Top Senior Python Jobs in San Diego, CA

Reposted 4 Days AgoSaved
Hybrid
San Diego, CA
114K-171K Annually
Senior level
114K-171K Annually
Senior level
Aerospace • Artificial Intelligence • Machine Learning • Robotics • Software
Design, build, and scale automated test frameworks and CI/CD infrastructure for distributed autonomy software. Develop Python tooling, GitLab CI pipelines, UI/API tests (Go/TypeScript), HIL simulators, and AI-assisted workflows. Integrate testing across simulation, edge, cloud, and hardware; analyze failures; improve coverage, observability, and verification for safety- and mission-critical aerospace systems.
Top Skills: C++Claude CodeCodexConanGitlab CiGoHardware-In-The-Loop (Hil)LinuxLlm PlatformsNixPipPoetryPythonSetuptoolsShell ScriptingTypescriptYaml
Reposted 4 Days AgoSaved
In-Office or Remote
San Diego, CA
150K-230K Annually
Senior level
150K-230K Annually
Senior level
Aerospace • Artificial Intelligence • Machine Learning • Robotics • Software
Design and implement full‑stack, low‑latency web-based Ground Control Station and C2 systems (map-centric UIs, real-time telemetry, video streaming), lead architecture and APIs, mentor engineers, support field tests and mission deployments, and ensure interoperability with C2 standards.
Top Skills: A-GraCC++CesiumjsDockerFfmpegGoGstreamerHlsK3DK3SKubernetesLeafletMaplibre GlMavlinkNode.jsOmsOpenapi/SwaggerOpenlayersPostgisPostgresPythonReactRtspSerialization/IdlStanag 4586TcpTypescriptUciUdpWebrtcWebsocket
Reposted 4 Days AgoSaved
Easy Apply
In-Office or Remote
San Diego, CA
Easy Apply
175K-240K Annually
Senior level
175K-240K Annually
Senior level
Machine Learning • Security • Software • Analytics • Defense
Lead full-stack mission engineering: design, build, deploy, and integrate secure software for DoD/IC missions. Lead engineering teams, collaborate with military/government users, prototype MVPs, perform field deployment and testing, and deliver high-performance, user-focused interfaces.
Top Skills: APIsPythonReactTypescript
Reposted 4 Days AgoSaved
Hybrid
San Diego, CA
124K-280K Annually
Senior level
124K-280K Annually
Senior level
Artificial Intelligence • Professional Services • Business Intelligence • Consulting • Cybersecurity • Generative AI
Lead enterprise-scale cloud modernization and migration programs to AWS, design end-to-end architectures (including AI agent integration), define AI-native engineering standards, mentor engineering teams, implement IaC and CI/CD, enforce security and governance, and deliver measurable business value through technical strategy and execution.
Top Skills: AngularApi GatewayAWSAws CdkBedrock Agent SdkCi/CdClaude Agent SdkClaude CodeCloudFormationCloudfrontCloudtrailCloudwatchCodepipelineCodexCognitoCursorDmsDockerDynamoDBEc2EcsEksGithub ActionsGithub CopilotIamJavaJenkinsKiroKubernetesLambdaLangchainMigration HubNode.jsPythonRdsReactS3SctTerraformVueX-Ray
Reposted 4 Days AgoSaved
Hybrid
San Diego, CA
99K-232K Annually
Senior level
99K-232K Annually
Senior level
Artificial Intelligence • Professional Services • Business Intelligence • Consulting • Cybersecurity • Generative AI
Lead and manage software engineering teams to design, build, and integrate enterprise applications. Drive coding, testing, code review, CI/CD practices, and mentor staff while overseeing project planning, budgeting, and client delivery to meet timelines and quality standards.
Top Skills: Acceptance Test Driven Development (Atdd)Api ManagementC++Ci/CdJavaJavaScriptPython
Reposted 7 Days AgoSaved
Easy Apply
In-Office
San Diego, CA
Easy Apply
157K-224K Annually
Senior level
157K-224K Annually
Senior level
Machine Learning • Security • Software • Analytics • Defense
The Lead Software Engineer will design, implement, and test software for advanced data communications and networking solutions, mentor junior engineers, and lead technical discussions in a fast-paced environment.
Top Skills: CC++Gnu/LinuxMatlabPython
Reposted 7 Days AgoSaved
In-Office
San Diego, CA
195K-350K Annually
Senior level
195K-350K Annually
Senior level
Aerospace • Artificial Intelligence • Machine Learning • Robotics • Software
Serve as the primary interface between perception software and flight test teams to integrate, deploy, and validate autonomy/perception algorithms on edge hardware. Lead sensor selection, calibration, time synchronization, test planning and execution, data quality management, and analysis to mature perception capabilities from algorithm to flight-verified system.
Top Skills: A-Pnt SensorsC++Camera-Imu CalibrationEmbedded LinuxEo/Ir SensorsHivemind PilotNvidia JetsonPython
Reposted 8 Days AgoSaved
In-Office
San Diego, CA
190K-290K Annually
Senior level
190K-290K Annually
Senior level
Aerospace • Artificial Intelligence • Machine Learning • Robotics • Software
Develop and integrate core platform software and infrastructure for autonomous systems. Own integration across SIL/HIL/VIL and edge deployment, build reference implementations and tooling, support embedded hardware bring-up, debug Linux-based systems and hardware interfaces, and partner cross-functionally to improve stability, APIs, and scalability.
Top Skills: BootloadersBspC++Device TreesEmbedded LinuxHilI.Mx8JetsonLinuxLogic AnalyzerOscilloscopeProtocol AnalyzerPythonQualcommSilVil
Reposted 10 Days AgoSaved
In-Office
San Diego, CA
163K-245K Annually
Senior level
163K-245K Annually
Senior level
Aerospace • Artificial Intelligence • Machine Learning • Robotics • Software
Develop, integrate, and field autonomy capabilities for novel platforms (space, maritime, unmanned helicopters). Own end-to-end integration from software- and hardware-in-the-loop to live tests, partner with platform and cross-functional teams, support on-site testing, debug hardware/software issues, document designs, and improve integration and testing processes.
Top Skills: Autopilot IntegrationC++Ci/CdDockerEmbedded SystemsHivemindsdkLinuxPythonReal-Time SystemsRobotics Frameworks
Reposted 10 Days AgoSaved
In-Office
San Diego, CA
110K-170K Annually
Senior level
110K-170K Annually
Senior level
Aerospace • Artificial Intelligence • Machine Learning • Robotics • Software
Lead development and execution of flight test plans validating autonomy features and integrations. Design operational test scenarios, build analysis and automation tooling, review flight logs/telemetry/rosbags for root-cause, mentor engineers, maintain SOPs, and support flight operations to improve Hivemind platform quality and readiness.
Top Skills: C++C++14C++17Ci/CdGenaiHardware-In-The-Loop (Hil)JSONLinuxNetworkingPythonRadio CommunicationsRosRosbagsSimulation ToolsTypescript
Reposted 10 Days AgoSaved
Hybrid
San Diego, CA
133K-226K Annually
Senior level
133K-226K Annually
Senior level
Aerospace • Hardware • Information Technology • Security • Software • Cybersecurity • Defense
Lead a DevSecOps team to design, implement, and maintain on-premises and cloud infrastructure with a focus on security, CI/CD, automation, containerization, monitoring, troubleshooting, and stakeholder collaboration in a fast-paced defense environment. Requires improving processes, disaster recovery, and ensuring system scalability and reliability.
Top Skills: Air-Gapped EnvironmentsAnsibleAws GcBashChefCi/CdContainerizationDockerDocker SwarmElk StackGitlabKubernetesLinux/UnixNagiosPowershellPrometheusPuppetPythonRancherVirtualization
Reposted 10 Days AgoSaved
Hybrid
San Diego, CA
130K-222K Annually
Senior level
130K-222K Annually
Senior level
Aerospace • Hardware • Information Technology • Security • Software • Cybersecurity • Defense
Lead design verification for FPGA/ASIC signal-processing and control systems: plan and build SystemVerilog/UVM/OVM/VHDL self-checking, constrained-random testbenches; develop test plans; collect/analyze coverage; create reusable VIP; lead and mentor DV teams; drive process improvements and execute schedules.
Top Skills: AsicBitbucketC++CadenceFpgaGitJavaJIRAMatlabMentor QuestaOvmPerlPythonSimulinkSystemverilogUvmVhdl
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Reposted 12 Days AgoSaved
Easy Apply
In-Office
San Diego, CA
Easy Apply
175K-240K Annually
Senior level
175K-240K Annually
Senior level
Machine Learning • Security • Software • Analytics • Defense
Lead DevOps engineer responsible for designing, building, and maintaining CI/CD pipelines and infrastructure across unclassified and classified environments. Support cloud toolsets, manage Kubernetes clusters, ensure security/compliance with DoD standards, liaise with corporate IT, coach teams on DevOps best practices, and operate in a hybrid setting with regular on-site access to government facilities.
Top Skills: AnsibleArgocdArtifactoryAWSAzureBash/Linux ShellChefCoverityDockerEksFluxGitlabGitlab CiGCPJIRAKubernetesNexusPodmanPythonRancherSonarqubeTerraform
Reposted 16 Days AgoSaved
In-Office
San Diego, CA
150K-220K Annually
Senior level
150K-220K Annually
Senior level
Aerospace • Artificial Intelligence • Machine Learning • Robotics • Software
Lead technical strategy and implementation of V-BAT fleet data analysis pipelines and tooling. Transform raw flight, simulation, and production data into metrics, dashboards, and reports; perform fleet-wide studies, anomaly investigations, and root-cause analysis; partner with cross-functional teams and mentor engineers on analysis best practices.
Top Skills: Cloud StorageData CatalogingData LakeDatabasesJupyterMatlabPythonTelemetry SystemsTime-Series Databases
21 Days AgoSaved
In-Office
San Diego, CA
160K-240K Annually
Senior level
160K-240K Annually
Senior level
Aerospace • Artificial Intelligence • Machine Learning • Robotics • Software
Design, implement, and deploy autonomy capabilities for space platforms including distributed optimization, tasking/scheduling, track fusion, RPO, and motion/behavior planning. Build high-performance, well-tested software modules, collaborate across perception, planning, simulation, hardware, and flight test teams, support deployments and mission log analysis, and contribute R&D and roadmaps to advance autonomy for satellites and missile defense.
Top Skills: AfsimC++NgtsPythonRtosUnmanned System Technologies
21 Days AgoSaved
In-Office
San Diego, CA
188K-281K Annually
Senior level
188K-281K Annually
Senior level
Aerospace • Artificial Intelligence • Machine Learning • Robotics • Software
Lead development of autonomy capabilities for space platforms including distributed optimization, tasking/scheduling, track fusion, RPO and motion planning. Build high-performance, well-tested software, integrate on real vehicles, support deployments and testing, and research/roadmap advanced autonomy techniques for defense applications.
Top Skills: AfsimC++NgtsPythonRtos
21 Days AgoSaved
In-Office
San Diego, CA
221K-331K Annually
Senior level
221K-331K Annually
Senior level
Aerospace • Artificial Intelligence • Machine Learning • Robotics • Software
Lead development of space autonomy capabilities including distributed optimization, tasking/scheduling, track fusion, rendezvous/RPO, and motion/behavior planning. Build high-performance, testable software, integrate and validate on real platforms, support deployments, and mentor engineers while contributing R&D and roadmaps.
Top Skills: AfsimC++Information FusionMlMotion PlanningNgtsOptimizationPythonRlRtosTrajectory Design
21 Days AgoSaved
Hybrid
San Diego, CA
118K-201K Annually
Senior level
118K-201K Annually
Senior level
Aerospace • Hardware • Information Technology • Security • Software • Cybersecurity • Defense
Senior systems administrator responsible for installing, configuring, monitoring, and securing Windows and Linux servers, virtualization, backup/disaster recovery, cloud identity (Azure AD), automation with PowerShell/Bash/Python, endpoint management, and Tier 1/2 support. Mentor junior admins, maintain documentation, support audits and compliance, and participate in incident response and maintenance activities.
Top Skills: Active DirectoryBackup And Disaster RecoveryBashDhcpDnsEncryption TechnologiesEndpoint ManagementEndpoint SecurityGroup PolicyMicrosoft Entra Id (Azure Ad)PowershellPythonRed Hat Enterprise LinuxRocky LinuxUbuntuVmware HorizonVmware VsphereVulnerability Management PlatformsWindows Server
22 Days AgoSaved
In-Office
San Diego, CA
170K-250K Annually
Senior level
170K-250K Annually
Senior level
Aerospace • Artificial Intelligence • Machine Learning • Robotics • Software
Senior technical lead for unmanned systems (UxS) integration and test readiness. Hands-on role integrating autonomy software with aircraft, onboard compute, radios, sensors, and ground equipment; leading platform evaluation, bench and field bring-up, troubleshooting, test execution, readiness criteria, and mentoring cross-functional teams to improve hardware-based autonomy validation and demonstrations.
Top Skills: ArdupilotBashEmbedded SystemsLinuxMatlabMavlinkMission PlannerNetworkingPixhawk/Cube-Class Flight ControllersPx4PythonQgroundcontrol
23 Days AgoSaved
In-Office
San Diego, CA
120K-180K Annually
Senior level
120K-180K Annually
Senior level
Aerospace • Artificial Intelligence • Machine Learning • Robotics • Software
Lead integration of autonomy software onto diverse platforms by designing and implementing interfaces between autonomy, vehicle subsystems, sensors, payloads, and communications. Configure Linux mission environments, middleware, containers, and deployment pipelines; support SIL/HIL/VIL validation, field tests, demonstrations, troubleshooting, and cross-team coordination while mentoring junior engineers.
Top Skills: ArdupilotC++Ci/CdContainersLinuxMiddlewarePx4PythonRosRtos
23 Days AgoSaved
Hybrid
San Diego, CA
133K-226K Annually
Senior level
133K-226K Annually
Senior level
Aerospace • Hardware • Information Technology • Security • Software • Cybersecurity • Defense
Lead design, implementation, and maintenance of on-premises and cloud infrastructure, build CI/CD pipelines, automate provisioning and configuration, monitor and optimize system performance, enforce DevSecOps security practices, troubleshoot production incidents, and collaborate with cross-functional teams to improve reliability and scalability.
Top Skills: AnsibleAws Gc (Govcloud)BashChefDockerDocker SwarmElkGitlabKubernetesLinuxNagiosPowershellPrometheusPuppetPythonRancherUnixVirtualization
23 Days AgoSaved
Hybrid
San Diego, CA
133K-226K Annually
Senior level
133K-226K Annually
Senior level
Aerospace • Hardware • Information Technology • Security • Software • Cybersecurity • Defense
Lead and develop on-premises and cloud platform infrastructure with a focus on security, scalability, and performance. Build and maintain CI/CD pipelines, automate provisioning/configuration, monitor systems, troubleshoot incidents, and implement DevSecOps best practices across containerized and air-gapped environments while collaborating with cross-functional teams.
Top Skills: Air-Gapped EnvironmentsAnsibleAws GcBashChefCloud ServicesDockerDocker SwarmElkGitlabKubernetesLinuxNagiosPowershellPrometheusPuppetPythonRancherUnixVirtualization
23 Days AgoSaved
Hybrid
San Diego, CA
133K-226K Annually
Senior level
133K-226K Annually
Senior level
Aerospace • Hardware • Information Technology • Security • Software • Cybersecurity • Defense
Lead design, implementation, and maintenance of on-premises infrastructure and CI/CD pipelines. Automate provisioning and configuration, monitor performance, troubleshoot production incidents, enforce security best practices, and collaborate with cross-functional teams to ensure scalable, reliable, and secure DevSecOps processes in a hybrid environment.
Top Skills: Air Gapped EnvironmentsAnsibleAws GcBashChefCi/CdCloud ServicesContainer OrchestrationDockerDocker SwarmElk StackGitlabKubernetesLinux/UnixNagiosPowershellPrometheusPuppetPythonRancherVirtualization
23 Days AgoSaved
Hybrid
San Diego, CA
133K-226K Annually
Senior level
133K-226K Annually
Senior level
Aerospace • Hardware • Information Technology • Security • Software • Cybersecurity • Defense
Lead design, implementation, and maintenance of on-prem and cloud (air-gapped/GovCloud) infrastructure. Build and maintain CI/CD pipelines, automate provisioning/configuration, monitor and optimize system performance, enforce DevSecOps security practices, troubleshoot production incidents, and collaborate with cross-functional teams to improve scalability, reliability, and deployment processes.
Top Skills: Air-Gapped EnvironmentsAnsibleAws Govcloud (Aws Gc)BashChefCi/CdDockerDocker SwarmElk StackGitlabKubernetesLinuxNagiosPowershellPrometheusPuppetPythonRancherUnixVirtualization
Reposted 26 Days AgoSaved
Hybrid
San Diego, CA
198K-268K Annually
Senior level
198K-268K Annually
Senior level
Artificial Intelligence • Internet of Things • Semiconductor
Drive SoC and server platform performance by characterizing real-world AI/HPC workloads on production silicon, designing microbenchmarks, diagnosing bottlenecks, and translating findings into architectural and system-level optimizations while collaborating with hardware and software teams.
Top Skills: C++CxlInfinibandPciePythonRoceSystemcTlm
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