Top Senior Machine Learning Jobs in St. Louis, MO

Design and develop scalable backend systems using Kotlin, Micronaut, and Spring. Build RESTful APIs, optimize PostgreSQL and Elasticsearch databases, implement RabbitMQ-based asynchronous processing, integrate AI tools, and create automated tests. Deploy and monitor services on GCP using Docker, Kubernetes, and Terraform. Collaborate cross-functionally, participate in code reviews, troubleshoot performance issues, and deliver reliable backend products.

Lead technical strategy and architecture for Azure Storage geo-replication, data protection, failover orchestration, and business continuity. Drive cross-team delivery, operational excellence, telemetry, automation, AI-assisted operations, and represent the team in executive and customer engagements.

Own the technical side of deal progression for airline deployments: qualify opportunities, run demos and POCs, author integration and deployment architectures (PSS, APIs, data feeds, DNS, identity, networking), respond to RFPs/security questionnaires, scope SOWs and NFRs, and build reusable demo/reference assets to drive adoption and expansion while liaising between sales, engineering, and customers.

Lead go-to-market strategy for Sprout Social’s AI portfolio, including the Trellis AI agent. Develop enterprise launch playbooks, positioning, executive messaging, campaigns, and enablement programs. Analyze market and competitive dynamics, influence product roadmaps, improve launch processes, and partner with Product, Sales, Revenue, Brand, and executive leadership to drive adoption, revenue growth, deal expansion, and category leadership. The role also mentors marketing team members and operates with substantial autonomy.

Designs and maintains automated, AI-enabled detection and response capabilities across enterprise security platforms. Integrates SIEM, EDR, SOAR, and threat intelligence technologies; analyzes security telemetry; develops and validates detection content and automation workflows; documents procedures and runbooks; and collaborates with SOC, threat intelligence, and incident response teams. The role also evaluates emerging security capabilities and supports continuous improvement of detection operations for a federal agency.

Owns the strategy, roadmap, development, and adoption of financial data products and APIs. Partners with data science and engineering to integrate predictive and machine-learning models into scalable, trustworthy capabilities. Defines quality metrics, requirements, documentation, and support models while ensuring privacy, security, regulatory compliance, and downstream adoption across consumer and business banking products.

Leads enterprise AI platform strategy, architecture, engineering, governance, and operations across machine learning, generative AI, agents, data, and business intelligence. Owns platform standards, reusable services, lifecycle management, security, compliance, reliability, vendor commitments, budgets, and consumption. Directs production-scale AI enablement, establishes responsible AI controls, and manages engineering teams, staffing, operating plans, and executive stakeholder alignment.

Own strategy and execution for integrated B2B marketing campaigns that drive enterprise pipeline, self-service growth, platform adoption, and category awareness. Coordinate ABM, content, paid media, events, lifecycle, social, partnerships, PR, and sales activation. Manage launches, optimize audiences and conversion paths, orchestrate teams and agencies, and measure impact across engagement, pipeline, acquisition, product adoption, and awareness.

Drafts, reviews, and negotiates complex data, content, licensing, distribution, vendor, and supplier agreements. Advises internal teams on intellectual property, data and content rights, AI and machine learning use cases, privacy, regulatory compliance, and commercial disputes. Partners with Content, Sales, Marketing, Finance, and Product teams; develops policies, playbooks, and project plans; monitors evolving AI and data regulations; and provides broader corporate legal support.

Lead presales strategy for Workday Adaptive Planning with large enterprise customers. Conduct executive discovery, design tailored solution strategies, deliver demonstrations, communicate value, support sales cycles, showcase AI-enabled planning capabilities, respond to RFPs, represent Workday at events, and mentor peers. The role focuses on FP&A, workforce and operational planning, forecasting, analytics, and executive engagement, with travel of up to 50%.

Provides advanced technical support for robotic systems during commissioning and 24/7 customer operations. Diagnoses hardware, software, controls, Linux, network, and automation failures; analyzes logs and telemetry; develops integrations and support workflows; leads major incidents; coordinates engineering, field service, and customer teams; manages cases and corrective actions; validates AI-assisted diagnostics; and mentors engineers while improving system reliability and recovery times.

Provides statistical leadership for Medical Affairs, real-world evidence, comparative effectiveness, HTA, and HEOR activities. Designs and analyzes observational, clinical, Phase IV, and indirect treatment comparison studies; evaluates data quality, bias, uncertainty, and applicability; supports evidence-generation strategies, reimbursement submissions, publications, and scientific communications. Collaborates with statistics, epidemiology, RWE, medical, and external scientific teams to translate complex analyses into actionable conclusions.

The Senior Business Development Representative will generate enterprise sales pipeline through account research, lead identification, outbound calls, emails, and social outreach. The role qualifies opportunities, maintains accurate Salesforce records, represents Rasa’s AI platform, collaborates with sales and marketing teams, and works toward exceeding quotas. This fully remote position requires strong communication, organization, customer empathy, autonomy, and comfort working in a fast-paced startup environment.

Own the strategy and roadmap for Constructor’s search quality and Product Discovery Engine. Drive measurable improvements in relevance, conversion, revenue per visit, and GMV across retail verticals. Partner with ML, data science, and engineering teams to productionize state-of-the-art retrieval, ranking, query understanding, personalization, and LLM capabilities. Establish evaluation frameworks, investigate quality issues, align multiple teams, and expand into chapter-wide product leadership.

Owns operations for Optain’s nationwide network of contracted optometrists and ophthalmologists. Responsibilities include creating provider policies and SOPs, running quality and performance programs, modeling capacity, managing recruitment, handling complaints and urgent findings workflows, and preparing governance decisions for the Medical Director. The role partners with Product and Engineering to automate network processes and requires experience in healthcare operations, clinician networks, clinical quality, credentialing, and multistate licensing.

Lead the technical direction of Quora’s recommendation ecosystem, including feed retrieval, ranking, re-ranking, optimization, data pipelines, feature engineering, model training, and production integration. Drive measurable improvements through experimentation, apply generative AI, mentor engineers, and partner across product, data science, and infrastructure teams.

Leads delivery of large-scale AWS and digital transformation programs, overseeing planning, execution, reporting, risk mitigation, quality, and customer outcomes. Manages multi-functional teams of business analysts and engineers, develops product and service roadmaps, drives continuous improvement, and resolves customer issues. The role also involves people management, recruiting, coaching, business development, stakeholder communication, and aligning program portfolios with organizational strategy.

Serve as the primary business intelligence and analytics partner for Governance, Risk & Assurance and the General Counsel Strategy Office. Analyze complex datasets, build dashboards and data models, support data governance and risk initiatives, identify automation and AI opportunities, and translate technical findings into business recommendations. Collaborate across enterprise functions, provide reporting and technology guidance, evaluate AI solutions, and drive adoption of data-informed practices.

Design, develop, and operate scalable software platforms and automation for Azure network qualification infrastructure. Build tools for device provisioning, configuration, lifecycle management, testing, telemetry, and health validation. Develop AI-powered agents for troubleshooting, root-cause analysis, and engineering productivity. Create reliable distributed systems with observability, diagnostics, automated recovery, and scalability while collaborating across software and network engineering teams.

Develop machine learning and statistical models to identify, measure, and manage credit and fraud risk. Partner with stakeholders to translate requirements into scalable solutions, analyze large application and transaction datasets, deploy end-to-end models, and improve risk decision-making. The role requires advanced Python or R and SQL skills, expertise in fraud and underwriting models, model deployment, statistical methods, and mentoring junior data scientists.

Lead agile design and development projects for mobile apps and digital products. Coordinate product, design, engineering, marketing, leadership, and client stakeholders; manage project plans, scope, requirements, backlogs, acceptance criteria, deadlines, workflows, and deliverables. Support scoping and client relationship management while ensuring successful end-to-end software launches and alignment with business objectives.

Own the end-to-end product strategy and lifecycle for AI research products, from model development and user research through launch, pricing, and go-to-market. Partner with research, engineering, design, and business teams to define requirements, ship products, analyze metrics, run experiments, and prioritize features. The role requires strong technical or quantitative foundations, product management experience, SQL and Python fluency, knowledge of machine learning, and experience taking products from zero to one.

Lead AI engineering teams to design, build, and deploy end-to-end AI solutions. Manage client relationships, plan and deliver projects, mentor staff, drive adoption of cloud-native microservices, CI/CD, vector databases and orchestration tools, and ensure high standards of quality, innovation, and compliance.

Leads Kaseya’s market and competitive intelligence function, including competitor analysis, market sizing, customer segmentation, Voice of Customer, win/loss research, marketing effectiveness, and predictive analytics. Advises executives on market trends, customer behavior, competitive threats, and growth opportunities. Partners with product, sales, marketing, data science, and revenue operations, embeds insights into sales enablement, and builds a high-performing intelligence team.

Leads company-wide data science priorities, KPI frameworks, measurement standards, causal modeling, scenario planning, and agentic analytical automation. Builds reproducible SQL and Python workflows, validates predictive and causal relationships, establishes trusted metrics, partners with Finance, Product, Commercial, Engineering, and Data Engineering, and mentors scientists. The role drives adoption of governed self-service analytics and communicates assumptions, uncertainty, and business trade-offs to leadership.