Top Senior Software Engineer Jobs in St. Louis, MO

Design, build, and maintain large-scale, resilient systems; develop features and automated tests; mentor engineers; implement CI/CD and cloud-native infrastructure; integrate AI tools; lead projects, code reviews, and cross-team initiatives while improving engineering practices and documentation.

Architect, implement, and optimize cloud-based solutions; mentor junior engineers; design and deploy automated, production-grade systems; monitor cloud health and resolve incidents; apply cloud security best practices and healthcare compliance to ensure reliable, scalable infrastructure.

Lead design and delivery of platform capabilities that power a Federated GraphQL API and event-driven systems. Build and optimize gRPC endpoints, GraphQL APIs, and SQL for scale; own observability (DataDog, Bugsnag), mentor engineers, drive integrations, improve performance and reliability, and support customer-facing product teams across the organization.

Design, build, and operate secure, scalable cloud infrastructure and platform capabilities. Implement IaC, improve CI/CD, observability, and automation. Lead incident response, reliability, and DevSecOps practices. Mentor engineers, drive platform standardization, document runbooks, and participate in a 24/7 on-call rotation to support production systems and remediation of systemic infrastructure issues.

Own the technical direction of a core Helius backend system, including architecture, reliability, performance, roadmap, and production operations. Design scalable distributed systems, storage, streaming, or edge infrastructure; drive profiling and performance improvements; establish operational excellence; partner with founders on strategy; mentor engineers; and lead ambiguous cross-team initiatives.

Own and advance a core Helius backend system supporting Solana infrastructure. Design and release high-performance products, optimize latency and throughput, make architectural decisions, improve observability and incident response, and mentor engineers. The role requires end-to-end ownership of production systems at scale, with close collaboration with founders and engineering leadership. Relevant systems include data streaming, historical APIs, account indexing, and access control infrastructure.

Develop full-stack solutions using TypeScript and AWS cloud technologies. Responsibilities include building GraphQL APIs, business logic libraries, AWS Lambda functions with CDK, AWS Glue automation, and Angular/Ionic user interfaces. The engineer will also support CI/CD, Git repositories, linting, developer workflows, requirements management, and HIPAA-compliant software development. Collaboration with engineers, management, and business analysts is required.

Design, develop, and maintain scalable AI-forward APIs, MCPs, and services for Microsoft 365. Lead features from concept through launch, write reusable code, document designs, estimate work, and support production services through on-call responsibilities. Improve reliability, performance, and scalability while mentoring engineers and establishing technical best practices across teams.

Design and build distributed storage systems optimized for AI and machine learning workloads at hyperscale. Lead architecture, development, testing, deployment, scalability, performance, security, and efficiency initiatives for zettabyte-scale Azure storage. Collaborate with AI researchers and cloud infrastructure teams, mentor engineers, evaluate emerging technologies, and solve complex problems involving availability, durability, replication, high-performance I/O, metadata, indexing, caching, and data placement.

Build and own backend, data architecture, and integrations for operations. Replace manual workflows with automations and AI agents, ship internal tools, ensure reliable data flows, monitoring, and documentation, and support production systems used by ops.

Own operations and reliability for hyperscale Azure GPU clusters and interconnect fabrics. Lead production incident triage, mitigation, recovery, root-cause analysis, and cross-stack debugging across hardware, GPUs, PCIe, firmware, drivers, and software. Develop automation, telemetry, diagnostics, playbooks, and escalation frameworks to improve observability, operational readiness, and mean time to mitigation for large-scale AI and HPC workloads.

Senior engineer responsible for designing, building, and operating scalable data ingestion, processing, storage, and member-facing membership application. Drive architecture decisions, mentor engineers, build data pipelines, APIs, and ensure reliability, observability, CI/CD, and documentation while partnering with product and analytics stakeholders.

Lead design and implementation of the Libraries Platform: services, pipelines, and package index to build, verify, and serve secure reproducible libraries. Automate artifact creation, CVE remediation, SBOM/provenance generation, AI-assisted patching, and operate registry/mirroring, CI/CD integrations, reliability, observability, and incident response while mentoring engineers.

Design, implement, and maintain backend services and core APIs (primarily Scala). Collaborate on architecture, improve system reliability, and deliver production software for legal AI products.

Design, architect, and implement cloud-native Java microservices and event-driven systems using Spring Boot and Kafka. Lead ETL and data migration efforts, ensure API governance and observability, drive SecDevOps practices, and integrate services with EHR systems using HL7/FHIR while mentoring engineers and collaborating on security and compliance.

Pipeline for software engineering roles at multiple levels. Work may include design, development, testing of embedded or application software, firmware and hardware-software integration, code review, debugging, performance optimization, Agile/Scrum practices, and cross-functional collaboration with systems, controls, and hardware teams.

Serve as the senior technical engineer on a delivery team, writing production code, shaping architecture, mentoring engineers, diagnosing complex issues, and owning software quality and reliability. Build TypeScript and JavaScript applications using Node.js, Express, React, PostgreSQL, REST APIs, testing, and observability. Modernize legacy systems, manage integrations and data synchronization, and use AI tools and automation to improve engineering workflows and delivery.

Seeking a Senior Software Engineer with 5+ years of experience to design and develop large-scale distributed systems, mentor junior engineers, and manage complex projects in a dynamic setting.

Design, build, and maintain backend services in TypeScript for millions of users; develop full‑stack features with React/React Native; participate in code reviews; provide technical leadership, mentorship, and architecture guidance; collaborate with PM and design; use monitoring/metrics and Agile practices to deliver scalable, user-focused products.

Develop and optimize Elasticsearch performance across distributed and serverless architectures. Responsibilities include implementing performance models, profiling systems, identifying bottlenecks, building benchmarks and regression detection, improving logging, metrics, vector search, and ES|QL performance, and creating AI-assisted optimization tools. The role also involves architectural and code-level optimization, technical analysis, peer reviews, and guidance for fellow engineers.

Develop and operate high-throughput, low-latency telemetry pipelines and cloud services for Azure AI/HPC infrastructure. Build observability, monitoring, analytics, and automation capabilities; own architecture through deployment and operations; and lead incident response, root-cause analysis, reliability improvements, and operational readiness. Partner across engineering and platform teams, influence technical roadmaps, mentor engineers, and apply distributed systems, AI infrastructure, and cloud operations practices at hyperscale.

Lead technical strategy and architecture for Azure Storage geo-replication, data protection, failover orchestration, and business continuity. Drive cross-team delivery, operational excellence, telemetry, automation, AI-assisted operations, and represent the team in executive and customer engagements.

Design and develop software to onboard hardware accelerators and optimize storage datapaths for Azure Storage. Drive design, debugging, performance tuning, operations, and cross-team collaboration across research, compute, and storage to improve throughput, scale, reliability, and observability.

Leads the design, implementation, optimization, and support of highly scalable Azure Storage services. Responsibilities include end-to-end performance testing, benchmarking, automation, profiling, bottleneck and root-cause analysis across compute, storage, and networking layers, KPI definition, scaling recommendations, and operational incident response. The role collaborates across teams, drives project and release plans, supports reliable and secure services, and mentors engineers while participating in on-call responsibilities.

Design and deliver large-scale, resilient AI and Kubernetes infrastructure for hybrid environments. Implement, optimize, and maintain cloud-native, container orchestration solutions; integrate AI capabilities; participate in on-call rotations; mentor engineers and drive reliability, observability, and performance at scale.