Top Senior Python Jobs in San Diego, CA

Reposted 6 Days AgoSaved
In-Office
San Diego, CA
160K-237K Annually
Senior level
160K-237K Annually
Senior level
Artificial Intelligence • Automotive • Semiconductor
The role involves designing, developing, and verifying complex micro-architecture and RTL for power management ICs while mentoring junior engineers and improving methodologies.
Top Skills: AxiCxlDdrEthernetPciePerlPythonSystemverilogTclUnix Shell
Reposted 6 Days AgoSaved
Remote or Hybrid
San Diego, CA
140K-230K Annually
Senior level
140K-230K Annually
Senior level
Aerospace • Defense
The engineer designs and implements software for manufacturing automation, integrates robotics, develops testing infrastructure, and ensures software-hardware interaction in production settings.
Top Skills: CC++Linux-Based Embedded SystemsPythonReal-Time Operating SystemsRos 2
Reposted 7 Days AgoSaved
In-Office
San Diego, CA
150K-203K Annually
Senior level
150K-203K Annually
Senior level
Artificial Intelligence • Information Technology • Machine Learning • Marketing Tech • Software • Biotech • Design
The Senior Manufacturing Test Engineer leads the development and optimization of manufacturing test solutions, collaborates with cross-functional teams, and drives quality improvements for Oura products.
Top Skills: CC++PythonRust
Reposted 7 Days AgoSaved
In-Office
San Diego, CA
115K-185K Annually
Senior level
115K-185K Annually
Senior level
Information Technology
The Lead Systems Engineer manages the Waveform System Team, conducts systems analysis, integration and test for wireless communication technologies, and ensures staff training and efficient verification.
Top Skills: CPythonRest ApiShellSQL
Reposted 7 Days AgoSaved
In-Office or Remote
San Diego, CA
184K-233K Annually
Senior level
184K-233K Annually
Senior level
Information Technology
The Senior Staff Software Engineer will design and develop scalable cloud backend services, lead architectural efforts, and collaborate on frontend and mobile applications, ensuring high standards for code quality and delivery.
Top Skills: AWSAws CdkCC++JavaScriptNode.jsPostgresPythonReactReact NativeRustTcp/Ip
8 Days AgoSaved
In-Office
San Diego, CA
79-119 Annually
Senior level
79-119 Annually
Senior level
Gaming
Design, architect, and implement full-stack web applications and RESTful APIs; define data models and manage databases; build responsive React front-ends; create documentation; provide task estimates; participate in on-call rotation and ensure performance, scalability, and maintainability.
Top Skills: AnsibleAWSCi/CdDockerGoJavaJenkinsKubernetesNoSQLPythonReactRelational DatabasesRest ApiTerraform
8 Days AgoSaved
In-Office
San Diego, CA
100K-165K Annually
Senior level
100K-165K Annually
Senior level
Information Technology
Extend and maintain a Python-based test automation framework for advanced radio systems: develop automated test cases, RF measurement automation, CI/CD test workflows, validation scripts for wireless protocols, debug and optimize test suites, and build data collection and reporting capabilities while collaborating with test and software teams in lab environments.
Top Skills: BashCi/CdDockerEmbedded LinuxGitJIRANetwork AnalyzersOopPytestPythonScpiSerialSignal GeneratorsSocket ProgrammingSpectrum AnalyzersSQLSshTcp/IpUdpUnittestVisaWireshark
Reposted 8 Days AgoSaved
In-Office
San Diego, CA
227K-336K Annually
Senior level
227K-336K Annually
Senior level
Artificial Intelligence • Automotive • Semiconductor
The Senior Director of Design Verification will develop SystemVerilog/UVM environments for complex SoCs, build teams, and enhance verification methodologies to ensure successful project deliverables.
Top Skills: Ai ToolsPythonQuestaSystemverilogUvmVcsXcelium
Reposted 8 Days AgoSaved
In-Office
San Diego, CA
145K-184K Annually
Senior level
145K-184K Annually
Senior level
Information Technology
The Senior QA Automation Engineer will validate complex systems across cloud services and IoT hardware, design test cases, and develop automated scripts to ensure product quality.
Top Skills: AWSIotNode.jsPython
Reposted 9 Days AgoSaved
In-Office
San Diego, CA
95K-165K Annually
Senior level
95K-165K Annually
Senior level
Aerospace • Defense
The Senior Flight Test Engineer will lead flight testing for UAVs, design test plans, conduct analysis, ensure safety, and collaborate with engineering teams.
Top Skills: C++MatlabPythonSimulink
9 Days AgoSaved
Hybrid
San Diego, CA
Senior level
Senior level
Financial Services
Design, develop, and maintain PEGA-based low-code/no-code solutions for Branch Operations. Lead technical discovery, troubleshoot production issues, coordinate releases, mentor junior developers, produce SDLC documentation, and optimize existing applications while collaborating with stakeholders, governance, and cross-functional teams.
Top Skills: ItilJavaLow-CodeMavenExcelMicrosoft PowerpointMicrosoft WordNo-CodePegaPython
9 Days AgoSaved
Hybrid
San Diego, CA
Senior level
Senior level
Artificial Intelligence • Software • Automation • Manufacturing
Design and implement backend services in Python with PostgreSQL, expose GraphQL APIs for AI agents and real-time frontends, optimize DB performance, contribute to CI/CD and Docker deployments, and enable real-time orchestration across human and AI agents.
Top Skills: Ci/CdDockerFastapiGraphQLPostgresPython
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9 Days AgoSaved
Hybrid
San Diego, CA
Senior level
Senior level
Artificial Intelligence • Software • Automation • Manufacturing
Build and operate GovCloud production infrastructure and Kubernetes clusters, own GitOps CI/CD, observability, security/compliance (SOC2/CMMC/FedRAMP), contribute backend code (Python/TypeScript), and improve developer experience and resilience.
Top Skills: ArgocdAws (EksAws Load Balancer ControllerCert-ManagerCucumberEcrEnvoy GatewayExternal DnsExternal Secrets OperatorFastapiFluent BitGithub ActionsGitopsGovcloud)GrafanaHelmIamKarpenterKubernetesLinuxLocustLokiOidcPlaywrightPostgresPrometheusPythonRdsSecrets ManagerShell ScriptingSqlalchemyTempoTemporalTypescriptVpc
9 Days AgoSaved
Hybrid
San Diego, CA
Senior level
Senior level
Artificial Intelligence • Software • Automation • Manufacturing
Design and implement modern frontend features and UI for an AI-native ERP using Next.js, React, and TailwindCSS. Build structured chat interfaces, real-time dashboards and tables, integrate GraphQL and client-side state, support streaming updates and collaborative UX, and partner with design and product to optimize performance, accessibility, and developer velocity.
Top Skills: FastapiGraphQLJestLlm/Agentic AiNext.JsPlaywrightPythonReactTailwindcssTypescript
9 Days AgoSaved
In-Office
San Diego, CA
Senior level
Senior level
Hardware • Information Technology • Virtual Reality • Wearables
Lead and execute cross-disciplinary engineering for humanoid lab robots as a player-coach: plan priorities with the CTO, run sprints and reviews, unblock teams, hire and grow engineers, and spend ~30–40% of time writing and shipping code across hardware, software, and ML systems.
Top Skills: Can BusGenerative AiLlmsMachine LearningNext.JsPythonReal-Time Control SystemsRobotics MiddlewareRust
9 Days AgoSaved
In-Office
San Diego, CA
Senior level
Senior level
Hardware • Information Technology • Virtual Reality • Wearables
Design, build, and iterate on mechatronic subsystems for a bimanual mobile manipulator. Work across mechanical, electrical, control, perception, and software stacks to integrate sensors, actuators, and real-time control; develop motion and force-control algorithms; validate robot skills in clinical lab environments; and collaborate with scientists to meet lab requirements.
Top Skills: 3D PrintingCadCamerasCollision/Obstacle AvoidanceDepth SensorsForce ControlForce/Torque SensorsGenerative AiImusLlmsMotion PlanningMotor ControllersNext.JsObject DetectionPower ElectronicsPythonReal-Time SystemsRustTactile Sensors/ArraysTrajectory Execution
Reposted 9 Days AgoSaved
In-Office
San Diego, CA
125K-175K Annually
Senior level
125K-175K Annually
Senior level
Hardware • Semiconductor • Quantum Computing • Manufacturing
The Optical Systems Engineer designs and executes testing for photonic systems, mentors junior engineers, and collaborates on risk assessment and system design.
Top Skills: Ansys Zemax OpticstudioLabviewLambda Research OsloOptical EngineeringPhoton Engineering FredPython
Reposted 9 Days AgoSaved
In-Office
San Diego, CA
125K-175K Annually
Senior level
125K-175K Annually
Senior level
Hardware • Semiconductor • Quantum Computing • Manufacturing
The Optical Engineer will execute complex engineering tasks, mentor junior engineers, and ensure the accuracy of execution schedule and data quality while engaging with team members and leadership.
Top Skills: Ansys Zemax OpticstudioLambda Research OsloPhoton Engineering FredPython
Reposted 9 Days AgoSaved
In-Office
San Diego, CA
Senior level
Senior level
Information Technology • Professional Services • Security • Consulting
Lead the container platform and CI/CD pipelines in AWS GovCloud, enabling Navy development teams with secure capabilities through modern DevSecOps practices.
Top Skills: ArgocdAws GovcloudBashCloudwatchDockerGitlabGitopsGoHelmInfluxdbKubernetesKustomizeOpentelemetryPrometheusPython
Reposted 9 Days AgoSaved
In-Office
San Diego, CA
141K-229K Annually
Senior level
141K-229K Annually
Senior level
Healthtech • Biotech • Pharmaceutical
Design and develop software for automated laboratory workflows, build data pipelines, implement machine learning models, and integrate various systems to enhance biotherapeutics discovery.
Top Skills: AWSAzureBashC#C++GitGitlabJavaScriptJmpMatlabPower BIPythonRSASSpotfireSQLTableauVBA
Reposted 10 Days AgoSaved
In-Office
San Diego, CA
106K-177K Annually
Senior level
106K-177K Annually
Senior level
Fintech
The Senior API Engineer is responsible for designing, building, and operating cloud-native REST APIs using Python on AWS, focusing on security, performance, and infrastructure management with Terraform and CI/CD practices.
Top Skills: Amazon Api GatewayAws LambdaPythonTerraform
Reposted 10 Days AgoSaved
In-Office or Remote
San Diego, CA
120K-170K Annually
Senior level
120K-170K Annually
Senior level
Big Data • Cloud • Hardware • Software • App development
The SSR Network Engineer will deploy and manage Juniper SSRs, maintain and troubleshoot Junos OS, and configure SD-WAN, focusing on routing quality and network security.
Top Skills: AnsibleAWSAzureGCPJuniper Session Smart RoutersJunos OsPythonYaml
Reposted 10 Days AgoSaved
In-Office
San Diego, CA
123K-140K Annually
Senior level
123K-140K Annually
Senior level
Software • Analytics • Semiconductor
The Sr. Vision Software Engineer will design, test, and integrate machine vision solutions, develop computer vision algorithms, and troubleshoot production issues while collaborating with engineering teams.
Top Skills: .NetC#C++OpencvPythonTensorFlowWpf
Reposted 11 Days AgoSaved
In-Office
San Diego, CA
106K-189K Annually
Senior level
106K-189K Annually
Senior level
Insurance
Designs and implements automation and process improvements for DevSecOps tools and processes, collaborates with teams to enhance systems, and mitigates risks.
Top Skills: AnsibleAWSChefCode CommitCode DeployCodebuildCodepipelineConfluenceDockerGitJenkinsJIRAKubernetesNutanixPowershellPuppetPythonSvnVMware
Reposted 11 Days AgoSaved
In-Office
San Diego, CA
198K-233K Annually
Senior level
198K-233K Annually
Senior level
Artificial Intelligence • Information Technology • Machine Learning • Marketing Tech • Software • Biotech • Design
As a Staff FEA Engineer, you will develop and validate FEA models, perform structural analyses, optimize designs, and collaborate with engineers to enhance wearable device performance and reliability.
Top Skills: AbaqusAnsysPython
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