Top Senior Machine Learning Jobs in St. Louis, MO

Lead a team of ML engineers to develop fraud detection models, defining strategies, driving model evolution, and ensuring effective integration with cross-functional teams.

Lead negotiation and closing of SaaS, cloud and AI-related commercial agreements; partner with sales, product, engineering and support; ensure data privacy, security, and evolving AI governance compliance; enable sales through training and high-volume deal support; find commercial solutions to close complex, time-sensitive deals.

Partner with functional leaders to translate business strategy into people strategy. Own org design, performance management, compensation, talent development, engagement, and retention. Provide coaching on career pathing, change management, and sensitive employee issues. Use people data to generate insights and recommendations, build compliant HR policies, manage global employee relations, and collaborate with People Team COEs to deliver cohesive people programs at scale.

Lead and transform the Fraud Intelligence Team into a high-impact function by improving operating models, QA, tooling, and metrics; build entry-level talent programs; connect labeling to measurable fraud prevention outcomes; deliver actionable insights to Product, R&D, Analytics, and GTM; and leverage AI and automation to increase productivity and business impact.

You will tackle AI challenges, develop scalable software and collaborate with teams to enhance healthcare navigation using AI solutions.

Own product strategy and delivery for chat, voice, and proactive support surfaces to maximize automation rates and CSAT. Build AI-integrated capabilities with ML/LLM teams and vendors, partner with Engineering, CX Operations, Data Science, and Compliance on platforms (Amazon Connect, Sprinklr, Salesforce), drive build-vs-buy decisions, and execute cross-functional delivery to optimize customer and agent experiences.

Serve as second-in-command for Coinbase Derivatives' Market Regulation Department, leading day-to-day regulatory compliance, managing exams and audits, advising on CFTC Core Principles, reviewing surveillance escalations and enforcement actions, and coordinating cross-functional regulatory workstreams to ensure the DCM meets obligations and resolves findings timely.

Provide legal guidance on Rubrik's AI use and products, ensuring compliance with laws and contracts, drafting and negotiating AI terms, coordinating generative AI review processes, educating employees, and improving AI review controls and workflows across cross-functional teams.

The Senior Data Scientist will analyze data to drive product strategy, optimize performance, and support product launches, collaborating with cross-functional teams.

The Senior Product Manager will oversee the strategy and development of telematics data products, manage cross-functional teams, and ensure product viability and market alignment through customer insights and technical fluency.

Lead incident management, operational resilience, and AIOps-driven automation across enterprise environments. Drive SRE practices, observability (Dynatrace), ServiceNow workflow automation, root-cause analysis, SLAs/SLOs, and build AI-powered self-healing workflows to reduce MTTD/MTTR and improve reliability.

Own and execute multi-year strategic partnerships with a hyperscaler and an AI lab, aligning technical integrations, commercial motions, and joint go-to-market plans. Coordinate cross-functional teams, run operational cadences, track measurable outcomes (pipeline, ARR, integrations), and represent partnerships to executives while driving hands-on execution and follow-through.

Design and deploy machine learning models for financial document processing, optimize large language models, collaborate with cross-functional teams, and guide junior peers in a fast-paced environment.

The Senior Staff Machine Learning Scientist will lead research initiatives in computer vision and multimodal understanding, develop novel models, and translate research into practical applications while mentoring team members.

The Senior Machine Learning Engineer will design, implement, and optimize machine learning models, drive AI initiatives, and collaborate cross-functionally to enhance SailPoint's AI capabilities.

Lead end-to-end ML systems for identity verification, including document authenticity, face match, liveness and deepfake detection. Build GNN-based identity graphs, behavioral/device-intelligence models, vendor benchmarking/evaluation, and production enforcement. Mentor engineers and align ML architecture with Product, Compliance, Risk, and Security stakeholders.

Lead architecture, development, and deployment of scalable AI-driven platforms. Collaborate cross-functionally, set technical strategy and best practices (MLOps, CI/CD, DevOps), ensure data privacy/security, mentor teams, and drive enterprise AI/ML initiatives.

Lead program management for Public Sector computer vision projects, coordinating engineering, delivery, and analytics to optimize data labeling workflows, improve data quality and throughput, and deliver ML-ready datasets for national security customers.

Design, build, and deploy production-grade ML systems for ICS/xOT cybersecurity, including threat detection, anomaly detection, NLP/LLM applications, and scalable data pipelines with observability and MLOps practices for cloud and on-prem environments.

Design, build, and deploy production ML systems for ICS/xOT cybersecurity, including threat detection, anomaly detection, NLP/LLM features, data pipelines, observability, MLOps, and containerized deployments across cloud and on-prem environments.

The Machine Learning Engineer develops production ML algorithms and recommendation systems, collaborates with teams, and optimizes user experiences.

The role involves defining the vision and strategy of the Outreach AI Platform, prioritizing the roadmap, collaborating with engineering and data science teams, and engaging with customers to refine AI strategies.

Lead complex, cross-functional AI programs end-to-end: translate strategy into integrated plans, drive multi-team execution, mitigate risks (data, model, compliance), apply ML lifecycle practices, use Agile/kanban methods, manage budgets/vendors, communicate to senior stakeholders, and mentor other program managers to improve AI program standards.

Lead product analytics to improve user growth, engagement, retention, and revenue. Design and analyze A/B and multivariate experiments, perform funnel/cohort analyses, maintain KPIs and dashboards, ensure event tracking, leverage ML and AI tools for advanced analyses, and translate insights into product recommendations across cross-functional teams.

Design and lead end-to-end AI solution architectures, ensuring scalability, security, and compliance. Translate business and regulatory requirements into technical designs, evaluate tools/platforms, document architecture standards, coordinate technical teams, and support deployment and ongoing improvements.