Top Senior IT Jobs in Buffalo, NY

Lead administration of Microsoft 365, Google Workspace, SaaS applications, Azure identity, and cloud infrastructure in a fully cloud-based organization. Provide Level 2/3 service desk escalation, execute migrations and cybersecurity projects, establish IT service processes, manage assets and vendors, and support onboarding, offboarding, incident response, change management, and M&A initiatives. The role partners with IT leadership and may help build and manage a growing internal technical team.

The Senior Clinical Trials IT Business Analyst bridges Clinical Development and IT, optimizing clinical trial technologies and managing system implementations, validations, and stakeholder engagement.

Leads enterprise architecture for Biogen’s Veeva ecosystem across Development, Quality, Regulatory, Safety, and Commercial functions. Translates business needs into scalable Veeva configurations and integrations, governs target-state architecture and platform standards, reviews solution designs, and oversees implementation and release planning. Mentors configuration teams, drives cross-vault consistency, manages architecture governance, aligns with Veeva product roadmaps, and advises IT leadership on platform strategy, investments, regulatory compliance, and business objectives.

Leads the design, development, integration, deployment, and operation of large-scale Zero Trust security solutions for DoD environments. Creates system architecture blueprints, selects technologies, integrates distributed systems across on-premise and cloud environments, optimizes performance, ensures compliance with DoD requirements, and leads engineering teams. Diagnoses system issues, implements solutions, and produces architecture documentation while supporting installation, migration, and configuration activities across multiple client locations.

Leads the architecture, design, integration, deployment, and operation of large-scale Zero Trust security solutions for DoD environments. Creates system blueprints, selects technologies, integrates distributed systems across on-premises, cloud, and hybrid environments, optimizes performance, resolves system issues, and ensures compliance with DoD requirements. Leads engineering teams, supports installation and migration at multiple locations, and documents architecture and implementation decisions.

Sell radiology IT solutions by building strategic account plans, managing long technical sales cycles, maintaining a 3-5× quota pipeline, forecasting in Salesforce, partnering with marketing/inside sales, and representing the company at industry conferences.

Leads business analysis for enterprise applications and reporting initiatives. Translates stakeholder needs into requirements and functional or technical specifications, partners with IT on scalable solutions, manages project scope and risks, maintains process documentation, supports UAT and change readiness, and drives process standardization. Establishes business analysis standards and best practices across a growing, multi-location organization.

The IT Manager, Product Owner - Finance drives financial process transformations, prioritizes product backlogs, and manages stakeholder relationships to ensure high-quality delivery of financial systems solutions.

Lead a team to design, build, and operate scalable, secure platform and MLOps capabilities on GCP and hybrid cloud. Drive DevSecOps, CI/CD, telemetry, and platform modernization to accelerate AI/ML and software delivery while managing delivery, budgets, vendors, and stakeholder alignment.

The IT Project Manager will oversee project planning, implementation, and client interactions while ensuring compliance with federal and state regulations in the public sector.

The IT Project Manager will lead public sector ERP migration projects, ensuring high-quality deliverables and strategic alignment while collaborating with various stakeholders.

Lead global IT sourcing strategy and a multi-year technology modernization agenda. Manage $450M spend, strategic supplier relationships, governance, risk, and value delivery. Oversee category management (cloud, software, infrastructure, cyber), negotiations with hyperscalers and SaaS vendors, stakeholder engagement, and build a high-performing sourcing organization.

Designs and operates IT services for laboratory environments, including networks, compute, security, private cloud, and SDN platforms. Translates business and IT requirements into secure, standardized architectures and operational processes. Leads deployments, design reviews, documentation, incident gap analysis, automation, and infrastructure optimization. Requires extensive enterprise networking, datacenter, virtualization, Linux, security, and ITIL experience.

Designs and operates laboratory IT services covering compute, networks, security, private and public cloud, and software-defined networking. Translates business requirements into secure, high-performance service offerings; defines architectures, configurations, processes, and operational procedures. Leads implementations, design reviews, documentation, incident analysis, gap remediation, automation, and infrastructure optimization across global laboratory environments.

Lead an Automation Center of Excellence to build and maintain IaC, automation pipelines, and configuration management across colo and multi-cloud (Azure, GCP, OCI). Drive standardization, governance, security controls, CI/CD integration, incident management, GitOps and policy-as-code adoption. Mentor team members, manage vendor relationships, measure automation KPIs, and provide executive reporting. Participate in on-call rotation and work outside normal hours as needed.

The Senior IT Project Manager oversees the delivery of technology and business transformation projects, supports PMO standards, manages project risks, and mentors junior managers.

Lead planning, execution, and delivery of enterprise technology projects. Manage scope, timelines, budgets, resources, risks, vendors, and stakeholder communications across Agile, Scrum, and Waterfall environments. Oversee software development, technology implementations, cloud transformation, application modernization, and other enterprise initiatives while coordinating cross-functional teams and multiple concurrent priorities.

Lead global IT operations for a HIPAA-regulated healthtech company, managing a small support team and hands-on ticketing. Build and maintain systems for compliance and visibility, optimize vendor costs, implement security/onboarding processes, drive process improvements with KPIs and automation, and serve as primary IT liaison to leadership and partners.

Drive national sales and account growth for IT cooling equipment, services, and software. Develop strategic customer relationships, pursue new business, manage channel partners, lead proposals and negotiations, forecast revenue, analyze market trends, and represent the company at industry events. The role requires technical knowledge of HVAC, mission-critical infrastructure, power quality, and data center solutions, along with strong commercial, communication, and relationship-management skills.

Provide frontline and advanced application support for radiology imaging workflows: incident triage, user provisioning, configuration changes, DICOM troubleshooting, monitoring interfaces, coordinating with networks/storage/vendors, maintaining SOPs and knowledge base, delivering end‑user training and on‑call doctor support to meet SLAs.

Design and develop scalable cloud applications using Node.js, microservices, Azure, and AWS. Build workflow, data integration, REST API, serverless, and event-driven solutions; integrate client applications with cloud storage; implement security, testing, CI/CD, and DevSecOps practices. Optimize performance and cost, collaborate with cross-functional teams, provide technical leadership and mentorship, conduct technology research, and communicate architecture and recommendations to stakeholders.

Deploy and maintain AI enablement infrastructure (MCP servers, AI agents, AI features in SaaS), manage service accounts and API keys, automate and containerize services, support enterprise IT systems, document integrations and runbooks, and mentor IT support staff.

Owns the company-wide IT and cybersecurity program, including SOC 2 compliance, cloud security, penetration-test remediation, business continuity testing, endpoint management, access controls, onboarding and offboarding, AI security governance, vendor reviews, security training, incident response, and employee IT support. The role partners with engineering, HR, Finance, leadership, auditors, and healthcare customers while managing security across AWS, Heroku, Cloudflare, Google Workspace, GitHub, and related tools.

Lead and manage a technical database team supporting Oracle and Microsoft SQL Server and middleware (WebLogic) across on‑prem and cloud. Oversee daily operations, service delivery, cloud migrations, incident response, people management, project execution, and continuous improvement while ensuring stakeholder engagement and modernization of services.

Analyze technical bills of materials, source and compare OEM/distributor quotes, identify substitutes and special pricing, negotiate terms, protect margin, manage high-volume quote requests, and maintain audit-ready procurement records while collaborating with sales and engineering.