Top Senior Python Jobs in San Diego, CA

Lead operations analysis, modeling and simulation (ModSim) efforts to support trade studies, mission effectiveness, and requirements. Develop physics-based RF algorithms, analytical models, and scripts (MATLAB/Python/C++/Java). Analyze Monte Carlo and sensitivity studies, visualize results, document findings, and present to technical and leadership stakeholders while supporting SAP and Top Secret environments.

Design, develop, and integrate embedded Linux software for next-generation radar products. Support R&D, production, system integration on custom hardware, and deployed customer systems. Collaborate on-board with small teams and travel occasionally between San Diego and Hawthorne.

Build and modernize Scribd’s core reading experience for millions of users. Responsibilities include migrating Rails frontend surfaces to microfrontends, developing React and Next.js features, creating GraphQL APIs, building Node, Python, and Go services, improving document ingestion infrastructure, collaborating with Data/ML, Design, and Product teams, contributing to the design system, and enhancing frontend performance, accessibility, SEO, and maintainability.

The role involves leading the design, implementation, and optimization of satellite-based network infrastructure focusing on routing frameworks and core routing management, in addition to team leadership and project management.

Design, develop, deploy, and operate custom web applications across AWS, Azure, and on-premises infrastructure. Build and maintain cloud infrastructure using Terraform and AWS CDK, and help technical users configure and optimize APIs and datasets. Provide technical support and guidance, troubleshoot Linux environments, resolve issues, optimize performance, and maintain reliable custom software solutions.

Own system-level inventory features from definition through customer release. Analyze RFID data with Python, SQL, and BigQuery; write system requirements and acceptance criteria; coordinate validation across hardware, firmware, software, sensors, mobile applications, and cloud analytics; lead triage and debugging; assess subsystem performance; align cross-functional teams; and make release go/no-go decisions.

Design, build, deploy, and maintain full-stack applications, APIs, data services, workflow tools, automation, and AI-enabled capabilities for oncology research and operations. Integrate scientific, laboratory, enterprise, and vendor systems; ensure data quality, security, testing, reliability, and observability; deploy on cloud infrastructure; support users and application lifecycles; evaluate technology options; collaborate with scientific and business stakeholders; and mentor junior engineers.

Lead design and implementation of real-time perception algorithms (detection, tracking, sensor fusion) for embedded maritime vehicles. Integrate ML and classical methods, optimize for embedded/GPU hardware, build tests and simulations, select and evaluate sensors, mentor engineers, and field-test algorithms on USVs.

Senior mechanical engineering analyst responsible for structural, shock, vibration, adhesive/joint reliability, optomechanics, and thermal/CFD simulations for photonics modules. Mentor junior engineers, perform complex analyses (FEA, transient shock, thermal-mechanical, creep/fatigue, fracture), use CAD and programming tools, and develop engineering practices in a startup environment. U.S. person required for export-controlled access.

Administers and supports telecom, networks, PCs, physical and virtual servers, Azure resources, data center infrastructure, and business applications. Provides Tier 2/3 technical support, manages unified communications systems, develops PowerShell and Python automation, evaluates technology solutions, and improves IT processes and documentation. The role also supports cybersecurity, compliance, vendors, help desk functions, multimedia systems, and team mentoring. It requires in-office work in San Diego and occasional after-hours or weekend availability.

Analyze and diagnose system faults in AV perception, planner, and other AI software using data from on-road tests and simulations. Triage, prioritize, and root-cause issues; produce reports and insights; develop tools and workflows; and collaborate across engineering, software, and testing teams to improve vehicle safety and robustness.

Join the Platform Infrastructure team to build and maintain cloud control plane and on-robot software that provisions devices, distributes OTA updates, publishes telemetry, and ensures fleet state convergence. You'll write production-quality backend and on-device code, work with AWS infrastructure (Terraform, ECS, Postgres, S3), pair with senior engineers, use AI-assisted development tools, and collaborate across firmware, cloud, and operations teams. Role requires on-site work in San Diego and focuses on device identity, security, and scalable provisioning.

Lead development and management of production test systems for satellite payloads and ground terminals, ensuring quality and reliability across hardware systems.

Develop, integrate, and maintain modular simulation and modeling software (C/C++, Python). Ensure interoperability, real-time performance, and model fidelity through verification/validation, static analysis, performance optimization, and CI/CD. Collaborate with systems engineers and stakeholders, support demonstrations, and troubleshoot technical issues. Position requires on-site work and occasional travel.

Design, implement, and deliver user-experience applications in an Agile environment. Collaborate with systems, cloud, DevSecOps, and test teams to develop JEE/SOA enterprise solutions, GUIs, and prototypes. Apply OOP, JMS, web services, XML technologies, and multiple programming languages (Java, C, C++, Python). Participate in integration, test, build/release, and lifecycle processes. Work full-time on-site in San Diego, require Top Secret clearance and SAP access; travel up to 10%.

Designs, develops, and optimizes Oracle Utilities batch processes supporting billing, metering, data conversion, and integrations. Builds shell-script automation for scheduling, monitoring, and recovery; collaborates with functional and architecture teams; documents dependencies and runbooks; leads SIT and UAT; troubleshoots failures; tunes performance; and manages batch sequencing during cutovers and production deployments.

Develop, calibrate, and defend steady-state and transient gas turbine performance models; analyze test and field data; build internal software, automation, and AI-accelerated tools to support design, testing, and product support across teams.

Develop and deliver scalable, distributed SaaS features for a clinical-trial software platform. Responsibilities include architecture and hands-on development, engineering best practices, technology innovation, cross-service and AI-powered feature integration, real-time systems, customer-focused product delivery, and mentoring software engineers. The role collaborates closely with a fast-moving team and contributes to the product roadmap.

Owns full-stack product features from concept through deployment and maintenance. Develops Python and Django back-end services, RESTful APIs, React front-end components, database schemas, and production-quality application code. Ensures performance, responsiveness, logging, testing, and code quality while collaborating on reviews. Works in Linux-based, containerized environments using OCI tools and contributes to deployment processes.

Design, implement, and maintain enterprise databases (Oracle, SQL Server, PostgreSQL) for mission-critical Navy LVC environments. Optimize performance, manage backup/recovery, replication, clustering, and high-availability solutions. Implement RMF/STIG-compliant security controls, support ATO/accreditation activities, capacity planning, monitoring, and troubleshooting. Ensure compliance with DoD/Navy cybersecurity policies and support system documentation and remediation.

Lead and grow a Data Engineering team to build production data pipelines, medallion datasets, and reusable data products. Drive architecture, engineering standards, design reviews, and cross-functional delivery. Partner with Product, Analytics, Data Science, and Platform to enable governed, reliable data foundations for analytics and AI. Mentor engineers and manage multiple concurrent initiatives to deliver predictable outcomes.

The Senior IT Manager will lead the IT team, manage infrastructure, oversee compliance, and drive operational improvements in a defense technology environment.

The Manager of Application Support leads a team of software developers, manages solution architecture, and ensures project alignment with business goals, utilizing Agile methodologies.

The Sr RF/MW Engineer develops and tests RF technologies, performs device characterization, analyzes data, leads projects, and collaborates with teams for wireless chipset solutions.

Validate cloud-native backend, APIs, and in-vehicle IoT hardware through manual and automated testing. Design test plans, write automation in Python/Node.js, run system/integration/regression/release tests, reproduce defects, and maintain test environments while collaborating with engineering and QA leadership.