Top Senior Software Engineer Jobs in St. Louis, MO

The Senior Mobile Software Engineer will develop user-facing features for a cross-platform app, ensuring code quality and functionality throughout the entire lifecycle of features.

Lead the bioinformatics pipeline team, setting technical strategy and architecture. Ensure engineering best practices, mentor staff, and oversee DevOps strategy for reliable software delivery in a regulated environment.

Design, implement, and ship end-to-end features across backend services and a React web client for a multi-tenant ERP. Own schema design, migrations respecting row-level security, integrations with platform services, and deliver high-quality, performant code with CI/CD, tests, and code review. Leverage AI coding assistants responsibly and collaborate cross-functionally to evolve shared platform libraries and developer tooling.

The role focuses on optimizing coding practices and collaboration within the engineering team, improving internal tooling, and communicating between teams and leadership.

The Senior Svelte Software Engineer will develop high-quality, scalable Svelte web components, collaborate on design systems, and ensure component reliability.

The Senior Software Engineer will lead teams to build secure, high-scale cloud applications, ensuring system reliability and delivering software solutions.

As an SDK Software Engineer, you will develop and maintain AI SDKs, collaborate with teams, and contribute to open-source projects.

Design, build, test, and deploy production software for an agentic chatbot platform across intake, orchestration, retrieval, answer generation, caching, and integrations. Collaborate with product and technical teams, provide code and merge-request review, mentor junior engineers, and contribute to design, performance, security, and delivery.

As a Senior Backend Software Engineer at Archy, you will lead major product updates, ensuring system stability and scalability, while collaborating with cross-functional teams to enhance dental practice management solutions.

As a Senior Software Engineer, you'll design, develop, and maintain full-stack applications, utilizing TypeScript and modern frameworks while collaborating cross-functionally to enhance user experience and performance.

Lead design and delivery of a reliability platform for production systems. Own quarterly goals, guide engineers through ambiguity, collaborate with PM/design/analytics, monitor and operate services (on-call), set quality and code standards, and mentor teammates. Integrate AI/LLM tooling to improve automation, debugging, and service health.

Lead delivery for the Batch Infrastructure team: design, build, and operate reliable, scalable compute platforms for scheduled and on-demand batch workloads. Collaborate with product/design/analytics, define technical plans, ensure availability (monitoring/on-call), set code and design standards, and mentor engineers to improve delivery and quality.

Design and build cloud-native ETL/ELT pipelines and microservices, modernize on-prem systems to distributed services, implement authentication/authorization and data governance, ensure data quality and observability, drive architecture and CI/CD best practices, mentor engineers, and collaborate with stakeholders across a US Navy-focused defense program.

Lead backend engineering for cloud-native, event-driven data pipelines and customer integrations (especially EHRs). Evolve core data models and APIs, improve scalability and reliability, mentor engineers, define best practices, and drive end-to-end testing and AWS-based solutions.

Build and maintain Doowii's core product: front-end interfaces and UX for data querying, backend APIs and cloud infrastructure, real-time data interaction and optimized data models, ingestion pipelines (NiFi->Kafka->Iceberg->BigQuery), and model evaluation/LLM-driven features to deliver accurate, performant conversational analytics for education.

Design and deliver scalable, secure, and maintainable software systems. Contribute to architecture, build CI/CD pipelines, design distributed systems and APIs, mentor engineers, collaborate with product and design, and improve observability, performance, and operational reliability across teams.

Lead design and build of scalable backend systems and data platforms; own architecture and production deployments; improve reliability, performance, and observability; mentor engineers and collaborate with Product, Data Science, SRE, and Security.

Build, operate, and extend data platform and application-layer services enabling secure, self-service data applications at scale. Implement provisioning, CI/CD, access control, integrations, observability, automation, and incident response while contributing to semantic layer and AI-ready tooling roadmaps.

Embed with U.S. government customers to design, build, deploy, and maintain mission software from prototype to production. Own end-to-end delivery, build backend systems and data integrations, collaborate with product and engineering to scale reusable capabilities, and serve as the technical point of contact to drive adoption and mission impact.

Owner of core clinical backend systems: design and build TypeScript/Nest.js APIs, model clinical domains in PostgreSQL/Prisma, implement onboarding/migration flows, ensure CI/CD, monitoring, HIPAA/SOC2 readiness, collaborate with clinical stakeholders, and build monitoring/reporting with Sentry/Datadog on AWS.

As a Senior Backend Engineer, you'll build cloud-native backend services using Golang, deploy in Kubernetes, and lead architecture projects in a startup environment.

The role involves developing APIs, building internal tools, and collaborating with teams to enhance system performance while solving engineering challenges.

The role involves optimizing hardware support within a software stack for AI model deployment, collaborating with teams and hardware vendors to enhance performance and portability across platforms.

Lead technical direction and execution for Code Plane products (Batch Changes, Agentic Batch Changes, Code Monitors, Code Insights, src CLI). Translate customer feedback into roadmap, ship agent-focused features, mentor engineers, own architecture and quality, participate in on-call, and partner with Product, Design, and Customer teams to deliver scalable AI-agent developer tools.

The Senior Software Engineer will lead the development of payment systems, oversee key subsystems, mentor engineers, and ensure high-quality code and architectural standards while collaborating with cross-functional teams.