Top Senior IT Jobs in Buffalo, NY

Lead strategy and execution of IT Computer System Validation and QA for GxP-regulated IT systems. Develop CSV strategy, SOPs, risk management, change control, and training. Oversee validation, vendor qualification, audits/inspections, and compliance of ERP and lab systems throughout the system lifecycle.

The Enterprise Architect leads architectural strategy and integration for technology and processes while aligning IT investments with business goals. Responsibilities include overseeing cloud modernization, governance, and communication with stakeholders.

The Senior Clinical Trials IT Business Analyst bridges Clinical Development and IT, optimizing clinical trial technologies and managing system implementations, validations, and stakeholder engagement.

The Senior IT Systems Administrator oversees the administration, security, and optimization of financial systems, ensuring reliability and compliance while leading system enhancements and integrations.

Provide remote technical support, troubleshoot issues, design security solutions, manage cloud and virtualization environments, and communicate with clients. Requires strong IT skills and customer service.

Manage full project lifecycle for IT Operations and Services, including enterprise applications, security, network/systems infrastructure, and process improvements. Create plans, governance, change management, vendor onboarding, KPIs, roadmaps, and transition projects to operations while communicating status and driving cross-team collaboration.

Lead and manage Level 1-3 Service Desk analysts supporting external clients, oversee daily operations, escalations, SLAs, and reporting. Improve service management, automation, and first-call resolution; partner with Engineering and Incident/Problem/Change Management to resolve production issues. Provide hands-on technical leadership across Splunk, Datadog, MuleSoft, SQL, and ServiceNow while managing client communications and operational metrics.

The IT Operations Director leads Service Desk and Infrastructure teams, overseeing IT operations lifecycle, managing metrics, enforcing security, and enhancing service quality through automation and ITIL processes.

The Enterprise Architect defines technology strategies, aligns investments with company goals, and leads cloud modernization and data analytics initiatives while ensuring compliance and governance.

Manage SAP ERP solutions for finance, design and implement configurations, provide user support, and ensure integration across relevant business areas.

The Senior Director Analyst at Gartner leads research initiatives, providing thought leadership, actionable insights, and market analysis to clients and organizations, while mentoring junior team members.

The role involves leading and improving IT operations, focusing on proactive service organization, process design, and team development while managing IT projects and vendor relationships.

Hands-on senior IT systems administrator responsible for administering Google Workspace and Microsoft 365 environments, endpoint and MDM support across ChromeOS/Windows/macOS, SaaS administration, help desk support, and executing compliance controls (CMMC/NIST800-171/ISO27001/SOC2). Uses AI tools to automate IT workflows, supports engineering teams' toolchains, and assists in audit readiness and evidence collection.

The IT Operations Manager will oversee day-to-day IT operations, including managing MSP, network and cloud infrastructure, identity management, systems administration, and user support, while ensuring security and optimal performance across all platforms.

The Senior IT Project Manager will lead client-facing IT infrastructure projects, manage timelines and expectations, and coordinate engineering teams while ensuring high-quality delivery of services.

Responsible for IT support and administration for Commercial systems. Partners with business owners to ensure system performance, compliance, and operational excellence across various business functions.

The Senior IT Engineer will provide advanced technical support, manage IT infrastructures, ensure security, and lead incident response efforts in a remote environment.

The IT Support Lead oversees L1/L2 IT support operations, leading a team, ensuring effective issue resolution, and managing IT support functions.

Lead and manage a remote US IT support team to deliver high-quality technical support. Oversee daily operations, SLAs, ticket triage, knowledge base, training, metrics reporting, and escalation for complex issues while coordinating cross-functional initiatives and adopting industry best practices to improve customer satisfaction.

Lead and grow a product support team for a live digital court reporting product (Maggie). Supervise analysts, triage and lead incident response for P0/P1 events, coordinate escalations to IT and engineering, run on-call rotations, develop runbooks/KB/training, track support metrics, provision hardware kits, and hire and train support staff.

Design, implement, and evolve enterprise IT architecture solutions across cloud/hybrid, SaaS, and on‑prem platforms. Lead cross-functional architecture initiatives, define integration approaches, support AI/automation enablement, ensure security and governance alignment, optimize performance and cost, mentor teams, and contribute to standards, vendor evaluations, and modernization efforts.

Own and operate core corporate IT systems including identity, endpoints, cloud infrastructure, and automations. Administer AWS, ServiceNow, MDM, and SaaS integrations; build workflows, govern AI tools, handle Tier 3 incidents and on-call duties, and partner with Security, People, and Enterprise apps to ensure reliability, security, and compliance.

The role involves strategic sourcing for indirect goods and services, overseeing supplier relationships, driving cost savings, and developing procurement strategies while collaborating with cross-functional teams.

Lead research and produce high-impact insights on outsourced managed security services and public cloud. Advise clients and vendors, develop thought leadership, deliver presentations, support sales, mentor analysts, improve research processes, and represent Gartner externally. Focus areas include MDR/SOC, cloud security operations, sourcing/contracts, and hyperscaler/cloud workload optimization. Up to 25% travel.

Lead enterprise IT procurement strategy, governance, and operations across hardware, software, cloud, and services. Own vendor relationships, commercial negotiations, licensing and asset lifecycle, M&A procurement integration, and procurement process/tooling. Mentor and scale the procurement team, partner with Finance, Legal, and Security, and deliver executive reporting and cost-optimization initiatives.