Top Senior Python Jobs in San Diego, CA

Reposted 2 Months AgoSaved
Hybrid
San Diego, CA
209K-283K Annually
Senior level
209K-283K Annually
Senior level
Artificial Intelligence • Internet of Things • Semiconductor
Drive SoC and server platform performance by characterizing real-world AI/HPC workloads on production silicon, designing microbenchmarks, diagnosing bottlenecks, and translating findings into architectural and system-level optimizations while collaborating with hardware and software teams.
Top Skills: C++CxlInfinibandPciePythonRoceSystemcTlm
2 Months AgoSaved
In-Office
San Diego, CA
114K-171K Annually
Senior level
114K-171K Annually
Senior level
Aerospace • Logistics • Security • Software • Cybersecurity
Design, architect, develop, integrate, test, and administer embedded real-time software for flight and mission-critical systems. Participate throughout the software development lifecycle, collaborate with multidisciplinary Agile teams, resolve system and programming issues, and deliver software products across multiple baselines. The role requires C, C++, Python, RTOS, multithreaded development, software integration and testing, and an active U.S. Secret clearance.
Top Skills: 1553Agile ScrumArinc-429CC++CoverityDevsecopsDiscreteEmbedded SystemsEthernet/IpFortifyGitlabGoogle Unit TestIntegrityJIRAMatlabPythonReal-Time Embedded LinuxRs-232Rs-422RtosRtx 64SerialSimulinkVxworks
2 Months AgoSaved
In-Office
San Diego, CA
160K-190K Annually
Senior level
160K-190K Annually
Senior level
Information Technology • Consulting • Cybersecurity • Defense
Architects and implements secure, scalable Palantir Foundry data solutions for Navy mission stakeholders. Designs ontologies, pipelines, workflows, applications, and dashboards; integrates disparate data sources; ensures data quality, lineage, interoperability, cybersecurity compliance, and accreditation. Translates operational needs into technical solutions, guides development teams, documents architectures and estimates, contributes to RFPs, collaborates with vendors, supports AI/ML integration, and mentors junior staff.
Top Skills: APIsCloud PlatformsPalantir FoundryPythonSQL
2 Months AgoSaved
In-Office
San Diego, CA
114K-213K Annually
Senior level
114K-213K Annually
Senior level
Aerospace • Logistics • Security • Software • Cybersecurity
Develops and tests guidance, navigation, and flight-control algorithms for manned and unmanned aircraft. Responsibilities include designing control laws, modeling aircraft dynamics, integrating software with simulation environments, conducting performance and flying-qualities analyses, supporting hardware-in-the-loop and flight testing, analyzing flight-test data, and preparing technical analyses for design reviews.
Top Skills: CC++Hardware-In-The-Loop SimulationLuaMatlabPythonSimulinkStateflow
2 Months AgoSaved
In-Office
San Diego, CA
165K-200K Annually
Senior level
165K-200K Annually
Senior level
Computer Vision
Own system-level inventory features from definition through customer release. Analyze RFID data with Python, SQL, and BigQuery; write system requirements and acceptance criteria; coordinate validation across hardware, firmware, software, sensors, mobile applications, and cloud analytics; lead triage and debugging; assess subsystem performance; align cross-functional teams; and make release go/no-go decisions.
Top Skills: BigQueryPythonRfidSQL
Reposted 2 Months AgoSaved
In-Office
San Diego, CA
180K-250K Annually
Senior level
180K-250K Annually
Senior level
Transportation • Travel
Lead design and implementation of real-time perception algorithms (detection, tracking, sensor fusion) for embedded maritime vehicles. Integrate ML and classical methods, optimize for embedded/GPU hardware, build tests and simulations, select and evaluate sensors, mentor engineers, and field-test algorithms on USVs.
Top Skills: C++CameraCudaCupyGpuLidarNumbaNumpyOpencvPythonRadarRosScipy
2 Months AgoSaved
In-Office
San Diego, CA
168K-198K Annually
Senior level
168K-198K Annually
Senior level
Cloud • Healthtech • Information Technology
Develop and deliver scalable, distributed SaaS features for a clinical-trial software platform. Responsibilities include architecture and hands-on development, engineering best practices, technology innovation, cross-service and AI-powered feature integration, real-time systems, customer-focused product delivery, and mentoring software engineers. The role collaborates closely with a fast-moving team and contributes to the product roadmap.
Top Skills: AgnoAIAWSAzureCSSDockerExpressGCPHTMLInversifyLlmMicroservicesMicrosoft Office Add-InsMulti-TenancyMySQLNode.jsPostgresPythonReactRedis CacheRestful ServicesSaaSTypescriptUvVite
Reposted 2 Months AgoSaved
In-Office
San Diego, CA
115K-160K Annually
Senior level
115K-160K Annually
Senior level
Aerospace • Information Technology • Cybersecurity • Defense
Design, implement, and maintain enterprise databases (Oracle, SQL Server, PostgreSQL) for mission-critical Navy LVC environments. Optimize performance, manage backup/recovery, replication, clustering, and high-availability solutions. Implement RMF/STIG-compliant security controls, support ATO/accreditation activities, capacity planning, monitoring, and troubleshooting. Ensure compliance with DoD/Navy cybersecurity policies and support system documentation and remediation.
Top Skills: Aws RdsAzure SqlOraclePostgresPowershellPythonRmfSQLSQL ServerStig
Reposted 2 Months AgoSaved
In-Office
San Diego, CA
118K-175K Annually
Senior level
118K-175K Annually
Senior level
Utilities
The Manager of Application Support leads a team of software developers, manages solution architecture, and ensures project alignment with business goals, utilizing Agile methodologies.
Top Skills: .NetAzure DevopsAzure FabricAzure FunctionsAzure Logic AppsJIRAAzurePythonSQL
Reposted 2 Months AgoSaved
In-Office
San Diego, CA
185K-245K Annually
Senior level
185K-245K Annually
Senior level
Aerospace • Hardware • Software • Transportation
The Flight Guidance Engineer will design, implement, and test guidance systems for uncrewed aircraft, integrating them into national airspace systems.
Top Skills: C++Python
Reposted 2 Months AgoSaved
In-Office or Remote
San Diego, CA
215K-300K Annually
Senior level
215K-300K Annually
Senior level
Aerospace • Hardware • Software • Transportation
As a Senior Flight Navigation Engineer, you will define navigation system requirements, analyze sensor solutions, develop sensor models, implement algorithms, and evaluate system performance to integrate uncrewed aircraft into airspace.
Top Skills: CC++Python
Reposted 2 Months AgoSaved
In-Office
San Diego, CA
139K-242K Annually
Senior level
139K-242K Annually
Senior level
Aerospace • Logistics • Security • Software • Cybersecurity
Lead a 10-20 person software team through full SDLC in an Agile environment. Coordinate with systems, test, DevSecOps, and program leads to deliver real-time/mission-critical embedded software, manage performance metrics, and ensure program and functional objectives are met.
Top Skills: Analog I/OAssemblyAtlassian Tool SuiteCC++Data Distribution Service (Dds)DevsecopsDiscrete I/OEthernet/IpFibre ChannelGreen Hills IntegrityJavaJava MicroservicesJIRAMil-Std-1553NoSQLPythonRealtime LinuxRs-232 SerialSonarqubeSQLUmlWind River Vxworks
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Reposted 2 Months AgoSaved
In-Office
San Diego, CA
150K-200K Annually
Senior level
150K-200K Annually
Senior level
Transportation • Travel
As a Senior Electronics Engineer, you'll design and develop reliable hardware systems for autonomous vehicles, balancing speed, reliability, and manufacturability. Responsibilities include electrical design, PCB layout, debugging, and collaborating with cross-functional teams while mentoring junior engineers and analyzing field data for continuous improvement.
Top Skills: Altium DesignerC/C++Python
Reposted 2 Months AgoSaved
In-Office
San Diego, CA
Senior level
Senior level
Hardware • Internet of Things
Design and architect digital subsystems for low-power IoT SoCs, implement RTL (SystemVerilog/Verilog), create testbenches and stimulus, manage multi-clock/power domains and timing closure, integrate security features (TrustZone, Secure Boot, PSA L2), and collaborate cross-functionally to deliver silicon to high-volume production.
Top Skills: AhbApbArm TrustzoneAxiEmbedded ProcessorsObiPsa Certified Level 2PythonSecure BootSoc ArchitectureStatic Timing AnalysisSystemverilogTclTiming ClosureUpfVerilog
Reposted 2 Months AgoSaved
In-Office
San Diego, CA
Senior level
Senior level
Mobile
The role involves designing and simulating RF power amplifiers, with a focus on innovation in CMOS SOI technology for Wi-Fi 7 systems.
Top Skills: CadenceEmxHfssMatlabMomentumPythonRfpro
2 Months AgoSaved
In-Office or Remote
San Diego, CA
182K-250K Annually
Senior level
182K-250K Annually
Senior level
Big Data • Machine Learning • Software • Analytics • Big Data Analytics
Build and productionize data and AI solutions for federal customers using Databricks. Own architecture, design decisions, data pipelines, ML/AI integrations, and user-facing applications. Lead technical delivery, advise customers, integrate client systems, provide training, and collaborate with engineering, product, support, and project teams. Contribute reusable frameworks and best practices while managing complex stakeholder relationships and delivering secure, scalable production systems.
Top Skills: Ai ApisSparkAWSAzureCi/CdDatabricksGCPJavaScriptMl/Ai ModelsMlopsPythonScalaTypescript
Reposted 2 Months AgoSaved
In-Office
San Diego, CA
114K-171K Annually
Senior level
114K-171K Annually
Senior level
Aerospace • Logistics • Security • Software • Cybersecurity
Lead integration of avionics/payload subsystems, resolving integration issues with IPTs and suppliers. Validate sensor performance, use RF test equipment, and support system-level testing. Work full-time on-site, collaborate with lab teams, and comply with required Top Secret/SCI/SAP clearances; travel up to 25% may be required.
Top Skills: CC++Ipv4Ipv6Mil-Std-1553Network AnalyzerPower MeterPythonRf Test EquipmentRs-232Rs-422Spectrum Analyzer
2 Months AgoSaved
In-Office
San Diego, CA
150K-175K Annually
Senior level
150K-175K Annually
Senior level
Aerospace • Defense
Lead build and release engineering: design and maintain CI/CD pipelines, automate reproducible builds and artifact management, integrate security/quality gates, optimize build performance, manage container images and registries, provision build environments with IaC, and produce audit/compliance evidence and runbooks.
Top Skills: AcrAksArgocdArtifactoryAWSAws GovcloudAzureAzure GovernmentBashBazelConanCosignDastDockerEcrEksFluxGitGithub ActionsGitlab CiGradleHelmJenkinsKubernetesMakeNexusPythonSastSbomScaSigstoreTerraform
Reposted 2 Months AgoSaved
In-Office
San Diego, CA
141K-207K Annually
Senior level
141K-207K Annually
Senior level
Healthtech • Biotech • Pharmaceutical
The Advisor Lab Automation Software Engineer will design and implement software integrations for lab automation, focusing on AI-driven processes, while providing technical leadership and mentoring.
Top Skills: Ci/CdDockerFastapiFlaskKubernetesPythonRedis
Reposted 2 Months AgoSaved
In-Office
San Diego, CA
125K-235K Annually
Senior level
125K-235K Annually
Senior level
Aerospace • Logistics • Security • Software • Cybersecurity
Lead survivability engineering activities including signature modeling/analysis (EM, IR, VIS, acoustic), RCS/RF test design and execution, materials/process development, mission systems integration, supplier coordination, and delivering test analysis and design recommendations to reduce system detectability.
Top Skills: C/C++CatiaKnowbellMatlabMethod Of MomentsNxPhysical OpticsPythonRcsRf MeasurementSaberSentriXpatch
Reposted 2 Months AgoSaved
In-Office
San Diego, CA
101K-188K Annually
Senior level
101K-188K Annually
Senior level
Aerospace • Logistics • Security • Software • Cybersecurity
Design, model, test, and analyze component- and system-level survivability across RF, IR, VIS, and acoustic spectrums. Plan and execute RCS/RF tests, develop materials/processes, integrate mission systems, coordinate with designers and suppliers, and deliver test analyses and recommendations to reduce system detectability.
Top Skills: C/C++CatiaKnowbellMatlabMethod Of MomentsNxPhysical OpticsPythonRcsSaberSentriXpatch
Reposted 2 Months AgoSaved
In-Office
San Diego, CA
110K-150K Annually
Senior level
110K-150K Annually
Senior level
Information Technology • Consulting • Cybersecurity • Defense
Engineer tactical communications standards and architectures, analyze system-of-systems interoperability, support SDRs and waveforms, modernize interface specifications, apply MBSE, scripting, AI/ML and automation, and support integration guidance and stakeholder collaboration for DoD customers.
Top Skills: Ai/MlC4IsrCi/Cd PipelinesCmossContainerizationFaceJSONMilitary Communications WaveformsModel-Based Systems Engineering (Mbse)MosaProtobufPythonSoftware-Defined Radio (Sdr)SosaTactical Data LinksXML
Reposted 2 Months AgoSaved
In-Office
San Diego, CA
110K-180K Annually
Senior level
110K-180K Annually
Senior level
Information Technology • Consulting • Cybersecurity • Defense
Design, build, and operationalize secure data pipelines and analytics for Naval and DoD missions. Develop event-streaming and distributed systems, normalize multi-format data, deploy cloud-native and containerized solutions, work with GIS and operational environments, and collaborate with cross-functional teams while meeting shipboard and Navy safety requirements.
Top Skills: AirbyteApache AirflowApache IcebergApache KafkaArcgisAws KinesisAws LambdaAws S3DaskDbtDockerEfsElasticsearchGoKubernetesPandasPostgisPostgresPythonRRabbitMQRdsRedisRustSnowflakeSnsSparkSQLSqsZeromq
Reposted 2 Months AgoSaved
In-Office
San Diego, CA
Senior level
Senior level
Artificial Intelligence • Hardware • Software • Defense • Manufacturing
Develop and maintain software across embedded, systems, and application layers for autonomous maritime platforms. Interface with sensors, actuators, networking, and onboard compute. Design distributed services, improve performance, reliability, and observability, and support lab and field testing alongside cross-functional teams.
Top Skills: Backend ServicesC++Cloud InfrastructureDeployment PipelinesDevice DriversDistributed SystemsEmbedded LinuxGoHardware Communication ProtocolsLinuxNetworkingPythonRosRos2RtosRust
Reposted 2 Months AgoSaved
In-Office
San Diego, CA
158K-289K Annually
Senior level
158K-289K Annually
Senior level
Aerospace • Logistics • Security • Software • Cybersecurity
Lead the Full Stack Software discipline by defining technical vision, governing tools/processes/training, building a community of practice, enabling sector-wide engineering toolchains, resolving technical shortfalls, embedding lessons learned, and improving software engineering KPIs and interoperability across multiple Aeronautics sites. This is a strategic leadership role focused on governance and enablement rather than day-to-day coding.
Top Skills: AnsibleAWSAzureAzure DevopsCesiumjsCSSCypressDockerGitlabGraphQLGrpcHTMLHTTPIstioJavaJavaScriptJenkinsKubernetesMil-Std-1472MongoDBNode.jsNoSQLOciOmsOpenstackPostgisPythonReactRestRmf/Nist 800-53SeleniumSQLStanag 4586TypescriptUciWebglWebsockets
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