Top Senior Data Science Jobs in St. Louis, MO

Seeking a skilled Data Scientist/Machine Learning Engineer to develop machine learning models, design AI systems, and collaborate in data analytics. Responsibilities include productionizing models, data engineering, and cross-functional collaboration.

Lead the technical development and automation of enrollment forecasting models, collaborating with various departments to enhance decision-making and forecast accuracy.

Design and deploy ML systems for enterprise search, recommendations, retrieval, and AI agents. Build scalable data/ML pipelines, evaluation frameworks, and metrics. Apply statistics, experimentation, and causal inference to guide product decisions. Collaborate cross-functionally, prototype LLM-based capabilities (embeddings, RAG), and mentor junior team members.

Lead design and deployment of ML systems for enterprise search, retrieval, recommendations, and AI agents. Build scalable data/ML pipelines, evaluation frameworks, and KPIs. Apply statistics, causal inference, experimentation, and analysis to guide product strategy. Prototype and productionize LLM-based features, mentor junior staff, and collaborate cross-functionally.

As a Senior Data Scientist, you'll optimize search relevance, retrieve content, analyze data, and collaborate with teams to enhance product strategies.

Lead design and production deployment of ML models focused on pricing, availability, forecasting, and optimization. Build data infrastructure, governance, testing/monitoring, and dashboards. Partner with executives and cross-functional teams, mentor others, and establish scalable data-science practices and experimentation frameworks.

Build and deploy end-to-end ML models for renter acquisition, supply optimization, ranking, personalization, and marketplace optimization. Lead technical projects from problem framing through experimentation, launch, monitoring, and iteration. Apply statistical methods, causal inference, and rigorous A/B testing. Partner cross-functionally, mentor other data scientists, and raise modeling and experimentation standards.

Build production AI retrieval and knowledge systems for rare disease research at NIH. Model biomedical ontologies in PostgreSQL, develop semantic search, retrieval-augmented services, ranking, evaluation, and observability, and deliver user interfaces with Next.js, React, and TypeScript. Deploy and operate services in on-premises and HPC Kubernetes environments, including GPU inference. Collaborate with NIH staff, clinicians, and researchers, and contribute to scientific publications.

Build and operate agentic AI systems for rare disease research, including multi-turn workflows, structured and validated outputs, tool calling, prompt testing, evaluation suites, asynchronous execution, streaming, observability, and failure handling. Collaborate with NIH staff, clinicians, geneticists, researchers, and patient communities to translate needs into reliable data models and system behavior. Own components through deployment, establish AI engineering standards, and contribute to scientific manuscripts, abstracts, and conference posters.

Lead org-wide business intelligence and experimentation efforts: build dashboards and metrics, design and analyze A/B and multivariate experiments, develop predictive and behavioral models, and translate insights into decision-ready recommendations across product and business functions.

Senior individual contributor responsible for leading pet/P&C insurance pricing model development (GLMs and ML), owning end-to-end projects, performing EDA and root-cause analysis, communicating results to stakeholders, and mentoring junior team members.

Develop and tune ML models, productionize and deploy strategies for ML systems, and align cross-functionally to communicate performance metrics.

Lead a 5–8 person Data Science team to develop and operationalize FWA detection models using SAS and Python on multi‑payer healthcare claims. Oversee model development, data pipelines, quality reviews, stakeholder presentations, and collaboration with SMEs and BI developers. Split role ~40% management, 60% hands-on coding/analysis.

The Senior Data Scientist will manage data collection, design study protocols, train juniors, lead report development, and support innovative analytics tools.

The Senior Data Scientist oversees data collection and preparation, designs study protocols, leads report development, trains junior employees, and manages project workstreams while collaborating with team members to optimize business performance.

Lead end-to-end machine learning and advanced analytics projects: frame problems, build and deploy predictive/prescriptive models, design ETL pipelines, create dashboards and A/B test metrics, and deliver actionable insights to business stakeholders to improve fleet, pricing, and ridesharing products.

Lead end-to-end development of fraud and risk ML systems: define problems, engineer features, build and evaluate models, collaborate with product and engineering, deploy with ML engineers, and monitor production performance to detect drift and trigger retraining.

As a Staff Data Scientist, you will lead initiatives to build and optimize machine learning models, collaborate across departments, and solve complex business problems using data.

As a Data Scientist, you will build predictive models, develop software tools, and analyze geoscientific data to support mineral exploration and discovery.

As a Data Scientist, you will develop predictive models, analyze geoscientific data, and collaborate with geoscientists to improve mineral exploration efforts.

Own the analytical function for a business area such as growth, product, AI and automation, or strategic partnerships. Define business problems, metrics, reports, analyses, and experiments; interpret data; and deliver recommendations that influence leadership decisions and business outcomes. The role requires independent analytical execution, strong SQL or Python skills, first-principles problem solving, persuasive communication, and ownership of ambiguous initiatives.

Own the analytical function for a core business area such as growth, product, AI and automation, or strategic partnerships. Define business problems, metrics, reports, analyses, and experiments; surface insights; and drive data-informed decisions with cross-functional stakeholders. The role requires independently structuring data, solving ambiguous problems, communicating findings clearly, and influencing leadership-level decisions using SQL or Python.

Owns the end-to-end development of cybersecurity vulnerability and exploit prediction models, including problem framing, feature engineering, training, evaluation, deployment, calibration, monitoring, and drift detection. The role addresses extreme class imbalance, hierarchical modeling, cold-start customers, and uncertainty quantification. It also requires explaining model outputs to security executives, publishing methodologies and benchmarks, and partnering with engineering to deploy reliable production systems.

Lead development and deployment of machine learning models, perform EDA and data engineering on large datasets, train models including LLMs and unstructured-data solutions, build Power BI dashboards, automate processes, present findings to leadership, and mentor junior data scientists while working with SQL, Python, AWS/Azure, Snowflake, and Salesforce.

Provides biostatistical data science and analytics support for clinical development and evidence generation. Collaborates with biostatistics, data management, clinical development, and medical affairs teams; applies statistics, mathematics, AI, and innovative technologies to clinical trial and real-world data. Contributes to clinical trial design, statistical analysis plans, clinical study reports, publications, and protocol development while following ICH and FDA guidelines.