Top Senior Software Engineer Jobs in St. Louis, MO

Modernize and evolve a large-scale React Native mobile app with offline-first architecture, BLE device integrations, local data storage and sync. Improve performance, reliability, and scalability, influence architecture, mentor developers, collaborate cross-functionally, and occasionally visit farms to understand user workflows.

Own HUD’s production infrastructure and backend platform systems, focusing on reliability, scalability, performance, cost, deployment safety, and developer experience. Build AWS infrastructure with Terraform and Kubernetes, improve CI/CD and observability, design resilient services and asynchronous systems, manage incidents, and develop internal automation and tooling. The role supports high-availability AI, marketplace, and data-heavy workloads.

Develop and launch scalable web and mobile healthcare applications, APIs, integrations, and cloud infrastructure. Contribute to the technical roadmap, observability, security, compliance, and AI/ML infrastructure. Partner with the founding team and data science leadership to incorporate LLMs, support HIPAA and SOC 2 requirements, and build reliable products for patients and enterprise healthcare customers.

Leads development of scalable backend systems and applications for the Mindbody ecosystem. Responsibilities include designing APIs and microservices, owning complex technical projects, collaborating with Product, Design, and QA, promoting engineering best practices, mentoring engineers, conducting code reviews and interviews, and leading incident postmortems. The role requires strong software architecture experience, large-scale SaaS development, cloud and database expertise, and effective cross-functional leadership.

Senior Software Engineer responsible for compliance validation, defect remediation, production migration support, monitoring, and operational documentation for a federal ESA Section 7 data integration platform. The role validates decision logic and consultation routing, develops migration runbooks and rollback procedures, resolves critical application defects, supports post-deployment operations, incorporates user feedback, and enforces code review and version control practices.

Design, build, and scale highly available backend and frontend systems powering Coinbase trading experiences for millions of users. Architect extensible support for multiple trading types and assets, evolve critical production infrastructure, partner with product and design, and promote engineering quality through code reviews, mentorship, and knowledge sharing.

Build and own automation systems that eliminate friction across engineering, operations, and compliance. Responsibilities include regulatory workflow automation, CI/CD and developer productivity tooling, AI- and LLM-enabled internal workflows, system integrations, and reliable production software with testing, observability, auditability, and failure handling.

Build and maintain Python backend services, APIs, healthcare integrations, and reliable platform infrastructure. Collaborate with product, frontend, engineering, and clinical teams to define functionality, ensure safety, troubleshoot production issues, and deliver projects end to end. Contribute to DevOps, CI/CD, observability, testing, code review, and technical architecture for an AI-powered healthcare platform.

Build and maintain reliable integrations between UpDoc and healthcare systems, EHRs, and external APIs. Own integration projects from discovery and architecture through deployment, monitoring, troubleshooting, and maintenance. Develop Python APIs and backend services using FastAPI and Pydantic, implement healthcare interoperability standards, handle failures and data integrity, and create automated tests. Collaborate with healthcare technology stakeholders while supporting security, HIPAA, SOC 2, observability, and clinical reliability requirements.

Design, develop, deploy, and maintain scalable cloud applications and client-installed agents using C# and .NET. Own platform integrations, troubleshoot production issues, optimize performance and costs, improve testing and automation, and uphold software security and quality. Collaborate with product, architecture, UX, support, and customers; contribute to technical and architectural decisions; and mentor engineers. The role also requires polyglot development across integrations and familiarity with cloud security, PAM, Azure, CI/CD, and automation practices.

Leads full-cycle technical implementations of a cloud-based digital banking platform, translating client requirements into configurations, custom SDK/API solutions, integrations, data conversions, testing, and production launches. Manages client environments, troubleshoots technical issues, supports post-launch operations, and coordinates with Product, Engineering, Services, and Support teams. The role also improves implementation processes, documents technical specifications, manages risks, supports performance testing, and mentors junior team members.

Lead and deliver quarterly goals for a backend team; guide engineers through ambiguous problems; collaborate with product, design, and analytics; identify and resolve project and technical issues; ensure operational availability and on-call readiness; set code and design quality standards; and mentor and develop team members.

Build and own scalable payments infrastructure for card issuing, transaction processing, and settlement. Design reliable integrations with Stripe, banking partners, and internal platforms using .NET, C#, Azure, DDD, CQRS, and event-driven architectures. Improve system reliability, observability, performance, security, and compliance while mentoring engineers and contributing to technical direction. Apply AI-assisted development across coding, testing, debugging, and engineering workflows.

The Senior Backend Software Engineer will design and scale backend systems using Python and FastAPI, collaborate with researchers, optimize infrastructure, and implement testing and monitoring systems.

The Senior Bilingual Software Engineer will align U.S. teams with the Platform Core team in Japan, focusing on high-impact problems and maximizing platform leverage through clear communication and collaboration.

The Backend Software Engineer will develop and maintain backend systems for data processing related to coffee farming, utilizing Python and PostgreSQL. Responsibilities include feature development, problem-solving, and adapting systems to regulatory changes while ensuring system resilience.

Develop and enhance software solutions for mineral exploration, collaborating with geologists and data scientists, and driving insights from data systems.

The Edge Functions Engineer will evolve the Supabase Edge Runtime, implement monitoring and optimizations, manage features, and work closely with the Deno open-source teams.

Design, build, and maintain scalable end-to-end systems and APIs/SDKs for an enterprise custody platform. Work full-stack across databases, cloud deployments, CI/CD, and security; troubleshoot issues, integrate emerging technologies, and mentor junior engineers.

Design, develop, and maintain scalable web applications using .NET backend and Angular/React frontend. Collaborate on requirements, implement RESTful APIs, optimize performance, debug, maintain documentation, support end-users, and work within CI/CD and DevOps workflows.

Design, develop, customize and integrate Microsoft Dynamics 365 CRM/CE solutions. Build entities, forms, workflows, plugins, reports and dashboards using CRM SDK, C#, JavaScript, ASP.NET and SQL. Troubleshoot issues, estimate implementation approaches, collaborate with stakeholders, document solutions, and mentor junior developers. Banking domain experience preferred.

Build and maintain secure, full-stack cybersecurity and compliance applications for cloud and on-premise environments. Develop APIs, integrations, data ingestion and normalization, risk analytics, relationship models, role-based access, CI/CD pipelines, and containerized deployments. Support post-quantum cryptography and compliance workflows while troubleshooting production issues and applying DevSecOps practices. Collaborate across engineering, cloud, cybersecurity, and compliance teams in a highly regulated, ambiguous product environment.

Design, develop, and maintain high-quality cloud-based applications within an Agile team. Collaborate on architecture, product requirements, and software development; troubleshoot production issues; evaluate technologies; provide technical leadership; and optimize performance through memory management, parallelization, and algorithm efficiency. The role also involves building multitenant database architectures, implementing secure APIs and event-driven systems, writing unit tests, and debugging complex software issues.

As a Founding Software Engineer, you'll design, develop, and maintain robust backend systems, create user-facing AI features, and collaborate with teams to enhance healthcare tools.

Lead full‑stack development and architecture for Spark’s broker platform. Deliver customer‑facing features, partner with product/design, mentor engineers, resolve technical debt, and set engineering standards while using AI developer tools.