Top Senior Data Science Jobs in St. Louis, MO

Reposted 7 Days AgoSaved
Easy Apply
Remote or Hybrid
St. Louis, MO
Easy Apply
135K-165K Annually
Senior level
135K-165K Annually
Senior level
Artificial Intelligence • Insurance • Machine Learning • Software • Analytics
Lead end-to-end development and deployment of predictive and hybrid deep learning/LLM models for insurance use cases. Prototype, validate, and productionize models using modern ML frameworks and MLOps, collaborate with product and engineering, and communicate technical results to stakeholders to drive measurable business impact.
Top Skills: APIsAWSAzureCi/CdDatabricksDockerExperiment TrackingFederated LearningGCPJupyterLightgbmLlmsModel ServingNeural NetworksNumpyPandasPipeline OrchestrationPythonPyTorchRelational DatabasesScikit-LearnSQLTensorFlowTime Series ModelingTransformersXgboost
Reposted 7 Days AgoSaved
Remote or Hybrid
St. Louis, MO
151K-323K Annually
Senior level
151K-323K Annually
Senior level
Consumer Web • Coupons • Healthtech • Social Impact • Pharmaceutical
Lead and deliver productionized ML solutions across audience, marketing, pharma direct, and employer analytics. Design segmentation, propensity, attribution, and identity models; apply causal inference and experimentation; operationalize models with MLOps; evaluate generative AI/LLM use cases; set technical roadmap and mentor data scientists to drive measurable business impact.
Top Skills: AWSAzureDatabricksEmrExperimentation PlatformsFeature StoreGCPGenerative AiLlmsMlopsModel MonitoringNumpyPandasPostgresPysparkPythonPyTorchRedshiftScikit-LearnSparkTensorFlow
2 Days AgoSaved
Remote
St. Louis, MO
120K-155K Annually
Senior level
120K-155K Annually
Senior level
AdTech • Big Data • Analytics
Leads graph analytics, identity resolution, forecasting, and predictive modeling initiatives for operational, commercial, and product decisions. Designs scalable graph data models, production-ready machine learning solutions, and time-series forecasts. Establishes validation, monitoring, governance, and experimentation practices while partnering with product, engineering, and platform teams. Translates complex analytical findings into business recommendations and provides technical leadership across graph science, forecasting, optimization, and decision-support capabilities.
Top Skills: AWSNeo4JNeptunePythonTigergraph
3 Days AgoSaved
Remote
St. Louis, MO
Senior level
Senior level
Information Technology • Software • Consulting • Automation
Build and deploy production-grade LLM applications, AI agents, models, and scalable RAG pipelines for investment and business workflows. Architect secure MCP integrations with enterprise systems, establish MLOps and LLMOps practices, optimize model performance and latency, and develop evaluation, monitoring, governance, and rollback processes. Collaborate with data engineering and platform teams to provide secure, governed access to organizational data.
Top Skills: Amazon BedrockAmazon CloudwatchAmazon S3Amazon SagemakerAWSAws LambdaContainersCrewaiDatabricksDeepevalDockerDvcEvent StreamsGenerative AiLangchainLlamaindexLlmopsLlmsLoraMachine LearningMlflowMlopsModel Context Protocol (Mcp)Prompt EngineeringPythonQloraRagRagasRest ApisRlhfSagemaker JumpstartSagemaker PipelinesSnowflakeVector DatabasesWeights & Biases
10 Days AgoSaved
Remote or Hybrid
St. Louis, MO
160K-170K Annually
Senior level
160K-170K Annually
Senior level
Artificial Intelligence • Automotive • Computer Vision • Information Technology • Internet of Things • Logistics • Software
Lead evaluation and data strategy for advanced AI, vision, and perception systems. Define metrics, build evaluation frameworks, audit artifacts, prioritize fixes, and translate model behavior into product decisions and data-improvement loops to ensure production readiness and downstream usefulness.
Top Skills: Computer VisionDeep LearningDetectionEvaluation FrameworksGenerative AiGeospatial AiLabel Quality AssessmentMappingMultimodal AiPerception SystemsSegmentationSimulationStructural Similarity (Ssim)Synthetic DataTemporal ConsistencyVideo Quality Metrics
Reposted 4 Days AgoSaved
In-Office or Remote
St. Louis, MO
109K-181K Annually
Senior level
109K-181K Annually
Senior level
Healthtech • Information Technology • Software
Provide analytics and data-driven insights for CoverMyMeds clients, prioritize work that drives commercial outcomes, build relationships with account teams, apply statistical and predictive methods, monitor portfolio health, deliver client-facing visuals and recommendations, support complex requests and escalations, and inform strategic decisions across product, analytics, and operations.
Top Skills: ExcelMatlabPythonRSASSQLTableau
Reposted 4 Days AgoSaved
Remote
St. Louis, MO
137K-252K Annually
Senior level
137K-252K Annually
Senior level
Kids + Family • Mobile
Own analysis and algorithmic solutions for ads delivery; train, deploy, and scale ML/optimization models into production; build logging, monitoring, and lineage; improve data pipelines; mentor data scientists; use agentic AI tools daily; collaborate with engineers to integrate models into ads systems and handle on-call production incidents.
Top Skills: AirflowAWSClaude CodeDatabricksDbtGCPKubeflowMlflowPysparkPythonSparkSparkmlSQLSynapse Ml
Reposted 5 Days AgoSaved
Remote
St. Louis, MO
Senior level
Senior level
AdTech • Big Data • Consumer Web • Digital Media • Marketing Tech
Lead end-to-end data science for a priority vertical (Insurance), building, validating, and deploying ML models that drive ROAS and lead quality. Partner with stakeholders and ML engineering to monitor live performance, iterate models, and identify new modeling opportunities to improve revenue and media efficiency.
Top Skills: AWSLtv ModelingMulti-Armed BanditPythonRanking SystemsRecommendation SystemsReinforcement LearningSQL
Reposted 5 Days AgoSaved
Remote
St. Louis, MO
100K-140K Annually
Senior level
100K-140K Annually
Senior level
Information Technology • Software • Analytics
Design, develop, and evaluate conversational AI agents and generative AI products. Collaborate with AI scientists, ML engineers, and Responsible AI/Model Validation teams to ensure state-of-the-art, ethical solutions and support deployment and integration of conversational systems.
Top Skills: A2AAdkSparkAWSAzureChain-Of-ThoughtConversational AiDatabricksDeep Research AgentsDockerETLGCPGenerative AiKubernetesLangchainLanggraphMachine LearningMcpMulti-Agent ArchitecturesNlpRag
Senior level
Pharmaceutical
Lead analytical efforts in Real World Data research, develop specifications and methodologies, manage projects, and communicate findings to stakeholders.
Top Skills: Cloud-Based SqlDarwinOhdsiPower BIPythonRSASSQLTableau
Reposted 5 Days AgoSaved
Remote
St. Louis, MO
125K-155K Annually
Senior level
125K-155K Annually
Senior level
eCommerce • Insurance • Software
The Lead Risk Analytics Data Scientist will develop risk pricing, design data models, automate workflows, and communicate insights to leadership. Responsibilities include owning the risk narrative, building analytics foundations, and utilizing AI to enhance efficiency.
Top Skills: DbtPythonRSnowflakeSQLStreamlitTableau
Reposted 15 Days AgoSaved
In-Office
St. Louis, MO
Senior level
Senior level
Information Technology • Software • Consulting • Defense
Lead design and implementation of scalable data processes and analytics for geospatial and intelligence datasets. Develop Python-based mission-ready solutions and visualizations, manage multiple projects, provide senior-level technical direction, quality control, and collaborate across NGA and the Intelligence Community to produce integrated analytic products.
Top Skills: Arcgis Model BuilderBrewlyticsJemaPython
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6 Days AgoSaved
Remote
St. Louis, MO
175K-250K Annually
Senior level
175K-250K Annually
Senior level
Artificial Intelligence • Fintech • Software • Financial Services
Develop and optimize machine learning and statistical models for fraud detection and anti-money laundering. Analyze large datasets to identify fraudulent patterns, build scalable data pipelines and features, evaluate model performance, and collaborate with engineering, product, and operations teams. Communicate insights to technical and non-technical stakeholders while maintaining data privacy and security compliance. The role offers significant ownership in building Oscilar’s early machine learning stack within a remote-first startup.
Top Skills: SparkAWSAzureDaskGCPMachine LearningMlopsPythonStatistical Modeling
6 Days AgoSaved
Remote
St. Louis, MO
130K-163K Annually
Senior level
130K-163K Annually
Senior level
Financial Services
Oversee development, validation, monitoring, and governance of consumer credit risk models used for loss forecasting, credit decisioning, regulatory reporting, and risk management. Apply statistical, econometric, and machine learning methods to PD, LGD, and EAD models; support CECL, stress testing, and macroeconomic scenario analysis. Assess model performance, data quality, and compliance while communicating findings to senior leaders, auditors, regulators, and other stakeholders.
Top Skills: Basel IiiCcarCeclDfastDodd-FrankEconometric ModelingIfrs 9Machine LearningPythonRSASSQLStatistical Modeling
12 Days AgoSaved
Remote or Hybrid
St. Louis, MO
140K-215K Annually
Senior level
140K-215K Annually
Senior level
Cloud • Computer Vision • Information Technology • Sales • Security • Cybersecurity
Lead development and deployment of large-scale LLM and GenAI solutions for cybersecurity. Drive research strategy, model training, evaluation, safety/red-teaming, and cross-functional productization. Mentor data scientists, set technical standards, and represent the team through publications and thought leadership.
Top Skills: Cloud TechnologiesDeep Learning FrameworksGenerative AiGpu TechnologiesLlmsPython
Reposted 7 Days AgoSaved
Remote
St. Louis, MO
67K-140K Annually
Senior level
67K-140K Annually
Senior level
Aerospace • Information Technology • Professional Services • Defense
Develop and refine predictive models, perform exploratory data analysis, and generate AI-driven insights for DoD missions. Integrate multi-source data, apply geospatial analytics, iterate models via Agile sprints, produce performance and cost reports, and optimize analytic workflows for operational deployment.
Top Skills: AgileAws SagemakerAzure Machine LearningGeospatial AnalyticsNumpyPandasPythonRScipySQL
Reposted 7 Days AgoSaved
Remote
St. Louis, MO
150K-160K Annually
Senior level
150K-160K Annually
Senior level
Insurance • Pet
Develop and maintain predictive pricing, retention, and conversion models using GLMs and advanced analytics; build monitoring tools for rating performance; support rate filings, product pricing analyses, competitor research, and cross-functional collaboration to inform pricing and enterprise risk decisions.
Top Skills: ClaudeElastic NetExcelGeminiGeneralized Linear Models (Glms)Geospatial StatisticsGithub CopilotK-Means ClusteringPythonRSerffSQL
Reposted 8 Days AgoSaved
Remote
St. Louis, MO
100K-720K Annually
Senior level
100K-720K Annually
Senior level
News + Entertainment
Lead research and experimentation to measure ad campaign performance and effectiveness. Design evaluation frameworks, build measurement solutions, develop models for lift, conversion, and attribution, run experiments and analyses, partner with product/engineering/design/sales, present insights, mentor teammates, and foster technical community and culture.
Top Skills: A/B TestingMachine LearningPythonRSQL
Reposted 8 Days AgoSaved
Remote
St. Louis, MO
372K-600K Annually
Senior level
372K-600K Annually
Senior level
News + Entertainment
Lead design and execution of scalable experimentation frameworks for Netflix Ads. Develop auction-based, biddable media models, solve cold-start measurement problems globally, apply causal inference and ML, partner with product and engineering, and translate analytic results into strategic recommendations to optimize marketplace dynamics and member experience.
Top Skills: Causal InferenceMachine LearningNetflix Experimentation PlatformPythonRSQL
Reposted 8 Days AgoSaved
Remote
St. Louis, MO
212K-318K Annually
Senior level
212K-318K Annually
Senior level
Gaming
Lead design, execution, and interpretation of A/B tests and quasi-experiments; apply causal inference methods; partner with product, engineering, and marketing; mentor data scientists; build experimentation frameworks; extract and analyze data using SQL and Python; communicate results to stakeholders.
Top Skills: A/B TestingCausal InferenceExperimentation FrameworksMachine LearningPythonQuasi-Experimental MethodsSQL
Reposted 10 Days AgoSaved
Remote
St. Louis, MO
Senior level
Senior level
Cloud • Software
Design and deploy predictive forecasting and analytics to support Revenue operations. Build models for forecasting, churn, expansion, and pipeline analytics; create scalable dashboards; partner with Revenue Operations, Finance, and Data Engineering to improve data quality, KPI governance, and executive reporting to drive data-driven decisions and AI readiness.
Top Skills: DashboardsData VisualizationForecastingPredictive AnalyticsPythonSQLStatistical Modeling
Reposted 10 Days AgoSaved
Remote
St. Louis, MO
Senior level
Senior level
Healthtech
Own end-to-end modeling for vendor matching, order routing, and supply-chain optimization. Build predictive, causal, RL and OR solutions; design autonomous decision logic; quantify counterfactual impact; ship production models with data engineering; mentor senior data scientists; write technical design docs; partner on quarterly priorities and expand into revenue cycle and finance domains.
Top Skills: Agentic AiCausal InferenceCausal MlDiscrete Event SimulationForecastingGitMachine LearningOperations ResearchPythonQueueing TheoryReinforcement LearningSQL
Reposted 11 Days AgoSaved
Remote
St. Louis, MO
145K-180K Annually
Senior level
145K-180K Annually
Senior level
Healthtech • Telehealth
Senior individual contributor who drives product analytics, experimentation, and applied modeling. Owns growth and performance analyses, designs experiments with robust statistical evaluation, builds repeatable reporting, and partners with Product, Engineering, Operations, Clinical, and Finance to translate data into actionable product and operational decisions.
Top Skills: BigQueryPandasPythonRedshiftScikit-LearnSnowflakeSQLStatsmodels
Reposted 11 Days AgoSaved
In-Office or Remote
St. Louis, MO
56K-196K Annually
Senior level
56K-196K Annually
Senior level
Agency • Information Technology
Build and scale production-ready generative AI applications: design multi-agent workflows, implement advanced RAG with vector DBs, integrate/swap LLMs, fine-tune models, and deploy scalable FastAPI/Docker services with monitoring and optimization for latency, cost, and reliability.
Top Skills: Async PythonCi/CdClaudeDockerFastapiGeminiHugging FaceLangchainLanggraphLlamaLlamaindexLlm Quantization/HostingModel Fine-TuningMulti-Agent SystemsOpenaiPostgresPrompt EngineeringPythonPyTorchTensorFlowVector Databases
Reposted 11 Days AgoSaved
In-Office or Remote
St. Louis, MO
48K-170K Annually
Senior level
48K-170K Annually
Senior level
Agency • Information Technology
Build and scale production Generative AI applications: design multi-agent systems and LangGraph workflows, implement advanced RAG with vector DBs, integrate and fine-tune LLMs, deploy FastAPI async services in Docker, and optimize GenAI performance, cost, and monitoring.
Top Skills: Api SecurityAsync PythonCi/CdClaudeDockerEmbedding ModelsFastapiGeminiHugging FaceLangchainLanggraphLlamaLlamaindexLlm MonitoringLlm QuantizationLocal Model DeploymentModel Fine-TuningMulti-Agent SystemsOpenaiPostgresPrompt EngineeringPythonPyTorchTensorFlowVector DatabasesVector Search
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