Top Senior Python Jobs in San Diego, CA

Designs and maintains secure AWS GovCloud infrastructure supporting AI/ML workloads and autonomous naval systems. Manages Kubernetes and OpenShift platforms, Infrastructure as Code, secure data flows, DevSecOps pipelines, monitoring, networking, and troubleshooting. Collaborates with AI/ML and software teams, documents systems for compliance, optimizes cloud performance and costs, and mentors junior engineers. The onsite San Diego role supports mission-critical DoD capabilities and requires up to 15% travel.

Lead DevOps engineer responsible for designing, building, and maintaining CI/CD pipelines and infrastructure across unclassified and classified environments. Support cloud toolsets, manage Kubernetes clusters, ensure security/compliance with DoD standards, liaise with corporate IT, coach teams on DevOps best practices, and operate in a hybrid setting with regular on-site access to government facilities.

Develop and maintain system-level models and simulations for architecture trades, requirements analysis, performance assessments, and design decisions. Plan and execute model verification and validation using test, flight, or operational data. Document assumptions and results, support risk identification and technical recommendations, and present trade-study findings to stakeholders. Collaborate across systems, software, hardware, and integration engineering teams on complex airborne ISR and mission systems.

Designs, develops, tests, documents, and integrates algorithms and software for intraoperative neuromonitoring medical devices. Responsibilities include machine learning model development using clinical data, software architecture, application development, root-cause analysis, cross-functional product collaboration, and full lifecycle ownership of algorithm projects. The role requires compliance with FDA regulations, ISO 13485, and related medical-device standards, with travel up to 10%.

Leads architecture, design, implementation, and delivery of complex embedded, connected-device, and application software for regulated medical products. Owns technical decisions, secure connectivity, device management, lifecycle traceability, verification, and software quality. Partners cross-functionally to address risk, cybersecurity, regulatory requirements, and delivery constraints. Mentors engineers, improves engineering practices, resolves architectural issues, and remains hands-on with C/C++, embedded Linux, RTOS, real-time behavior, networking, and software development tools.

Build and maintain CI/CD pipelines, automate infrastructure, and support secure containerized platforms for U.S. Navy mission software. The role partners with software and cybersecurity engineers to resolve delivery issues, adapt technical stacks, and enable rapid microservice deployment to orchestration platforms. Responsibilities include infrastructure automation, container platform support, and pipeline engineering in regulated environments.

Develop, integrate, and maintain system-level models and simulations for architecture trades, requirements analysis, and performance assessments. Plan and execute model verification and validation using test, flight, or operational data. Collaborate across engineering disciplines, document model assumptions and credibility, analyze results, identify risks, and present technical findings to stakeholders and leadership. The role supports the AISR&T airborne ISR program and requires an active Secret clearance.

Build a new Physical AI product line spanning edge devices, cloud infrastructure, and user-facing safety tools. Own real-time ingestion, multi-tenant access control, dashboards, compliance analytics, operator coaching workflows, and AI agent features. Work directly with customers, run pilots, ship rapidly, and measure product usage. The role requires broad full-stack range across backend, cloud infrastructure, DevOps, frontend, and real-time data experiences.

Manage configuration identification, control, status accounting, audits, baselines, change requests, repositories, release processes, and configuration metrics for aerospace ISR systems. Coordinate with engineering, integration, testing, logistics, and program management to ensure hardware, software, documentation, and system configurations remain traceable, controlled, compliant, and accurately documented.

Designs, develops, tests, and debugs embedded software for satellite systems. Responsibilities include bootloaders, board support packages, device drivers, embedded operating systems, hardware integration, verification planning, and architectural leadership. The role requires solving complex low-level software problems, developing test programs, improving engineering processes, and collaborating cross-functionally. Key expertise includes C, Python, VxWorks, Embedded Linux, RTEMS, Buildroot, Yocto Linux, NAND flash file systems, and laboratory debugging equipment.

Design and implement control plane software spanning SDN, ground systems, satellites, and terminals. Build scalable services and APIs for provisioning, configuration, automation, telemetry, and network operations. Address dynamic network conditions and integrate with cloud and on-premises platforms. Collaborate across data plane, platform, embedded systems, product, and quality teams while contributing to architecture, implementation, testing, debugging, and system integration.

Develop and maintain software configuration management, release engineering, build, deployment, and version-control processes for DoD software programs. Support ClearCase, ClearQuest, Jira, GitHub, scripting, databases, build environments, release schedules, configuration control boards, and platform integration builds. Troubleshoot system and deployment issues, automate productivity tools, maintain documentation and standards, administer related repositories and SharePoint structures, and coordinate with developers, QA, administrators, vendors, and customers.

Lead technical strategy and implementation of V-BAT fleet data analysis pipelines and tooling. Transform raw flight, simulation, and production data into metrics, dashboards, and reports; perform fleet-wide studies, anomaly investigations, and root-cause analysis; partner with cross-functional teams and mentor engineers on analysis best practices.

Lead NPI from first silicon to high-volume manufacturing for precision analog and mixed-signal ICs. Develop and optimize wafer sort and final test solutions (Teradyne UltraFlex IGXL), correlate bench and ATE results, establish production limits, design/validate test hardware (load boards, probe cards, sockets), perform silicon debug/root-cause analysis, support qualification and transfer to OSAT, and create automation tools using Python and JMP to improve throughput and quality.

Designs and simulates FPGA/modem systems using Ultrascale+ and Versal platforms. Develops VHDL and SystemVerilog designs, works with high-speed SerDes and communication interfaces, and uses scripting languages for development and automation. The role requires extensive FPGA experience and offers contract-to-permanent potential. Software-defined radio/modem, PetaLinux, RF design, encryption, and active government clearance experience are preferred.

Lead development of autonomy capabilities for space platforms including distributed optimization, tasking/scheduling, track fusion, RPO and motion planning. Build high-performance, well-tested software, integrate on real vehicles, support deployments and testing, and research/roadmap advanced autonomy techniques for defense applications.

Design, implement, and deploy autonomy capabilities for space platforms including distributed optimization, tasking/scheduling, track fusion, RPO, and motion/behavior planning. Build high-performance, well-tested software modules, collaborate across perception, planning, simulation, hardware, and flight test teams, support deployments and mission log analysis, and contribute R&D and roadmaps to advance autonomy for satellites and missile defense.

Lead development of space autonomy capabilities including distributed optimization, tasking/scheduling, track fusion, rendezvous/RPO, and motion/behavior planning. Build high-performance, testable software, integrate and validate on real platforms, support deployments, and mentor engineers while contributing R&D and roadmaps.

Build automated end-to-end tests, frameworks, harnesses, services, and infrastructure for autonomous aircraft software across SIL, HIL, and VIL environments. Automate release testing, orchestration, data collection, analysis, and reporting; debug failures across software, networking, hardware, and simulation; expand system coverage; and integrate testing into CI/CD and release workflows.

Build and own the Linux-based edge platform powering factory, deployable, and air-gapped Crucible environments. Responsibilities include system provisioning, networking, security, updates, recovery, device lifecycle management, hardware and peripheral integrations, disconnected operation, fleet management, and full-stack debugging across applications, operating systems, networks, and physical equipment. The role also partners on edge-to-cloud architecture, deployment topology, and system security.

Senior systems administrator responsible for installing, configuring, monitoring, and securing Windows and Linux servers, virtualization, backup/disaster recovery, cloud identity (Azure AD), automation with PowerShell/Bash/Python, endpoint management, and Tier 1/2 support. Mentor junior admins, maintain documentation, support audits and compliance, and participate in incident response and maintenance activities.

Leads the design, development, integration, testing, and qualification of advanced control solutions for high-precision mechatronic systems supporting semiconductor production. Translates product needs into requirements and verification plans, investigates performance issues, manages technical risks, coordinates cross-functional teams and suppliers, and mentors three to five engineers.

Senior technical lead for unmanned systems (UxS) integration and test readiness. Hands-on role integrating autonomy software with aircraft, onboard compute, radios, sensors, and ground equipment; leading platform evaluation, bench and field bring-up, troubleshooting, test execution, readiness criteria, and mentoring cross-functional teams to improve hardware-based autonomy validation and demonstrations.

Lead integration of autonomy software onto diverse platforms by designing and implementing interfaces between autonomy, vehicle subsystems, sensors, payloads, and communications. Configure Linux mission environments, middleware, containers, and deployment pipelines; support SIL/HIL/VIL validation, field tests, demonstrations, troubleshooting, and cross-team coordination while mentoring junior engineers.

Owns end-to-end development and support of the Sage 300 ERP ecosystem, including customizations, .NET and Python applications, legacy VB6 maintenance, third-party integrations, SQL Server database design and optimization, reporting, and BI solutions. Collaborates with business and technical stakeholders, contributes to architecture, mentors junior developers, improves processes, documents solutions, and resolves production issues.