Top Senior Machine Learning Jobs in St. Louis, MO

Lead end-to-end LLM inference performance across serving systems, models, GPU hardware, and workloads. Define rigorous benchmarks, diagnose bottlenecks from scheduling through kernels and interconnects, optimize single- and multi-node deployments, and deliver production-ready runtimes and configurations. Collaborate with product and infrastructure teams, evaluate inference technologies, and implement runtime fixes. The role requires strong Python engineering, production experience with serving engines such as vLLM or SGLang, GPU profiling, and knowledge of modern inference optimization techniques.

Design, build, and support high-throughput, low-latency LLM inference and data pipelines; collaborate with data scientists to post-train and evaluate models; implement scalable, production-ready systems with strong testing, monitoring, and performance focus; mentor engineers and iterate on architecture, reliability, and user-facing AI applications.

Own and improve Headway’s privacy program across HIPAA, 42 CFR Part 2, state privacy laws, individual rights, incidents, vendor governance, and AI use. Maintain controls, data maps, metrics, training, and operational workflows. Conduct product, vendor, and AI privacy assessments; manage rights requests and incident investigations; coordinate notifications and regulatory submissions; and translate complex requirements into practical guidance for cross-functional teams.

Develop autonomy evaluation metrics, statistical and machine-learning analyses, dashboards, and pipelines for simulation and on-road autonomous vehicle testing. Analyze perception, prediction, and planning performance; identify anomalous behavior and critical scenarios; apply VLMs and LLMs where appropriate; and support release gating and safety decisions. The role requires production Python, C++ debugging, technical leadership, cross-functional collaboration, and rigorous software engineering practices.

Define architecture and metrics for autonomous driving evaluation, lead cross-functional integration across autonomy and simulation teams, develop statistical and machine learning methods, analyze large-scale time-series data, manage evaluation KPIs and release gates, and communicate safety and readiness insights through dashboards and stakeholder presentations.

Serves as the technical bridge between customers, Sales, and technology teams. Leads technical discovery, solution architecture, demonstrations, workshops, proofs of concept, and evaluations using HERE data, APIs, mapping, routing, spatial analytics, cloud, AI, and enterprise integration. Partners with Sales to qualify opportunities, reduce technical risk, develop proposals and reusable presales assets, and guide customers toward location-intelligence solutions.

Design and lead the technical strategy for search across Vannevar’s products. Build and improve full-text, vector, and LLM-powered retrieval systems, optimizing latency, relevance, index quality, freshness, and performance. Collaborate with ML, product, design, and mission strategy teams to translate user needs into search innovations. Apply expertise in information retrieval, NLP, machine learning, indexing, ranking, query parsing, tokenization, vector search, and evaluation frameworks.

Drive revenue growth across large enterprise accounts by building pipeline, meeting license, support, and services targets, and expanding strategic customer relationships. Develop account plans, orchestrate complex deals, use channel partnerships, and collaborate cross-functionally. The role requires enterprise software sales experience and involves consultative, solution, and target-account selling, with emphasis on SaaS, cloud, security, DevOps, analytics, and machine learning solutions.

Design and scale automation and AI-driven solutions for security governance, risk, and compliance. Build pipelines to collect and validate evidence, integrate GRC platforms with security and IT systems, automate control monitoring and audit preparation, and deploy LLM-based workflows for testing, policy mapping, and risk reporting. Establish AI guardrails and quality controls while collaborating with security, engineering, data, and business teams to improve compliance and security posture.

Leads enterprise security strategy and operations across Microsoft MCAPS-Core. Oversees security programs, governance, risk management, threat intelligence, incident response, compliance, security reviews, performance metrics, budgets, and cross-organizational partnerships. Directs teams and suppliers, develops AI-enabled security capabilities, assesses geopolitical and operational threats, communicates executive-level risk insights, and ensures security controls are adopted without disrupting business or customers.

Build and evaluate machine learning models and features for fraud detection across account opening, account takeover, and identity risk. Analyze complex datasets to identify fraud patterns, develop hypotheses, validate models, and measure technical and business performance. Write tested Python code, support production deployment and monitoring, communicate findings, and follow standards for privacy, explainability, validation, documentation, and governance.

Designs, develops, tests, implements, maintains, and supports custom software applications across internet security, content delivery, APIs, machine learning, and cloud computing. The role improves platform functionality, develops new capabilities, automates product operations, contributes to architecture and software design, and expands automated unit, functional, integration, and end-to-end testing.

Serve as the persistent technical partner for strategic and premium customers, diagnosing workflows, labeling, configurations, model behavior, and technical health. Build success plans with Customer Success Managers, guide implementations and model releases, conduct technical health reviews, coordinate fraud incident responses, and communicate technical findings to business and engineering stakeholders. Identify recurring customer patterns and provide feedback to Product and Engineering while supporting account retention and growth.

Own technical relationships with insurance carrier accounts by leading discovery, solution design, integrations, deployment support, defect management, QA, documentation, API and payload validation, SQL-based account monitoring, and incident management. The role partners with client engagement and engineering teams to ensure deployments meet carrier requirements and progressively assumes greater ownership of technical account relationships.

Design and deliver secure, high-performance microservices and APIs. Develop backend services in Java and Python, integrate ML components, build front-end service layers, deploy containerized applications to cloud platforms, and collaborate in Agile teams to ensure scalable, test-driven solutions.

Owns the backlog, sprint cadence, releases, and production health of enterprise AI products. Translates product strategy into requirements, user stories, work packages, and sprint goals while coordinating engineers, data scientists, business partners, and dependent teams. Leads Scrum ceremonies, PI planning, testing, release communications, and uptime monitoring. Applies AI tooling to improve delivery and uses technical fluency to prototype, review pull requests, and support responsible AI implementation.

Lead and grow a team of Conversation Designers to build and scale conversational AI experiences. Partner with Product, Engineering, Analytics, and ML teams to drive strategy, tooling, evaluation, and quality practices. Recruit and remove roadblocks, own strategic initiatives, and remain hands-on in designing, testing, and improving AI-driven conversational products.

Leads strategy, roadmap, execution, commercialization, and customer outcomes for a major enterprise software product area. Conducts market and customer discovery, prioritizes opportunities, partners with engineering and design, establishes outcome-based metrics, and supports sales enablement. Builds and coaches the product management team, manages executive and customer relationships, and helps transition the company from services-led to product-led operations. The role emphasizes legal technology, eDiscovery, AI-enabled workflows, enterprise data, and regulated-industry requirements.

Lead architecture and technical strategy for a remote engineering organization building a React, Node.js, PostgreSQL, and AWS platform. Mentor engineers, establish engineering standards, drive JavaScript-to-TypeScript migration, design ETL and AI/LLM integration systems, resolve technical debt, and oversee technical design reviews, production support, incident response, hiring, and delivery. Partner with product, clinical, and business stakeholders to build scalable, reliable software.

Develop machine learning, AI, statistical, and predictive models using Snowflake and other data sources. Perform data extraction, cleansing, feature engineering, experimentation, visualization, and quality analysis. Partner with business and technical teams to deliver data products, conversational analytics, and actionable recommendations. Lead discovery sessions, communicate insights to nontechnical audiences, mentor analysts, and support enterprise data science projects.

Own technical delivery and account health for insurer software deployments. Responsibilities include discovery, solution design, integrations, API and payload review, QA testing, defect documentation, workflow mapping, SQL-based production monitoring, incident management, and technical communication with carrier accounts and engineering teams.

Lead hands-on engineering for an AI-powered email application across backend, mobile, and desktop platforms. Design reliable AI workflows involving orchestration, state, tool use, retries, fallbacks, and failure handling. Define APIs and abstractions, make architecture and scalability decisions, improve observability and reliability, and lead a small team of senior engineers through technical reviews, mentorship, and production delivery.

Build and scale accounting software synchronization solutions connecting BILL’s payment network with third-party accounting platforms. Lead end-to-end software design and delivery, develop scalable AWS microservices, improve platform performance, guide testing and CI/CD practices, resolve customer problems, mentor engineers, and use generative AI to accelerate development.

Lead Runpod’s Americas sales organization and revenue number across new business, expansion, and renewals. Manage and coach Account Executives and Account Managers, oversee forecasting and pipeline, lead complex enterprise deals and contract negotiations, build regional go-to-market strategy and sales playbooks, and convert product-led demand into revenue. Partner with Marketing, Product, Legal, and Finance while improving sales efficiency through AI and developing a remote-first team.

Designs, builds, scales, and operates distributed CI/CD services supporting millions of builds, tests, and releases. Develops code for Azure-based infrastructure spanning virtual machines, containers, and custom lab environments. Responsibilities include requirements analysis, architecture and design documentation, estimation, debugging, optimization, operational playbooks, on-call incident response, monitoring, reliability improvements, and mentoring engineers.