Top Senior Python Jobs in Baltimore, MD

Senior level
Agency • HR Tech • Information Technology • Professional Services
Develop and integrate Python microservices for SIGINT mission systems. Containerize services with Docker, deploy them to Kubernetes using Helm, integrate system interfaces, support service-oriented architecture, automate development and deployment with Bash, and troubleshoot Linux-based containerized services. The role is onsite at Fort Meade and requires active TS/SCI clearance with a full-scope polygraph.
Top Skills: BashCi/CdDockerGitHelmKubernetesLinuxMicroservicesPythonService-Oriented ArchitectureShell ScriptingUnix
One Month AgoSaved
Remote
Baltimore, MD
Senior level
Senior level
Artificial Intelligence • Logistics • Software • Transportation
Designs and develops APIs, system integrations, and AI-agent workflows for enterprise applications. Builds integrations with platforms such as Salesforce and REST APIs, deploys and supports solutions on AWS, and develops AI-powered automation using LLMs, tool calling, and multi-step workflows. The role includes client requirements gathering, troubleshooting, reliability optimization, cross-functional collaboration, and mentoring junior developers.
Top Skills: Ai AgentsApi GatewayAWSEcsLambdaLarge Language Models (Llms)PythonRdsRest ApisSalesforceSnsSqsTerraform
One Month AgoSaved
Remote
Baltimore, MD
140K-200K Annually
Senior level
140K-200K Annually
Senior level
Cloud • Software • Cybersecurity
Designs, develops, deploys, and operates scalable Go and Python microservices in distributed production environments. Responsibilities include API design, Kubernetes deployment, monitoring, scaling, troubleshooting incidents, system architecture, security, testing, code reviews, and continuous improvements to development processes and infrastructure. The role requires end-to-end service ownership, strong Linux and Docker expertise, observability knowledge, and experience with reliability, performance, and CI/CD practices.
Top Skills: AWSAzureCi/CdClickhouseDatadogDjangoDockerElkFastapiFlaskGCPGitGoGrafanaJwtKeycloakKubernetesLinuxMySQLOauth 2.0OpentelemetryPrometheusPythonRedisRestful Apis
One Month AgoSaved
Remote or Hybrid
Baltimore, MD
190K-240K Annually
Senior level
190K-240K Annually
Senior level
eCommerce • Information Technology • Machine Learning • Marketing Tech • Database • Analytics • Big Data Analytics
Lead backend-focused software architecture and development across distributed systems, data ingestion, experimentation platforms, AI workflows, and product capabilities. Build primarily in Python while contributing to React and TypeScript frontend work. Translate ambiguous product needs into scalable production systems, guide technical direction, partner with product and data teams, mentor engineers, and improve engineering practices.
Top Skills: Ai WorkflowsAPIsData Processing SystemsDistributed SystemsMicroservicesNear-Real-Time Data InfrastructurePythonReactRole-Based Access Control (Rbac)Typescript
One Month AgoSaved
Remote
Baltimore, MD
Senior level
Senior level
Artificial Intelligence • Machine Learning • Natural Language Processing • Software • Generative AI
Develop and maintain open-source Python frameworks and ML developer tools, architect scalable libraries, grow early-stage projects, build real-time streaming capabilities, integrate modern frontend technologies, and collaborate with open-source contributors and the broader developer community.
Top Skills: JavaScriptPythonReactSvelteTypescriptWebrtcWebsockets
2 Months AgoSaved
Remote
Baltimore, MD
100K-130K Annually
Senior level
100K-130K Annually
Senior level
Healthtech • Pharmaceutical • Hospitality
Build and maintain scalable backend applications, serverless functions, microservices, data workflows, ETL pipelines, and cloud-native architectures using Python and AWS. Manage databases, APIs, batch jobs, and real-time integrations while optimizing performance, scalability, security, compliance, and cost. Collaborate with product, engineering, analytics, and data teams; contribute to architecture, CI/CD, infrastructure automation, development standards, and technical mentorship. Healthcare claims data experience is required.
Top Skills: Amazon Api GatewayAmazon AuroraAmazon KinesisAmazon RdsAmazon RedshiftAmazon S3AWSAws GlueAws LambdaAws Step FunctionsCi/CdData LakesData WarehousesDevOpsETLHipaaHl7Infrastructure As CodeMicroservicesMySQLPostgresPythonServerless ComputingSQLStored Procedures
Reposted 2 Months AgoSaved
In-Office
Baltimore, MD
155K-175K Annually
Senior level
155K-175K Annually
Senior level
Security
The Senior-Level Python Developer will support a cybersecurity initiative, developing network protocol parsers, analytics solutions, and detection capabilities for anomalous network activity.
Top Skills: C++ConfluenceGitGitlabJIRAJupyter NotebooksPythonSpark
Reposted 2 Months AgoSaved
In-Office
Baltimore, MD
155K-175K Annually
Senior level
155K-175K Annually
Senior level
Security
The Senior-Level Full-Stack Developer will capture software requirements, develop and deploy analytic solutions, and ensure compliance with policies.
Top Skills: JavaJupyterPython
Reposted 2 Months AgoSaved
In-Office
Baltimore, MD
155K-175K Annually
Senior level
155K-175K Annually
Senior level
Security
The Senior-Level Analytic Engineer will develop and deploy analytic capabilities, maintain applications, and collaborate with stakeholders to enhance network data analysis.
Top Skills: JavaJupyter NotebooksMapreducePython
Reposted 2 Months AgoSaved
In-Office
Baltimore, MD
155K-175K Annually
Senior level
155K-175K Annually
Senior level
Security
The Principal-Level Software Engineer develops custom analytics, integrates solutions, collaborates with data scientists, and supports operationalizing data science at scale.
Top Skills: ConfluenceGitlabJavaJava MapreduceJIRAJupyter NotebooksPythonPython Pyspark
Reposted 2 Months AgoSaved
In-Office
Baltimore, MD
170K-260K Annually
Senior level
170K-260K Annually
Senior level
Big Data • Cloud • Security • Software • Analytics
Develop, test, deploy, and sustain Python-based REST endpoints and microservices using Django/Flask, interfacing with MariaDB or MongoDB, providing middleware and backend support for mission-critical government systems focused on automation and continuous monitoring.
Top Skills: DjangoDockerFlaskJSONMariadbMicroservicesMongoDBPythonRest
2 Months AgoSaved
Remote
Baltimore, MD
200K-225K Annually
Senior level
200K-225K Annually
Senior level
Artificial Intelligence • Computer Vision • Machine Learning • Analytics
Develop open source SDKs, enterprise APIs, UIs, and backend systems supporting large-scale computer vision datasets. Build scalable, maintainable, performant, and well-tested software for unstructured data and AI workflows. Contribute to enterprise deployments across customer clouds and on-premises environments, while improving tooling, automation, engineering practices, and open source community initiatives in a remote-first team.
Top Skills: DocumentdbElasticsearchMongoDBPythonTypescript
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Reposted 2 Months AgoSaved
In-Office or Remote
Baltimore, MD
135K-155K Annually
Senior level
135K-155K Annually
Senior level
Machine Learning • Other
The Backend Software Engineer will develop and maintain backend systems for data processing related to coffee farming, utilizing Python and PostgreSQL. Responsibilities include feature development, problem-solving, and adapting systems to regulatory changes while ensuring system resilience.
Top Skills: AWSCi/CdDockerPostgresPostgresql/PostgisPythonTerraform
Reposted 2 Months AgoSaved
Remote
Baltimore, MD
Senior level
Senior level
Artificial Intelligence • Information Technology • Professional Services • Software
The Senior Full Stack Developer will design, develop, test, and debug software solutions, collaborating with teams and optimizing applications. Responsibilities include user interaction design, back-end functionality, and ensuring software scalability and security.
Top Skills: CSSDjangoDockerFastapiFlaskGitGnu/LinuxHTMLJavaScriptMongoDBMySQLNode.jsOraclePostgresPythonReactSvnVue
Reposted 3 Months AgoSaved
In-Office
Baltimore, MD
60K-60K Annually
Senior level
60K-60K Annually
Senior level
Artificial Intelligence • Information Technology • Software • Consulting
Develop and maintain high-scale, high-availability Python server applications. Build and consume REST/SOAP/JSON APIs, integrate message-bus systems, work with Cassandra and distributed system frameworks, and apply algorithms, networking, and OS knowledge within Agile/Scrum teams.
Top Skills: ActivemqApache KafkaApache ZookeeperCassandraDjangoFlaskJSONNoSQLPythonRabbitMQRestSoap
Reposted 3 Months AgoSaved
In-Office
Baltimore, MD
130K-270K Annually
Senior level
130K-270K Annually
Senior level
Software
The DevOps Engineer will implement infrastructure, automate deployment processes, manage Kubernetes containers, and ensure service reliability, scalability, and continuous improvement.
Top Skills: AnsibleAWSGitKubernetesLinuxPythonTerraform
Reposted 3 Months AgoSaved
In-Office
Baltimore, MD
130K-270K Annually
Senior level
130K-270K Annually
Senior level
Software
The Cloud Platform Engineer will develop software components, integrate open-source code, and manage virtual infrastructure in AWS, requiring strong systems integration skills and cloud technology experience.
Top Skills: AWSJavaLinuxPython
Reposted 3 Months AgoSaved
In-Office
Baltimore, MD
130K-270K Annually
Senior level
130K-270K Annually
Senior level
Software
Looking for a Cloud Platform Engineer to develop custom software, manage infrastructure in AWS, and solve complex problems autonomously in a hybrid environment.
Top Skills: AnsibleAWSCi/CdConfluenceGitGitlabJavaJIRAKubernetesLinuxMavenPuppetPythonShell
Reposted 3 Months AgoSaved
In-Office
Baltimore, MD
130K-270K Annually
Senior level
130K-270K Annually
Senior level
Software
Seeking a highly motivated DevOps Engineer with extensive experience in AWS, Linux, and automation. Responsibilities include managing cloud infrastructure, automating deployment processes, and collaborating with development teams to enhance reliability and performance.
Top Skills: AnsibleAWSBashGitKubernetesLinuxPythonTerraform
Reposted 3 Months AgoSaved
In-Office
Baltimore, MD
130K-270K Annually
Senior level
130K-270K Annually
Senior level
Software
The DevOps Engineer will automate deployment processes, manage cloud infrastructure, and collaborate with development teams to ensure reliable services. This role involves troubleshooting, monitoring systems, and continuous improvement of processes.
Top Skills: AnsibleAWSBashCi/CdDrillEksElasticsearchGitHadoopHiveImpalaJavaKubernetesLinuxPostgresPrestoPythonSparkTerraformTrino
Reposted 3 Months AgoSaved
In-Office
Baltimore, MD
130K-270K Annually
Senior level
130K-270K Annually
Senior level
Software
The Cloud Platform Engineer will develop software components, manage cloud infrastructure in AWS, and ensure system integration while enhancing existing codebases.
Top Skills: AWSBashCi/CdConfluenceDockerGitGitlabJavaJIRALinuxPythonShell
Reposted 2 Months AgoSaved
In-Office or Remote
Baltimore, MD
Senior level
Senior level
Cloud • Software
The Python Engineer will write maintainable Python software, lead technical initiatives, collaborate globally, and contribute to community engagement at Canonical.
Top Skills: CC++DockerGoKubernetesLinuxNoSQLPythonRustSQL
Reposted 2 Months AgoSaved
In-Office or Remote
Baltimore, MD
Senior level
Senior level
Digital Media
Develop and enhance features for EnrollWise, contribute to a scalable software architecture, review code, collaborate on design and technical feasibility, and maintain software quality.
Top Skills: ApolloAWSDjangoDjango OrmGraphQLNextjsPythonReact
2 Months AgoSaved
Remote
Baltimore, MD
Senior level
Senior level
Information Technology • Software • Consulting
Build and maintain full-stack wealth management platform features using Python and Angular or React. Design service-oriented architectures and REST/SOAP APIs, work with relational databases and ORMs, contribute to AWS or Azure cloud architecture, and deploy using container technologies. Collaborate in Agile/Scrum ceremonies, participate in code reviews and demos, and work independently with distributed teams.
Top Skills: AngularAWSAzureConfluenceDjangoDockerEcsFlaskJavaScriptJIRAJSONKubernetesMySQLOracleOrmPostgresPythonReactRestSoapSQLSQL Server
2 Months AgoSaved
Remote or Hybrid
Baltimore, MD
165K-210K Annually
Senior level
165K-210K Annually
Senior level
eCommerce • Information Technology • Machine Learning • Marketing Tech • Database • Analytics • Big Data Analytics
Design and implement scalable backend and distributed systems for a marketing intelligence platform. Build near-real-time ingestion and processing, scale an incrementality/experimentation product, integrate AI-powered workflows, improve data ingestion/exports and connection-state systems, and contribute frontend components to deliver end-to-end product experiences.
Top Skills: AIAPIsData ProcessingDistributed SystemsMachine LearningMicroservicesPythonRbacReactReal-Time Data IngestionTypescript
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