Top Senior Machine Learning Jobs in Indianapolis, IN

Reposted 6 Days AgoSaved
In-Office or Remote
Indianapolis, IN
53K-188K Annually
Senior level
53K-188K Annually
Senior level
Agency • Information Technology
Design, build, and productionize generative AI solutions: advanced Python development, LLM prompt engineering and fine-tuning, agent frameworks, RAG pipelines with vector DBs, API and cloud deployment, MLOps/LLMOps, model evaluation and Responsible AI practices, and translate business needs into scalable AI applications.
Top Skills: AdkAWSAzureETLFaissFastapiFine-TuningGCPLangchainLanggraphLlmsMicroservicesMlopsPineconePrompt EngineeringPythonRestRetrieval-Augmented Generation (Rag)Streaming
Reposted 6 Days AgoSaved
In-Office or Remote
Indianapolis, IN
62K-217K Annually
Senior level
62K-217K Annually
Senior level
Agency • Information Technology
Design, build, and scale production Generative AI applications: multi-agent systems, advanced RAG pipelines, LLM integration and fine-tuning, scalable FastAPI backends, vector search, monitoring, and Dockerized deployments.
Top Skills: Async PythonCi/CdClaudeDockerEmbedding ModelsFastapiGeminiHugging FaceLangchainLanggraphLlamaLlamaindexLlm MonitoringLocal LlmsLocal Model QuantizationModel Fine-TuningMulti-Agent SystemsOpenaiPostgresPrompt EngineeringPythonPyTorchTensorFlowVector DatabasesVector Search
Reposted 6 Days AgoSaved
In-Office or Remote
Indianapolis, IN
62K-217K Annually
Senior level
62K-217K Annually
Senior level
Agency • Information Technology
Design, build, and deploy production Generative AI applications: orchestrate multi-agent workflows, implement advanced RAG with vector DBs, integrate and fine-tune LLMs, develop scalable FastAPI/async backends, containerize with Docker, and optimize GenAI systems for latency, cost, and reliability.
Top Skills: Async PythonCi/CdClaudeDockerEmbedding ModelsFastapiGeminiHugging FaceLangchainLanggraphLlamaLlamaindexLlm MonitoringLocal LlmsMulti-Agent SystemsOpenaiPostgresPrompt EngineeringPythonPyTorchRagTensorFlowVector DatabasesVector Search
Reposted 6 Days AgoSaved
In-Office or Remote
Indianapolis, IN
Senior level
Senior level
Agency • Information Technology
Design, develop, and deploy end-to-end machine learning models using statistical and ML algorithms. Prepare and enrich data, implement scalable PySpark/Databricks solutions, and collaborate with product and engineering to create personalized customer experiences and actionable insights.
Top Skills: DatabricksJupyter NotebooksNumpyPandasPysparkPythonPyTorchScikit-LearnSparkTensorFlow
Reposted 6 Days AgoSaved
Remote
Indianapolis, IN
47K-166K Annually
Senior level
47K-166K Annually
Senior level
Agency • Information Technology
Design, build, and deploy production-grade ML and AI systems end-to-end, combining classical ML, deep learning, and LLM/agentic integrations. Implement MLOps, monitoring, CI/CD, model serving, vector search/RAG pipelines, and scalable APIs; mentor engineers and drive engineering best practices.
Top Skills: AnthropicAutogenChromaCi/CdCrewaiDockerFastapiFlaskGeminiHadoopKubernetesLangchainLanggraphLlamaindexLoraMilvusMlflowNumpyOpenaiPandasPineconePrompt EngineeringPythonPyTorchQloraRagSagemakerScikit-LearnSparkSQLTensorFlowVector SearchVertex AiWeaviate
Reposted 6 Days AgoSaved
In-Office or Remote
Indianapolis, IN
79K-276K Annually
Senior level
79K-276K Annually
Senior level
Agency • Information Technology
Design, build, and scale production Generative AI applications including multi-agent systems, advanced RAG pipelines, and local/frontier LLM deployments. Implement high-performance backends with FastAPI and async Python, fine-tune and quantize models, integrate vector databases and retrieval systems, and deploy/monitor containerized AI services for reliability, latency, and cost optimization.
Top Skills: Async PythonCi/CdClaudeDockerEmbedding ModelsFastapiGeminiHugging FaceLangchainLanggraphLlamaLlamaindexLlm MonitoringLocal Llm Quantization/HostingModel Fine-TuningMulti-Agent SystemsOpenaiPostgresPrompt EngineeringPythonPyTorchRagTensorFlowVector Databases
Reposted 6 Days AgoSaved
In-Office or Remote
Indianapolis, IN
79K-276K Annually
Senior level
79K-276K Annually
Senior level
Agency • Information Technology
Build and scale production Generative AI applications: design multi-agent systems and LangGraph workflows, implement advanced RAG with LlamaIndex and vector DBs, integrate and fine-tune various LLMs, and deploy containerized FastAPI services with monitoring, CI/CD, and performance/cost optimizations.
Top Skills: Api SecurityAsync PythonCi/CdClaudeDockerEmbedding ModelsFastapiGeminiGenai OptimizationHugging FaceLangchainLanggraphLlamaLlamaindexLlm MonitoringLlm QuantizationLocal Llm DeploymentModel Fine-TuningMulti-Agent SystemsOpenaiPostgresPrompt EngineeringPythonPyTorchTensorFlowVector DatabasesVector SearchWorkflow Design
Reposted 6 Days AgoSaved
Remote
Indianapolis, IN
Senior level
Senior level
Artificial Intelligence • Edtech • HR Tech • Software
Design, build, deploy, and operate production-grade AI/ML and LLM systems (including RAG and agentic pipelines). Integrate AI capabilities with product workflows, run evaluation and monitoring, optimize model and system performance, and apply strong engineering practices (testing, CI/CD, versioning).
Top Skills: Ci/CdCloudLlmsPythonRag
Reposted 6 Days AgoSaved
Remote
Indianapolis, IN
165K-190K Annually
Senior level
165K-190K Annually
Senior level
Big Data
Design and implement production ML features, close behavior gaps with common frameworks, investigate divergences, improve performance and stability, and document designs and tests for geospatial and large-scale ML workflows.
Top Skills: C++JavaScalaScikit-LearnSpark MlXgboost
Reposted 6 Days AgoSaved
Remote
Indianapolis, IN
180K-210K Annually
Senior level
180K-210K Annually
Senior level
eCommerce • Insurance • Software
Lead a team of machine learning data scientists, overseeing model development for fraud detection and risk assessment, and ensuring quality throughout the model lifecycle while mentoring the team.
Top Skills: AWSPythonPyTorchScikit-LearnSQLXgboost
Reposted 6 Days AgoSaved
Remote
Indianapolis, IN
220K-260K Annually
Senior level
220K-260K Annually
Senior level
Artificial Intelligence • Healthtech • Software
As a Staff Machine Learning Research Scientist, you will lead ML research, develop evaluation frameworks, mentor researchers, and collaborate on clinical AI solutions.
Top Skills: AirflowAWSDeepspeedGitJaxKubernetesPythonPyTorchSlurmSnowflakeTorchtune
Reposted 6 Days AgoSaved
Remote
Indianapolis, IN
128K-165K Annually
Senior level
128K-165K Annually
Senior level
Financial Services
The Senior Analyst in Predictive Analytics and Machine Learning develops and maintains statistical models to support business decisions, monitors model performance, and collaborates with stakeholders across the company.
Top Skills: PythonRSASSQL
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7 Days AgoSaved
Remote
Indianapolis, IN
159K-234K Annually
Senior level
159K-234K Annually
Senior level
Fashion • Marketing Tech • Wearables
Own end-to-end production ML systems for search, recommendations, and ranking: architecture, training pipelines, inference, deployment, monitoring, drift detection, and retraining. Partner with data, product, and backend teams to ship reliable, low-latency ML-driven product experiences and set standards for ML infrastructure and model health.
Top Skills: AirflowCloud WarehouseDbtDrift DetectionExperiment TrackingModel VersioningPipeline OrchestrationPythonRanking/Recommendation SystemsSearch/Retrieval SystemsSQL
7 Days AgoSaved
Remote
Indianapolis, IN
Senior level
Senior level
Big Data • Food • Mobile • Payments
Lead and grow a team of ML engineers building production ML systems for Fetch's Ad Platform. Translate product strategy into roadmaps, guide design and implementation of models for ranking, targeting, bidding and forecasting, set metrics and experimentation, enforce architectural and operational standards, manage trade-offs across performance and reliability, and drive cross-functional alignment to improve advertiser and member outcomes.
Top Skills: Automated Training And Deployment PipelinesCloud-Based Data SystemsCloud-Based Ml SystemsDistributed SystemsFeature PlatformsLarge-Scale Data ProcessingMachine Learning FrameworksMlopsModel MonitoringPythonSQL
Reposted 16 Days AgoSaved
In-Office or Remote
Indianapolis, IN
Senior level
Senior level
Artificial Intelligence • Software
The role involves designing and scaling ML infrastructure for LLMs, including building training pipelines and deploying models in cloud and on-prem environments. Collaboration with engineers and managing GPU/TPU workloads is key.
Top Skills: AWSDockerGCPKubernetesPythonPyTorchTensorFlow
Reposted 7 Days AgoSaved
Remote
Indianapolis, IN
221K-292K Annually
Senior level
221K-292K Annually
Senior level
Financial Services
Lead design, deployment, and monitoring of predictive models for credit risk, collections, and operations. Drive adoption of modern ML and MLOps, mentor data scientists, define strategic roadmap, advise senior leadership, and ensure model governance and regulatory compliance.
Top Skills: AWSAzureGCPKubeflowMlflowPythonRSASSQL
Reposted 7 Days AgoSaved
Remote
Indianapolis, IN
175K-220K Annually
Senior level
175K-220K Annually
Senior level
Software
Design, build, and ship AI-powered observability features using LLMs and agentic workflows. Rapidly prototype, iterate with real users, integrate AI into alerting, runbooks, and developer workflows, and ensure solutions are scalable, maintainable, and production-ready while collaborating cross-functionally.
Top Skills: AWSAzureGCPGenerative AiLlmsObservability ToolsPrompt Engineering
Reposted 8 Days AgoSaved
Remote
Indianapolis, IN
203K-245K Annually
Senior level
203K-245K Annually
Senior level
HR Tech • Software
The Machine Learning Engineer will execute the full ML lifecycle, collaborating on model implementation and improving customer experiences through data-driven insights.
Top Skills: AirflowSparkBeamJavaKerasPythonPyTorchScalaSQLTensorFlowVertexai
Reposted 8 Days AgoSaved
Remote
Indianapolis, IN
157K-294K Annually
Senior level
157K-294K Annually
Senior level
Artificial Intelligence • Software
Lead the end-to-end machine learning lifecycle for AI products, managing data pipelines and model development to optimize performance and accuracy in production.
Top Skills: AWSGCPJaxNumpyPandasPythonPyTorchTensorFlow
Reposted 8 Days AgoSaved
Remote or Hybrid
Indianapolis, IN
153K-198K Annually
Senior level
153K-198K Annually
Senior level
AdTech • Digital Media • eCommerce • Marketing Tech • Mobile • Software
The Senior Machine Learning Engineer will manage the full ML lifecycle, collaborating with teams to develop scalable systems that improve product decisions and empower monetization strategies.
Top Skills: AirflowAWSDbtPythonPyTorchRedisScikit-LearnSparkSQLTensorFlow
Reposted 8 Days AgoSaved
Remote
Indianapolis, IN
158K-208K Annually
Senior level
158K-208K Annually
Senior level
Biotech
Lead the strategy and implementation of AI solutions in R&D, driving adoption and improving operational efficiency through advanced analytics. Collaborate with cross-functional teams to design AI/ML models and evaluate new technologies.
Top Skills: AWSAzureDatabricksNumpyPandasPower BIPythonPyTorchRR ShinySASScikit-LearnSQLTensorFlow
Reposted 8 Days AgoSaved
Remote
Indianapolis, IN
Senior level
Senior level
Artificial Intelligence • Machine Learning • Natural Language Processing • Software • Generative AI
Lead end-to-end technical programs for ML infrastructure (inference, serving, efficiency, endpoints). Coordinate cross-functional teams, prioritize overlapping projects, manage timelines, budgets and scope, drive incident management and continuous improvement, and communicate status to engineering and leadership.
Reposted 8 Days AgoSaved
Remote
Indianapolis, IN
Senior level
Senior level
Artificial Intelligence • Automotive • Transportation
Lead research on humanistic AI for autonomous systems. Collaborate with teams, design experiments, and publish findings in top-tier publications.
Top Skills: C++Python
Reposted 8 Days AgoSaved
Remote
Indianapolis, IN
164K-205K Annually
Senior level
164K-205K Annually
Senior level
Automotive • Insurance • Machine Learning • Mobile • Software
As a Lead Machine Learning Engineer at Root, you'll build scalable ML systems, partner with data scientists, and improve operational practices for customer lifetime value modeling.
Top Skills: AirflowAWSAzureDagsterDatabricksDbtGCPMlflowPythonSnowflakeSparkTerraform
One Month AgoSaved
Remote
Indianapolis, IN
Senior level
Senior level
Gaming • Machine Learning • News + Entertainment • Design • Conversational AI • Generative AI
Lead technical execution across backend, frontend, mobile, AI, and data. Translate ambiguous product goals into technical plans, unblock hard engineering problems, coordinate cross-domain work, raise engineering quality, define hiring needs and technical evaluation standards, and build internal AI workflows to foster an AI-native engineering culture.
Top Skills: Ai AgentsAi SystemsAndroidData InfrastructureData PipelinesExperimentationFlutterGoiOSLlm WorkflowsMachine LearningNext.JsPythonReactReact NativeRecommendation Systems
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