Top Senior IT Jobs in St. Louis, MO

Leads complex, cross-regional IT programs from business case through deployment and stabilization, with emphasis on SAP implementations and transformations. Establishes governance, plans, budgets, risk controls, dependencies, and executive reporting. Coordinates business, technical, data, testing, integration, and deployment teams while managing consulting partners, systems integrators, and vendors. Also supports recovery planning, portfolio prioritization, PMO standards, and coaching of project managers.

Lead a 24/7 production support team using Scrum and SAFe practices. Establish operational goals, facilitate ceremonies and incident reviews, coordinate high-severity incident response, manage backlogs and SLAs, maintain Jira visibility, drive root-cause analysis and corrective actions, and improve team workflows. Collaborate with product owners, development, security, platform, and operations teams while communicating risks, incidents, and performance to stakeholders.

Designs DevSecOps automation strategies for a federal mainframe modernization program. The role develops cloud-native architectures, modernizes CI/CD pipelines, integrates security and testing, evaluates legacy workflows, creates technical roadmaps, and guides engineering teams and customer stakeholders through adoption of containerized, scalable modernization solutions.

Lead enterprise cloud financial operations for the Department of Veterans Affairs, overseeing forecasting, cost optimization, reporting, allocation, tagging, showback/chargeback, anomaly monitoring, and financial governance across Azure, AWS, and VAEC environments. Develop cost models, dashboards, unit economics, performance packages, and optimization recommendations while collaborating with engineering, finance, cybersecurity, hosting, and federal stakeholders. Drive continuous improvement, automation, stakeholder briefings, and FinOps maturity.

Lead the IT workstream for complex business separations, divestitures, and Transition Services Agreements. Manage integrated plans, milestones, dependencies, risks, issues, vendors, and technology impacts across applications, infrastructure, data, cybersecurity, networks, and end-user technology. Coordinate internal teams and service providers, align technology requirements with business needs, and deliver executive reporting and recommendations throughout transition, stabilization, and exit activities.

Administer and secure identity, email, network, firewall, and collaboration infrastructure for a distributed workforce. Responsibilities include Okta or equivalent SSO management, email security controls, incident response, network administration, routing, switching, VPNs, firewall policies, documentation, vendor management, and infrastructure improvement. The role partners with Security and Help Desk teams, troubleshoots complex issues, supports onboarding and offboarding, and manages moderately complex projects independently.

Owns IT infrastructure, endpoint management, identity and access, security, compliance, vendor relationships, and employee support across corporate and clinical teams. The role designs scalable systems, resolves hardware and software issues, manages provisioning and deprovisioning, develops IT policies and documentation, supports HIPAA and SOC 2 compliance, and maintains disaster recovery and cybersecurity response practices. Periodic travel to regional offices is required.

Leads security operations and corporate IT for a healthcare technology company handling PHI. Responsibilities include incident response, application and cloud security, IAM, endpoint management, vendor reviews, security policies, compliance support for HIPAA, SOC 2, and HITRUST, and management of three direct reports. The role also builds AI-driven automation tools and workflows for IT and security operations while partnering with executives, engineers, customers, auditors, and compliance leaders.

Provides advanced desktop and systems administration support for an intelligence customer. Responsibilities include troubleshooting hardware and software, installing upgrades, managing Windows and VDI environments, configuring networked systems, conducting audits, supporting backups and recoverability, training users, documenting work, and mentoring junior staff. The role is onsite in St. Louis and requires an active Top Secret/SCI clearance with the ability to obtain a polygraph.

Supports the IHS Electronic Health Records Modernization program by designing, integrating, installing, configuring, testing, and maintaining biomedical and end-user devices. Develops solutions for complex device engineering, infrastructure, security, backup, and redundancy challenges; maintains technical documentation; collaborates with cyber and implementation teams; and may lead or mentor others. The role is fully remote, requires Oracle Health experience, and may involve up to 25% travel.

Leads the internal IT organization’s AI-first transformation, including systems strategy, AI tool deployment, platform uptime, governance, security coordination, helpdesk automation, budgeting, and cross-functional adoption. Owns IT roadmaps, prioritization processes, AI metrics, compliance frameworks, and teams of up to 30 contributors while partnering with security, infrastructure, legal, and other business functions.

Facilitates IT demand intake, evaluation, prioritization, and portfolio governance. Develops business cases, dashboards, scoring frameworks, capacity views, and executive decision materials. Administers demand lifecycles and ServiceNow Strategic Portfolio Management workflows while coordinating compliance, risk, resource planning, and portfolio health activities. Partners with IT, business, PMO, project, and operational leaders to align initiatives with strategy, funding, capacity, and organizational priorities.

Administer and optimize Databricks workspaces across development, test, and production environments. Manage clusters, jobs, workflows, security, governance, monitoring, backups, performance, and cost controls. Automate provisioning and policy enforcement using infrastructure as code, integrate CI/CD pipelines, troubleshoot platform issues, and provide Tier 2/3 support. Collaborate with data, analytics, security, and IT teams while documenting procedures, onboarding users, and promoting Databricks best practices.

Leads business process reengineering and modernization projects for Defense Logistics Agency initiatives. Responsibilities include process mapping, data modeling, requirements analysis, stakeholder interviews, change management, training, methodology development, performance measurement, and quality improvement. The specialist collaborates with process, product, development, and functional owners to define system requirements, user stories, business rules, and acceptance criteria while tracking project risks, issues, milestones, and deliverables.

Leads national IT and non-clinical recruiting operations, manages and develops recruiters, establishes KPIs, monitors production, improves staffing processes, and partners with sales and account management to fulfill client hiring needs.

Leads product strategy, vision, roadmap, prioritization, and backlog management within a scaled SAFe environment. Translates business requirements into epics, features, and stories; facilitates PI Planning; collaborates with stakeholders, Agile Release Trains, engineering, compliance, security, and business teams; monitors product performance; manages risks and dependencies; and promotes Agile maturity using VersionOne.

Manage and scale global Apple and Windows endpoint fleets using Jamf and Intune. Develop scalable device-management runbooks for M&A, enforce security baselines, support systems integration, lead technical projects, resolve cross-functional workflow issues, and participate in IT escalation support. The role requires expertise in cloud platforms, identity and SSO, API integrations, endpoint compliance, security frameworks, regulatory requirements, and IT strategy.

Develops, secures, deploys, and supports PACER and court-record systems across the software lifecycle. Responsibilities include building applications and web services, managing CI/CD pipelines, containerized applications, cloud technologies, source control, vulnerability remediation, PCI and FISMA compliance, architecture, testing, performance tuning, disaster recovery, documentation, and Agile collaboration. The role also provides technical support, stakeholder communication, training, and recommendations for emerging technologies.

Owns end-to-end enterprise application architecture for secure, scalable court-record systems. Responsibilities include designing microservices, REST APIs, micro-frontends, cloud and hybrid-cloud solutions, authentication frameworks, workflows, and integrations; leading architectural reviews, code reviews, DevSecOps and CI/CD initiatives; mentoring technical teams; evaluating technologies; and ensuring security, compliance, accessibility, and governance standards.

Develop, operate, and support secure PACER and court-record systems across the full software development lifecycle. Build and maintain enterprise software, secure web services, automated DevSecOps pipelines, and containerized applications. Ensure PCI, FISMA, ATO, and other security compliance; manage vulnerabilities, architectures, source control, deployments, performance, disaster recovery, and continuity planning. Collaborate in Agile teams, document technical solutions, support stakeholders, and evaluate technologies that improve system efficiency and sustainability.

Develop, secure, deploy, operate, and support PACER and related court-record systems. Build enterprise software and secure web services, manage DevSecOps pipelines, remediate vulnerabilities, maintain compliance with PCI, ATO, and FISMA requirements, and support cloud and containerized applications. Responsibilities also include architecture, testing, performance tuning, disaster recovery, configuration management, documentation, stakeholder collaboration, and Agile ceremonies.

Leads OLIPOP’s IT strategy, operations, security, compliance, vendor management, and cross-functional technology projects. Oversees cloud systems, networking, endpoint management, SaaS lifecycle, helpdesk operations, onboarding and offboarding, access governance, and user support. Manages IT policies, budgets, audits, security tools, incident response, and vendor relationships while balancing strategic planning with hands-on technical execution.

Owns the strategy and execution of eDiscovery and information governance programs across business functions and enterprise platforms. Partners with engineering teams to improve EDRM capabilities, translates regulatory requirements into system controls, manages roadmaps, dependencies, risks, and audit documentation, and validates compliance tooling through comprehensive testing. The role also identifies automation opportunities, responsibly applies generative AI and workflow tools, and drives organizational adoption.

Maintains and deploys desktop, laptop, and mobile hardware, operating systems, configurations, patches, and applications. Tests hardware and updates, troubleshoots operating system and application issues, supports deployment teams, coordinates vendor escalations, identifies automation opportunities, and creates technical documentation. The role requires strong endpoint support experience across Windows and Mac environments, occasional night or weekend work, and up to 10% overnight travel.

Leads IT QA teams and quality outcomes across products and delivery areas. Responsibilities include people management, talent development, QA governance, test automation strategy, release readiness, risk management, quality metrics, stakeholder partnership, resource planning, and continuous improvement. The role manages up to 15 QA analysts and drives scalable testing practices, automation adoption, delivery confidence, and customer-focused quality results.