Top Senior Level Jobs in San Diego, CA

Lead and mentor a San Diego engineering team while staying hands-on building production LLM systems (RAG, agents, document processing). Drive architecture, evaluate models and tooling, own end-to-end delivery, collaborate with clients, and create reusable internal tooling and best practices to improve team performance and client outcomes.

Leads the design and delivery of AI-enabled research intelligence, data products, and agentic workflows for pharmaceutical R&D. Partners with scientists and business stakeholders to translate complex research questions into scalable data, tooling, and decision-support solutions. Engineers integrations, semantic context, retrieval, APIs, evaluation, observability, governance, and production support. Provides technical leadership, mentors engineers and analysts, manages delivery roadmaps, and promotes reusable, responsible AI capabilities across the research data ecosystem.

Leads principal-gifts fundraising for the American Cancer Society, managing a portfolio of high-net-worth individuals, foundations, and corporations to secure $5M+ gifts. Develops donor strategies, cultivates executive and board relationships, coordinates cross-functional fundraising efforts, creates proposals and cases for support, and tracks performance through CRM systems. Requires extensive experience closing major gifts and frequent collaboration with senior leaders, volunteers, and organizational teams.

Develop and manage client relationships while delivering holistic financial planning across investments, insurance, retirement, estate, and business needs. Grow assets under management, generate referrals and partnerships, collaborate with specialists, and build a scalable advisory practice. The role also involves maintaining compliance, supporting client service, developing a personal brand or team, and potentially acquiring or mentoring within an advisory practice.

Own the company’s business process automation layer by identifying inefficient workflows, designing and maintaining Google Workspace tools, integrating platforms, and building AI-powered workflows. The role partners cross-functionally to redesign processes, automate onboarding, reporting, HR, and operational handoffs, while managing validation, error handling, documentation, training, governance, and end-user support.

The Senior Portfolio Strategist oversees investment portfolios, forecasts long-term fixed-income market trends, and guides portfolio positioning and firm strategy. The role leads strategic research, product and service innovation, cross-functional initiatives, client relationships, and organizational change while ensuring consistency across portfolio management. Candidates need extensive fixed-income asset management experience, advanced analytical and financial modeling skills, strong leadership, strategic planning expertise, and the ability to communicate complex investment strategies.

Leads supply chain, purchasing, inventory, vendor, equipment, asset, and preventive maintenance programs across high-volume veterinary hospitals. Establishes inventory controls, negotiates with suppliers, manages equipment lifecycles and service agreements, oversees budgets and capital planning, analyzes performance data, develops teams, and implements standardized processes that improve availability, efficiency, cost control, and operational reliability.

Leads project management for one to two healthcare or pharmaceutical brands, overseeing complex cross-agency initiatives, integrated planning, budgets, timelines, resourcing, and operational execution. Manages PM teams, develops talent, partners with clients and department leaders, mitigates risks, improves workflows, and supports new business. The role also oversees financial forecasting and reconciliation, drives PMO initiatives, and integrates emerging AI-enabled tools into agency processes.

Direct hotel revenue management by forecasting demand, optimizing room and catering pricing, managing inventory and distribution channels, analyzing competitors, and monitoring revenue performance. Leads revenue strategy meetings, supports budgeting and business planning, maintains historical data, produces performance reports, and collaborates with sales, marketing, and hotel leadership to increase market share and profitability.

Leads human-centered design strategy, mixed-method research, systems thinking, strategic visualization, storytelling, and stakeholder workshops for government and industry clients. Partners with executives and cross-functional teams to frame complex challenges, synthesize insights, develop recommendations, and drive organizational alignment. Mentors design practitioners, establishes quality standards, and supports client success through service design, experience design, and strategic planning. The role is full-time, primarily on-site with clients 2–3 days weekly, and includes some travel.