Top Senior Machine Learning Jobs in St. Louis, MO

Lead strategic vision and execution of next-generation bioinformatics technologies. Identify and evaluate emerging computational methods, translate research into production-grade pipelines and prototypes, support product roadmaps and technology transfer, and partner cross-functionally to commercialize genomic and AI-driven healthcare solutions.

Provide senior legal and regulatory counsel for digital health and medical device products (SaMD), guiding product lifecycle, FDA and global filings, AI-enabled features, labeling, compliance, post-market obligations, and cross-functional governance. Lead strategy, manage external counsel, and translate regulatory developments into business guidance.

Develop and scale machine learning training systems for robotics data, optimize training pipelines, and collaborate with ML researchers to enhance autonomy models.

Lead design, development, and production deployment of ML and algorithmic solutions. Own end-to-end ML systems, support distributed production reliability, communicate tradeoffs, and apply generative AI, LLM fine-tuning, RAG, and agentic techniques to product problems.

Senior individual contributor responsible for leading pet/P&C insurance pricing model development (GLMs and ML), owning end-to-end projects, performing EDA and root-cause analysis, communicating results to stakeholders, and mentoring junior team members.

Own the strategy, roadmap, and underwriting models for Dave’s consumer credit products, including ExtraCash, Flex card, and future offerings. Partner with Data Science, Engineering, Risk, and Product teams to build scalable underwriting infrastructure, expand alternative data signals, manage credit KPIs, and lead rigorous experimentation. Present risk trade-offs to senior leadership, identify new underwriting-driven opportunities, and mentor product managers while balancing credit access, growth, retention, and losses.

Responsible for fine-tuning state-of-the-art LLMs, optimizing models for deployment, and driving AI architectural decisions. Collaborate with cross-functional teams to develop impactful AI products.

Build and maintain scalable ML and generative AI platforms and backend infrastructure; deploy and manage production applications; create services exposing ML/AI products; implement RAG solutions and vector databases; integrate LLM orchestration and foundation model APIs; collaborate cross-functionally and mentor teammates.

Lead development of an AI-enabled Ethereum Layer 2 platform: build front-end and back-end systems, deploy and optimize AI models, create data pipelines, collaborate on model training, and contribute to product innovation and other company projects.

The Manager of RevOps/Yield analyzes patterns and data to optimize ad operations, manage vendor relationships, and oversee a remote team for revenue generation.

Embed with clients to gather requirements and design AI-driven solutions for fraud and fincrime. Architect, train, evaluate, and deploy custom AI agents and workflows, optimize model performance, establish risk metrics and evaluation pipelines, and collaborate with engineering/product teams to scale into production.

Sell HiddenLayer's AI security platform to federal agencies by developing account strategies, driving pipeline and revenue, leading technical and executive engagements, navigating federal acquisition and contracting, coordinating cross-functional teams, and supporting adoption, expansion, and renewals across the Intelligence Community, DoD, DHS, and civilian agencies.

Own Oscilar's AML product suite (transaction monitoring, KYC/KYB, screening, case management, SAR filing, AI agents). Define detection rules, model calibration, data strategy, and defensible audit trails. Collaborate with engineers and compliance, use AI across discovery/design/analysis, deliver PRDs, validate models, and ship production features.

Lead end-to-end research applying advanced ML/DL (transformers, GNNs, RL, ensembles) to generate alpha across digital asset markets, build production-grade pipelines, prevent leakage/overfitting, analyze microstructure and on-chain data, and mentor junior researchers.

As Director of AI/ML, lead the ML organization, set technical vision, mentor a high-performing team, and contribute to model development and production deployment.

The AI & Data Science Director will lead AI strategies, foster technical leadership, support team development, and integrate generative AI into products.

Lead high-impact strategy and BizOps workstreams including M&A diligence, investor relations, new-market expansion, and cross-market operations. Frame ambiguous, board-level problems, build analysis and recommendations, align stakeholders, and own execution end-to-end while leveraging AI and automation.

The AI Sales Executive drives new business growth and expands client relationships by selling AI-driven solutions for engineering and manufacturing sectors, managing the full sales cycle with a consultative approach.

The Senior Generative AI Engineer will design and deploy AI/ML solutions, focusing on Generative AI systems and their operational excellence across various sectors like R&D and Clinical Trials.

The Technical Product Owner will lead product initiatives by defining requirements, managing the product backlog, and ensuring successful payment integrations while collaborating with engineering and risk teams.

This role involves leading strategic planning, product innovation, and cross-functional collaboration to enhance pharmacy analytics and drive growth initiatives for CVS Health.

Conduct ML research for query understanding, ranking, clustering, and AI-powered search. Prototype and productionize algorithms, define data and evaluation requirements, design scalable systems, collaborate with engineers, run experiments, and publish patents/papers to integrate state-of-the-art ML into Yahoo Search products.

Design and deploy production recommendation and retrieval engines, build data orchestration pipelines for multiple modalities, implement agentic workflow frameworks, and prototype, optimize, and scale models with monitoring, governance, and low-latency SLAs.

Lead design, training, fine-tuning, and deployment of ML and generative models (LLMs, diffusion). Build scalable MLOps pipelines, vectorization and data ingestion, integrate models into microservices for low-latency inference, implement evaluation/alignment/bias-mitigation, optimize models (quantization, distillation), and mentor engineers while influencing the AI product roadmap.

As a Senior Machine Learning Engineer, you will design and maintain ML systems for content recommendations, search, and spam detection, while augmenting user experience and system performance.