Top Senior Python Jobs in San Diego, CA

Leads systems engineering across compute, camera, and radio portfolios, including requirements development, architecture, interface definition, integration, verification, qualification, testing, and lifecycle oversight. Coordinates technical teams, develops specifications and test plans, performs trade studies, and ensures customer requirements are satisfied. The role requires embedded software, flight and ground systems, processor, communications protocol, and technical leadership experience.

Conduct preliminary design, performance analysis, and sizing of advanced manned and unmanned aircraft. Develop and document technical solutions, brief customers, guide design teams, support proposals and business development, and analyze mission, aerodynamic, propulsion, maneuvering, takeoff, and landing performance. The role supports government programs and requires active Secret clearance, Special Program Access eligibility, and travel.

Integrate, modify, test, and maintain mission systems software across the full software development lifecycle. Responsibilities include requirements development, architecture, implementation, hardware-software integration, verification, qualification, deployment, and maintenance. The role supports Agile Scrum teams developing safety-critical embedded real-time software and requires collaboration with systems, hardware, and test engineers. Candidates need experience with C, C++, or Python, RTOS environments, RHEL, software testing, and government clearance requirements.

Lead trajectory prediction and aircraft-response modeling for safety-critical runtime assurance systems. Develop and validate models using Python, simulation, hardware-in-the-loop, and flight-test data. Integrate trajectory behavior with autopilot interfaces, analyze vehicle-state and telemetry data, support flight-test campaigns, and contribute to C/C++ implementation, testing, and debugging. Coordinate with algorithms, software, systems, test, and platform teams while producing validation evidence and algorithm handoff artifacts.

Provides technical leadership for automated testing and verification across autonomy software, machine learning systems, distributed services, simulation environments, hardware-in-the-loop platforms, and GPU infrastructure. Owns test architecture, MLOps quality, CI/CD and continuous training workflows, ML validation, observability, failure triage, scenario-based testing, and scalable Python automation. Collaborates across software, autonomy, data, simulation, and systems engineering teams while governing AI-assisted testing workflows.

Build and operate Forge, a full-stack engineering platform for developing, testing, deploying, and diagnosing AI autonomy capabilities. Design composable user interfaces, typed versioned APIs, backend services, application lifecycle workflows, and AI-agent tool integrations. Ensure consistent behavior across local and remote environments while partnering with simulation, autonomy, ML, infrastructure, security, product, and design teams.

Develop and integrate safety-critical Run-Time Assurance software for autonomous aircraft. Responsibilities include modern C++ development, real-time embedded systems, hardware and simulation integration, HIL and flight testing, interface design, testing, CI, static and dynamic analysis, documentation, traceability, and collaboration across software, systems, test, and platform teams.

Architect, deploy, and operate secure, resilient Oracle Cloud Infrastructure environments. Responsibilities include landing-zone design, Terraform-based infrastructure as code, workload migration, CI/CD, Kubernetes operations, observability, incident response, security, cost optimization, and support for Oracle and non-Oracle workloads. The engineer will collaborate with database, application, and security teams to deliver mission-critical cloud platforms.

Lead hands-on development of enterprise-grade Python applications, data-intensive services, and automation platforms. Responsibilities include system design, application development, database design and query tuning, automated testing, debugging, production support, reliability improvements, secure coding, and CI/CD practices. The role partners with product, data, and infrastructure teams, manages multiple projects, and mentors teams through strong technical and business communication.

Integrate and verify autonomy software on aircraft hardware across SIL, HIL, ground, and flight-test environments. Develop test plans, test cards, schedules, and automation; identify and resolve interface, timing, protocol, and hardware/software integration gaps. Coordinate with aircraft vendors, configure test benches, troubleshoot anomalies, assess flight readiness, and analyze post-flight data. The role requires Linux and Python proficiency, cross-functional coordination, periodic travel, and eligibility for a U.S. DoD SECRET clearance.

Performs structural analysis and testing for advanced UAV airframes and components. Builds finite element models, conducts static, modal, fatigue, vibration, and shock analyses, validates results through hand calculations, and analyzes telemetry and test data. Collaborates with engineering teams to optimize lightweight composite and metallic structures for strength, weight, safety, and manufacturability. Documents technical findings and supports structural test planning, certification, and continuous improvement of analysis methods.

Develop and optimize low-level C/C++ firmware for avionics, flight controllers, mission payloads, and embedded subsystems. Port software to new hardware and RTOS platforms, create drivers and BSPs, integrate safety and reliability features, and perform testing and fault diagnosis. Collaborate across hardware, networking, RF, and manufacturing teams to support UAS development, field integration, and deployment. Produce technical specifications, test plans, integration documentation, and troubleshooting guides.

Build low-latency, high-reliability trading, risk, and analytics systems for fintech applications. Translate quantitative models into production software, collaborate with quants and traders, implement market data and FIX systems, and optimize performance through concurrency, profiling, debugging, and high-performance computing. The role also includes code and design reviews, stakeholder collaboration, documentation, and mentoring junior engineers.

Design, build, and integrate software for autonomous robots across the full robotics stack. Responsibilities include sensor integration, perception, localization, motion planning, control, behavioral systems, sensor fusion, real-time debugging, simulation, field testing, and hardware integration. The role also involves cross-functional collaboration, code and design reviews, production delivery, technical documentation, and mentoring junior engineers.

Designs, builds, and improves test automation frameworks and production-quality test code across unit, integration, end-to-end, performance, and security testing. Partners with cross-functional teams to embed quality throughout the software development lifecycle, validates APIs and databases, supports CI/CD automation, and works with distributed systems and modern web architectures. The role also involves code and design reviews, debugging, documentation, communication, and mentoring junior engineers.

Operate and support enterprise PLM platforms, including installation, configuration, upgrades, migrations, integrations, performance tuning, and high availability/disaster recovery. Partner with engineering, manufacturing, and functional teams to maintain a reliable and secure PLM ecosystem. Required expertise includes Windchill or Teamcenter, database and Linux administration, scripting, troubleshooting, and PLM middleware. Cloud, infrastructure-as-code, CI/CD, certification, and large-scale CAD integration experience are preferred.

Designs, implements, and maintains CI/CD pipelines, GitOps workflows, Kubernetes infrastructure, and automated software deployment systems across on-premises and public cloud environments. Manages containerization, infrastructure as code, observability, security scanning, API deployment automation, and developer tooling. Collaborates with development and operations teams, recommends technology improvements, documents processes, and trains IT staff. The role is fully onsite in San Diego and requires up to 10% domestic travel.

Develop and maintain C++ and Python software for distributed, hard- and soft-real-time control systems. Responsibilities include designing modular solutions, integrating complex hardware and communication protocols, conducting unit and on-target testing, evaluating technical risks, gathering requirements, and supporting the full software development lifecycle. The role involves collaboration with architects and cross-functional engineers, continuous process improvement, and potential AI integration. Work is primarily onsite in San Diego and may require cleanroom access.

Designs, deploys, and operates secure, resilient Azure cloud platforms and production workloads. Responsibilities include cloud architecture, infrastructure as code, automation, security hardening, cost optimization, observability, AKS cluster operations, CI/CD, troubleshooting, and operational excellence. Partners with application development, security, and SRE teams to deliver scalable, reliable, and compliant cloud-native solutions.

Designs and builds end-to-end Industrial IoT systems spanning factory-floor edge devices, industrial protocols, secure connectivity, cloud ingestion, real-time analytics, and operational dashboards. Develops production-quality software, integrates OT and IT environments, troubleshoots systems, participates in design and code reviews, communicates with cross-functional stakeholders, and mentors junior engineers. Preferred experience includes digital twins, predictive maintenance machine learning, time-series databases, and Unified Namespace patterns.

Design and build software tooling, firmware, and infrastructure supporting semiconductor design, verification, manufacturing, and post-silicon validation. Collaborate with hardware and EDA teams, develop scalable compute infrastructure and data pipelines, automate workflows, debug complex systems, and translate ambiguous requirements into production-quality solutions. The role also involves code and design reviews, cross-functional communication, documentation, and mentoring junior engineers.

Develop MBSE artifacts, technical requirements, system models, interfaces, specifications, and verification plans for aerospace modernization and sustainment programs. Collaborate across integrated product teams, engineering disciplines, stakeholders, and customers; maintain configuration-controlled systems engineering artifacts; and communicate technical analyses and recommendations. The role requires Secret and SAP clearance eligibility, requirements management experience, Python or scripting, DOORS, and MBSE expertise.

Build and operate Kubernetes-native platform services and distributed orchestration capabilities supporting AI workloads across cloud, on-premises, edge, sovereign, and air-gapped environments. Design production software, data-processing infrastructure, observability, deployment patterns, and operational standards. Establish reference architectures, reliability practices, benchmarks, and recovery procedures while partnering with autonomy, ML, simulation, infrastructure, and product teams. Provide hands-on technical leadership in distributed systems architecture, implementation, troubleshooting, performance analysis, and platform reliability.

Designs, deploys, maintains, and supports datacenter, LAN, WAN, VPN, routing, switching, and firewall infrastructure. Provides Tier III troubleshooting, network performance and security monitoring, vulnerability remediation, capacity planning, automation, documentation, and change management. Leads technical projects, supports maintenance and upgrades, coordinates vendors, trains operations teams, and provides occasional after-hours on-call support. The role is hybrid after 90 days onsite and requires occasional travel.

Leads and mentors engineers developing, integrating, testing, deploying, and operating complex DoD software and hardware systems. Defines requirements, architects solutions, manages program execution, troubleshoots system and network issues, and coordinates field test events. The role works directly with Navy warfighters, test directors, and government sponsors while ensuring quality, cost, schedule, and operational objectives. Travel up to 25% is required, along with eligibility to obtain and maintain an active Secret clearance.