Top Senior Software Engineer Jobs in Buffalo, NY

Build and scale ML-optimized HPC infrastructure, manage Kubernetes-based GPU/TPU superclusters, optimize for AI/ML training, and mentor teams while innovating in ML infrastructure.

Build and maintain reliable, secure, scalable backend systems for Lithic’s product platform. Own projects end to end across API key management, reliability, audit logging, search, and API infrastructure. Improve system reliability, reduce technical debt, participate in on-call rotations, and lead team process improvements while collaborating asynchronously across time zones.

Build and operate highly scalable storage infrastructure supporting petabyte-scale imagery data. Responsibilities include developing backend services and APIs, managing object storage and metadata indexing, tuning Elasticsearch, improving disaster recovery, monitoring performance, responding to incidents, contributing to architecture and roadmaps, and advising engineers. The role requires strong production software engineering experience with Go or Python, cloud-native systems, relational and non-relational databases, and highly available services.

Lead technical strategy and architecture for Affirm Bank's cloud, data, vendor integrations, and operational tooling. Design, build, and operate high-stakes systems end-to-end, own incident response, vendor selection, and the Bank↔Affirm Inc integration boundary. Ensure examiner-ready documentation, compliance, reliability, and observability while mentoring engineers and pushing AI-assisted engineering practices to increase velocity and product safety.

Build and improve frontend interfaces for DogByte and other internal products used by veterinary hospitals. Own projects from problem framing through production release, collaborate with Design and Product, uphold accessibility and performance standards, evolve shared components and design systems, review technical work, and contribute to backend or full-stack development as needed. Apply AI tools thoughtfully across development workflows while maintaining quality and reliability.

Lead architecture and implementation of software for autonomous UAS systems; mentor engineers; ensure compliance with aerospace standards; optimize CI/CD pipelines.

Develop and enhance the new Stores platform while supporting various e-commerce tools to improve seller success online.

As a Senior Fullstack Software Engineer at Vanta, you will lead complex projects, set technical direction, design and develop new functionalities, and contribute to the engineering culture while mentoring other engineers.

The Software Engineer will develop and support the MEMX Trading system, focusing on high throughput event-sourcing applications and resolving production issues.

Seeking experienced Senior Backend Engineers to join a collaborative team, focusing on backend systems, shared services, and product features aimed at improving user experiences and monetization.

Design and implement DataPath on silicon. Write efficient, modular code with thorough testing. Requires experience in packet forwarding and virtualized Linux environments.

The Senior Full Stack Software Engineer will oversee technical development in a B2B SaaS healthcare environment, mentor junior engineers, and lead product features.

The Software Engineer will develop customer-facing integrations, build APIs, enhance security, and improve system reliability while collaborating with multiple teams.

The Senior Web Software Engineer will build and maintain web components, own features from inception to production, implement designs, partner with teams, and impact product evolution.

The Senior Mobile Software Engineer will develop user-facing features for a cross-platform app, ensuring code quality and functionality throughout the entire lifecycle of features.

As a Senior Backend Software Engineer at Step, you'll own features from inception to production, improve Kotlin services, ensure code quality, and work collaboratively in a small team.

Lead the bioinformatics pipeline team, setting technical strategy and architecture. Ensure engineering best practices, mentor staff, and oversee DevOps strategy for reliable software delivery in a regulated environment.

Design, implement, and ship end-to-end features across backend services and a React web client for a multi-tenant ERP. Own schema design, migrations respecting row-level security, integrations with platform services, and deliver high-quality, performant code with CI/CD, tests, and code review. Leverage AI coding assistants responsibly and collaborate cross-functionally to evolve shared platform libraries and developer tooling.

The role focuses on optimizing coding practices and collaboration within the engineering team, improving internal tooling, and communicating between teams and leadership.

The Senior Svelte Software Engineer will develop high-quality, scalable Svelte web components, collaborate on design systems, and ensure component reliability.

The Senior Software Engineer will lead teams to build secure, high-scale cloud applications, ensuring system reliability and delivering software solutions.

Build and improve scalable, secure, performant web applications and data pipelines for healthcare challenges. Develop technical roadmaps with engineering, product, and business stakeholders using Agile processes. Mentor junior engineers, conduct thorough code reviews, and promote observability, testing, alerting, metrics, and frequent incremental releases. Work with large-scale data processing, databases, APIs, cloud technologies, containerization, orchestration, and CI/CD systems.

Lead design, implementation, and maintenance of scalable backend systems and services. Improve performance, reliability, and deployments; operate production systems (incident response rotation); conduct code reviews; mentor engineers; collaborate with product, sales, and customers.

Designs, develops, and maintains scalable QA automation frameworks using C#, Selenium, RestSharp, Appium, SQL, and Azure. Leads CI/CD automation infrastructure, test strategy, code reviews, failure investigation, quality metrics, and process improvements. Collaborates with development, product, and business teams throughout the software lifecycle, mentors QA automation engineers, supports customers and business analysts, identifies test coverage gaps, and provides technical guidance on complex software quality issues.

Designs and implements protocols and features for highly scalable distributed block storage, focusing on durability, availability, performance, reliability, and observability. Responsibilities include coding, optimization, debugging, design documentation, stakeholder collaboration, incident response, on-call operations, and mentoring engineers. The role requires expertise in C or C++, distributed systems, cloud backend development, multithreaded programming, and large-scale software delivery.