Top Senior Python Jobs in San Diego, CA

Reposted 8 Days AgoSaved
In-Office
San Diego, CA
114K-171K Annually
Senior level
114K-171K Annually
Senior level
Aerospace • Logistics • Security • Software • Cybersecurity
Lead integration of avionics/payload subsystems, resolving integration issues with IPTs and suppliers. Validate sensor performance, use RF test equipment, and support system-level testing. Work full-time on-site, collaborate with lab teams, and comply with required Top Secret/SCI/SAP clearances; travel up to 25% may be required.
Top Skills: CC++Ipv4Ipv6Mil-Std-1553Network AnalyzerPower MeterPythonRf Test EquipmentRs-232Rs-422Spectrum Analyzer
Reposted 9 Days AgoSaved
In-Office
San Diego, CA
190K-280K Annually
Senior level
190K-280K Annually
Senior level
Aerospace • Security • Defense
Develop and maintain C++ and Python constellation-level simulation and data-processing infrastructure that models spacecraft motion, link availability, routing, timing, coverage, and network behavior. Build services to generate navigation-derived products, scenario tooling, visualization, validation tests, and scalable simulation pipelines to support engineering trades, operational rehearsals, anomaly investigation, and stakeholder-facing analysis.
Top Skills: APIsAstrodynamics/Mission Simulation ToolsAutomated TestingC++CcsdsGitLinuxPythonRouting ProtocolsSoftware-Defined Networking (Sdn)Visualization Frameworks
9 Days AgoSaved
In-Office
San Diego, CA
150K-175K Annually
Senior level
150K-175K Annually
Senior level
Aerospace • Defense
Lead build and release engineering: design and maintain CI/CD pipelines, automate reproducible builds and artifact management, integrate security/quality gates, optimize build performance, manage container images and registries, provision build environments with IaC, and produce audit/compliance evidence and runbooks.
Top Skills: AcrAksArgocdArtifactoryAWSAws GovcloudAzureAzure GovernmentBashBazelConanCosignDastDockerEcrEksFluxGitGithub ActionsGitlab CiGradleHelmJenkinsKubernetesMakeNexusPythonSastSbomScaSigstoreTerraform
Reposted 9 Days AgoSaved
In-Office
San Diego, CA
141K-207K Annually
Senior level
141K-207K Annually
Senior level
Healthtech • Biotech • Pharmaceutical
The Advisor Lab Automation Software Engineer will design and implement software integrations for lab automation, focusing on AI-driven processes, while providing technical leadership and mentoring.
Top Skills: Ci/CdDockerFastapiFlaskKubernetesPythonRedis
Reposted 9 Days AgoSaved
In-Office
San Diego, CA
132K-242K Annually
Senior level
132K-242K Annually
Senior level
Aerospace • Logistics • Security • Software • Cybersecurity
Lead a 10–20 person software team through the full SDLC in an Agile environment, delivering real-time/mission-critical software. Manage planning, execution, EVMS/Agile metrics, risks, cross-discipline collaboration, technical mentoring, and functional HR responsibilities.
Top Skills: Analog I/OAngularCC++DdsDiscrete I/ODockerEthernet/IpFiber ChannelJavaJava SwingJavafxKubernetesMicroservicesMil-Std-1553NoSQLPythonRs-232SQLUml
Reposted 9 Days AgoSaved
In-Office
San Diego, CA
125K-235K Annually
Senior level
125K-235K Annually
Senior level
Aerospace • Logistics • Security • Software • Cybersecurity
Lead survivability engineering activities including signature modeling/analysis (EM, IR, VIS, acoustic), RCS/RF test design and execution, materials/process development, mission systems integration, supplier coordination, and delivering test analysis and design recommendations to reduce system detectability.
Top Skills: C/C++CatiaKnowbellMatlabMethod Of MomentsNxPhysical OpticsPythonRcsRf MeasurementSaberSentriXpatch
Reposted 9 Days AgoSaved
In-Office
San Diego, CA
83K-155K Annually
Senior level
83K-155K Annually
Senior level
Aerospace • Logistics • Security • Software • Cybersecurity
Implement and audit software quality standards across programs, ensure compliance with contractual and process requirements, review designs and tests, support CMMI/AS9100 audits, collect/report software metrics, evaluate suppliers, and witness qualification and acceptance testing.
Top Skills: AgileAs9100CC++CmmiJavaPythonSpiralWaterfall
Reposted 9 Days AgoSaved
In-Office
San Diego, CA
101K-188K Annually
Senior level
101K-188K Annually
Senior level
Aerospace • Logistics • Security • Software • Cybersecurity
Design, model, test, and analyze component- and system-level survivability across RF, IR, VIS, and acoustic spectrums. Plan and execute RCS/RF tests, develop materials/processes, integrate mission systems, coordinate with designers and suppliers, and deliver test analyses and recommendations to reduce system detectability.
Top Skills: C/C++CatiaKnowbellMatlabMethod Of MomentsNxPhysical OpticsPythonRcsSaberSentriXpatch
Reposted 10 Days AgoSaved
Hybrid
San Diego, CA
Senior level
Senior level
Financial Services
Design, develop, configure, and maintain systems software and infrastructure; integrate hardware, software, networks, and databases; build custom software, automations, and data integrations; troubleshoot, monitor, and ensure reliability and disaster recovery; support cloud technologies, lead small projects, and document enhancements to improve audit platform capabilities and operational efficiency.
Top Skills: AICloud-Based TechnologiesCSSDatabasesHTMLJavaScriptNetworksPowershellPythonServersSQLSQL ServerSystem Monitoring And Alerting ToolsWorkflow Automations
Reposted 10 Days AgoSaved
In-Office
San Diego, CA
110K-150K Annually
Senior level
110K-150K Annually
Senior level
Information Technology • Consulting • Cybersecurity • Defense
Engineer tactical communications standards and architectures, analyze system-of-systems interoperability, support SDRs and waveforms, modernize interface specifications, apply MBSE, scripting, AI/ML and automation, and support integration guidance and stakeholder collaboration for DoD customers.
Top Skills: Ai/MlC4IsrCi/Cd PipelinesCmossContainerizationFaceJSONMilitary Communications WaveformsModel-Based Systems Engineering (Mbse)MosaProtobufPythonSoftware-Defined Radio (Sdr)SosaTactical Data LinksXML
Reposted 10 Days AgoSaved
In-Office
San Diego, CA
110K-180K Annually
Senior level
110K-180K Annually
Senior level
Information Technology • Consulting • Cybersecurity • Defense
Design, build, and operationalize secure data pipelines and analytics for Naval and DoD missions. Develop event-streaming and distributed systems, normalize multi-format data, deploy cloud-native and containerized solutions, work with GIS and operational environments, and collaborate with cross-functional teams while meeting shipboard and Navy safety requirements.
Top Skills: AirbyteApache AirflowApache IcebergApache KafkaArcgisAws KinesisAws LambdaAws S3DaskDbtDockerEfsElasticsearchGoKubernetesPandasPostgisPostgresPythonRRabbitMQRdsRedisRustSnowflakeSnsSparkSQLSqsZeromq
Reposted 10 Days AgoSaved
In-Office
San Diego, CA
110K-180K Annually
Senior level
110K-180K Annually
Senior level
Information Technology • Consulting • Cybersecurity • Defense
Design, build, and maintain secure AWS GovCloud infrastructures and container platforms (Kubernetes/OpenShift). Implement IaC (Terraform/Ansible/CloudFormation), support DevSecOps pipelines, ensure DoD cybersecurity/STIG compliance, optimize cloud resources, troubleshoot cloud/network/container issues, integrate AI/ML platforms, produce documentation, mentor junior engineers, and support mission-critical naval systems.
Top Skills: AirflowAnsibleApacheAWSAws GovcloudAzureBashCloudFormationCloudwatchDevsecopsDockerDomino Data LabsElasticsearchFiddlerGithub ActionsGitlab CiGrafanaJenkinsKafkaKibanaKubernetesLinuxOpenshiftPythonRabbitMQStigTcp/IpTerraformTlsTobiasVpc
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Reposted 10 Days AgoSaved
In-Office or Remote
San Diego, CA
Senior level
Senior level
Industrial • Automation
Lead design and delivery of scalable, secure full‑stack features and services. Build maintainable front-end and backend code, implement integrations and data models, enable cloud-native CI/CD workflows, use containers and IaC, and act as a technical leader influencing architecture and delivery across teams while leveraging AI-assisted tools.
Top Skills: .NetAngularAnsibleArmAWSAzureBicepBitbucketCi/CdClaudeCursorDockerEpicGCPGitGithub CopilotGitlabJavaJavaScriptMs Sql ServerNode.jsNoSQLOraclePythonReactRestful ApisSQLTerraformTypescriptVue
Reposted 10 Days AgoSaved
In-Office or Remote
San Diego, CA
Senior level
Senior level
Industrial • Automation
Design and deliver end-to-end full stack healthcare applications across UI, API, and data layers. Build secure, testable, cloud-native services, implement integrations and IaC, support CI/CD and monitoring, leverage AI-assisted tools, and mentor engineers while partnering with cross-functional teams.
Top Skills: .NetAngularAnsibleArmAWSAzureBicepBitbucketCi/CdClaudeCursorDockerEpicGCPGitGithub CopilotGitlabJavaJavaScriptMs Sql ServerNode.jsNoSQLOraclePythonReactRestTerraformTypescriptVue
Reposted 10 Days AgoSaved
In-Office or Remote
San Diego, CA
Senior level
Senior level
Artificial Intelligence • Hardware • Internet of Things • Industrial
Design, implement, and secure scalable cloud infrastructure across AWS and OCI; manage CI/CD (GitHub Actions), Kubernetes and ECS clusters (including GPU workloads); integrate observability (Datadog, Grafana, OpenTelemetry, Sentry); enforce security and compliance (SOC2, ISO 27001); handle DevOps/SRE intake, vulnerability response, and migrations from EKS to OKE.
Top Skills: AWSAws EcsAzureBashCloudflareDatadogDockerDocker KomposeEksGCPGithub ActionsGithub EnterpriseGrafanaHelmJIRAKubernetesOciOkeOpentelemetryPowershellPythonSentryTerraform
Reposted 10 Days AgoSaved
In-Office
San Diego, CA
Senior level
Senior level
Artificial Intelligence • Hardware • Software • Defense • Manufacturing
Develop and maintain software across embedded, systems, and application layers for autonomous maritime platforms. Interface with sensors, actuators, networking, and onboard compute. Design distributed services, improve performance, reliability, and observability, and support lab and field testing alongside cross-functional teams.
Top Skills: Backend ServicesC++Cloud InfrastructureDeployment PipelinesDevice DriversDistributed SystemsEmbedded LinuxGoHardware Communication ProtocolsLinuxNetworkingPythonRosRos2RtosRust
Reposted 10 Days AgoSaved
In-Office
San Diego, CA
170K-240K Annually
Senior level
170K-240K Annually
Senior level
Hardware • Industrial
Lead a Product Integration and Test team to integrate software and hardware into a unified autonomy product. Manage engineers, drive SIL/HIL and real-world testing on USV/UAV platforms, oversee verification/validation, CI/CD, configuration management, and collaborate with Perception/Fusion/Autonomy teams to ensure robust deployments.
Top Skills: C++DdsGitlab CiHardware-In-The-Loop (Hil)Iceoryx2JenkinsLinuxProtobufPythonRosSoftware-In-The-Loop (Sil)Zeromq
Reposted 10 Days AgoSaved
In-Office or Remote
San Diego, CA
Senior level
Senior level
Information Technology
The Senior Site Reliability Engineer is responsible for architecting reliability strategies, implementing SRE frameworks, mentoring engineers, and ensuring system resilience and performance in government systems.
Top Skills: Cloud ArchitectureDevsecopsGoInfrastructure As Code (Iac)JavaKubernetesLinuxNist 800-53PythonRmf
Reposted 10 Days AgoSaved
In-Office
San Diego, CA
114K-171K Annually
Senior level
114K-171K Annually
Senior level
Aerospace • Logistics • Security • Software • Cybersecurity
Design, develop, integrate, and test embedded real-time software for mission/flight-critical systems. Work on architecture, implementation, and SW lifecycle in Agile teams, collaborating with systems, DevSecOps, test, and cloud groups. Support integration, qualification, and delivery; maintain security clearances and obtain SAP access.
Top Skills: Black DuckCC++CoverityDockerFortifyGitlabIntegrityJIRAPythonReal-Time Embedded LinuxRhel 8.10Vxworks
Reposted 10 Days AgoSaved
In-Office
San Diego, CA
79K-171K Annually
Senior level
79K-171K Annually
Senior level
Aerospace • Logistics • Security • Software • Cybersecurity
Adapt mobile control station applications to a cloud environment, build Infrastructure-as-Code and containerized deployments (Docker/Kubernetes), implement networking/security, instrumentation and integration, and support system testing in an Agile, multidisciplinary team. Work includes cloud adoption, environment prototyping, and DevOps toolchain integration.
Top Skills: AclArgocdAWSAws IamAzureAzure AdCC++Comptia Cloud+Comptia Security+ConfluenceContainersDockerFluxGitGitlabIl-5 CloudInfrastructure As Code (Iac)JavaJIRAKubernetesLinuxMicroservicesPythonRbacSecurity GroupsSoftware-Defined NetworkingVmsWafWindows
Reposted 10 Days AgoSaved
In-Office
San Diego, CA
158K-289K Annually
Senior level
158K-289K Annually
Senior level
Aerospace • Logistics • Security • Software • Cybersecurity
Lead the Full Stack Software discipline by defining technical vision, governing tools/processes/training, building a community of practice, enabling sector-wide engineering toolchains, resolving technical shortfalls, embedding lessons learned, and improving software engineering KPIs and interoperability across multiple Aeronautics sites. This is a strategic leadership role focused on governance and enablement rather than day-to-day coding.
Top Skills: AnsibleAWSAzureAzure DevopsCesiumjsCSSCypressDockerGitlabGraphQLGrpcHTMLHTTPIstioJavaJavaScriptJenkinsKubernetesMil-Std-1472MongoDBNode.jsNoSQLOciOmsOpenstackPostgisPythonReactRestRmf/Nist 800-53SeleniumSQLStanag 4586TypescriptUciWebglWebsockets
Reposted 10 Days AgoSaved
In-Office
San Diego, CA
142K-213K Annually
Senior level
142K-213K Annually
Senior level
Aerospace • Logistics • Security • Software • Cybersecurity
Lead design and delivery of scalable on‑premises and hybrid IaaS datacenter systems. Decompose customer requirements, build infrastructure blueprints, automate deployments, produce technical documentation, mentor cloud/infrastructure engineers, and ensure consistent implementation and acceptance criteria across programs. Requires Top Secret clearance and SAP access.
Top Skills: .NetAnsibleCC#JavaAzureMkdocsPowershellPuppetPythonSphinxTerraformVcfVisual BasicVmware Esxi
Reposted 10 Days AgoSaved
In-Office
San Diego, CA
92K-171K Annually
Senior level
92K-171K Annually
Senior level
Aerospace • Logistics • Security • Software • Cybersecurity
Design, analyze, test and integrate complex aeronautical hardware and software systems. Develop requirements, architectures, and MBSE artifacts; participate in Agile teams, review test plans, investigate anomalies, and produce technical reports, ICDs, VCRM, and presentations. Support system integration, verification, and continuous improvement of SW/HW interfaces.
Top Skills: Ansible EngineC++ClearquestConfluenceDoorsGitJavaJIRAKubernetesMbseOpenshiftPythonSw Test AutomationVMware
Reposted 10 Days AgoSaved
In-Office
San Diego, CA
75K-138K Annually
Senior level
75K-138K Annually
Senior level
Aerospace • Logistics • Security • Software • Cybersecurity
Individual contributor systems engineer working on aerospace programs: develop and manage requirements, define interfaces, perform analysis, support integration/testing, maintain systems engineering artifacts, coordinate IPTs, use tools like JIRA and DOORS, and support verification/validation and MBSE efforts.
Top Skills: AgileCameoCi/CdDoors DxlIbm DoorsJIRAModel-Based Systems Engineering (Mbse)Python
Reposted 10 Days AgoSaved
In-Office
San Diego, CA
92K-171K Annually
Senior level
92K-171K Annually
Senior level
Aerospace • Logistics • Security • Software • Cybersecurity
Develop, integrate, test and maintain desktop/web applications and Java microservices; build and maintain CI/CD pipelines; collaborate with SW, HW and test teams; identify technical risks and report to leadership; work in an Agile, process-oriented environment. On-site in San Diego, requires Top Secret clearance and up to 25% travel.
Top Skills: ActivemqAnsibleBambooBashBitbucketCi/CdCloudnativepgConfluenceDocker/ContainerizationElasticsearchGitlabJavaJaxbJIRAJmsKafkaMavenMongoDBPostgresPowershellPythonRedisXMLXpathXsdXslt
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