Top Senior Machine Learning Jobs in St. Louis, MO

Lead architecture and technical strategy for a remote engineering organization building a React, Node.js, PostgreSQL, and AWS platform. Mentor engineers, establish engineering standards, drive JavaScript-to-TypeScript migration, design ETL and AI/LLM integration systems, resolve technical debt, and oversee technical design reviews, production support, incident response, hiring, and delivery. Partner with product, clinical, and business stakeholders to build scalable, reliable software.

Lead technical discovery and solution design for U.S. Government customers adopting trusted AI platforms. Develop architectures, demonstrations, prototypes, and proof-of-concepts; translate mission needs into actionable implementation approaches; present to technical and executive stakeholders; collaborate with engineering, data science, and product teams; support sales, proposals, and capture efforts; and manage concurrent customer engagements.

Develop and deploy machine learning, AI, causal inference, and statistical solutions for advertising measurement products. Own projects from prototyping through production, conduct experiments, explore large-scale data, and collaborate with product, engineering, analysts, and account teams to improve attribution and marketing ROI.

Develop and operate production ML and AI systems powering patient experiences such as matching, ranking, recommendations, onboarding, and personalization. Build reusable ML infrastructure, pipelines, evaluation, observability, and model-serving capabilities. Provide technical leadership across the ML lifecycle, guide architecture, evaluate custom versus foundation-model approaches, and partner with ML and Patient Engineering teams to deliver reliable, scalable AI products.

Secure software and cloud environments through threat modeling, code review, vulnerability remediation, security automation, detection engineering, and attack simulations. The role partners closely with Engineering, manages Snyk and Docker Scout findings, integrates security into CI/CD, coordinates third-party penetration testing for SOC 2 and HITRUST, and helps define secure architecture for mobile, data lake, AI, and production cloud systems.

Manage technology operations across three global studios, including systems administration, infrastructure, technical support, equipment management, business and creative tool administration, vendor coordination, and troubleshooting. Partner with global IT, information security, and privacy teams on policies, compliance, and content security. Drive AI and machine-learning integrations to improve workflows and business efficiency while supporting clients and global technology initiatives.

Own and advance Wonderlic’s AI-powered Jobs Engine, using production machine learning and NLP to analyze labor-market data and infer job characteristics at scale. Partner with product, engineering, and I-O psychology teams to integrate responsible AI into assessment and workforce solutions. Apply fairness, explainability, legal defensibility, and rigorous evaluation practices to employment-related AI systems, including generative AI outputs and assessment interpretation.

Leads client-facing management consulting and transformation programs spanning revenue operations, marketing, sales, customer growth, data, analytics, and AI. Advises senior executives, develops operating models and transformation roadmaps, leads solutioning and proposals, oversees delivery governance, and translates business needs into implementable data and technology solutions. Builds thought leadership, reusable consulting assets, and high-performing teams while supporting strategic growth and client relationships.

Leads and develops a fraud analyst team responsible for investigating emerging threats, responding to incidents, and improving fraud-risk strategies. Owns investigative standards, playbooks, workflows, and tools while serving as an escalation resource for complex cases. Partners with Data Science, Customer Success, Product, Engineering, and business leaders to convert fraud insights into scalable signals, model improvements, and better customer outcomes. Supports customer conversations as a fraud subject-matter expert and coaches analysts on communicating risk decisions.

Design, scale, and optimize ClickUp's search infrastructure using OpenSearch/Elasticsearch. Improve relevance, speed, and real-time indexing, build vector search capabilities, create evaluation frameworks, and collaborate with AI/backend/product teams to integrate and troubleshoot search at scale.

Prototype and develop generative AI applications for business software, including automated model evaluation, synthetic video, and consistent image and brand asset generation. Own projects from experimentation through product delivery, combining system architecture, quantitative reasoning, product judgment, and creative LLM application development.

Lead analytics for client engagements across data onboarding, study planning, predictive modeling, production deployment, and ongoing optimization. Develop models for audience targeting, segmentation, propensity scoring, and campaign optimization, primarily for commercial pharmaceutical applications. Partner with business, analytics, and IT stakeholders, lead technical workshops, present findings to senior audiences, and manage client relationships. Build machine learning pipelines using Python, SQL, and cloud technologies, while contributing client insights to internal product development.

Develop and maintain Power BI reports, dashboards, visualizations, semantic models, and analytics solutions. Translate business requirements into scalable technical solutions, optimize queries and data models, ensure reporting accuracy and performance, and support data governance. Serve as the primary liaison for business users, provide training and troubleshooting, manage tickets, and collaborate with Data and QA teams. The role also advances AI and machine learning capabilities, mentors colleagues, and contributes to automation, documentation, and code reviews.

Conduct applied AI and machine learning research focused on multimodal data, foundation models, agents, evaluation, and data enrichment. Monitor research trends, prototype emerging techniques, design experiments, validate opportunities, and translate findings into briefs and recommendations. Partner with product and engineering teams to guide data strategy, training corpus generation, and longer-term opportunity prioritization.

Leads technical sales engagements for identity verification and fraud prevention solutions. Responsibilities include discovery, solution design, technical workshops, proof-of-concept development, product demonstrations, and advising enterprise clients. Partners with Sales, Product, Data Science, Engineering, and Customer Success; translates technical capabilities into business value; provides domain expertise in fraud, risk, compliance, and regulated industries; contributes to thought leadership; and mentors junior consultants.

Leads the AI Engineering team across applied AI features and foundational ML infrastructure. Responsibilities include managing Senior and Staff engineers, hiring and coaching, deploying LLM-powered capabilities, building MLOps and AI observability platforms, balancing product delivery with platform investment, and ensuring privacy, compliance, evaluation rigor, and clinical safety in production systems.

Set the technical vision for data science, lead complex statistical and machine learning model development from concept through production, and architect scalable modeling platforms and pipelines. Develop credit risk, pricing, and loss forecasting models; establish model governance standards; partner with senior leaders; mentor data scientists; and communicate technical strategy to executives. The role emphasizes production deployment, monitoring, cloud architecture, and high-impact decision-making across the business.

Own the clinical infrastructure and program portfolio powering Arine’s medication management platform. Evolve the clinical recommendation engine, expand data inputs, standardize program configuration, and create repeatable frameworks for launching and scaling clinical programs. Partner with clinical, engineering, data science, implementation, and customer success teams to translate needs into requirements, improve onboarding, maintain regulatory alignment, and prioritize work using clinical safety, user value, and business impact.

Leads engineering for one or more product-domain teams, partnering with Engineering Managers, Product, Data Science, Analytics, and Insurance stakeholders. Responsibilities include setting technical strategy and roadmaps, coaching engineers, driving cross-team initiatives, contributing code, leading incident response and resiliency improvements, and establishing engineering standards. Requires strong Ruby on Rails expertise, Rust familiarity, software leadership experience, and excellent communication skills.

Lead the demand generation function by translating go-to-market priorities into segmented campaigns across email, search, social, content, webinars, and events. Own HubSpot automation, Salesforce integration, lead scoring, funnel analytics, marketing-sourced pipeline, budgets, and agency performance. Collaborate with Sales and Commercial Operations to improve lead handoffs and conversion. Apply AI and automation to increase execution efficiency while coaching team members and building the future demand generation team.

Leads new business development, account growth, commercial discussions, client relationships, and sales operations for AI and GenAI data solutions. Partners with engineering, delivery, and customer success teams to understand frontier lab needs, structure projects, close opportunities, and expand client accounts. Requires quota-based technology sales experience, startup experience, STEM education, and strong AI/ML market knowledge.

Develop and maintain production machine learning models, build scalable training and serving technologies, optimize real-time and batch ML pipelines, and monitor model performance and drift. The role involves deep neural networks, recommendation systems, automated retraining, ML research, engineering excellence, and communicating technical concepts to diverse audiences. Candidates need 6+ years of industry ML experience, strong coding skills, and experience deploying neural networks at scale.

Own audience or measurement products for Fetch’s monetization business, from problem framing through delivery. Build predictive models, datasets, population inferences, and causal measurement studies using receipt, partner, panel, survey, and contextual data. Partner with Product, Engineering, Sales, and GTM to productionize analyses, communicate methods and limitations to customers, and improve products using campaign outcomes, holdouts, and fresh data.

Lead the design, productionization, and operation of machine learning and agentic AI capabilities. Partner with product engineering, shape AI/ML architecture, build evaluation systems and data pipelines, and develop reliable MLOps tooling. Champion responsible AI, safety, latency, cost, and error handling. Serve as a technical resource for engineers, influence direction, mentor others, and occasionally explain AI functionality to customers or customer-facing teams.

Lead the vision, strategy, and evolution of LTK’s creator experience and commerce products. Define creator workflows, identify AI-powered opportunities, analyze behavioral data, establish outcome metrics, and drive experimentation to improve engagement, retention, earnings, and product quality. Collaborate across Product, Engineering, Design, Data, and Creator Success while influencing senior stakeholders and guiding complex, multi-quarter initiatives.