Top Senior Python Jobs in San Diego, CA

Design, develop, and maintain enterprise-level toolsets to exploit large operational data sets. Build CI/CD pipelines, collaborate across engineering disciplines (Cloud, Networking, DevSecOps, Test), perform data analysis/predictive trending (including AI/ML), manage databases and containers, interpret ICDs, and support mission-critical, on-site defense systems requiring high security clearance.

Lead DevOps strategy and execution for mission engineering software: own CI/CD pipelines, automation, build/deploy tooling, collaborate with cybersecurity and development teams, apply security/compliance practices, troubleshoot build/deploy issues, and document runbooks. On-site role with travel and SAP clearance requirements.

Design, model, and integrate optical components and lenses for survivability systems. Perform raytrace-based optical design, simulate infrared/visual signatures, build and test hardware in lab and flight, collaborate in IPTs, support requirements, and meet customer goals while maintaining required security clearances.

Lead systems engineering activities for modernization and sustainment programs: develop and verify requirements, manage interfaces, maintain SE artifacts, lead cross-functional teams, manage control accounts and EVMS, oversee HW/SW integration and Agile execution, coordinate stakeholders, perform risk and change management, and ensure technical quality, cost, and schedule adherence.

The Sr. Database Administrator will manage SQL Server databases, perform optimization and troubleshooting, and develop data pipelines using Databricks, focusing on enterprise data platforms.

Lead and grow an engineering team focused on delivering digital health solutions on AWS. Oversee technical direction, code quality, and team development while contributing hands-on to software projects.

Lead development and integration of flight-critical embedded firmware for UAS avionics. Duties include low-level C/C++ development, BSP/HAL ports to new RTOS/hardware, peripheral driver creation, safety and secure-boot features, testing and MISRA compliance, cross-domain troubleshooting, and supporting field deployments and automation tooling using Python and shell scripting.

The AI Architect II leads the modernization of the company’s technology platform by establishing AI architectural standards, integrating AI services, overseeing MLOps practices, and collaborating with stakeholders to design scalable cloud architectures and AI solutions.

The role involves designing, developing, and supporting software for complex electro-mechanical systems in semiconductor manufacturing. Responsibilities include full lifecycle development, troubleshooting, and collaboration across teams.

Lead development and implementation of automated test strategies, frameworks, and test environments for the eLxr Linux distribution. Design, integrate, and verify tests for safety-critical embedded and enterprise systems, mentor engineers, improve tooling and workflows, and collaborate with product and global engineering teams to deliver scalable, high-quality solutions.

Manage and automate enterprise Linux/Unix platforms across on-prem and hybrid VMware environments. Ensure availability, security compliance (SOX/FFIEC), perform patching, tuning, incident (P1/P2) response and RCA. Build Puppet modules for provisioning and drift remediation, script with Bash/Python, support backup/DR (Zerto), and execute changes via ServiceNow while maintaining runbooks and audit-ready documentation.

Senior individual contributor owning Axos Banks Azure platform, identity governance, security posture, cost management, and automation. Design, deploy, and maintain Azure infrastructure and Entra ID; drive security remediation, compliance reporting, cost optimization, and ServiceNow-based change management. Act as technical peer for architecture, support hybrid identity, and enable audited operational discipline for a federally regulated financial institution.

Lead design, implementation, and operation of large-scale, low-latency distributed data platforms and stream processing. Own RTAP architecture, build/optimize services (Flink, Spark, ClickHouse, Druid), integrate batch/stream lakehouse patterns, apply AI tooling to automate platform workflows, mentor engineers, and lead production incident response and reliability improvements.

Lead development, integration, and delivery of modular modeling and simulation software. Provide architecture and technical leadership, ensure verification/validation and model fidelity, optimize performance and CI/CD pipelines, integrate simulation components with system interfaces, and coordinate with systems, hardware, and test teams. On-site role requiring active Top Secret clearance and ability to obtain SAP/PAR.

Design and implement embedded and real-time software for manufacturing cell automation. Integrate industrial cobots, build and operate HIL/SIL/VIL test infrastructure, develop edge agents and hardware abstraction layers, create firmware bring-up and flashing tools, and partner with manufacturing and hardware teams to define automation strategies and validate hardware-software integration.

Design, implement, and support enterprise datacenter and lab network infrastructure (routers, switches, firewalls); monitor and optimize performance; automate deployments; troubleshoot complex network issues; support software integration labs; create and maintain network documentation and standards; collaborate with engineers and technicians. Must hold/obtain required DoD Top Secret/SCI clearance and SAP access.

Lead multiple software engineering teams to design, modernize, and support cloud-native and hybrid trading platforms. Drive AWS cloud modernization, architecture reviews, reliability, automation, and engineering best practices. Partner with product, data, infrastructure, and business stakeholders to deliver scalable, resilient, and high-performance solutions while mentoring teams and monitoring operational metrics.

Lead propulsion development and integration for small piston and micro-turbojet engines across test-stand and flight operations. Own engine selection, calibration, fuel systems, propeller specification, failure investigations, test planning, OEM/vendor interfaces, and documentation to deliver reliable powerplants for sUAS platforms.

Design and maintain end-to-end computer system architectures for defense programs. Integrate emerging technologies, implement engineering changes, configure networks, apply STIGs, support labs, and coordinate with peers and government engineers. Full on-site role with occasional travel.

Design, build, integrate, upgrade, and support enterprise-scale Oracle CPQ and Java-based solutions. Partner with stakeholders, implement integrations and APIs, perform production support, execute upgrades/patches, ensure technical governance, and contribute across the software development lifecycle.

Design, implement, and deliver enterprise Java/JEE solutions and GUIs in an Agile environment. Collaborate with systems engineering, DevSecOps, test automation, and cloud teams across the SDLC. Develop microservices and SOA-based systems, use OOP and design patterns, integrate web services/JMS/XML technologies, and support build/test/release. Must work on-site and meet government security and SAP access requirements.

Maintain and extend C++ swarm code for ground stations and drones, develop swarming algorithms and communication protocols, improve software architecture and engineering processes, and support Python-based ground station web services.

Lead definition, configuration, and management of system and subsystem Interface Control Documents (ICDs). Define hardware, software, and data interfaces, perform functional analysis and verification, coordinate interface working groups, support Agile/Jira workflows, and communicate ICD status, risks, and impacts to leadership and customers.

The Software Engineer will focus on data quality engineering and functional integration, working within an agile team to manage and write test cases based on a large data schema.

The DevOps Consultant will design, implement, and support software applications, manage deployments, and collaborate with engineering teams, requiring strong expertise in automation tools and programming languages.