Top Senior Python Jobs in San Diego, CA

Reposted 2 Months AgoSaved
In-Office
San Diego, CA
234K-351K Annually
Senior level
234K-351K Annually
Senior level
Aerospace • Artificial Intelligence • Machine Learning • Robotics • Software
Design and implement tactical autonomy algorithms and high-performance software for unmanned air/land/sea platforms. Build behavior architectures, integrate classical and learning-based methods, run simulations and field tests, analyze mission data, and support defense programs and deployments.
Top Skills: AfsimC++MlNgtsOms StandardsPythonReinforcement LearningRtosUci Standards
Reposted 2 Months AgoSaved
In-Office
San Diego, CA
173K-259K Annually
Senior level
173K-259K Annually
Senior level
Aerospace • Artificial Intelligence • Machine Learning • Robotics • Software • Defense Technology
Lead and mentor a team integrating and validating the Hivemind autonomy platform across SIL, HIL, and flight environments. Drive architecture and tooling for integration, review logs/telemetry/rosbags, triage cross-system defects, partner with Engineering/Product/Program teams, and ensure capabilities meet product and customer requirements while remaining hands-on in system integration and debugging.
Top Skills: C++Embedded SystemsHardware-In-The-Loop (Hil)Hivemind SdkNetworkingOperating SystemsPythonRadio CommunicationsRosRosbagSoftware-In-The-Loop (Sil)
Reposted 2 Months AgoSaved
In-Office or Remote
San Diego, CA
150K-230K Annually
Senior level
150K-230K Annually
Senior level
Aerospace • Artificial Intelligence • Machine Learning • Robotics • Software
Design and implement full‑stack, low‑latency web-based Ground Control Station and C2 systems (map-centric UIs, real-time telemetry, video streaming), lead architecture and APIs, mentor engineers, support field tests and mission deployments, and ensure interoperability with C2 standards.
Top Skills: A-GraCC++CesiumjsDockerFfmpegGoGstreamerHlsK3DK3SKubernetesLeafletMaplibre GlMavlinkNode.jsOmsOpenapi/SwaggerOpenlayersPostgisPostgresPythonReactRtspSerialization/IdlStanag 4586TcpTypescriptUciUdpWebrtcWebsocket
One Month AgoSaved
In-Office
San Diego, CA
175K-220K Annually
Senior level
175K-220K Annually
Senior level
Aerospace • Defense
Lead Firestorm’s Simulation team and develop a reusable UAS simulation platform supporting aircraft models, sensors, propulsion, flight software, SIL/HIL testing, scenario orchestration, distributed execution, training, and demonstrations. Manage simulation infrastructure, integrations, automated test environments, cross-platform deployment, and team growth. The role requires hands-on software and simulation expertise across complex aircraft, robotics, networking, and hardware systems.
Top Skills: Aircraft SimulationAirsimArdupilotC++Ci/CdFlightgearGazeboHilJsbsimMavlinkNetworkingPx4PythonRoboticsSilUas
Reposted One Month AgoSaved
In-Office
San Diego, CA
180K-260K Annually
Senior level
180K-260K Annually
Senior level
Hardware • Semiconductor • Quantum Computing • Manufacturing
Senior individual-contributor responsible for designing and implementing automated test infrastructure, performing device- and system-level opto-electronic characterization (L-I-V, spectral, beam quality, noise, LIDT), developing validation and environmental test protocols, ensuring regulatory and laser-safety compliance, authoring test documentation, and providing technical leadership and guidance across development and production.
Top Skills: Data AcquisitionInstrument ControlLabviewLock-In AmplifierNetwork AnalyzerOptical Spectrum AnalyzerOscilloscopePower MeterPython
One Month AgoSaved
In-Office
San Diego, CA
131K-237K Annually
Senior level
131K-237K Annually
Senior level
Information Technology • Software
Leads architecture and development for complex, high-performance classified software systems. Oversees development teams, makes architectural decisions, manages software complexity, and supports Agile delivery. Designs, documents, tests, and debugs software; evaluates requirements, cost, schedule, cybersecurity, CI/CD, interfaces, and monitoring strategies. Collaborates with program, integration, testing, and information assurance teams, leads customer technical discussions, and coaches developers.
Top Skills: AgileC++C++17Catch2Clang-FormatClang-TidyCmakeCpplintCryptographyFlawfinderGitGitlab Ci/CdGitlab EnterpriseGoogle Protocol BuffersJetbrains ClionMicrosoft Sql ServerMySQLNngOracle RdbmsOsi ModelsPerlPythonQt/QmlRubyScrumSecurity+SqliteTcp/IpValgrindVcpkgVisual Studio Code
One Month AgoSaved
In-Office
San Diego, CA
143K-196K Annually
Senior level
143K-196K Annually
Senior level
Hardware • Software • Semiconductor
Leads the design, development, integration, testing, and optimization of advanced control and automation systems for ASML’s EUV light source. Develops control algorithms, system identification, signal processing, and optimization solutions; performs laboratory and cleanroom testing; troubleshoots system failures; defines requirements and architectures; supports product roadmaps and verification; and mentors junior engineers. The role also coordinates projects, technical specifications, design reviews, and system improvements using sensor, actuator, software, and data analysis expertise.
Top Skills: CC++MatlabExcelMicrosoft PowerpointMicrosoft WordPythonSimulink
One Month AgoSaved
In-Office
San Diego, CA
202K-224K Annually
Senior level
202K-224K Annually
Senior level
Aerospace • Payments • Security • Transportation • Cybersecurity
Leads complex FPGA and RTL/firmware engineering initiatives for mission-critical defense systems. Provides architecture, technical direction, mentorship, design reviews, testing strategy, integration, performance improvements, and risk mitigation. Develops high-assurance DoD/NSA firmware, collaborates with cross-functional teams and customers, supports technical documentation and briefings, evaluates vendor technologies, and drives engineering process improvements.
Top Skills: Build ScriptsCC++Cdl WaveformsComsecDspFirmwareFixed-Point RtlFpgaHdlIsr DatalinksLinuxMatlabModemNetworking ProtocolsProtected WaveformsPythonRfsocRtlSatcomVersion ControlVhdlXilinx
Reposted 2 Months AgoSaved
Easy Apply
In-Office
San Diego, CA
Easy Apply
157K-224K Annually
Senior level
157K-224K Annually
Senior level
Machine Learning • Security • Software • Analytics • Defense
The Lead Software Engineer will design, implement, and test software for advanced data communications and networking solutions, mentor junior engineers, and lead technical discussions in a fast-paced environment.
Top Skills: CC++Gnu/LinuxMatlabPython
One Month AgoSaved
In-Office
San Diego, CA
230K-323K Annually
Senior level
230K-323K Annually
Senior level
Aerospace
Lead mixed-signal design verification methodology, define co-simulation EDA infrastructure, and develop models for complex system-on-chip designs. Create Verilog and SystemVerilog test benches and behavioral models for analog and mixed-mode circuits, establish block- and chip-level verification methods, support analog and digital teams during model bring-up, and perform analog/mixed-signal simulations.
Top Skills: Cadence VirtuosoCmosEdaFinfetMatlabPythonSystemverilogVerilog
One Month AgoSaved
In-Office
San Diego, CA
135K-273K Annually
Senior level
135K-273K Annually
Senior level
Software • Cybersecurity • Big Data Analytics • Automation
Leads a technical team designing, architecting, integrating, deploying, testing, and operating complex software and hardware systems for DoD and Navy missions. Translates stakeholder requirements into solutions, manages program quality, cost, schedules, and resources, troubleshoots advanced system and network issues, leads field test execution, and collaborates with warfighters, test directors, and government sponsors. Requires active Secret clearance, on-site work in San Diego, and travel up to 25%.
Top Skills: Aegis Weapon SystemC++CecDistributed SystemsHardware SystemsJavaJavaScriptLink-16MatlabNetwork SystemsPythonSoftware SystemsSystems Engineering V-ModelTactical Systems
Reposted One Month AgoSaved
In-Office
San Diego, CA
83K-155K Annually
Senior level
83K-155K Annually
Senior level
Aerospace • Logistics • Security • Software • Cybersecurity
Implement and audit software quality standards across programs, ensure compliance with contractual and process requirements, review designs and tests, support CMMI/AS9100 audits, collect/report software metrics, evaluate suppliers, and witness qualification and acceptance testing.
Top Skills: AgileAs9100CC++CmmiJavaPythonSpiralWaterfall
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One Month AgoSaved
Hybrid
San Diego, CA
130K-200K Annually
Senior level
130K-200K Annually
Senior level
Internet of Things • Semiconductor
Leads digital design verification for IP blocks, subsystems, and full mixed-signal ICs. Develops SystemVerilog/UVM testbenches, verification plans, coverage models, constrained-random and directed tests, regression infrastructure, and CI flows. Performs RTL, gate-level, formal, CDC/RDC, low-power, and mixed-signal verification; debugs failures and supports silicon validation. Collaborates across system, hardware, firmware, analog, test, product, and applications teams while mentoring junior engineers and driving verification methodologies.
Top Skills: ArmCadence XceliumCpfI2CI3CJaspergoldMipiPicPythonRisc-VSiemens QuestaSpiSpyglass CdcSpyglass LintStm32Sv-RnmSynopsys Vc FormalSynopsys VcsSystemverilogUpfUvmVerilogVerilog-Ams
One Month AgoSaved
In-Office
San Diego, CA
Senior level
Senior level
Biotech
Designs, develops, and executes comprehensive testing for C# thick-client, web, cloud, bioinformatics, and hardware-integrated software. Responsibilities include functional, regression, integration, and performance testing; defect tracking in Azure DevOps; test automation; pull request reviews; cross-functional collaboration; and improving QA processes. The role also ensures software quality standards and industry compliance.
Top Skills: AzureAzure DevopsC#Ci/CdGitLinuxNumpyNunitPythonPyTorchScipySeleniumSpecflowVisual StudioWindows
Reposted 2 Months AgoSaved
In-Office
San Diego, CA
190K-290K Annually
Senior level
190K-290K Annually
Senior level
Aerospace • Artificial Intelligence • Machine Learning • Robotics • Software
Develop and integrate core platform software and infrastructure for autonomous systems. Own integration across SIL/HIL/VIL and edge deployment, build reference implementations and tooling, support embedded hardware bring-up, debug Linux-based systems and hardware interfaces, and partner cross-functionally to improve stability, APIs, and scalability.
Top Skills: BootloadersBspC++Device TreesEmbedded LinuxHilI.Mx8JetsonLinuxLogic AnalyzerOscilloscopeProtocol AnalyzerPythonQualcommSilVil
One Month AgoSaved
In-Office
San Diego, CA
165K-220K Annually
Senior level
165K-220K Annually
Senior level
Transportation • Travel
Design and scale backend services for real-time and historical vehicle telemetry, fleet management APIs, customer integrations, and high-volume time-series and geospatial data. Improve system reliability, scalability, observability, and cloud efficiency while handling intermittent connectivity and distributed-system challenges. Collaborate with vehicle software and UI teams, guide backend architecture, lead projects, and mentor engineers.
Top Skills: DockerGoInfluxdbKubernetesMqttPostgisPostgresPythonRestTerraformTimescaledbWebsocket
One Month AgoSaved
In-Office
San Diego, CA
165K-220K Annually
Senior level
165K-220K Annually
Senior level
Transportation • Travel
Own software and vehicle release engineering, including versioning, build artifacts, packaging, staged rollouts, Infrastructure-as-Code, deployment pipelines, rollout monitoring, rollback tooling, and developer workflows. Integrate vehicle software, cloud services, and third-party systems while improving security, reliability, cost efficiency, and production support for maritime robotic fleets.
Top Skills: BashCloudFormationDockerGithub ActionsGoJenkinsKubernetesLinuxPostgresPythonTerraformTime-Series Databases
One Month AgoSaved
In-Office
San Diego, CA
125K-195K Annually
Senior level
125K-195K Annually
Senior level
Aerospace
Designs and validates RF subsystems, schematics, and PCB layouts from UHF through Ka-band. Troubleshoots complex RF circuit boards, develops test procedures, supports manufacturing and system integration, and participates in design reviews, proposals, trade studies, and customer meetings. The role requires expertise in LNAs, power amplifiers, RF simulations, testing, and accelerated product development schedules.
Top Skills: AdsAltiumAwr/MwoCC++EdaEmi/EmcGenesysKa-BandKu-BandMatlabPcbPcbaPythonRfRf SchematicsRf Test EquipmentScriptingTest AutomationUhf
One Month AgoSaved
In-Office
San Diego, CA
100K-135K Annually
Senior level
100K-135K Annually
Senior level
Information Technology
Builds, integrates, and delivers secure software capabilities for regulated government and DoD environments. Responsibilities include software architecture and development, Agile delivery, Git workflows, automated testing, Kubernetes or cloud deployment, DevSecOps security gates, resilient DDIL and afloat/ashore PaaS architectures, and secure Cross-Domain Solutions integration.
Top Skills: C#C++Ci/CdCloud ComputingContainer ScannersCross-Domain SolutionsDastDdilDevsecopsEvent-Driven ArchitectureGitGitflowGoJavaKubernetesMicroservicesNavy AcsOvermatch Software ArmoryPaasPlatform OnePythonSastScaServerlessTrunk-Based DevelopmentUsmc CheVirtualized Environments
Reposted 2 Months AgoSaved
In-Office
San Diego, CA
163K-245K Annually
Senior level
163K-245K Annually
Senior level
Aerospace • Artificial Intelligence • Machine Learning • Robotics • Software
Develop, integrate, and field autonomy capabilities for novel platforms (space, maritime, unmanned helicopters). Own end-to-end integration from software- and hardware-in-the-loop to live tests, partner with platform and cross-functional teams, support on-site testing, debug hardware/software issues, document designs, and improve integration and testing processes.
Top Skills: Autopilot IntegrationC++Ci/CdDockerEmbedded SystemsHivemindsdkLinuxPythonReal-Time SystemsRobotics Frameworks
Reposted 2 Months AgoSaved
In-Office
San Diego, CA
110K-170K Annually
Senior level
110K-170K Annually
Senior level
Aerospace • Artificial Intelligence • Machine Learning • Robotics • Software
Lead development and execution of flight test plans validating autonomy features and integrations. Design operational test scenarios, build analysis and automation tooling, review flight logs/telemetry/rosbags for root-cause, mentor engineers, maintain SOPs, and support flight operations to improve Hivemind platform quality and readiness.
Top Skills: C++C++14C++17Ci/CdGenaiHardware-In-The-Loop (Hil)JSONLinuxNetworkingPythonRadio CommunicationsRosRosbagsSimulation ToolsTypescript
230K-323K Annually
Senior level
Aerospace
Designs, simulates, characterizes, and validates custom mixed-signal and digital interface circuits. Develops Liberty timing models across PVT, slew, load, and parasitic conditions; performs SPICE-based waveform analysis; automates characterization flows; and integrates models with synthesis, implementation, STA, signoff, and verification workflows. Collaborates with analog, digital, physical design, and verification teams while documenting methodologies and mentoring junior engineers.
Top Skills: Ade AssemblerAde ExplorerCadence LiberateCadence VirtuosoCmosDspfEldoExtracted-Netlist SimulationFastspiceFinesimFusion CompilerHspiceInnovusLiberty .LibMonte Carlo AnalysisPerlPrimetimePvt AnalysisPythonShellSkillSolido Characterization SuiteSpectreSpefSpiceStatic Timing AnalysisSynopsys SiliconsmartSystemverilogTclTempusTransistor-Level SimulationVerilogVerilog-AXa
One Month AgoSaved
In-Office
San Diego, CA
139K-208K Annually
Senior level
139K-208K Annually
Senior level
Gaming
Develop and maintain cross-platform build, packaging, and release pipelines for AAA games across consoles and mobile platforms. Bring engines up on new hardware, manage SDK upgrades, resolve low-level crashes and memory issues, and evolve internal tools for profiling, metrics, and data packaging. Lead infrastructure modernization, maintain build automation, and coordinate branch integration across engineering, QA, and production teams.
Top Skills: AndroidAndroid NdkBatch ScriptingBuild AutomationC#C++Code ObfuscationCrash ReportingData-Packaging PipelinesGradleiOSJenkinsMsbuildPerforcePlatform SdksPythonShell ScriptingVisual StudioWinforms
One Month AgoSaved
In-Office
San Diego, CA
140K-180K Annually
Senior level
140K-180K Annually
Senior level
Hardware • Industrial
Defines system requirements and architectures, integrates software onto autonomous vehicles and defense systems, and deploys and validates robotics, sensor, perception, communication, and autonomy systems. The role includes field testing, simulation, troubleshooting, system modeling, cross-functional collaboration, and technical documentation in operationally challenging environments.
Top Skills: APIsArp 4754AC++CamerasDdsDo-178CFaceFcadeLinuxPx4PyramidPythonRadarRosRos 2Simulation EnvironmentsVehicle Autopilots
One Month AgoSaved
In-Office
San Diego, CA
Senior level
Senior level
Security
Develop and integrate software and AI capabilities for expeditionary tactical systems, including sensors, unmanned systems, command-and-control platforms, and TAK. Responsibilities include building Rust and JavaScript applications, integrating machine learning models, managing real-time data meshes and pipelines, converting tactical data formats, testing systems during field experiments, and advising technical leadership. The role requires collaboration with machine learning, data, and systems engineers and supports Department of the Navy technology strategy.
Top Skills: AirbyteAmazon S3Apache AirflowApache IcebergApache KafkaArcgisAws KinesisCsvDbtDockerElasticsearchGoJavaScriptJSONKubernetesOrcParquetPostgisPostgresPythonRabbitMQReactRedisRustSnowflakeTactical Assault Kit (Tak)XMLZenohZeromq
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