Top Senior Machine Learning Jobs in Buffalo, NY

Build and maintain scalable ML and generative AI platforms and backend infrastructure; deploy and manage production applications; create services exposing ML/AI products; implement RAG solutions and vector databases; integrate LLM orchestration and foundation model APIs; collaborate cross-functionally and mentor teammates.

Lead development of an AI-enabled Ethereum Layer 2 platform: build front-end and back-end systems, deploy and optimize AI models, create data pipelines, collaborate on model training, and contribute to product innovation and other company projects.

The Manager of RevOps/Yield analyzes patterns and data to optimize ad operations, manage vendor relationships, and oversee a remote team for revenue generation.

Embed with clients to gather requirements and design AI-driven solutions for fraud and fincrime. Architect, train, evaluate, and deploy custom AI agents and workflows, optimize model performance, establish risk metrics and evaluation pipelines, and collaborate with engineering/product teams to scale into production.

Sell HiddenLayer's AI security platform to federal agencies by developing account strategies, driving pipeline and revenue, leading technical and executive engagements, navigating federal acquisition and contracting, coordinating cross-functional teams, and supporting adoption, expansion, and renewals across the Intelligence Community, DoD, DHS, and civilian agencies.

Own Oscilar's AML product suite (transaction monitoring, KYC/KYB, screening, case management, SAR filing, AI agents). Define detection rules, model calibration, data strategy, and defensible audit trails. Collaborate with engineers and compliance, use AI across discovery/design/analysis, deliver PRDs, validate models, and ship production features.

Lead end-to-end research applying advanced ML/DL (transformers, GNNs, RL, ensembles) to generate alpha across digital asset markets, build production-grade pipelines, prevent leakage/overfitting, analyze microstructure and on-chain data, and mentor junior researchers.

As Director of AI/ML, lead the ML organization, set technical vision, mentor a high-performing team, and contribute to model development and production deployment.

The AI & Data Science Director will lead AI strategies, foster technical leadership, support team development, and integrate generative AI into products.

Lead high-impact strategy and BizOps workstreams including M&A diligence, investor relations, new-market expansion, and cross-market operations. Frame ambiguous, board-level problems, build analysis and recommendations, align stakeholders, and own execution end-to-end while leveraging AI and automation.

The AI Sales Executive drives new business growth and expands client relationships by selling AI-driven solutions for engineering and manufacturing sectors, managing the full sales cycle with a consultative approach.

The Senior Generative AI Engineer will design and deploy AI/ML solutions, focusing on Generative AI systems and their operational excellence across various sectors like R&D and Clinical Trials.

The Technical Product Owner will lead product initiatives by defining requirements, managing the product backlog, and ensuring successful payment integrations while collaborating with engineering and risk teams.

This role involves leading strategic planning, product innovation, and cross-functional collaboration to enhance pharmacy analytics and drive growth initiatives for CVS Health.

Conduct ML research for query understanding, ranking, clustering, and AI-powered search. Prototype and productionize algorithms, define data and evaluation requirements, design scalable systems, collaborate with engineers, run experiments, and publish patents/papers to integrate state-of-the-art ML into Yahoo Search products.

Lead integration of AI/ML (LLMs, RAG, generative workflows) into a cloud-native full‑stack platform. Architect serverless backends, optimize data pipelines, modernize legacy PHP APIs, maintain CI/CD, mentor engineers, and support secure, defense-constrained deployments.

Design and deploy production recommendation and retrieval engines, build data orchestration pipelines for multiple modalities, implement agentic workflow frameworks, and prototype, optimize, and scale models with monitoring, governance, and low-latency SLAs.

Lead design, training, fine-tuning, and deployment of ML and generative models (LLMs, diffusion). Build scalable MLOps pipelines, vectorization and data ingestion, integrate models into microservices for low-latency inference, implement evaluation/alignment/bias-mitigation, optimize models (quantization, distillation), and mentor engineers while influencing the AI product roadmap.

As a Senior Machine Learning Engineer, you will design and maintain ML systems for content recommendations, search, and spam detection, while augmenting user experience and system performance.

Design real-world ML and NLP tasks, build reference solutions and evaluation frameworks in Python, assess LLM outputs for correctness and reasoning, identify failure modes, create scoring rubrics, and collaborate with experts to improve model capabilities. Part-time, remote contractor (~20 hours/week).

Lead design and delivery of scalable AI systems for autonomous threat detection and response. Build and productionize LLMs, graph reasoning engines, streaming feature pipelines, and orchestration frameworks. Own evaluation, reliability, and cross-functional collaboration while mentoring engineers and experimenting with RAG, tool-calling agents, and multi-modal models.

The AI/Machine Learning Engineer will develop systems for automating health benefits decisions, integrating large language models with rule-driven patterns, and ensuring compliance with regulations.

Lead design, development, and productionization of advanced ML models and data pipelines. Drive architecture, experimentation, validation, and best practices while mentoring ML engineers and delivering scalable, business-driving AI solutions.

Lead architecture and delivery of scalable, production-grade ML/AI platforms and Python SDKs. Design Agentic AI and multi-agent systems, build FastAPI services, implement CI/CD, observability with Galileo, mentor engineers, and troubleshoot distributed AI systems for high availability and performance.

The Machine Learning Engineer will develop software solutions, optimize data pipelines, and deploy machine learning models using cloud platforms and best practices.