually
Senior level
62K-217K Annually
Senior level
Agency • Information Technology
Design, build, and scale production Generative AI systems: multi-agent orchestration, advanced RAG with vector databases, LLM integration and fine-tuning, scalable FastAPI backends, Dockerized deployment, monitoring, and GenAI optimization for latency, cost, and reliability.
Top Skills: Async PythonCi/CdClaudeDockerEmbedding ModelsFastapiGeminiHugging FaceLangchainLanggraphLlamaLlamaindexLlm MonitoringLocal Llm DeploymentMulti-Agent Systems (Mas)OpenaiPostgresPrompt EngineeringPythonPyTorchTensorFlowVector DatabasesVector Search
YesterdaySaved
In-Office or Remote
St. Louis, MO
53K-188K Annually
Senior level
53K-188K Annually
Senior level
Agency • Information Technology
Design, build, and productionize generative AI solutions: advanced Python development, LLM prompt engineering and fine-tuning, agent frameworks, RAG pipelines with vector DBs, API and cloud deployment, MLOps/LLMOps, model evaluation and Responsible AI practices, and translate business needs into scalable AI applications.
Top Skills: AdkAWSAzureETLFaissFastapiFine-TuningGCPLangchainLanggraphLlmsMicroservicesMlopsPineconePrompt EngineeringPythonRestRetrieval-Augmented Generation (Rag)Streaming
YesterdaySaved
In-Office or Remote
St. Louis, MO
79K-276K Annually
Senior level
79K-276K Annually
Senior level
Agency • Information Technology
Design, build, and scale production Generative AI applications including multi-agent systems, advanced RAG pipelines, and local/frontier LLM deployments. Implement high-performance backends with FastAPI and async Python, fine-tune and quantize models, integrate vector databases and retrieval systems, and deploy/monitor containerized AI services for reliability, latency, and cost optimization.
Top Skills: Async PythonCi/CdClaudeDockerEmbedding ModelsFastapiGeminiHugging FaceLangchainLanggraphLlamaLlamaindexLlm MonitoringLocal Llm Quantization/HostingModel Fine-TuningMulti-Agent SystemsOpenaiPostgresPrompt EngineeringPythonPyTorchRagTensorFlowVector Databases
YesterdaySaved
In-Office or Remote
St. Louis, MO
53K-188K Annually
Senior level
53K-188K Annually
Senior level
Agency • Information Technology
Design, build, and deploy production-grade generative AI systems: multi-agent orchestration, advanced RAG with vector databases, integrate/swap LLMs, fine-tune models, optimize prompts and latency, and containerize services with monitoring and CI/CD.
Top Skills: Api SecurityAsynchronous ProgrammingCi/CdClaudeDockerEmbedding ModelsFastapiGeminiHugging FaceLangchainLanggraphLlamaLlamaindexLlm MonitoringLocal LlmsModel Fine-TuningMulti-Agent SystemsOpenaiPostgresPrompt EngineeringPythonPyTorchQuantizationRagTensorFlowVector Databases
YesterdaySaved
In-Office or Remote
St. Louis, MO
53K-188K Annually
Senior level
53K-188K Annually
Senior level
Agency • Information Technology
Build, optimize, and scale production Generative AI applications. Design multi-agent systems and LangGraph workflows, implement advanced RAG with LlamaIndex and vector DBs, fine-tune and deploy LLMs, and create high-performance FastAPI async backends. Improve latency, cost, and reliability, containerize services with Docker, and manage monitoring, API security, and CI/CD for ML deployments.
Top Skills: Api SecurityAsync PythonCi/CdClaudeDockerEmbedding ModelsFastapiGeminiHugging FaceLangchainLanggraphLlamaLlamaindexLlm MonitoringLlm Quantization/HostingLocal Model DeploymentModel Fine-TuningMulti-Agent SystemsOpenaiPostgresPrompt EngineeringPythonPyTorchTensorFlowVector DatabasesVector Search
YesterdaySaved
In-Office or Remote
St. Louis, MO
71K-249K Annually
Senior level
71K-249K Annually
Senior level
Agency • Information Technology
Design, build, and deploy production generative AI applications: orchestrate multi-agent workflows, implement advanced RAG with vector databases, integrate/benchmark LLMs, fine-tune models, and deploy scalable FastAPI-based services with monitoring, CI/CD, and Dockerized production pipelines.
Top Skills: Async PythonCi/CdClaudeDockerEmbedding ModelsFastapiGeminiHugging FaceLangchainLanggraphLlamaLlamaindexLlm MonitoringLlm QuantizationLocal Llm DeploymentModel Fine-TuningMulti-Agent SystemsOpenaiPostgresPrompt EngineeringPythonPyTorchRagTensorFlowVector DatabasesVector Search
YesterdaySaved
In-Office or Remote
St. Louis, MO
Senior level
Senior level
Information Technology
Lead advanced analytics and ML projects: perform EDA, feature engineering, statistical modeling, and build/optimize production ML and Generative AI solutions (LLMs, embeddings, RAG). Collaborate with engineering and MLOps to deploy and monitor models, create visualizations and dashboards, translate insights for stakeholders, and mentor junior team members.
Top Skills: AWSAzureCi/CdDockerEmbeddingsGCPKubernetesLlmsMlflowMlopsPower BIPrompt EngineeringPythonPyTorchRagScikit-LearnSQLTableauTensorFlowXgboost
Senior level
Pharmaceutical
Lead analytical efforts in Real World Data research, develop specifications and methodologies, manage projects, and communicate findings to stakeholders.
Top Skills: Cloud-Based SqlDarwinOhdsiPower BIPythonRSASSQLTableau
2 Days AgoSaved
Remote
St. Louis, MO
83K-138K Annually
Senior level
83K-138K Annually
Senior level
Retail • Sports
Design, build, and deploy search and recommendation ML systems (ranking, retrieval, personalization, query understanding) using embeddings and LLM approaches. Collaborate with engineers and product to create scalable data pipelines, integrate models via APIs, run A/B tests, and monitor online/offline metrics to improve relevance and engagement.
Top Skills: A/B TestingSparkElasticsearchEmbeddingsLangchainLlmsOpenai ApiPythonPyTorchRest ApisSolrTensorFlow
2 Days AgoSaved
Remote
St. Louis, MO
100K-206K Annually
Senior level
100K-206K Annually
Senior level
Healthtech
Lead data science across Growth and Membership Operations: define problems, build scalable data models and pipelines, develop analytical and ML solutions, partner cross-functionally, and integrate AI tools to optimize sales, marketing, telesales, and enrollment operations.
Top Skills: DbtLlmsLookerMlPythonSnowflakeSQL
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Reposted 2 Days AgoSaved
Remote
St. Louis, MO
Senior level
Senior level
Big Data • Analytics • Business Intelligence • Big Data Analytics
The Senior Data Scientist will design and deploy time-series forecasting models, collaborate with stakeholders, and operationalize models in cloud environments, focusing on demand planning across various industries.
Top Skills: AIArimaAzureData ScienceDemand ForecastingEtsGbmLightgbmMachine LearningPythonRandom ForestSarimaSQLTime-Series ModelingXgboost
Reposted 2 Days AgoSaved
Remote
St. Louis, MO
128K-267K Annually
Senior level
128K-267K Annually
Senior level
AdTech • Digital Media • Information Technology • Other
As a Senior Data Scientist at Yahoo Mail, you will enhance user growth strategies via product innovation, overseeing research projects and analytics.
Top Skills: BigQueryHadoopHiveLookerPythonSparkSQLTableau
Reposted 2 Days AgoSaved
Remote or Hybrid
St. Louis, MO
160K-208K Annually
Senior level
160K-208K Annually
Senior level
AdTech • Digital Media • eCommerce • Marketing Tech • Mobile • Software
Design, iterate, and productionize ML models for recommendation, ranking, routing, and monetization. Lead A/B testing and causal measurement, build dashboards and analytics, define metrics, collaborate with Product and Engineering, and scale ML/analytics infrastructure and model lifecycle management.
Top Skills: APIsAWSDistributed SystemsHigh-Volume Data PipelinesPythonSQL
Reposted 2 Days AgoSaved
Remote
St. Louis, MO
120K-182K Annually
Senior level
120K-182K Annually
Senior level
Biotech
The Senior Associate Scientist will analyze and visualize data, collaborate on screening strategies, and validate hits for drug discovery using the EMMI platform.
Top Skills: LinuxMoePythonRdkitSchrodingerSpotfireSQL
Reposted 25 Days AgoSaved
Remote
St. Louis, MO
60K-180K Annually
Senior level
60K-180K Annually
Senior level
Cloud • Information Technology • Software • Consulting
This role involves leading data science projects, designing technical solutions, implementing machine learning methodologies, and developing data workflows for cybersecurity applications.
Top Skills: Automation And ResponseC++Cloud Service ProviderDockerInfrastructure As A ServiceJavaJSONKubernetesPlatform As A ServicePythonRScalaSecurity Information & Event ManagementSecurity OrchestrationSoftware As A Service
3 Days AgoSaved
Remote
St. Louis, MO
174K-174K Annually
Senior level
174K-174K Annually
Senior level
Edtech
Lead advanced analytics and ML for partner-facing teams: build end-to-end predictive models (churn, lead scoring, health scores), marketing attribution and mix models, and maintain ML lifecycle standards. Develop agentic workflows and Claude Skills to accelerate work, mentor analytics team, and translate model outputs into actionable insights for Sales, Marketing, and CX.
Top Skills: ClaudeClaude SkillsCursorLlm-Based AutomationsPrompt LibrariesPythonSQL
3 Days AgoSaved
Remote
St. Louis, MO
Senior level
Senior level
Pharmaceutical
Develop and validate SDTM and ADaM datasets using R per CDISC standards, support TLF generation in R or SAS, perform QC and reconciliation, collaborate with biostatistics and clinical teams, contribute to automation, documentation, and version control for regulatory-compliant clinical trial deliverables.
Top Skills: AdamCdiscRSASSdtm
3 Days AgoSaved
Remote
St. Louis, MO
Senior level
Senior level
Healthtech • Pharmaceutical • Manufacturing
Design, implement, and evaluate advanced NLP/NLU systems for clinical text using transformer and research-oriented neural architectures. Prepare and enrich clinical datasets, run experiments and error analyses, mitigate model risks (bias, drift, hallucination), and partner with ML engineers to deploy models into a compliant cloud environment.
Top Skills: Agentic Ai FrameworksAttention MechanismsAWSCi/CdCnnsDistributed Data FrameworksGitHugging FaceLlmsPysparkPythonPyTorchSpark NlpTransformers
Reposted 3 Days AgoSaved
Remote
St. Louis, MO
Senior level
Senior level
Artificial Intelligence • Information Technology • Professional Services • Consulting
The Senior Data Scientist will design and deploy machine learning models, analyze complex datasets, develop analytical solutions, and mentor junior team members in a remote environment.
Top Skills: Amazon AwsDatabricksGoogle GcpLookerAzurePower BIPythonPyTorchRScikit-LearnSnowflakeSparkSQLTableauTensorFlow
4 Days AgoSaved
Remote
St. Louis, MO
160K-195K Annually
Senior level
160K-195K Annually
Senior level
Food
Lead retention and churn efforts by building survival and lifecycle-state models, classifying churn reasons, creating personalized win-back and next-best-action interventions, optimizing offers/promos, designing uplift experiments, and owning production model lifecycle, monitoring, and MLOps across Product, CRM, Marketing, and Engineering.
Top Skills: A/B TestingChatgptCi/CdClaudeContainerizationDeep LearningEmbeddingsGradient BoostingMlopsModel RegistryOrchestrationPandasPythonRecommender SystemsScikit-LearnSQLSurvival ModelingUplift/Causal Inference (Econml)
Reposted 4 Days AgoSaved
Remote
St. Louis, MO
215K-260K Annually
Senior level
215K-260K Annually
Senior level
Security • Software
Lead Data Scientist responsible for creating ML-driven risk assessments and AI workflows within a SaaS security platform, ensuring effective decision-making and system reliability.
Top Skills: AIMachine LearningStatistical Modeling
Reposted 4 Days AgoSaved
In-Office or Remote
St. Louis, MO
Senior level
Senior level
Logistics • Software
Lead development of digital twin and simulation models for warehouse operations, deploy AI-driven decision systems, build forecasting and optimization models, validate experiments linking operational metrics to financial impact, and partner with engineers, operations, and external AI/academic partners to scale innovations across fulfillment networks.
Top Skills: Agentic AiAnylogicContinuous SimulationDigital TwinDiscrete-Event SimulationFlexsimLlmsMachine LearningOmsOptimizationPythonRSimioSQLWms
Reposted 4 Days AgoSaved
Remote
St. Louis, MO
150K-177K Annually
Senior level
150K-177K Annually
Senior level
Big Data • Machine Learning • Software • Analytics
The Sr. Data Scientist will design, develop, and deploy AI models and tools, mentor teams, and drive data-driven insights while collaborating with cross-functional teams.
Top Skills: AIAlteryxAWSAzure AiGCPGeminiLangchainLanggraphOpenaiPythonSnowflakeSQLTableau
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