Top Senior Machine Learning Jobs in Indianapolis, IN

Lead a Big Data Engineering team to deliver production-grade ETL and data pipelines at scale. Own team execution, code quality, morale, and roadmap execution with product managers. Remove roadblocks, coach and develop engineers, promote engineering best practices, and enable data-driven and AI-powered product features (personalization, recommendations, search, ranking, matching).

Evaluate and strengthen AI model behavior on cybersecurity topics by writing expert prompts, annotating and grading model responses for accuracy and safety, and applying structured guidelines to classify sensitive content. Work part-time on AI safety tasks with emphasis on secure, responsible handling of dual-use information.

Lead manufacturing process improvements for precision optical production: analyze data, reduce cycle time and costs, design/qualify tooling and automation, apply Lean/Six Sigma and AI-enabled analytics, maintain process documentation, partner cross-functionally, drive CAPEX and continuous improvement projects, and train production staff.

Seeking a Senior Full Stack .NET Developer to work on a social good project, with strong skills in C#, AngularJS, design, and UX. Requires 5+ years of experience.

The Senior Data Scientist will design and deploy time-series forecasting models, collaborate with stakeholders, and operationalize models in cloud environments, focusing on demand planning across various industries.

Lead end-to-end development of AI and machine learning solutions for a medical claims synthesis product. Design and deploy LLM-driven features, hybrid statistical ML and RAG systems, document extraction, and human-in-the-loop summarization workflows. Make architecture decisions, optimize production systems, evaluate model performance, collaborate with SMEs and product teams, and mentor engineers. Translate emerging AI research into reliable, scalable production applications.

Lead document-vision research and production systems for multimodal legal evidence understanding. Define evaluation standards, frame hard problems, design and ship models, run efficacy studies and monitoring, mentor senior scientists, and advise leadership on scientific direction.

Drive Midwest SLED revenue by selling analytics-driven SaaS identity and fraud solutions. Build pipeline, manage full sales cycle, develop partnerships/channels, collaborate with product, forecast accurately, and travel up to 50% to close deals and ensure customer success.

The Engineering Manager will lead teams in developing and managing Blackbaud's Data & AI platform, focusing on scalability, security, and cost-efficiency.

Lead end-to-end deployments of AI for hotel revenue teams: integrate PMS/CRS/RMS, ship ML/optimization models and agentic workflows, validate recommendations with revenue managers, define metrics, drive adoption, and hire/mentor the forward deployed engineering team.

Lead strategy, roadmap, and lifecycle for payer analytics and automation products. Translate market, customer, regulatory, and data insights into product requirements, drive cross-functional delivery with Engineering and Data Science, support go-to-market and adoption, and measure product performance to inform investment and portfolio decisions. Build product practices and partner with stakeholders across sales, customer success, clinical, actuarial, and executive teams.

Lead Growth Engineering architecture and implementation: build Go-based data pipelines, audit/replace martech, create experimentation infrastructure, ship full-stack Go/TypeScript features, productionize ML, review team work, and apply AI-assisted development daily.

Lead execution of Product Engineering AI and automation initiatives across photonics products. Build and deploy reusable AI/automation tools, transform engineering data into AI-ready systems, and drive cross-functional adoption to improve development, qualification, manufacturing, and reliability processes.

Set the technical direction for machine learning at Payabli by maturing production risk models and launching new models across the payments lifecycle. Establish experimentation, monitoring, drift detection, benchmarking, retraining, and incident-response foundations. Translate payments challenges into modeling opportunities, connect model performance to business outcomes, influence the ML roadmap, and mentor engineers while partnering with product, engineering, and risk operations.

Design, build, deploy, and operate production machine learning systems for personalization, recommendations, optimization, decisioning, experimentation, and measurement. Build reusable ML platforms, pipelines, and tooling; manage model monitoring, quality, drift detection, retraining, governance, and reliability. Partner with data scientists, engineers, and product teams to productionize models, make architectural decisions, and provide technical leadership through mentorship, reviews, and engineering standards.

Lead a consortium advancing AI-driven neurodegeneration research: set strategy, build partnerships, manage multidisciplinary executive team, oversee product development and deployment, secure funding, ensure ethical AI and scientific integrity, and scale the platform to broader biomedical domains.

Lead development of digital twin and simulation models for warehouse operations, deploy AI-driven decision systems, build forecasting and optimization models, validate experiments linking operational metrics to financial impact, and partner with engineers, operations, and external AI/academic partners to scale innovations across fulfillment networks.

The Business Development Director will lead strategic engagement with Google Cloud, focusing on partnership growth, go-to-market strategies, and revenue generation through cloud solutions.

Lead design and scaling of a unified fraud and risk platform. Own roadmap, fraud metrics, SQL-based analysis, A/B testing, real-time detection models, and cross-functional delivery to balance customer experience and risk mitigation.

Lead fraud detection and mitigation for a conversational BNPL product. Define fraud typologies, own repayment and chargeback analytics, manage fraud KPIs, design operational policies, collaborate on ML models and decisioning workflows, and coordinate SARs and compliance reporting.

Lead fraud detection and mitigation for a conversational BNPL product: define fraud typologies, analyze repayment/chargeback trends, own fraud KPIs, design policies, collaborate on ML models and decisioning workflows, and coordinate SARs with Compliance.

Lead fraud risk for a conversational lending product (SNPL): define first-party fraud typologies, analyze repayment and chargeback trends, own fraud KPIs, design automated/manual blocking policies, coordinate ML/rules with central Fraud and Data teams, and liaise with Compliance on SARs and loan abuse.

The AI Engineer will design and build production systems, focusing on LLM integration, system reliability, evaluation frameworks, and high-quality product features while maintaining strong engineering practices.

Lead end-to-end delivery of LOIS by owning the master program plan, coordinating cross-functional teams (engineering, product, design, ML, data, SRE, operations), resolving blockers and dependencies, establishing lightweight delivery infrastructure and tooling, partnering on release planning, and maintaining transparent status, risks, and accountability to deliver complex features to customers.

Drive new business and expand accounts by selling AI-driven services and software to engineering and manufacturing customers. Manage full sales cycle from prospecting to close, align solutions to measurable ROI, collaborate with technical and marketing teams, and meet revenue targets while attending industry events and maintaining CRM pipeline accuracy.