Top Senior Machine Learning Jobs in St. Louis, MO

Develop new enterprise and upper mid-market business, manage client accounts, and serve as a trusted consulting advisor. Prospect and qualify leads, collaborate with technical teams to create proposals and close SOW contracts, identify business improvement opportunities, build channel partnerships, maintain CRM records, and support localized marketing activities. The role is remote within specified target markets, includes up to 10% travel, and has no direct reports.

Lead partner analytics by building scalable dashboards, forecasting and ROI models, and experimental designs to evaluate and optimize partner performance. Collaborate with Product, BD, Marketing, and Data Engineering to improve pipelines, translate insights into recommendations, and mentor analysts to scale partner growth.

Designs and maintains high-volume HL7 and FHIR ingestion pipelines, secure Epic and hospital integrations, data validation systems, and compliant healthcare data exchanges. Builds enterprise SaaS microservices using ReactJS, Python, and AWS services; optimizes distributed and hybrid-cloud environments; leads testing, code reviews, production troubleshooting, architecture documentation, and customer communications. Preferred experience includes Epic App Orchard, healthcare integration engines, clinical workflows, GenAI/ML, DevOps, data pipelines, and NoSQL.

Own and improve the end-to-end AI engine powering real-time voice drive-thru agents. Design conversational and order-taking logic, address turn-taking and noisy audio challenges, build evaluation infrastructure, and ensure accurate recommendations, substitutions, pricing, and POS integrations across restaurant brands. The role involves researching and deploying new AI techniques, training and productionizing machine learning models, and converting ambiguous quality issues into measurable improvements.

Tune AML and fraud detection models using customers’ live transaction data. Investigate missed cases, alert quality, pattern drift, and false positives; validate changes through backtesting and sample review; document regulatory rationale; and present model performance and business value to compliance, risk, and data science stakeholders. Partner with customer teams on account strategy and relay customer-specific or systemic findings to product and model functions.

Drive net-new enterprise customer acquisition from lead generation through contract closure. Build C-level relationships, develop account strategies, manage CRM pipelines and forecasts, negotiate complex contracts, and close large AI, machine learning, and data talent engagements. Partner with marketing, customer success, and talent teams to deliver customer outcomes and expand Factored AI’s enterprise footprint.

Consult as a fractional data scientist for hedge funds, private equity firms, and family offices. Lead data science initiatives: build infrastructure, develop and deploy models, create portfolio dashboards, monitor post-deployment performance, and partner with investment teams to turn data into actionable investment insights. Advise on vendor selection, data quality, technology stacks, KPIs, and governance.

Lead presales for data and AI initiatives: design and present Microsoft Fabric-based data platforms, run discovery and AI workshops, scope proposals, translate technical designs into business value, mentor delivery, and support go-to-market and thought leadership.

Lead development of Root’s machine learning platform for insurance pricing. Build and operate feature pipelines, model training and orchestration, registries, validation, serving, observability, and reproducibility tooling. Partner with researchers to convert experimentation into reliable production systems, explore LLM-enabled data science automation, drive technical roadmaps and execution, and mentor engineers while maintaining high standards for reliability and correctness.

Coordinates data platform incident response, triage, escalation, root cause analysis, problem management, post-incident reviews, and operational improvements. Maintains runbooks, documentation, metrics, dashboards, and stakeholder communications. Implements and monitors security controls, supports security incident response, vulnerability remediation, compliance audits, regulatory reporting, disaster recovery exercises, and cross-functional coordination across data, cloud, infrastructure, DevSecOps, application, and governance teams.

Develop and deploy predictive and causal models for personalization, retention, monetization, and product strategy. Design experimentation and measurement frameworks, analyze user and marketing behavior, quantify business impact, and translate complex findings into strategic decisions. Collaborate with Product, Engineering, Marketing, and Data Product teams to build scalable data solutions. Mentor peers, promote rigorous model validation and governance, and apply Python, SQL, Snowflake, dbt, Airflow, Spark, and AWS to production-ready data science initiatives.

Lead the design and implementation of large-scale AI and machine learning systems for Yahoo Search across multiple teams. Define data strategies, evaluation frameworks, and scalable production-serving approaches. Drive technical alignment among engineering, product, design, and research teams; guide adoption of large language models, vision models, generative AI, and agentic AI; and oversee data analysis informing strategic product decisions.

Drive enterprise sales growth across North American banking, credit card, and financial services accounts. Develop strategic account and business development plans, build customer and partner relationships, close complex multi-million-dollar technology deals, and engage C-level stakeholders. Represent the company at industry events, collaborate with commercial and leadership teams, manage pipeline forecasting and reporting, and apply MEDDPICC methodology. The role focuses on cybersecurity, fraud prevention, authentication, and SaaS or cloud solutions, with 50% domestic and international travel.

As Director of Product, you will define and drive Kobie's data platform strategy to enhance marketing and loyalty programs, focus on AI integration, and develop commercial models.

Design, build, validate, and deploy predictive models using Python and SQL. Apply causal inference, A/B testing, matching models, and AutoML to evaluate interventions. Partner with product and engineering to deliver scalable analytics, ensure data quality and model performance, and communicate insights to stakeholders.

Lead the architecture, implementation, integration, and optimization of Oracle EPM Planning solutions. Design planning, budgeting, forecasting, modeling, security, metadata, and reporting frameworks; configure Oracle EPM modules; and apply AI-driven forecasting capabilities. Lead requirements workshops, testing, deployment, stakeholder presentations, and pre-sales activities. Mentor consultants and developers while advising finance and executive stakeholders on enterprise planning transformation initiatives.

Own the technical side of deal progression for airline deployments: qualify opportunities, run demos and POCs, author integration and deployment architectures (PSS, APIs, data feeds, DNS, identity, networking), respond to RFPs/security questionnaires, scope SOWs and NFRs, and build reusable demo/reference assets to drive adoption and expansion while liaising between sales, engineering, and customers.

Lead the design, development, deployment, and governance of advanced analytics, machine learning, and AI solutions using large healthcare datasets. Responsibilities include data preparation, statistical and predictive modeling, model monitoring, explainability, visualization, stakeholder communication, and translating findings into clinical and operational improvements. The role also mentors data professionals, advises leaders, manages initiative priorities and risks, and promotes responsible AI and Agile practices.

You will tackle AI challenges, develop scalable software and collaborate with teams to enhance healthcare navigation using AI solutions.

Lead and transform the Fraud Intelligence Team into a high-impact function by improving operating models, QA, tooling, and metrics; build entry-level talent programs; connect labeling to measurable fraud prevention outcomes; deliver actionable insights to Product, R&D, Analytics, and GTM; and leverage AI and automation to increase productivity and business impact.

Partner with functional leaders to translate business strategy into people strategy. Own org design, performance management, compensation, talent development, engagement, and retention. Provide coaching on career pathing, change management, and sensitive employee issues. Use people data to generate insights and recommendations, build compliant HR policies, manage global employee relations, and collaborate with People Team COEs to deliver cohesive people programs at scale.

Serve as second-in-command for Coinbase Derivatives' Market Regulation Department, leading day-to-day regulatory compliance, managing exams and audits, advising on CFTC Core Principles, reviewing surveillance escalations and enforcement actions, and coordinating cross-functional regulatory workstreams to ensure the DCM meets obligations and resolves findings timely.

The Staff Machine Learning Engineer will design and build scalable ML systems, mentor engineers, and drive AI strategy at SailPoint, focusing on AI-powered identity security solutions.

Provide legal guidance on Rubrik's AI use and products, ensuring compliance with laws and contracts, drafting and negotiating AI terms, coordinating generative AI review processes, educating employees, and improving AI review controls and workflows across cross-functional teams.

Build and lead detection-as-code, AI/ML, automation, and response capabilities for a global security operation. Develop production AI/ML pipelines for investigation, triage, enrichment, and detection generation; establish version-controlled detection standards, testing, and CI/CD deployment across SIEM, XDR, and EDR platforms. Create SOAR workflows, response playbooks, and containment integrations. Maintain MITRE ATT&CK coverage, partner with threat intelligence and hunting teams, validate defenses through purple teaming and breach-and-attack simulation, and lead technical projects as the senior individual contributor.