Top Senior Software Engineer Jobs in St. Louis, MO

The Senior Backend Software Engineer will design and scale backend systems using Python and FastAPI, collaborate with researchers, optimize infrastructure, and implement testing and monitoring systems.

Design, build, and maintain scalable end-to-end systems and APIs/SDKs for an enterprise custody platform. Work full-stack across databases, cloud deployments, CI/CD, and security; troubleshoot issues, integrate emerging technologies, and mentor junior engineers.

Lead the development of analytics infrastructure for clinical AI/ML products, focusing on product performance monitoring, data management, and cross-functional collaboration.

Develop and enhance software solutions for mineral exploration, collaborating with geologists and data scientists, and driving insights from data systems.

The Senior Bilingual Software Engineer will align U.S. teams with the Platform Core team in Japan, focusing on high-impact problems and maximizing platform leverage through clear communication and collaboration.

Join Supabase as a Software Engineer to own the Terraform provider, improving reliability, driving technical strategy, and creating documentation for seamless IaC workflows.

Design, develop, and maintain scalable web applications using .NET backend and Angular/React frontend. Collaborate on requirements, implement RESTful APIs, optimize performance, debug, maintain documentation, support end-users, and work within CI/CD and DevOps workflows.

Design, develop, customize and integrate Microsoft Dynamics 365 CRM/CE solutions. Build entities, forms, workflows, plugins, reports and dashboards using CRM SDK, C#, JavaScript, ASP.NET and SQL. Troubleshoot issues, estimate implementation approaches, collaborate with stakeholders, document solutions, and mentor junior developers. Banking domain experience preferred.

The Backend Software Engineer will develop and maintain backend systems for data processing related to coffee farming, utilizing Python and PostgreSQL. Responsibilities include feature development, problem-solving, and adapting systems to regulatory changes while ensuring system resilience.

Provides cross-team technical leadership by architecting scalable systems, leading design reviews, resolving complex technical issues, shipping production code, mentoring engineers, reducing technical debt, and translating business priorities into technical roadmaps. The role requires hands-on full-stack software development, AI-paired delivery, strong communication, and influence without formal authority.

Develops and maintains complex enterprise ERP solutions supporting HR, payroll, supply chain, finance, nurse scheduling, and information systems. Designs, enhances, implements, and supports Oracle ERP applications, contributes to business transformation initiatives, and may lead medium-sized project or work teams. Responsibilities include application lifecycle management, deployment, support, maintenance, and delivery of medium to complex development projects.

The Staff Software Engineer will architect and implement scalable data systems, collaborate with teams, mentor engineers, and ensure data integrity.

Leads a small engineering pod building and operating Humana’s NBA orchestration platform. Designs durable Temporal workflows, Node.js/TypeScript services, Kafka event pipelines, transactional outbox processing, activation integrations, acknowledgment and reconciliation workflows, and distributed-systems reliability controls. Provides hands-on coding, architecture leadership, observability, operational support, cross-team coordination, mentoring, and delivery accountability across the member action lifecycle.

Architects, develops, and operates scalable microservices and policy platforms for real-time decisioning. Designs evolving database schemas, versioned APIs, and high-throughput services; integrates deterministic enterprise rules engines; and applies AI-assisted engineering tools. Builds automated tests, observability, reliability, governance, auditability, and compliance capabilities. Collaborates with platform, data, and machine learning teams, participates in architecture reviews, mentors engineers, and establishes technical standards.

Build and own full-stack MarTech services, scalable APIs, event-driven systems, data pipelines, and customer-facing web experiences. Develop with Java, Spring Boot, TypeScript, React, and AWS while integrating advertising, analytics, messaging, and conversion platforms. Partner cross-functionally with marketing, product, data, design, and engineering teams to launch measurable growth features and experiments. The role also involves mentoring engineers, improving technical standards, and supporting high-scale acquisition and retention systems.

Leads cross-team software delivery and technical direction across Alkami’s digital banking platform. Designs scalable architectures, secure APIs, microservices, integrations, and data contracts; writes and reviews production code; improves reliability, performance, observability, testing, and CI/CD; manages technical dependencies and tradeoffs; mentors engineers; leads incident response and root-cause analysis; and partners with product, security, architecture, data, and site reliability teams.

Lead full-stack cloud engineering for SteelSeries’ gaming web and cloud platforms. Build scalable, reliable, high-availability services and user interfaces; evaluate and improve architecture; define APIs connecting hardware, applications, and cloud services; guide platform roadmaps; mentor engineers; promote strong testing, documentation, observability, resilience, and engineering best practices.

Build and maintain scalable full-stack cloud systems and web experiences for gamers. Design back-end and user-interface architectures, ship platform features, improve reliability and observability, and drive refactoring and technology adoption. Collaborate with hardware, software, design, and product teams while promoting testing, documentation, clean code, and knowledge sharing.

Build and scale full-stack platforms for independent insurance agents, with a front-end focus. Develop, test, deploy, monitor, and support resilient software solutions; collaborate with Design, Product, engineering teammates, and business stakeholders; investigate customer problems; resolve production incidents; document work; and improve code and development processes.

Build and lead scalable frontend products for Airbnb’s Community Support Engineering organization. Responsibilities include architecting web applications, developing reusable frontend components, designing supporting server-side APIs, implementing testing and experimentation, optimizing accessibility and performance, collaborating with product, design, machine learning, and generative AI teams, shaping technical direction, and mentoring junior engineers.

Design, build, and improve highly scalable, available payment systems supporting global transactions and payouts. Lead cross-functional technical initiatives, architect complex features, optimize performance, improve engineering quality and operational excellence, and mentor junior engineers. Drive technical strategy, align stakeholders, and collaborate with product, data science, operations, and other engineering teams.

Build and scale full-stack healthcare applications using TypeScript, React, and/or .NET on Azure. Design event-driven integrations, translate complex requirements into technical solutions, support production systems, and contribute to planning and design reviews. Lead through mentoring, code reviews, pairing, and technical problem-solving while delivering software predictably. Preferred experience includes healthcare applications, EHR and FHIR integrations, RPA, CI/CD, automated testing, and open-source contributions.

Build and operate product and technical initiatives across Boulevard’s event-driven platform, including scheduling, booking, marketing automation, and business tools. Partner with Product and Design, contribute to architecture, develop frontend or backend systems, maintain software quality through testing and observability, support production systems, mentor engineers, and improve delivery practices using AI-assisted development tools.

Lead the architecture and development of scalable computer systems and application software. Make technology and design decisions, solve complex technical problems, mentor junior developers, conduct code reviews, and promote engineering best practices. The role requires cloud expertise across Azure and AWS, AI agent integration, data system architecture, and microservices experience, with opportunities to collaborate cross-functionally and guide technical direction.

Lead design and implementation of high-throughput, low-latency programmatic bidding systems. Collaborate with ML engineers to deploy real-time inference, optimize distributed microservices, run experiments and quantitative analysis, and partner with product to ship scalable features. Foster operational excellence, mentor engineers, and continuously improve performance and reliability.